Karbalaei M, Sahebkar A, Keikha M. Helicobacter pylori infection and susceptibility to cardiac syndrome X: A systematic review and meta-analysis. World J Meta-Anal 2021; 9(2): 208-219 [DOI: 10.13105/wjma.v9.i2.208]
Corresponding Author of This Article
Masoud Keikha, PhD, Doctor, Instructor, Teaching Assistant, Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Park Square, Mashhad 9177948974, Iran. masoud.keykha90@gmail.com
Research Domain of This Article
Infectious Diseases
Article-Type of This Article
Meta-Analysis
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Mohsen Karbalaei, Department of Microbiology and Virology, Faculty of Medicine, Jiroft University of Medical Sciences, Jiroft 43317803, Iran
Amirhossein Sahebkar, Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
Amirhossein Sahebkar, Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Masoud Keikha, Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad 9177948974, Iran
Author contributions: Keikha M and Sahebkar A equally contributed to the conception and design of the study; Karbalaei M and Keikha M conducted the literature review and analyses; All authors equally contributed to drafting and critical revision and editing of the manuscript, and approved the final version.
Conflict-of-interest statement: No potential conflicts of interest.
PRISMA 2009 Checklist statement: The manuscript was revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Masoud Keikha, PhD, Doctor, Instructor, Teaching Assistant, Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Park Square, Mashhad 9177948974, Iran. masoud.keykha90@gmail.com
Received: December 30, 2020 Peer-review started: December 30, 2020 First decision: February 28, 2021 Revised: March 3, 2021 Accepted: April 23, 2021 Article in press: April 23, 2021 Published online: April 28, 2021
ARTICLE HIGHLIGHTS
Research background
Cardiac syndrome X (CSX) is multilateral condition that not well characterized.
Research motivation
For the first time, we investigated the probable association between Helicobacter pylori (H. pylori) infection and risk of develop to cardiac syndrome.
Research objectives
In the present study, the association between H. pylori infection and CSX was investigated.
Research methods
We searched several databases to collecting all available documents relevant to impact of H. pylori infection and susceptibility to CSX. odds ratio (OR) is used for estimation of probable link between H. pylori infection and CSX.
Research results
There is a positive association between H. pylori infection and risk of develop to CSX (OR: 5.65, 95%CI: 4.17-7.64, I2: 82.20).
Research conclusions
In this study, we found that H. pylori infection increases the risk of CSX. We showed that there is no significant relationship between cagA status and progression to CSX. The frequency of vascular endothelial destructive risk factors such as hyperlipidemia and hypertension in patients infected with H. pylori was significantly higher than the control group.
Research perspectives
Infectious agents such as H. pylori infection can provide a condition to susceptibility of CSX.
