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World J Meta-Anal. Aug 26, 2013; 1(2): 90-96
Published online Aug 26, 2013. doi: 10.13105/wjma.v1.i2.90
Published online Aug 26, 2013. doi: 10.13105/wjma.v1.i2.90
Subclinical hypothyroidism and the metabolic syndrome: A meta-analysis of cross-sectional studies
Yi-Cong Ye, Hong-Zhi Xie, Xi-Liang Zhao, Shu-Yang Zhang, Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China
Author contributions: Zhang SY contributed to the concept design, data analysis and manuscript revision; Ye YC and Xie HZ contributed to the database search, study selection, quality assessment, statistic analysis, data interpretation and drafting the manuscript; Zhao XL contributed to data analysis and drafting the manuscript.
Correspondence to: Dr. Shu-Yang Zhang, Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Dongcheng District Dongdansantiao, Beijing 100730, China. zhangebmg@gmail.com
Telephone: +86-10-69155068 Fax: +86-10-69155068
Received: February 20, 2013
Revised: May 23, 2013
Accepted: June 1, 2013
Published online: August 26, 2013
Revised: May 23, 2013
Accepted: June 1, 2013
Published online: August 26, 2013
Core Tip
Core tip: A recent meta-analysis of individual data concluded that subclinical hypothyroidism (SCH) is associated with an increased risk of coronary heart disease (CHD) and CHD mortality. Meanwhile, it has been well recognized that the metabolic syndrome (MS) is associated with increased cardiovascular events and all-cause mortality. Our meta-analysis of cross-sectional data demonstrated that SCH may be associated with an increased risk of the MS, which may explain the relationship between SCH and increased risk of CHD.