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Yang H, Xiang Z, Chen P. Clinical efficacy and safety of antibiotic combination therapy in the treatment of community-acquired pneumonia in children. Pak J Med Sci 2025; 41:958-962. [PMID: 40290216 PMCID: PMC12022586 DOI: 10.12669/pjms.41.4.10236] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/27/2024] [Revised: 01/31/2025] [Accepted: 02/25/2025] [Indexed: 04/30/2025] Open
Abstract
Objective To determine the efficacy and safety of cefotaxime combined with azithromycin in the treatment of children with community-acquired pneumonia (CAP) and its effect on inflammatory factors. Methods This is an observational study. A total of 118 children with CAP admitted to our hospital from June, 2022 to December, 2023 were randomly selected. According to the random number table method, they were divided into a control group and a combination treatment group, with 59 children in each group. The children in the control group were treated with azithromycin, and those in the combination treatment group were treated with cefotaxime combined with azithromycin. Both groups were treated for a week. The disappearance time of symptoms (fever, pulmonary rales, cough) and the improvement of inflammatory indicators (serum interleukin-6 (IL-6), serum C-reactive protein (CRP), and serum interleukin-8 (IL-8)) after treatment were compared. The clinical efficacy and adverse reactions were compared between the two groups. Results The disappearance time of fever, pulmonary rales, and cough in the combination treatment group was significantly shorter than that in the control group (P < 0.05). After treatment, the serum levels of CRP, IL-6, and IL-8 in the two groups were lower than those before treatment, and the reduction in the combination treatment group was larger than that in the control group (P < 0.05). The total efficacy of the combination treatment group was significantly higher than that of the control group (P < 0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P > 0.05). Conclusion Cefotaxime combined with azithromycin in the treatment of CAP in children can significantly improve the efficacy, quickly relieve clinical symptoms, improve the body's defense mechanism, inhibit inflammatory response, and has high safety, which is worthy of clinical promotion.
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Affiliation(s)
- Huan Yang
- Huan Yang, Department of Pediatrics, The Central Hospital of Enshi, Tujia and Miao Autonomous Prefecture, Enshi, Hubei, 445000, China
| | - Zhengke Xiang
- Zhengke Xiang, Department of Pediatrics, The Central Hospital of Enshi, Tujia and Miao Autonomous Prefecture, Enshi, Hubei, 445000, China
| | - Peiwei Chen
- Peiwei Chen, Department of Pediatrics, The Central Hospital of Enshi, Tujia and Miao Autonomous Prefecture, Enshi, Hubei, 445000, China
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Sun R, Zhang Y, Cheng F, Zhao Y. Effect of pulmonary rehabilitation nursing approach with integrated traditional Chinese and western medicine in children with Mycoplasma Pneumonia after Bronchoalveolar Lavage. Pak J Med Sci 2025; 41:1105-1109. [PMID: 40290258 PMCID: PMC12022583 DOI: 10.12669/pjms.41.4.9787] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/07/2024] [Revised: 10/17/2024] [Accepted: 01/15/2025] [Indexed: 04/30/2025] Open
Abstract
Objective To investigate the effect of pulmonary rehabilitation nursing approach with integrated traditional Chinese and Western medicine in children with mycoplasma pneumonia after bronchoalveolar lavage. Methods This was a clinical comparative study conducted at Pediatrics Department of Xingtai People's Hospital from October 2019 to May 2023. One hundred and sixty children with mycoplasma pneumonia were selected for pulmonary rehabilitation and randomly divided into the observation group(n=80) and the control group(n=80). Both groups were given the same clinical treatment, the patients in the control group received routine pneumonia nursing interventions, while the observation group received the pulmonary rehabilitation with integrated traditional Chinese and Western medicine based on interventions for the control group. The comfort level, compliance, psychological status of children, and nursing satisfaction were investigated after nursing interventions in both groups. Results The post-intervention comfort levels in both groups significantly improved compared to the pre-intervention levels, with a significantly greater improvement in the observation group than in the control group (p<0.05). The total compliance rate in the observation group was 95.00%, higher than the 83.75% in the control group (p<0.05). Meanwhile, the post-intervention SCARED and DSRSC scores in both groups were significantly higher than the pre-intervention scores, with a significantly greater improvement in the observation group than in the control group (p<0.05). Conclusion The nursing approach with integrated traditional Chinese and Western medicine for pulmonary rehabilitation in children with mycoplasma pneumonia is significantly effective, which can improve children's comfort and compliance, and boost acceptance of nursing measures.
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Affiliation(s)
- Ruixue Sun
- Ruixue Sun Department of Pediatrics, Xingtai People’s Hospital, Xingtai 054000, Hebei, China
| | - Yanling Zhang
- Yanling Zhang Department of Pediatrics, Xingtai People’s Hospital, Xingtai 054000, Hebei, China
| | - Fang Cheng
- Fang Cheng Department of Pediatrics, Xingtai People’s Hospital, Xingtai 054000, Hebei, China
| | - Yan Zhao
- Yan Zhao Department of Pediatrics, Xingtai People’s Hospital, Xingtai 054000, Hebei, China
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Yue Y, Liang Q, Shi L, Bai WJ, Fu J. Effect of comprehensive nursing intervention on the efficacy of spleen aminopeptide combined with aerosol inhalation in the treatment of pediatric pneumonia. Pak J Med Sci 2023; 39:1086-1090. [PMID: 37492332 PMCID: PMC10364302 DOI: 10.12669/pjms.39.4.7195] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/29/2022] [Revised: 01/14/2023] [Accepted: 04/27/2023] [Indexed: 07/27/2023] Open
Abstract
Objective To analyze the effect of comprehensive nursing intervention on the efficacy of spleen aminopeptide combined with aerosol inhalation in the treatment of pediatric pneumonia. Methods This is a retrospective study. Eighty children with pneumonia admitted to Baoding children's Hospital from March 2020 to March 2021 were included and randomly divided into two groups. Children in the control group received routine treatment and nursing measures, while those in the experimental group received comprehensive nursing intervention on the basis of routine treatment in the control group. The differences in clinical effect, symptom improvement time, nursing quality score and satisfaction score between the two groups were compared and analyzed. Results The efficacy of the experimental group was significantly higher than that of the control group (p=0.02). After comprehensive nursing intervention, the cough disappearance time, body temperature recovery time, pulmonary rales disappearance time and hospitalization time in the experimental group were significantly shorter than those in the control group, with statistically significant differences (p<0.05). The scores of nursing quality such as health guidance, nursing operation, and medication management in the experimental group were higher than those in the control group, with significant differences in the data comparison between the groups (p<0.05). The satisfaction of the experimental group was 100%, which was higher than 90% of the control group, with a statistically significant difference (p=0.04). Conclusion Comprehensive nursing intervention boasts various significant effects in the treatment of pediatric pneumonia, such as rapid amelioration of the condition, improvement of efficacy, and enhancement of nursing quality and satisfaction.
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Affiliation(s)
- Yuan Yue
- Yuan Yue Department of Outpatient, Baoding Children’s Hospital, Baoding 071000, Hebei, China
| | - Qian Liang
- Qian Liang Department of Emergency, Baoding Children’s Hospital, Baoding 071000, Hebei, China
| | - Lei Shi
- Lei Shi, Department of Outpatient, Baoding Children’s Hospital, Baoding 071000, Hebei, China
| | - Wen-jing Bai
- Wen-jing Bai Department of Outpatient, Baoding Children’s Hospital, Baoding 071000, Hebei, China
| | - Juan Fu
- Juan Fu Department of Outpatient, Baoding Children’s Hospital, Baoding 071000, Hebei, China
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Fu X, Yang N, Ji J. Application of CT images based on the optimal atlas segmentation algorithm in the clinical diagnosis of Mycoplasma Pneumoniae Pneumonia in Children. Pak J Med Sci 2021; 37:1647-1651. [PMID: 34712299 PMCID: PMC8520366 DOI: 10.12669/pjms.37.6-wit.4860] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/09/2021] [Revised: 06/12/2021] [Accepted: 07/08/2021] [Indexed: 11/15/2022] Open
Abstract
Objective Use of optimal Atlas segmentation algorithm to study the imaging signs of mycoplasma pneumonia with multi-slice spiral CT (HRCT), and to explore the value of HRCT in the diagnosis and efficacy in evaluation of mycoplasma pneumonia in children. Methods The study retrospectively analyzed 72 patients diagnosed with mycoplasma pneumonia in our hospital from January 2017 to January 2019. The imaging data and clinical data of 72 patients were collected. The optimal Atlas segmentation algorithm was used to analyze the characteristics of CT examination, and the value of CT in the diagnosis of mycoplasma pneumonia and the evaluation of curative effect was summarized. Results Among all patients, 37 cases were unilateral lesions, 35 cases were bilateral lesions, 19 cases were in the left upper lobe, 24 cases were in the left lower lobe, 21 cases were in the right upper lobe, 13 cases were in the right middle lobe, 25 The lesion was located in the right lower lobe. The main CT findings of the lesions before treatment were large patchy, spot-shaped shadows, and strip-shaped or ground-glass shadows. After treatment, the main CT findings of the lesions were reduced lesion density and reduced lesion range. Conclusion CT can clearly show the pulmonary lesions of mycoplasma pneumonia, and its unique imaging signs can improve the clinical diagnosis accuracy. In addition, CT scans can evaluate the treatment effect according to the changes in the characteristics of the lesion, which has important value for the evaluation of the effect for clinical diagnosis and efficacy evaluation of mycoplasma pneumonia.
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Affiliation(s)
- Xilin Fu
- Xilin Fu, Attending Physician, Department of Pediatrics, Yiwu Central Hospital, Yiwu, 322000, China
| | - Ningfei Yang
- Ningfei Yang, Attending Physician, Department of Pediatrics, Yiwu Central Hospital, Yiwu, 322000, China
| | - Jianwei Ji
- Jianwei Ji, Attending Physician, Department of Pediatrics, Yiwu Central Hospital, Yiwu, 322000, China
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Zhang MY, Zhao Y, Liu JF, Liu GP, Zhang RY, Wang LM. Efficacy of different antibiotics in treatment of children with respiratory mycoplasma infection. World J Clin Cases 2021; 9:6717-6724. [PMID: 34447818 PMCID: PMC8362522 DOI: 10.12998/wjcc.v9.i23.6717] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 03/02/2021] [Revised: 04/06/2021] [Accepted: 05/15/2021] [Indexed: 02/06/2023] Open
Abstract
BACKGROUND Respiratory infections in children are common pediatric diseases caused by pathogens that invade the respiratory system. Children are considerably susceptible to Mycoplasma pneumoniae infection. There has been widespread clinical attention on treatment strategies for this disease.
AIM To analyze the clinical efficacy of different antibiotics in treating pediatric respiratory mycoplasma infections.
METHODS We included 106 children with a confirmed diagnosis of respiratory mycoplasma infection who were admitted to our hospital from April 2017 to July 2019 and grouped them using a random number table. Among them, 53 children each received clarithromycin or erythromycin. The clinical efficacy of both drugs was evaluated and compared. We performed the multiplex polymerase chain reaction (MP-PCR) test and determined the MP-PCR negative rate in children after the end of the treatment course. We compared the incidence of toxic and side effects, including nausea, diarrhea, and abdominal pain; further, we recorded the length of hospitalization, antipyretic time, and drug costs. Additionally, we evaluated and compared the compliance of the children during treatment.
RESULTS The erythromycin group showed a significantly higher total effective rate of clinical treatment than the clarithromycin group. MP-PCR test results showed that the clarithromycin group had a significantly higher MP-PCR negative rate than the erythromycin group. Moreover, children in the clarithromycin group had shorter fever time, shorter hospital stays, and lower drug costs than those in the erythromycin group. The clarithromycin group had a significantly higher overall drug adherence rate than the erythromycin group. The incidence of toxic and side effects was significantly lower in the clarithromycin group than in the erythromycin group (P < 0.05).
CONCLUSION Our findings indicate that clarithromycin has various advantages over erythromycin, including higher application safety, stronger mycoplasma clearance, and higher medication compliance in children; therefore, it can be actively promoted.
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Affiliation(s)
- Mei-Ying Zhang
- Department of Pediatrics, Qingdao Municipal Hospital, Qingdao 266011, Shandong Province, China
| | - Yan Zhao
- Department of Pediatrics, Qingdao Municipal Hospital, Qingdao 266011, Shandong Province, China
| | - Jin-Feng Liu
- Department of ICU, Jinan City People’s Hospital, Jinan 271199, Shandong Province, China
| | - Guo-Ping Liu
- Department of Interventional Radiology, Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong Province, China
| | - Rui-Yun Zhang
- Department of Pediatrics, Qingdao Municipal Hospital, Qingdao 266011, Shandong Province, China
| | - Li-Min Wang
- Department of Pediatrics, Qingdao Municipal Hospital, Qingdao 266011, Shandong Province, China
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