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Nagaishi M, Tanaka Y, Iwatate K, Yokoo H, Ueki K, Hyodo A, Nakazato Y. Polar spongioblastoma: A high-grade glioma that does not contain the IDH1 mutation or 1p/19q LOH. Neuropathology 2010; 30:547-52. [PMID: 20102524 DOI: 10.1111/j.1440-1789.2009.01087.x] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/27/2022]
Abstract
We report a case of an unusual glioma termed "primitive polar spongioblastoma" that displayed characteristic palisading tumor cells at the light microscopic level. The patient was a 52-year-old woman who underwent subtotal removal for a left frontotemporal tumor. The palisading pattern was present throughout the tumor. Several glial markers were revealed by immunohistochemical examination, but no neuronal markers were observed. Genetic studies showed O-6-methylguanine-DNA methyltransferase (MGMT) methylation, wild type IDH1, and the absence of 1p/19q loss of heterozygosity (LOH) in the tumor genes. Based on histological and genetic features, this tumor might not be suited to any of neuroepithelial tumor in the recent WHO classification. We consider that cases such as this should be temporarily set under a separate heading and be entrusted to future investigation after more cases have been accumulated.
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Affiliation(s)
- Masaya Nagaishi
- Department of Human Pathology, Gunma University Graduate School of Medicine, Gunma,Department of Neurosurgery, Koshigaya hospital Dokkyo University School of Medicine, Saitama andDepartment of Neurosurgery, Dokkyo University School of Medicine, Tochigi, Japan
| | - Yoshihiro Tanaka
- Department of Human Pathology, Gunma University Graduate School of Medicine, Gunma,Department of Neurosurgery, Koshigaya hospital Dokkyo University School of Medicine, Saitama andDepartment of Neurosurgery, Dokkyo University School of Medicine, Tochigi, Japan
| | - Kensho Iwatate
- Department of Human Pathology, Gunma University Graduate School of Medicine, Gunma,Department of Neurosurgery, Koshigaya hospital Dokkyo University School of Medicine, Saitama andDepartment of Neurosurgery, Dokkyo University School of Medicine, Tochigi, Japan
| | - Hideaki Yokoo
- Department of Human Pathology, Gunma University Graduate School of Medicine, Gunma,Department of Neurosurgery, Koshigaya hospital Dokkyo University School of Medicine, Saitama andDepartment of Neurosurgery, Dokkyo University School of Medicine, Tochigi, Japan
| | - Keisuke Ueki
- Department of Human Pathology, Gunma University Graduate School of Medicine, Gunma,Department of Neurosurgery, Koshigaya hospital Dokkyo University School of Medicine, Saitama andDepartment of Neurosurgery, Dokkyo University School of Medicine, Tochigi, Japan
| | - Akio Hyodo
- Department of Human Pathology, Gunma University Graduate School of Medicine, Gunma,Department of Neurosurgery, Koshigaya hospital Dokkyo University School of Medicine, Saitama andDepartment of Neurosurgery, Dokkyo University School of Medicine, Tochigi, Japan
| | - Yoichi Nakazato
- Department of Human Pathology, Gunma University Graduate School of Medicine, Gunma,Department of Neurosurgery, Koshigaya hospital Dokkyo University School of Medicine, Saitama andDepartment of Neurosurgery, Dokkyo University School of Medicine, Tochigi, Japan
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