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Félix H, Oliveira ES. Non-Invasive Intracranial Pressure Monitoring and Its Applicability in Spaceflight. Aerosp Med Hum Perform 2022; 93:517-531. [DOI: 10.3357/amhp.5922.2022] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/24/2022]
Abstract
INTRODUCTION: Neuro-ophthalmic findings collectively defined as Spaceflight-Associated Neuro-ocular Syndrome (SANS) are one of the leading health priorities in astronauts engaging in long duration spaceflight or prolonged microgravity exposure. Though multifactorial in etiology,
similarities to terrestrial idiopathic intracranial hypertension (IIH) suggest these changes may result from an increase or impairing in intracranial pressure (ICP). Finding a portable, accessible, and reliable method of monitoring ICP is, therefore, crucial in long duration spaceflight. A
review of recent literature was conducted on the biomedical literature search engine PubMed using the search term “non-invasive intracranial pressure”. Studies investigating accuracy of noninvasive and portable methods were assessed. The search retrieved different methods that
were subsequently grouped by approach and technique. The majority of publications included the use of ultrasound-based methods with variable accuracies. One of which, noninvasive ICP estimation by optical nerve sheath diameter measurement (nICP_ONSD), presented the highest statistical correlation
and prediction values to invasive ICP, with area under the curve (AUC) ranging from 0.75 to 0.964. One study even considers a combination of ONSD with transcranial Doppler (TCD) for an even higher performance. Other methods, such as near-infrared spectroscopy (NIRS), show positive and promising
results [good statistical correlation with invasive techniques when measuring cerebral perfusion pressure (CPP): r = 0.83]. However, for its accessibility, portability, and accuracy, ONSD seems to present itself as the up to date, most reliable, noninvasive ICP surrogate and a valuable spaceflight
asset.Félix H, Santos Oliveira E. Non-invasive intracranial pressure monitoring and its applicability in spaceflight. Aerosp Med Hum Perform. 2022; 93(6):517–531.
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Anderson AP, Covington KB, Rieke CC, Fellows AM, Buckey JC. Detecting changes in distortion product otoacoustic emission maps using statistical parametric mapping and random field theory. THE JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA 2020; 147:3444. [PMID: 32486767 DOI: 10.1121/10.0001235] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Subscribe] [Scholar Register] [Received: 10/01/2019] [Accepted: 04/24/2020] [Indexed: 06/11/2023]
Abstract
Distortion product otoacoustic emission (DPOAE) maps collect DPOAE emissions over a broad range of frequencies and ratios. One application of DPOAE mapping could be monitoring changes in intracranial pressure (ICP) in space, where non-invasive measures of ICP are an area of interest. Data were collected in two experiments to statistically assess changes in DPOAE maps. A repeatability study where four maps per subject were collected across four weeks to establish "normal" variability in DPOAE data, and a posture study where subjects were measured supine and prone with lower body negative pressure, lower body positive pressure (LBPP), and at atmospheric pressure. DPOAE amplitude maps were analyzed using statistical parametric mapping and random field theory. Postural changes produced regional changes in the maps, specifically in the range of 5-7.5 kHz and between primary tone ratios of 1.13-1.24. These regional changes were most pronounced in the prone LBPP condition, where amplitudes were lower from baseline for the Postural Cohort than the Repeatability Cohort. Statistical parametric mapping provided a sensitive measure of regional DPOAE map changes, which may be useful clinically to monitor ICP noninvasively in individuals or for research to identify differences within in cohorts of people.
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Affiliation(s)
- A P Anderson
- Smead Department of Aerospace Engineering Sciences, University of Colorado-Boulder, Boulder, Colorado 80303, USA
| | - K B Covington
- Smead Department of Aerospace Engineering Sciences, University of Colorado-Boulder, Boulder, Colorado 80303, USA
| | - C C Rieke
- Department of Medicine, Geisel School of Medicine at Dartmouth, Dartmouth College Geisel School of Medicine, Lebanon, New Hampshire 03756, USA
| | - A M Fellows
- Department of Medicine, Geisel School of Medicine at Dartmouth, Dartmouth College Geisel School of Medicine, Lebanon, New Hampshire 03756, USA
| | - J C Buckey
- Department of Medicine, Geisel School of Medicine at Dartmouth, Dartmouth College Geisel School of Medicine, Lebanon, New Hampshire 03756, USA
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Kreitmayer C, Marcrum SC, Picou EM, Steffens T, Kummer P. Subclinical conductive hearing loss significantly reduces otoacoustic emission amplitude: Implications for test performance. Int J Pediatr Otorhinolaryngol 2019; 123:195-201. [PMID: 31129459 DOI: 10.1016/j.ijporl.2019.05.025] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 04/04/2019] [Revised: 05/16/2019] [Accepted: 05/19/2019] [Indexed: 11/26/2022]
Abstract
OBJECTIVES Distortion product otoacoustic emissions (DPOAEs) are a time-efficient, non-invasive means of assessing the integrity of active inner ear mechanics. Unfortunately, the presence of even relatively minor conductive hearing loss (CHL) has been suggested to reduce the clinical utility of DPOAEs significantly. The primary aims of this study were to systematically evaluate the impact of CHL on DPOAE amplitude and to determine if ear-specific primary tone level manipulations can be used to mitigate CHL impact and recover DPOAE measurability. METHODS For 30 young adults (57 ears) with normal hearing, DPOAEs were obtained for f2 = 1-6 kHz. Observed DPOAE amplitudes were used to generate ear- and frequency-specific models with the primary tone levels, L1 and L2, as inputs and predicted DPOAE amplitude, LDP, as output. These models were then used to simulate the effect of CHL (0-15 dB), as well as L1 manipulations (0-15 dB), on DPOAE measurability. RESULTS Mean LDP for every CHL condition was significantly different from that for all other conditions (p = <.001), with a mean LDP attenuation of 8.7 dB for every 5 dB increase in CHL. Mean DPOAE measurability in response to a standard clinical stimulation paradigm of L1/L2 = 65/55 (dB SPL) was determined to be 99%, 84%, 37%, and 9% in the presence of 0, 5, 10, and 15 dB CHL, respectively. In the presence of 10 dB CHL, altering L1 resulted in an approximately 25% increase in DPOAE responses. CONCLUSION Subclinical CHL loss is sufficient to significantly impair DPOAE measurability in a meaningful proportion of otherwise healthy ears. However, through strategic alteration of primary tone levels, the clinician can mitigate CHL impact and at least partially recover DPOAE measurability.
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Affiliation(s)
- Christoph Kreitmayer
- Department of Otolaryngology, University Hospital Regensburg, Regensburg, Germany
| | - Steven C Marcrum
- Department of Otolaryngology, University Hospital Regensburg, Regensburg, Germany.
| | - Erin M Picou
- Department of Hearing and Speech Sciences, Vanderbilt University Medical Center, Nashville, USA
| | - Thomas Steffens
- Department of Otolaryngology, University Hospital Regensburg, Regensburg, Germany
| | - Peter Kummer
- Department of Otolaryngology, University Hospital Regensburg, Regensburg, Germany
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Nag DS, Sahu S, Swain A, Kant S. Intracranial pressure monitoring: Gold standard and recent innovations. World J Clin Cases 2019; 7:1535-1553. [PMID: 31367614 PMCID: PMC6658373 DOI: 10.12998/wjcc.v7.i13.1535] [Citation(s) in RCA: 127] [Impact Index Per Article: 21.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 03/04/2019] [Revised: 05/11/2019] [Accepted: 05/23/2019] [Indexed: 02/05/2023] Open
Abstract
Intracranial pressure monitoring (ICP) is based on the doctrine proposed by Monroe and Kellie centuries ago. With the advancement of technology and science, various invasive and non-invasive modalities of monitoring ICP continue to be developed. An ideal monitor to track ICP should be easy to use, accurate, reliable, reproducible, inexpensive and should not be associated with infection or haemorrhagic complications. Although the transducers connected to the extra ventricular drainage continue to be Gold Standard, its association with the likelihood of infection and haemorrhage have led to the search for alternate non-invasive methods of monitoring ICP. While Camino transducers, Strain gauge micro transducer based ICP monitoring devices and the Spiegelberg ICP monitor are the emerging technology in invasive ICP monitoring, optic nerve sheath diameter measurement, venous opthalmodynamometry, tympanic membrane displacement, tissue resonance analysis, tonometry, acoustoelasticity, distortion-product oto-acoustic emissions, trans cranial doppler, electro encephalogram, near infra-red spectroscopy, pupillometry, anterior fontanelle pressure monitoring, skull elasticity, jugular bulb monitoring, visual evoked response and radiological based assessment of ICP are the non-invasive methods which are assessed against the gold standard.
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Affiliation(s)
- Deb Sanjay Nag
- Department of Anaesthesiology and Critical Care, Tata Main Hospital, Jamshedpur 831001, India
| | - Seelora Sahu
- Department of Anaesthesiology and Critical Care, Tata Main Hospital, Jamshedpur 831001, India
| | - Amlan Swain
- Department of Anaesthesiology and Critical Care, Tata Main Hospital, Jamshedpur 831001, India
| | - Shashi Kant
- Department of Anaesthesiology and Critical Care, Tata Main Hospital, Jamshedpur 831001, India
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Effect of Elevated Intracranial Pressure on Amplitudes and Frequency Tuning of Ocular Vestibular Evoked Myogenic Potentials Elicited by Bone-Conducted Vibration. Ear Hear 2018; 37:e409-e413. [PMID: 27467406 DOI: 10.1097/aud.0000000000000326] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.6] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/26/2022]
Abstract
OBJECTIVE Recently, it could be demonstrated that an increased intracranial pressure causes a modulation of the air conducted sound evoked ocular vestibular evoked myogenic potential (oVEMP). The mechanism for this modulation is not resolved and may depend on a change of either receptor excitability or sound energy transmission. DESIGN oVEMPs were elicited in 18 healthy subjects with a minishaker delivering 500 and 1000 Hz tone bursts, in supine and tilted positions. RESULTS The study could confirm the frequency tuning of oVEMP. However, at neither stimulus frequency could a modulating effect of increased intracranial pressure be observed. CONCLUSION These data suggest that the observed modulation of the oVEMP response by an increased intracranial pressure is primarily due to the effect of an increased intralabyrinthine pressure onto the stiffness of the inner ear contents and the middle ear-inner ear junction. Future studies on the effect of intracranial pressure on oVEMP should use air-conducted sound and not bone-conducted vibration.
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The Effect of Elevated Intracranial Pressure on Frequency Tuning of Air-Conducted Ocular Vestibular Myogenic Potentials in Ménière's Disease Patients. Otol Neurotol 2017; 38:916-920. [DOI: 10.1097/mao.0000000000001436] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/26/2022]
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Estimation of Minor Conductive Hearing Loss in Humans Using Distortion Product Otoacoustic Emissions. Ear Hear 2017; 38:391-398. [DOI: 10.1097/aud.0000000000000415] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/25/2022]
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Khan MN, Shallwani H, Khan MU, Shamim MS. Noninvasive monitoring intracranial pressure - A review of available modalities. Surg Neurol Int 2017; 8:51. [PMID: 28480113 PMCID: PMC5402331 DOI: 10.4103/sni.sni_403_16] [Citation(s) in RCA: 44] [Impact Index Per Article: 5.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/12/2016] [Accepted: 01/26/2017] [Indexed: 12/28/2022] Open
Abstract
Background: Intracranial pressure (ICP) monitoring is important in many neurosurgical and neurological patients. The gold standard for monitoring ICP, however, is via an invasive procedure resulting in the placement of an intraventricular catheter, which is associated with many risks. Several noninvasive ICP monitoring techniques have been examined with the hope to replace the invasive techniques. The goal of this paper is to provide an overview of all modalities that have been used for noninvasive ICP monitoring to date. Methods: A thorough literature search was conducted on PubMed, selected articles were reviewed in completion, and pertinent data was included in the review. Results: A total of 94 publications were reviewed, and we found that over the past few decades clinicians have attempted to use a number of modalities to monitor ICP noninvasively. Conclusion: Although the intraventricular catheter remains the gold standard for monitoring ICP, several noninvasive modalities that can be used in settings when invasive monitoring is not possible are also available. In our opinion, measurement of optic nerve sheath diameter and pupillometry are the two modalities which may prove to be valid options for centers not performing invasive ICP monitoring.
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Affiliation(s)
| | - Hussain Shallwani
- Endovascular Research Fellow, University of Buffalo Neurosurgery, Buffalo, New York, USA
| | - Muhammad Ulusyar Khan
- Division of Biological and Biomedical Sciences, Aga Khan University Hospital, Karachi, Pakistan
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Robba C, Bacigaluppi S, Cardim D, Donnelly J, Bertuccio A, Czosnyka M. Non-invasive assessment of intracranial pressure. Acta Neurol Scand 2016; 134:4-21. [PMID: 26515159 DOI: 10.1111/ane.12527] [Citation(s) in RCA: 95] [Impact Index Per Article: 10.6] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 10/01/2015] [Indexed: 11/29/2022]
Abstract
Monitoring of intracranial pressure (ICP) is invaluable in the management of neurosurgical and neurological critically ill patients. Invasive measurement of ventricular or parenchymal pressure is considered the gold standard for accurate measurement of ICP but is not always possible due to certain risks. Therefore, the availability of accurate methods to non-invasively estimate ICP has the potential to improve the management of these vulnerable patients. This review provides a comparative description of different methods for non-invasive ICP measurement. Current methods are based on changes associated with increased ICP, both morphological (assessed with magnetic resonance, computed tomography, ultrasound, and fundoscopy) and physiological (assessed with transcranial and ophthalmic Doppler, tympanometry, near-infrared spectroscopy, electroencephalography, visual-evoked potentials, and otoacoustic emissions assessment). At present, none of the non-invasive techniques alone seem suitable as a substitute for invasive monitoring. However, following the present analysis and considerations upon each technique, we propose a possible flowchart based on the combination of non-invasive techniques including those characterizing morphologic changes (e.g., repetitive US measurements of ONSD) and those characterizing physiological changes (e.g., continuous TCD). Such an integrated approach, which still needs to be validated in clinical practice, could aid in deciding whether to place an invasive monitor, or how to titrate therapy when invasive ICP measurement is contraindicated or unavailable.
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Affiliation(s)
- C. Robba
- Neurosciences Critical Care Unit; Addenbrooke's Hospital; Cambridge United Kingdom
- Brain Physics Lab; Division of Neurosurgery; Department of Clinical Neurosciences; University of Cambridge; United Kingdom
| | - S. Bacigaluppi
- Department of Neurosurgery; Galliera Hospital; Genova Italy
| | - D. Cardim
- Brain Physics Lab; Division of Neurosurgery; Department of Clinical Neurosciences; University of Cambridge; United Kingdom
| | - J. Donnelly
- Brain Physics Lab; Division of Neurosurgery; Department of Clinical Neurosciences; University of Cambridge; United Kingdom
| | - A. Bertuccio
- Department of Neurosurgery; S. George's Hospital; University of London; United Kingdom
| | - M. Czosnyka
- Brain Physics Lab; Division of Neurosurgery; Department of Clinical Neurosciences; University of Cambridge; United Kingdom
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Gürkov R, Speierer G, Wittwer L, Muri R, Kalla R. Differential effect of elevated intralabyrinthine pressure on ocular vestibular evoked myogenic potentials elicited by air conducted sound and bone conducted vibration. Clin Neurophysiol 2016; 127:2115-8. [PMID: 26806721 DOI: 10.1016/j.clinph.2015.12.019] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/08/2015] [Revised: 12/11/2015] [Accepted: 12/29/2015] [Indexed: 11/17/2022]
Affiliation(s)
- Robert Gürkov
- Department of Otorhinolaryngology Head and Neck Surgery, University Hospital Munich, Campus Grosshadern, Munich, Germany.
| | - Guillaume Speierer
- Department of Neurology, Division of Cognitive and Restorative Neurology, University Hospital Bern, Bern, Switzerland
| | - Luis Wittwer
- Department of Neurology, Division of Cognitive and Restorative Neurology, University Hospital Bern, Bern, Switzerland
| | - René Muri
- Department of Neurology, Division of Cognitive and Restorative Neurology, University Hospital Bern, Bern, Switzerland
| | - Roger Kalla
- Department of Neurology, Division of Cognitive and Restorative Neurology, University Hospital Bern, Bern, Switzerland
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Olzowy B, Abendroth S, von Gleichenstein G, Mees K, Stelter K. No Evidence of Intracranial Hypertension in Trekkers with Acute Mountain Sickness When Assessed Noninvasively with Distortion Product Otoacoustic Emissions. High Alt Med Biol 2014; 15:364-70. [DOI: 10.1089/ham.2013.1120] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/13/2022] Open
Affiliation(s)
- Bernhard Olzowy
- Department of Otorhinolaryngology, Head and Neck Surgery, University of Rostock Medical Center, Rostock, Germany
| | | | | | - Klaus Mees
- Department of Otorhinolaryngology, Head and Neck Surgery, Ludwig Maximilians University of Munich Medical Center, München, Germany
| | - Klaus Stelter
- Department of Otorhinolaryngology, Head and Neck Surgery, Ludwig Maximilians University of Munich Medical Center, München, Germany
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Janky KL, Zuniga MG, Schubert MC, Carey JP. The effect of increased intracranial pressure on vestibular evoked myogenic potentials in superior canal dehiscence syndrome. Clin Neurophysiol 2014; 126:780-6. [PMID: 25103787 DOI: 10.1016/j.clinph.2014.06.049] [Citation(s) in RCA: 7] [Impact Index Per Article: 0.6] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/05/2013] [Revised: 04/14/2014] [Accepted: 06/30/2014] [Indexed: 11/28/2022]
Abstract
OBJECTIVE To determine if vestibular evoked myogenic potential (VEMP) responses change during inversion in patients with superior canal dehiscence syndrome (SCDS) compared to controls. METHODS Sixteen subjects with SCDS (mean: 43, range 30-57 years) and 15 age-matched, healthy subjects (mean: 41, range 22-57 years) completed cervical VEMP (cVEMP) in response to air conduction click stimuli and ocular VEMP (oVEMP) in response to air conduction 500 Hz tone burst stimuli and midline tap stimulation. All VEMP testing was completed in semi-recumbent and inverted conditions. RESULTS SCDS ears demonstrated significantly larger oVEMP peak-to-peak amplitudes in comparison to normal ears in semi-recumbency. While corrected cVEMP peak-to-peak amplitudes were larger in SCDS ears; this did not reach significance in our sample. Overall, there was not a differential change in o- or cVEMP amplitude with inversion between SCDS and normal subjects. CONCLUSIONS Postural-induced changes in o- and cVEMP responses were measured in the steady state regardless of whether the labyrinth was intact or dehiscent. SIGNIFICANCE VEMP responses are blunted during inversion. Although steady-state measurements of VEMPs during inversion do not increase diagnostic accuracy for SCDS, the findings suggest that inversion may provide more general insights into the equilibration of pressures between intracranial and intralabyrinthine fluids.
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Affiliation(s)
- Kristen L Janky
- Johns Hopkins University, Otolaryngology - Head and Neck Surgery, Baltimore, MD 21287-0910, USA; Boys Town National Research Hospital, Department of Audiology, Omaha, NE 68131, USA.
| | - M Geraldine Zuniga
- Johns Hopkins University, Otolaryngology - Head and Neck Surgery, Baltimore, MD 21287-0910, USA; Department of Otolaryngology Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, TN 37232, USA
| | - Michael C Schubert
- Johns Hopkins University, Otolaryngology - Head and Neck Surgery, Baltimore, MD 21287-0910, USA; Johns Hopkins University, Physical Medicine and Rehabilitation, Baltimore, MD 21287-0910, USA
| | - John P Carey
- Johns Hopkins University, Otolaryngology - Head and Neck Surgery, Baltimore, MD 21287-0910, USA
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Effects of the intensity of masking noise on ear canal recorded low-frequency cochlear microphonic waveforms in normal hearing subjects. Hear Res 2014; 313:9-17. [DOI: 10.1016/j.heares.2014.04.004] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.1] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 12/24/2013] [Revised: 04/09/2014] [Accepted: 04/15/2014] [Indexed: 11/20/2022]
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Posture-induced changes of ocular vestibular evoked myogenic potentials suggest a modulation by intracranial pressure. Exp Brain Res 2014; 232:2273-9. [PMID: 24682408 DOI: 10.1007/s00221-014-3918-9] [Citation(s) in RCA: 14] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/16/2013] [Accepted: 03/16/2014] [Indexed: 02/02/2023]
Abstract
Ocular vestibular evoked myogenic potentials (oVEMPs) represent extraocular muscle activity in response to vestibular stimulation. We sought to investigate whether oVEMPs are modulated by increasing intracranial pressure (ICP). Air-conducted oVEMPs were elicited in 20 healthy subjects lying supine on a tilt table. In order to elevate the ICP, the table was stepwise tilted from the horizontal plane to a 30° declination, corresponding to a 0°, 10°, 20° and 30° head-down position. At each inclination angle, oVEMP recording was performed in two head positions: (1) the head in line with the body and (2) the head positioned horizontally with the body tilted. When tilting both the body and head, oVEMP amplitudes gradually declined from 4.59 μV at 0° to 2.24 μV at 30° head-down position, revealing a highly significant reduction in amplitudes for all tilt angles when compared to the baseline value (p < 0.001). In parallel, the response prevalence decreased and latencies prolonged. Similar effects were observed when the body was tilted but the head positioned horizontally, even though the decrease in oVEMP amplitudes was less pronounced. A gravitoinertial force effect upon the otolith organs could thereby be excluded as a possible confounder. Hence, oVEMPs were most likely modulated by increasing ICP. In the range of the horizontal plane to a 30° head-down tilt, there was a linear correlation between oVEMP amplitudes and the inclination angle. oVEMPs might in principle be suited for non-invasive ICP monitoring.
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Modulation of oVEMP amplitudes by lateral head tilts. Clin Neurophysiol 2013; 124:1911-2. [DOI: 10.1016/j.clinph.2013.02.017] [Citation(s) in RCA: 9] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/23/2012] [Revised: 02/22/2013] [Accepted: 02/26/2013] [Indexed: 11/22/2022]
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Mao Z, Zhao L, Pu L, Wang M, Zhang Q, He DZZ. How well can centenarians hear? PLoS One 2013; 8:e65565. [PMID: 23755251 PMCID: PMC3673943 DOI: 10.1371/journal.pone.0065565] [Citation(s) in RCA: 16] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/06/2013] [Accepted: 04/26/2013] [Indexed: 12/03/2022] Open
Abstract
With advancements in modern medicine and significant improvements in life conditions in the past four decades, the elderly population is rapidly expanding. There is a growing number of those aged 100 years and older. While many changes in the human body occur with physiological aging, as many as 35% to 50% of the population aged 65 to 75 years have presbycusis. Presbycusis is a progressive sensorineural hearing loss that occurs as people get older. There are many studies of the prevalence of age-related hearing loss in the United States, Europe, and Asia. However, no audiological assessment of the population aged 100 years and older has been done. Therefore, it is not clear how well centenarians can hear. We measured middle ear impedance, pure-tone behavioral thresholds, and distortion-product otoacoustic emission from 74 centenarians living in the city of Shaoxing, China, to evaluate their middle and inner ear functions. We show that most centenarian listeners had an “As” type tympanogram, suggesting reduced static compliance of the tympanic membrane. Hearing threshold tests using pure-tone audiometry show that all centenarian subjects had varying degrees of hearing loss. More than 90% suffered from moderate to severe (41 to 80 dB) hearing loss below 2,000 Hz, and profound (>81 dB) hearing loss at 4,000 and 8,000 Hz. Otoacoustic emission, which is generated by the active process of cochlear outer hair cells, was undetectable in the majority of listeners. Our study shows the extent and severity of hearing loss in the centenarian population and represents the first audiological assessment of their middle and inner ear functions.
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Affiliation(s)
- Zhongping Mao
- Department of Otolaryngology – Head and Neck Surgery, Shaoxing Second Hospital, Shaoxing, P. R. China
- * E-mail: (DH); (ZM)
| | - Lijun Zhao
- Department of Otolaryngology – Head and Neck Surgery, Shaoxing Second Hospital, Shaoxing, P. R. China
| | - Lichun Pu
- Department of Otolaryngology – Head and Neck Surgery, Shaoxing Second Hospital, Shaoxing, P. R. China
| | - Mingxiao Wang
- Department of Otolaryngology – Head and Neck Surgery, Shaoxing Second Hospital, Shaoxing, P. R. China
| | - Qian Zhang
- Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska, United States of America
| | - David Z. Z. He
- Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska, United States of America
- Ningbo University School of Medicine, Ningbo, P. R. China
- * E-mail: (DH); (ZM)
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