Meta-Analysis
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World J Meta-Anal. Aug 26, 2013; 1(2): 78-82
Published online Aug 26, 2013. doi: 10.13105/wjma.v1.i2.78
Ophthalmic adverse drug reactions: A nationwide detection using hospital databases
Ana Miguel, Filipe Henriques, Bernardo Marques, Joana Marques, Alberto Freitas, Fernando Lopes, Luís Azevedo, Altamiro Costa Pereira
Ana Miguel, Bernardo Marques, Alberto Freitas, Fernando Lopes, Luís Azevedo, Altamiro Costa Pereira, Centre for Research in Health Technologies and Information Systems, Faculty of Medicine, University of Porto, 4430-182 V.N.Gaia, Portugal
Ana Miguel, Filipe Henriques, Department of Ophthalmology, Central University Hospital of Coimbra, 3040-091 Coimbra, Portugal
Joana Marques, Northern Pharmacovigilance Centre, Faculty of Medicine, University of Porto, 4430-182 V.N.Gaia, Portugal
Author contributions: All authors contributed to this paper.
Correspondence to: Ana Miguel, MD, Centre for Research in Health Technologies and Information Systems, Faculty of Medicine, University of Porto, Rua Quinta do Sardoal, VE3, nº10, 4430-182 V.N.Gaia, Portugal. myworld_ana@hotmail.com
Telephone: +35-193-2482477 Fax: +35-123-9119864
Received: February 4, 2013
Revised: June 10, 2013
Accepted: July 18, 2013
Published online: August 26, 2013
Core Tip

Core tip: We used International Classification of Diseases - 9th Revision - Clinical Modification coding data for the detection of adverse drug reactions (ADRs). From 11944725 episodes, we identified 1524 probable ophthalmic ADRs. 113 spontaneous reports arose from that population. This was the first nationwide study of ophthalmic ADRs and may represent a new Pharmacovigilance approach, with a higher detection than spontaneous reporting.