Meta-Analysis
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World J Meta-Anal. Nov 26, 2013; 1(3): 147-156
Published online Nov 26, 2013. doi: 10.13105/wjma.v1.i3.147
Accuracy of early detection of colorectal tumours using stool methylation markers: A meta-analysis
Hu Zhang, You-Qing Zhu, Jian Qi, Qi-Xian Wang, Sha-Sha Cai, Si-Ying Zhu, Xiao-Wen Zhu, Xin-Tao Wang
Hu Zhang, You-Qing Zhu, Jian Qi, Qi-Xian Wang, Sha-Sha Cai, Si-Ying Zhu, Xiao-Wen Zhu, Xin-Tao Wang, Department of Gastroenterology and Clinical Center of Intestinal and Colorectal Diseases of Hubei Province, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei Province, China
Author contributions: Qi J and Zhu YQ designed this study and critically revised the article; Zhang H and Qi J were responsible for data acquisition and extracted the data; Zhang H drafted the manuscript, analyzed the data and interpreted the results; Wang QX, Cai SS, Zhu SY, Zhu XW and Wang XT were involved in editing the manuscript; all authors read and approved the final manuscript to be published.
Supported by The National Natural Science Foundation of China Youth Science Fund, No. 81101868; The Natural Science Foundation of Hubei Province of China, No. 2011CDB505
Correspondence to: Dr. Jian Qi, Department of Gastroenterology and Clinical Center of Intestinal and Colorectal Diseases of Hubei Province, Zhongnan Hospital of Wuhan University, 169 Wuchang Donghu Lu, Wuhan 430071, Hubei Province, China. qiqidelizi@aliyun.com
Telephone: +86-27-87336141 Fax: +86-27-87336141
Received: July 9, 2013
Revised: October 21, 2013
Accepted: November 2, 2013
Published online: November 26, 2013
Core Tip

Core tip: The analysis of stool methylation markers as a non-invasive test is important for the early diagnosis of colorectal tumours. However, no consensus has been reached with regard to the role of stool methylation markers in colorectal tumour diagnosis. We performed a meta-analysis of 34 articles, and the pooled results showed that stool methylation markers could be used as a valuable diagnostic and predictive tool for colorectal tumours and SFRP2 methylation serves as a promising marker with great potential in early colorectal cancer diagnosis.