Published online Aug 28, 2021. doi: 10.13105/wjma.v9.i4.342
Peer-review started: March 28, 2021
First decision: April 28, 2021
Revised: July 3, 2021
Accepted: August 24, 2021
Article in press: August 24, 2021
Published online: August 28, 2021
Troponin-I on admission has a high predicting value for coronavirus disease 2019 (COVID-19) related mortality. Troponin-I on admission has a high predicting value for COVID-19 related morbidity. Troponin-I can strongly predict disease sequels including acute respiratory distress syndrome (ARDS), kidney injury, and Intensive care units (ICU) admission requirement.
Accurate and early diagnosis and determination of COVID-19 severity can prevent its further progression. The increase in circulating troponin-I in the blood of patients suffering COVID-19 can be a strong prognostic factor for predicting disease poorer outcome. We systematically reviewed the literatures to approve this claim.
The increase in circulating troponin-I in the blood of patients suffering COVID-19 can be a strong prognostic factor for predicting disease poorer outcome.
Deeply searching the manuscript databanks was planned. All studies that evaluated the link between the serum level of troponin-I and two COVID-19 related parameters including disease severity and mortality were considered to be eligible for primary assessment. The review papers, case presentations, letter to editors, non-English studies, and abstracts without full text access were all excluded. The manuscript reviewing was done by two blinded reviewers, screening the titles and abstracts followed by profound appraisement of the full texts independently to assess the inclusion appropriateness. The presence of any disagreement between them was judged and checked again by another reviewer as the last arbiter.
Comparing outcome of COVID-19 disease in the groups with raised troponin level and normal level of this markers showed increased the likelihood of death [hazard ratio (HR) = 4.967, P < 0.001], acute respiratory distress syndrome (HR = 5.914, P < 0.001), acute kidney injury (HR = 3.849, P < 0.001), and ICU admission (HR = 3.780, P < 0.001) following raise of troponin. The pooled analysis showed significantly higher concentration of this marker in the survived group compared to non-survived group (weighted mean differences of 22.278, 95%CI: 15.647 to 28.927, P < 0.001).
In conclusion, according to our findings, regardless of the history of myocardial injuries or the presence of cardiovascular risk profile, the value of troponin-I should be accurately assessed on admission because of its high predicting value for COVID-19 related mortality and morbidity.
The value of troponin-I should be accurately assessed on admission because of its high predicting value for COVID-19 related mortality and morbidity.