Systematic Review
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Meta-Anal. Jun 30, 2019; 7(6): 297-308
Published online Jun 30, 2019. doi: 10.13105/wjma.v7.i6.297
Treatment options for rumination syndrome: A systematic review
Andrew Ming-Liang Ong, Shu-Wen Tay, Yu-Tien Wang
Andrew Ming-Liang Ong, Shu-Wen Tay, Yu-Tien Wang, Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore 169856, Singapore
Andrew Ming-Liang Ong, Yu-Tien Wang, Duke-NUS Graduate Medical School, Singapore 169856, Singapore
Author contributions: Ong AML wrote the manuscript and performed the research. Wang YT and Tay SW performed the research and contributed to the editing of the manuscript. All authors have approved the final version of the manuscript. The manuscript is original work of author. All data, tables, figures, etc. used in the manuscript are prepared originally by authors, otherwise the sources are cited and reprint permission should be attached.
Conflict-of-interest statement: The authors have no conflict of interest to declare.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Andrew Ming-Liang Ong, MBChB, MRCP, Assistant Professor, Doctor, Department of Gastroenterology and Hepatology, Singapore General Hospital, 20 College Road, Level 3, Academia Building, Singapore 169856, Singapore.
Telephone: +65-6321-4684 Fax: +65-6227-3623
Received: April 22, 2019
Peer-review started: April 23, 2019
First decision: May 24, 2019
Revised: May 31, 2019
Accepted: June 10, 2019
Article in press: June 10, 2019
Published online: June 30, 2019
Research background

Rumination syndrome (RS) is a relatively common yet underdiagnosed condition.

Research motivation

There is no consensus on how to treat patients diagnosed with runination syndrome.

Research objectives

Our objectives are to systematically review the literature on the efficacy of treatment options for adults with RS.

Research methods

We conducted a systematic review according to PRISMA guidelines. We searched Medline (1946 to February 2019), EMBASE (1947 to February 2019), PsycINFO (1806 to February 2019) and Cochrane central register of controlled trials for articles discussing treatment options for adult patients (> 18 years) with RS. All relevant articles were accessed in full text. We extracted data on study designs, patient profiles, duration of symptoms, follow up periods, date, diagnostic criteria, interventions and outcomes. Risk of bias assessment was carried out independently by 3 reviewers via Cochrane Risk of Bias tool and Newcastle Ottawa Scale for RCTs and Cohort studies respectively.

Research results

12 articles were identified. The strongest evidence pointed towards diaphragmatic breathing (DB), and less so for baclofen. A total of 254 patients were included in the analysis.

Research conclusions

DB has the strongest evidence for efficacy in adults with RS.

Research perspectives

The quality of the evidence is still weak. More research needs to be done in this field.