Meta-Analysis
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World J Meta-Anal. Nov 26, 2013; 1(3): 138-146
Published online Nov 26, 2013. doi: 10.13105/wjma.v1.i3.138
Relationship between apolipoprotein E gene polymorphism and total cholesterol level in patients with kidney diseases
Tian-Biao Zhou, Zong-Pei Jiang, Sheng-Sheng Yin, Yuan-Han Qin
Tian-Biao Zhou, Zong-Pei Jiang, Sheng-Sheng Yin, Department of Nephrology, The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510655, Guangdong Province, China
Tian-Biao Zhou, Sheng-Sheng Yin, Yuan-Han Qin, Department of Pediatric Nephrology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Author contributions: Zhou TB and Jiang ZP contributed equally to this work; Zhou TB, Jiang ZP, Yin SS and Qin YH performed the literature search, study selection and data extraction; Zhou TB and Jiang ZP analyzed the results; Zhou TB, Jiang ZP and Yin SS did the statistical analysis; Zhou TB wrote the manuscript; all authors have approved the final manuscript.
Supported by Beijing NOVA Programme, No. Z131107000413067; and the Research Fund of the China-Japan Friendship Hospital, Nos. 2013-QN-07 and 2013-QN-06
Correspondence to: Tian-Biao Zhou, Associate Research Scientist, Department of Nephrology, The Sixth Affiliated Hospital of Sun Yat-Sen University, Tianhe District, Guangzhou 510655, Guangdong Province, China. a126tianbiao@126.com
Telephone: +86-771-2326191 Fax: +86-771-2326191
Received: April 14, 2013
Revised: June 13, 2013
Accepted: August 4, 2013
Published online: November 26, 2013
Core Tip

Core tip: The available evidence for an association between apolipoprotein E (apoE) and total cholesterol (TC) in kidney disease is weak and has conflicting results. This meta-analysis based on 21 included studies indicated that subjects with apoE E3E4 and 4 had a higher TC level and subjects with apoE E2E3 and ε2 had a higher TC level in patients with kidney disease.