Systematic Review
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Meta-Anal. Jun 30, 2019; 7(6): 269-289
Published online Jun 30, 2019. doi: 10.13105/wjma.v7.i6.269
Significance of multivisceral resections in oncologic surgery: A systematic review of the literature
Giorgi Nadiradze, Can Yurttas, Alfred Königsrainer, Philipp Horvath
Giorgi Nadiradze, Can Yurttas, Alfred Königsrainer, Philipp Horvath, Department of General, Visceral and Transplant Surgery, University of Tübingen, Comprehensive Cancer Center, Tübingen 72076, Germany
Philipp Horvath, National Center for Pleura and Peritoneum, Tübingen 72076, Germany
Author contributions: Nadiradze G and Yurttas C contributed equally to this work. Königsrainer A initiated the study and approved the final version of the manuscript; Nadiradze G and Yurttas C participated in developing the manuscript and approved the final version of the manuscript. Horvath P led the literature research, abstracted and analyzed the data and developed the manuscript.
Conflict-of-interest statement: We declare that we have no conflict of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared according to the PRISMA 2009 checklist.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Philipp Horvath, MD, Surgeon, Surgical Oncologist, Department of General, Visceral and Transplant Surgery, University of Tübingen, Comprehensive Cancer Center, Hoppe-Seyler-Strasse 3, Tübingen 72076, Germany.
Telephone: +49-7071-2986620 Fax: +49-7071-295588
Received: March 20, 2019
Peer-review started: March 20, 2019
First decision: May 16, 2019
Revised: June 7, 2019
Accepted: June 16, 2019
Article in press: June 17, 2019
Published online: June 30, 2019
Research background

Multivisceral resections (MVR) still constitute a challenge for the interdisciplinary team. The indications to perform MVR are not clearly defined.

Research motivation

Motivation was generated by the fact that there are no recommendations regarding MVR.

Research objectives

In order to define indications and factors associated with beneficial oncologic outcomes and reduced perioperative morbidity and mortality this systematic review was conducted.

Research methods

We performed a PubMed-search from 2000 to 2018 including articles reporting on MVR in pa-tients with colon-, rectal- and gastric cancer.

Research results

Available data shows that MVR from locally advanced colorectal and gastric cancer is a feasible option which is associated with acceptable morbidity- and mortality-rates. Oncologic outcome is favorable when clear resection margins can be obtained.

Research conclusions

Patients who are clinically fit and preoperative imaging does not reveal obvious contraindication for radical surgery, the option of MVR should not be abandoned. Clear resection margins are the main goal of aggressive surgical approach.

Research perspectives

Perspectives are to evaluate more patient- and treatmenspecific parameters in order to define more clearly patients who are likely to benefit from this approach.