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Zheng ZH, Shao B, Xu CM, Wang K, Wen JZ, Luo LK, Guan JC. Primary parenchymal squamous cell carcinoma of the kidney: A case report. World J Clin Cases 2025; 13:100037. [PMID: 39917575 PMCID: PMC11586791 DOI: 10.12998/wjcc.v13.i4.100037] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 08/05/2024] [Revised: 09/27/2024] [Accepted: 10/29/2024] [Indexed: 11/15/2024] Open
Abstract
BACKGROUND Primary squamous cell carcinoma (SCC) of the renal parenchyma is extremely rare, with only nine cases reported. CASE SUMMARY This study reports a 51-year-old man with primary SCC of the renal parenchyma. The patient was admitted with recurrent dull pain and discomfort in the right lumbar region, which had worsened over 2 weeks, accompanied by painful gross hematuria. SCC antigen (SCCA) levels were elevated, and imaging revealed a renal mass with associated calculi. The patient underwent laparoscopic unilateral nephrectomy and lymph node dissection. Postoperative pathology confirmed highly differentiated SCC with necrosis in the right renal parenchyma, with negative renal pelvis and ureter. The pathological stage was Pt3aN1M0. Four months after surgery, the tumor recurred with involvement of the liver, right psoas major muscle, and inferior vena cava. The patient refused chemotherapy and succumbed to the disease 6 months postoperatively due to disease progression. CONCLUSION We report a case of primary SCC of the renal parenchyma, a rare renal malignancy. The clinical symptoms, laboratory tests, and imaging findings are nonspecific, making accurate and timely diagnosis challenging. According to the literature, for patients with renal calculi accompanied by a renal mass, elevated serum SCCA levels, and magnetic resonance imaging showing cystic or cystic-solid masses within the kidney with pseudocapsules and heterogeneous mild enhancement, the possibility of this disease should be considered.
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Affiliation(s)
- Zhi-Hui Zheng
- Department of Ultrasound, The Second People’s Hospital of Quzhou, Quzhou 324000, Zhejiang Province, China
| | - Bo Shao
- Department of Radiology, Shulan (Quzhou) Hospital, Quzhou 324000, Zhejiang Province, China
| | - Chao-Min Xu
- Department of Ultrasound, The Second People’s Hospital of Quzhou, Quzhou 324000, Zhejiang Province, China
| | - Ke Wang
- Department of Radiology, The Second People’s Hospital of Quzhou, Quzhou 324000, Zhejiang Province, China
| | - Jia-Zhu Wen
- Department of Radiology, The Second People’s Hospital of Quzhou, Quzhou 324000, Zhejiang Province, China
| | - Li-Kang Luo
- Department of Pathology, The Second people’s Hospital of Quzhou, Quzhou 324000, Zhejiang Province, China
| | - Jia-Cheng Guan
- Department of Radiology, The Second People’s Hospital of Quzhou, Quzhou 324000, Zhejiang Province, China
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2
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Junejo NN, Kamal MH, Aquil S, Al Rahbi F, Al Badaai GAR, Siddiqui KM. Primary Squamous Cell Carcinoma of the Kidney: A Case Series. Oman Med J 2025; 40:e721. [PMID: 40357431 PMCID: PMC12066939 DOI: 10.5001/omj.2025.04] [Citation(s) in RCA: 1] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/02/2023] [Accepted: 06/20/2023] [Indexed: 05/15/2025] Open
Abstract
Primary squamous cell carcinoma (SCC) of the renal parenchyma without a history of urolithiasis is a rare entity. Renal SCC is usually associated with other conditions like renal stone disease, chronic inflammation, and infection. We report three cases of primary SCC with no history of renal stone disease or identifiable risk factors. We also present a current review of the literature and a detailed description of the morphological features.
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Affiliation(s)
- Noor Nabi Junejo
- Department of Urology, Sultan Qaboos University Hospital, Muscat, Oman
- College of Medicine, Sultan Qaboos University Hospital, Muscat, Oman
| | | | - Shahid Aquil
- Department of Urology, Sultan Qaboos University Hospital, Muscat, Oman
- College of Medicine, Sultan Qaboos University Hospital, Muscat, Oman
| | - Fathiya Al Rahbi
- Department of Pathology and Laboratory Medicine, Sultan Qaboos University Hospital, Muscat, Oman
- College of Medicine, Sultan Qaboos University Hospital, Muscat, Oman
| | - Ghalib Amur Rashid Al Badaai
- Department of Urology, Sultan Qaboos University Hospital, Muscat, Oman
- College of Medicine, Sultan Qaboos University Hospital, Muscat, Oman
| | - Khurram Mutahir Siddiqui
- Department of Urology, Sultan Qaboos University Hospital, Muscat, Oman
- College of Medicine, Sultan Qaboos University Hospital, Muscat, Oman
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3
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Pagan Santini RA, Bhaskaran M, Nair V, Nair G, Fahmy A. Primary Squamous Cell Carcinoma in a Transplanted Kidney: A Unique Case Highlighting Challenges in Diagnosis and Management. Cureus 2025; 17:e77154. [PMID: 39925577 PMCID: PMC11805597 DOI: 10.7759/cureus.77154] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 01/08/2025] [Indexed: 02/11/2025] Open
Abstract
Kidney transplantation is the preferred treatment for end-stage renal disease, but it involves risks, including an increased chance of malignancy due to several variables. We present a rare case of primary renal squamous cell carcinoma (SCC) in an allograft kidney. This patient, who had a renal transplant one year prior, presented with oliguria, elevated creatinine, and asthenia. Imaging done raised suspicion of a mass-like structure and biopsy subsequently done confirmed a primary SCC in the transplanted kidney, leading to a total nephrectomy and hemodialysis initiation. This case highlights the different cancer risks faced by transplant recipients, particularly due to immunosuppressive medications. We discuss emerging alternatives in immunosuppression that may mitigate these risks. Given the rarity of primary SCC in allografts, determining the cancer's origin whether primary or metastatic is critical for effective management since this distinction could shape future approaches to managing allograft malignancies. We also emphasize the importance of establishing imaging and monitoring guidelines and how combining imaging with serum and urine studies may enhance cancer surveillance, aiding in long-term graft health and transplant longevity.
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Affiliation(s)
- Ricardo A Pagan Santini
- Department of Internal Medicine, Long Island Jewish Forest Hills, Northwell Health, New York, USA
| | - Madhu Bhaskaran
- Department of Nephrology and Transplant Nephrology, Northwell Health, New York, USA
| | - Vinay Nair
- Department of Nephrology, Division of Transplant Surgery, Northwell Health, New York, USA
| | - Gayatri Nair
- Department of Nephrology, Division of Transplant Surgery, Northwell Health, New York, USA
| | - Ahmed Fahmy
- Department of Surgery, Division of Transplant Surgery, Northwell Health, New York, USA
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Takanashi M, Asaoka M, Imano M, Fujioka A, Oishi Y, Matsuda G, Chiba S, Hirai K. Primary squamous cell carcinoma of the kidney with hepatic invasion. IJU Case Rep 2024; 7:408-413. [PMID: 39224682 PMCID: PMC11366424 DOI: 10.1002/iju5.12771] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/04/2024] [Accepted: 08/04/2024] [Indexed: 09/04/2024] Open
Abstract
Introduction Primary squamous cell carcinoma of the kidney is rare, with only a few cases reported to date. Case presentation A right renal mass was detected in a 73-year-old asymptomatic man. Dynamic contrast-enhanced computed tomography showed a hypodensity mass extending from the upper pole of the kidney to the right lobe of the liver. Renal biopsy revealed that this tumor was squamous cell carcinoma. One month later, computed tomography showed rapid tumor growth. Radical nephrectomy and partial hepatic resection were performed. Pathological analysis indicated that this tumor originated from the tubular epithelium, and the patient was diagnosed with primary squamous cell carcinoma of the kidney.Following up without adjuvant therapy, he developed retroperitoneal recurrence and multiple lung metastases and expired. Conclusion In this case, squamous cell carcinoma of the kidney invaded the liver and progressed rapidly. Considering these observations, surgical resection should be promptly performed in suspected cases.
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Affiliation(s)
- Masato Takanashi
- Department of UrologyNational Hospital Organization Yokohama Medical CenterYokohamaKanagawaJapan
| | - Miho Asaoka
- Department of UrologyNational Hospital Organization Yokohama Medical CenterYokohamaKanagawaJapan
| | - Masashi Imano
- Department of UrologyNational Hospital Organization Yokohama Medical CenterYokohamaKanagawaJapan
| | - Azumi Fujioka
- Department of UrologyNational Hospital Organization Yokohama Medical CenterYokohamaKanagawaJapan
| | - Yuka Oishi
- Department of SurgeryNational Hospital Organization Yokohama Medical CenterYokohamaKanagawaJapan
| | - Goro Matsuda
- Department of SurgeryNational Hospital Organization Yokohama Medical CenterYokohamaKanagawaJapan
| | - Sawako Chiba
- Department of Diagnostic PathologyNational Hospital Organization Yokohama Medical CenterYokohamaKanagawaJapan
| | - Kotaro Hirai
- Department of UrologyNational Hospital Organization Yokohama Medical CenterYokohamaKanagawaJapan
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5
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Liang K, Yuan Y, Lv B, Ke Z. Primary squamous cell carcinoma of renal parenchyma: A case report and literature review. Front Oncol 2023; 13:1037156. [PMID: 37064145 PMCID: PMC10098210 DOI: 10.3389/fonc.2023.1037156] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/05/2022] [Accepted: 03/20/2023] [Indexed: 04/01/2023] Open
Abstract
RationalePrimary renal parenchymal squamous cell carcinoma (SCC) is an extremely rare tumor that is difficult to diagnose by hematology and imaging studies and is often diagnosed later than other primary renal cancers.DiagnosisA 52-year-old male patient was found to have cysts in both kidneys for 1 week. No urgency and frequency of urination, no dysuria, no gross hematuria, and no significant changes in recent body weight were reported.InterventionsThe upper pole of the right kidney is a cystic and solid mass (8.3 cm * 8.2 cm * 8.1 cm), the cystic part has long T1 and long T2 signals, the solid part has mixed signals, and some parts have limited diffusion. There were nodular long T1 and short T2 calcification signals. An enhanced scan of the solid part showed uneven enhancement and continuous enhancement of the mass capsule. Cystic renal cancer was considered because of the multiple cysts in both kidneys. Surgical treatment was performed. Postoperative pathology revealed well-differentiated squamous cell carcinoma of the right kidney with cystic degeneration, 8.5 cm * 6 cm in size, infiltrating the renal parenchyma, and the cutting edge was negative. The pathological stage was pT2bN0M0.OutcomeAt the follow-up 5 months after the operation, no metastasis was found.ConclusionRenal SCC is rare and easily misdiagnosed and missed. Pathological diagnosis is still the gold standard for its diagnosis. However, with active surgical treatment, the short-term prognosis of the patient is good.
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Affiliation(s)
- Ke Liang
- Department of Urology, The No. 1 People’s Hospital of Pinghu, Pinghu, China
- Department of Urology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China
| | - Yichu Yuan
- Department of Urology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China
| | - Bodong Lv
- Department of Urology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China
| | - Zunjin Ke
- Department of Urology, The No. 1 People’s Hospital of Pinghu, Pinghu, China
- *Correspondence: Zunjin Ke,
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6
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Victor C, Patil A, Ganpule A, Singh AG, Soni SM, Sabnis RB, Desai MR. A case report: a renal squamous cell carcinoma presenting as a nephrocutaneous fistula. AFRICAN JOURNAL OF UROLOGY 2023. [DOI: 10.1186/s12301-022-00331-5] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/04/2023] Open
Abstract
Abstract
Background
Primary renal squamous cell carcinoma is a scarce entity, and its presentation as a discharging sinus is still exceptionally rare. We hereby report a case of a renal cell carcinoma in a young gentleman.
Case presentation
We report a case of a 20-year-old gentleman who presented with clinical features suggestive of left side xanthogranulomatous pyelonephritis (XGPN). He had undergone multiple endourological procedures for left side renal calculi in the past. We present the clinical presentation, diagnostic dilemmas and treatment for this patient. We performed an open radical nephrectomy for this patient. Our case report is unique from the point of view of nature of presentation to the final histopathological outcome in terms of age group of the patient.
Here we present the clinical management and dilemmas in the management of this unusual and rare case.
Conclusions
Our case report and presentation has taught us that we as clinicians must have a high index of suspicion for a renal malignancy when treating patients who present with pyonephrosis associated with long-standing calculi diseases, irrespective of the age group of the patient.
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7
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Varshney B, Nalwa A, Yadav T, Choudhary G. Renal Squamous Cell Carcinoma Presenting With Renohepatic Fistula: A Rare Amalgam. Ochsner J 2023; 23:72-76. [PMID: 36936493 PMCID: PMC10016222 DOI: 10.31486/toj.22.0039] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/08/2022] Open
Abstract
Background: Primary squamous cell carcinoma (SCC) of the kidney, a rare malignancy that accounts for less than 1% of all urinary tract malignancies, is usually diagnosed in late stages because of the lack of characteristic clinical and imaging features and aggressive behavior. Case Report: A 66-year-old male presented with complaints of right flank pain. Imaging suggested the differential diagnoses of xanthogranulomatous pyelonephritis or renal malignancy extending into segment VI of the liver. Right subcapsular nephrectomy was performed, and nonbilious fluid from the liver cavitary lesions was drained. Histopathologic examination showed that the lesion was a renal SCC with contiguous malignant infiltration of the liver that led to a renohepatic fistula. Conclusion: Renal SCC is a rare high-grade neoplasm and can present in an unusual form with a poor prognosis.
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Affiliation(s)
- Bharti Varshney
- Department of Pathology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
| | - Aasma Nalwa
- Department of Pathology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
| | - Taruna Yadav
- Department of Diagnostic and Interventional Radiology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
- Address correspondence to Taruna Yadav, MD, Department of Diagnostic and Interventional Radiology, All India Institute of Medical Sciences, Basni Phase II, Jodhpur 342005, Rajasthan, India. Tel: +91 0291 283 1961.
| | - Gautam Choudhary
- Department of Urology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
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8
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Liu XH, Zou QM, Cao JD, Wang ZC. Primary squamous cell carcinoma with sarcomatoid differentiation of the kidney associated with ureteral stone obstruction: A case report. World J Clin Cases 2022; 10:11942-11948. [PMID: 36405295 PMCID: PMC9669857 DOI: 10.12998/wjcc.v10.i32.11942] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 07/03/2022] [Revised: 09/02/2022] [Accepted: 10/11/2022] [Indexed: 11/07/2022] Open
Abstract
BACKGROUND Primary squamous cell carcinoma (SCC) with sarcomatoid differentiation of the kidney was rarely reported. This disease is usually related to renal stones, and due to a lack of symptoms and radiological features, patients usually attend the hospital with late stage disease.
CASE SUMMARY A 54-years-old female presented with left flank pain and an abdominal mass for 6 mo. Imaging studies revealed that the left kidney was enlarged and massive hydronephrosis was present. A stone was seen in the ureteropelvic junction. The patient subsequently underwent left radical nephrectomy, and histopathological examination of the mass revealed a poorly differentiated renal SCC with sarcomatoid differentiation. After primary surgery, the patient received four cycles of tirelizumab. Four months later, the patient developed adrenal, lymph, and uterine appendage metastases.
CONCLUSION SCC of the kidney has a poor prognosis, and should be considered in patients with a renal mass, long-standing urinary calculi and massive hydronephrosis.
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Affiliation(s)
- Xue-Hua Liu
- Department of Urology Surgery, Fangcun Hospital of Guangdong Provincial Hospital of traditional Chinese Medicine, Guangzhou 510120, Guangdong Province, China
| | - Qian-Ming Zou
- Department of Urology Surgery, Fangcun Hospital of Guangdong Provincial Hospital of traditional Chinese Medicine, Guangzhou 510120, Guangdong Province, China
| | - Jia-Dong Cao
- Department of Urology Surgery, Fangcun Hospital of Guangdong Provincial Hospital of traditional Chinese Medicine, Guangzhou 510120, Guangdong Province, China
| | - Zhi-Chao Wang
- Department of Urology Surgery, Fangcun Hospital of Guangdong Provincial Hospital of traditional Chinese Medicine, Guangzhou 510120, Guangdong Province, China
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9
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Kim SSY, Rendon RA, Thana M, Wood L, Wang C, Mason RJ. Rare case of upper urinary tract squamous cell carcinoma presenting with significant paraneoplastic syndrome. Urol Ann 2020; 12:388-391. [PMID: 33776339 PMCID: PMC7992520 DOI: 10.4103/ua.ua_111_19] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/05/2019] [Accepted: 02/27/2020] [Indexed: 11/04/2022] Open
Abstract
Squamous cell carcinoma of the upper urinary tract is a rare entity associated with rapidly progressive disease and poor outcomes. Here, we describe a case of a squamous cell carcinoma of the upper urinary tract associated with significant progression and paraneoplastic syndrome. Post-operatively, the patient had near complete resolution of her paraneoplastic syndromes with significant improvements in her functional status.
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Affiliation(s)
- Sandra S Y Kim
- Department of Urology, Dalhousie University, Halifax, NS, Canada
| | - Ricardo A Rendon
- Department of Urology, Dalhousie University, Halifax, NS, Canada
| | - Myuran Thana
- Department of Medicine, Dalhousie University, Division of Medical Oncology, Halifax, NS, Canada
| | - Lori Wood
- Department of Medicine, Dalhousie University, Division of Medical Oncology, Halifax, NS, Canada
| | - Cheng Wang
- Department of Pathology, Dalhousie University, Halifax, NS, Canada
| | - Ross J Mason
- Department of Urology, Dalhousie University, Halifax, NS, Canada
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10
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Zhang X, Zhang Y, Ge C, Zhang J, Liang P. Squamous cell carcinoma of the renal parenchyma presenting as hydronephrosis: a case report and review of the recent literature. BMC Urol 2020; 20:107. [PMID: 32689976 PMCID: PMC7372804 DOI: 10.1186/s12894-020-00676-5] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/09/2019] [Accepted: 07/13/2020] [Indexed: 11/10/2022] Open
Abstract
BACKGROUND Primary squamous cell carcinoma of the renal parenchyma is extremely rare, only 5 cases were reported. CASE PRESENTATION We probably report the fifth case of primary Squamous cell carcinoma (SCC) of the renal parenchyma in a 61-year-old female presenting with intermittent distending pain for 2 months. Contrast-enhanced computed tomography (CECT) revealed hydronephrosis of the right kidney, but a tumor cannot be excluded completely. Finally, nephrectomy was performed, and histological analysis determined that the diagnosis was kidney parenchyma squamous cell carcinoma involving perinephric adipose tissue. CONCLUSIONS The present case emphasizes that it is difficult to make an accurate preoperative diagnosis with the presentation of hidden malignancy, such as hydronephrosis.
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Affiliation(s)
- Xirong Zhang
- Department of Urology, The Second Affiliated Hospital of Chongqing Medical University, Yuzhong, Chongqing, 400010, China.,Department of Urology, Jiangmen Central Hospital, Jiangmen, 529030, Guangdong, China
| | - Yuanfeng Zhang
- Department of Urology, The Second Affiliated Hospital of Chongqing Medical University, Yuzhong, Chongqing, 400010, China
| | - Chengguo Ge
- Department of Urology, The Second Affiliated Hospital of Chongqing Medical University, Yuzhong, Chongqing, 400010, China
| | - Junyong Zhang
- Department of Urology, The Second Affiliated Hospital of Chongqing Medical University, Yuzhong, Chongqing, 400010, China
| | - Peihe Liang
- Department of Urology, The Second Affiliated Hospital of Chongqing Medical University, Yuzhong, Chongqing, 400010, China.
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Deng S, Zhang B, Huang Y, Li J, Sang S, Zhang W. Case report of primary renal pelvis squamous cell carcinoma coexisting with long-standing calculi in left kidney on 18F-FDG PET/CT. Medicine (Baltimore) 2017; 96:e6341. [PMID: 28296764 PMCID: PMC5369919 DOI: 10.1097/md.0000000000006341] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 11/26/2022] Open
Abstract
RATIONALE Primary renal pelvis squamous cell carcinoma (SCC) is an extremely rare neoplasm. In many patients, the SCC was associated with renal calculi. PATIENT CONCERNS A 61-year-old male presented with intermittent pain at the left lumbar region for 3 days. The PET/CT images demonstrated increased F-FDG uptake in the upper pole of the left kidney and left renal hilar lymph nodes. DIAGNOSES Pathologic examination revealed well-moderately differentiated renal pelvis SCC with lymphatic metastasis. INTERVENTIONS The patient underwent a left nephrectomy a few days after the initial staging PET/CT study. OUTCOMES No growing lesion or metastasis was observed during a 6-month follow-up. LESSONS Our case demonstrates that F-FDG PET/CT is a useful diagnostic tool to evaluate primary renal pelvic SCC and detect metastatic lymph nodes in patients with long-standing calculi.
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12
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Khoo HW, Lee CH. Renal squamous cell carcinoma mimicking xanthogranulomatous pyelonephritis: Case report and review of literature. Radiol Case Rep 2016; 11:74-7. [PMID: 27257454 PMCID: PMC4878933 DOI: 10.1016/j.radcr.2016.02.012] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/18/2016] [Accepted: 02/28/2016] [Indexed: 10/27/2022] Open
Abstract
Primary renal squamous cell carcinoma (SCC) is a rare primary malignancy of the kidney. Diagnosis is usually delayed because of its lack of characteristic clinical and imaging features and inherent aggressive nature. We present a case of primary renal SCC in a 66-year-old woman with bilateral renal calculi and a complex right lower pole renal mass. The diagnosis of primary renal SCC was established based on the histopathology after right nephrectomy.
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Affiliation(s)
- Hau Wei Khoo
- Department of Diagnostic Radiology, Tan Tock Seng Hospital, 11, Jalan Tan Tock Seng, Singapore 308433
| | - Chau Hung Lee
- Department of Diagnostic Radiology, Tan Tock Seng Hospital, 11, Jalan Tan Tock Seng, Singapore 308433
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13
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WANG ZHAO, YAN BIN, WEI YONGBAO, HU NA, SHEN QIN, LI DUO, YANG JINRUI, YANG XIN. Primary kidney parenchyma squamous cell carcinoma mimicking xanthogranulomatous pyelonephritis: A case report. Oncol Lett 2016; 11:2179-2181. [PMID: 26998145 PMCID: PMC4774481 DOI: 10.3892/ol.2016.4200] [Citation(s) in RCA: 7] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/17/2014] [Accepted: 01/22/2016] [Indexed: 11/06/2022] Open
Abstract
Primary kidney parenchyma squamous cell carcinoma is extremely rare, and this is the forth case to be reported. In the present study, a case of a 61-year old man is discussed. The man presented with recurrent lumbago, gross hematuria for nearly 2 months, and suspicious inflammatory kidney diseases on contrast-enhanced computed tomography (CT) and fludeoxyglucose-positron emission tomography (FDG-PET)/CT, but a tumor can not be excluded completely prior to surgery. Finally, radical nephrectomy was performed, and histological analysis determined that the diagnosis was kidney parenchyma squamous cell carcinoma with inflammation invasion. The present case highlights the potential confusion of preoperative diagnosis of renal tumor with inflammation, and introduces the potential role of FDG-PET in its diagnosis and survival evaluation in renal malignancies.
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Affiliation(s)
- ZHAO WANG
- Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China
- Department of Urology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China
| | - BIN YAN
- Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China
| | - YONG-BAO WEI
- Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China
- Department of Urology, Fujian Provincial Hospital, The Teaching Hospital of Fujian Medical University, Fuzhou, Fujian 350001, P.R. China
| | - NA HU
- Department of PET/CT Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China
| | - QIN SHEN
- Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China
| | - DUO LI
- Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China
| | - JIN-RUI YANG
- Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China
| | - XIN YANG
- Department of Oncology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China
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14
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Squamous cell carcinoma of kidney and its prognosis: a case report and review of the literature. Case Rep Urol 2015; 2015:469327. [PMID: 25699197 PMCID: PMC4325206 DOI: 10.1155/2015/469327] [Citation(s) in RCA: 8] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/30/2014] [Revised: 01/08/2015] [Accepted: 01/17/2015] [Indexed: 11/23/2022] Open
Abstract
Primary squamous cell carcinoma of the renal parenchyma is an extremely rare entity. The diagnosis of squamous cell carcinoma of the renal pelvis is usually unsuspected due to the rarity and inconclusive clinical and radiological features. Most of the patients are diagnosed at an advanced stage and are with poor outcome. Radical nephrectomy is the mainstay of the treatment. We reported a case of squamous cell carcinoma of the kidney in a 50-year-old female who presented with the right sided abdomen pain. The patient was treated with radical nephrectomy.
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