Meta-Analysis
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World J Meta-Anal. Aug 26, 2014; 2(3): 91-97
Published online Aug 26, 2014. doi: 10.13105/wjma.v2.i3.91
Role of statin on mortality outcome in pneumonia patients: A meta-analysis
Lekha Saha, Narinder Kumar, Pratibha Khosla, Sharonjeet Kaur
Lekha Saha, Pratibha Khosla, Sharonjeet Kaur, Department of Pharmacology, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India
Narinder Kumar, Department of Statistics, Panjab University, Chandigarh 160014, India
Author contributions: Saha L, Khosla P and Kaur S were equally involved in planning, data extraction, calculating and writing the manuscript; Kumar N is involved in data extraction, statistical analysis and writing of the manuscript.
Correspondence to: Dr. Lekha Saha, Assistant Professor, Department of Pharmacology, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh 160012, India. lekhasaha@rediffmail.com
Telephone: +91-172-2645262 Fax: +91-172-2744401
Received: March 11, 2014
Revised: May 23, 2014
Accepted: June 18, 2014
Published online: August 26, 2014
Core Tip

Core tip: The relation between statin treatment and improvement in outcomes in patients with pneumonia have been reported in published literatures. This is believed to be due to anti-inflammatory and immunoregulatory effects rather than an effect on cholesterol metabolism. Recently, however, the potential benefit of statins has been called into question and the study has suggested that there may be confounding factor responsible for the observed benefit. All the studies were observational. In this present meta-analysis of randomized controlled trials, results showed the non-significant effect of the statin on mortality outcome.