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Moreira GDS, Marchiori LLDM, Ciquinato DSDA, Marchiori GDM, Okamura LST, Branco BHM, Poli-Frederico RC. Plasmatic Levels of Cytokines and Quality of Life among Elderly Individuals with Dizziness. Int Arch Otorhinolaryngol 2025; 29:1-7. [PMID: 39845140 PMCID: PMC11753860 DOI: 10.1055/s-0044-1791731] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/06/2023] [Accepted: 08/21/2024] [Indexed: 01/24/2025] Open
Abstract
Introduction Few studies have investigated the relationship between cytokines and dizziness in elderly individuals. Objective To assess the levels of inflammatory biomarkers and their relationship with quality of life (QoL) among elderly individuals with dizziness. Methods We conducted a cross-sectional study with 103 participants (90 women and 13 men) who were assessed through the Visual Analogue Scale (VAS) and the Dizziness Handicap Inventory (DHI). The plasma levels of cytokines were measured through the cytometric bead array (CBA) method. Cross-tabulations with the Chi-squared test were used to verify sample homogeneity, and parametric tests were used to analyze the data. Results Out of the total sample of 103 individuals, dizziness was reported by 40 women and 5 men. A difference between the groups with and without dizziness was observed regarding the levels of interleukin 4 (IL-4; p = 0.011): the group without dizziness presented a higher mean level (2.1 ± 2.8 pg/mL) when compared to the group that presented dizziness (1.0 ± 1.7 pg/mL). Another difference was found between the DHI classifications and the plasma levels of tumor necrosis factor alpha (TNF-α;) p = 0.015): the groups without any losses in QoL presented lower TNF-α levels (1.4 pg/mL) compared to the group that presented moderate QoL loss (6.3 pg/mL). Conclusion Dizziness affects the functional, physical and emotional dimensions of QoL and plays a role in the decrease in the levels of IL-4 and in the presence of fullness and tinnitus. Higher VAS scores are related to dizziness in the elderly. Moreover, the increased levels of TNF-α were associated to light-to-moderate losses in QoL among elderly patients with dizziness.
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Affiliation(s)
- Gislaine da Silva Moreira
- Program in Rehabilitation Sciences, Universidade Estadual de Londrina (UEL)/Universidade Pitágoras Unopar Anhanguera (UNOPAR), Londrina, PR, Brazil
| | - Luciana Lozza de Moraes Marchiori
- Interdisciplinary Laboratory of Intervention in Health Promotion (LIIPS), Universidade Cesumar (UNICESUMAR), Maringá, PR, Brazil
- Research Group on Physical Education, Physiotherapy, Sports, Nutrition, and Performance (GEFFEND), Universidade Cesumar (UNICESUMAR), Maringá, PR, Brazil
- Postgraduate Program in Health Promotion, Universidade Cesumar (UNICESUMAR), Maringá, PR, Brazil
| | - Daiane Soares de Almeida Ciquinato
- Research Group on Physical Education, Physiotherapy, Sports, Nutrition, and Performance (GEFFEND), Universidade Cesumar (UNICESUMAR), Maringá, PR, Brazil
- Postgraduate Program in Health Promotion, Universidade Cesumar (UNICESUMAR), Maringá, PR, Brazil
| | - Glória de Moraes Marchiori
- Interdisciplinary Laboratory of Intervention in Health Promotion (LIIPS), Universidade Cesumar (UNICESUMAR), Maringá, PR, Brazil
- Research Group on Physical Education, Physiotherapy, Sports, Nutrition, and Performance (GEFFEND), Universidade Cesumar (UNICESUMAR), Maringá, PR, Brazil
| | - Licia Sayuri Tanaka Okamura
- Research Group on Physical Education, Physiotherapy, Sports, Nutrition, and Performance (GEFFEND), Universidade Cesumar (UNICESUMAR), Maringá, PR, Brazil
| | - Braulio Henrique Magnani Branco
- Interdisciplinary Laboratory of Intervention in Health Promotion (LIIPS), Universidade Cesumar (UNICESUMAR), Maringá, PR, Brazil
- Research Group on Physical Education, Physiotherapy, Sports, Nutrition, and Performance (GEFFEND), Universidade Cesumar (UNICESUMAR), Maringá, PR, Brazil
- Postgraduate Program in Health Promotion, Universidade Cesumar (UNICESUMAR), Maringá, PR, Brazil
| | - Regina Célia Poli-Frederico
- Program in Rehabilitation Sciences, Universidade Estadual de Londrina (UEL)/Universidade Pitágoras Unopar Anhanguera (UNOPAR), Londrina, PR, Brazil
- Molecular Biology Laboratory, Universidade Pitágoras Unopar Anhanguera (UNOPAR), Londrina, PR, Brazil
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Zheng J, Xu J, Wu Y, Xu S, Gao Y. Intergenerational support, activities of daily living, and the interaction on psychological distress in older adults. Front Psychol 2024; 15:1454662. [PMID: 39703877 PMCID: PMC11655216 DOI: 10.3389/fpsyg.2024.1454662] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/25/2024] [Accepted: 11/18/2024] [Indexed: 12/21/2024] Open
Abstract
Objectives The purpose of this study is to examine the effects of intergenerational support and activities of daily living (ADL) on psychological distress in older adults, and to analyse the effects of the interaction between ADL and intergenerational support on psychological distress in older adults. Methods A probability sample of 1,065 older adults aged 60 and above was conducted in Xuzhou, China, from 18 June to 26 August 2023. ADL was assessed using the ADL scale combined with the Barthel Index; Intergenerational support was measured using the Intergenerational Support Scale; and psychological distress was measured using the Kessler 10 scale. An ordered multichotomous logistic regression model was constructed to analyse the factors influencing psychological distress in the elderly. The interaction model was constructed by one-way analysis of variance to further analyse the effect of the interaction between financial support, instrumental support and emotional support and ADL on psychological distress in the elderly. Results Elderly living in rural areas, with an annual household income of less than 30,000 yuan, who engaged in manual labor before retirement, who did not receive financial support and who received instrumental support were more likely to experience psychological distress, and the higher the degree of restriction in ADL, the higher the risk of psychological distress. A significant interaction was observed between ADL and financial support (F = 221.570, p < 0.05), as well as between ADL and emotional support (F = 399.805, p < 0.01). Additionally, a significant interaction was found among ADL, financial support, and instrumental support (F = 227.187, p < 0.05). Conclusion (1) A significant association between place of residence, annual household income, occupation, financial support, instrumental support, ADL, and psychological distress in older adults; (2) When the level of ADL was moderate, the risk of psychological distress in older adults who received emotional support was significantly lower than that of older people who did not receive emotional intergenerational support; When the level of ADL was completely independent, financial support was beneficial in reducing psychological distress in the elderly; (3) the risk of psychological distress in the elderly who received instrumental support increased with the severity of ADL limitations, regardless of whether they received additional financial support.
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Affiliation(s)
- Juan Zheng
- School of Management, Xuzhou Medical University, Xuzhou, Jiangsu, China
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Adamczak BB, Kuźnik Z, Makles S, Wasilewski A, Kosendiak AA. Physical Activity, Alcohol, and Cigarette Use in Urological Cancer Patients over Time since Diagnosis. Healthcare (Basel) 2023; 12:59. [PMID: 38200965 PMCID: PMC10779175 DOI: 10.3390/healthcare12010059] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/05/2023] [Revised: 12/22/2023] [Accepted: 12/24/2023] [Indexed: 01/12/2024] Open
Abstract
Urological cancers represent a substantial global public health concern, exerting far-reaching effects on both individuals and their families. There is an urgent need to comprehensively understand the transformations in patients' lifestyles and behaviors, given their critical role in the treatment process and overall well-being. This study, involving 128 urological cancer patients, aims to investigate changes in physical activity levels, problematic drinking behaviors assessed through the Alcohol Use Disorders Identification Test (AUDIT), and smoking habits assessed using the Fagerström Test for Nicotine Dependence (FTND) over four distinct time intervals over the subsequent three years from the time of diagnosis and among individuals diagnosed more than three years ago. The results reveal a significant decrease in physical activity levels between study intervals (p < 0.0001), declining from 69% to 45% between the first and second post-diagnosis assessments. Furthermore, the highest levels of problematic substance use, indicated by mean scores, were noted in the first year following diagnosis (AUDIT: 4.20, p = 0.01; FTND: 4.83, p = 0.08). Given the significant impact of physical activity on the prospects of recovery, it is imperative to delve more deeply into the factors contributing to this decline and devise targeted interventions for its improvement. In the context of substance use, it is essential to ascertain whether the initially high levels are a result of coping with the cancer diagnosis or represent a turning point at which patients modify their behaviors and cease their addiction. A more thorough understanding of this phenomenon would enhance the effectiveness of precisely focused interventions.
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Affiliation(s)
- Bartosz Bogusz Adamczak
- Student Scientific Association, Department of Physical Education and Sport, Wroclaw Medical University, 51-601 Wroclaw, Poland
| | - Zofia Kuźnik
- Student Scientific Association, Department of Physical Education and Sport, Wroclaw Medical University, 51-601 Wroclaw, Poland
| | - Szymon Makles
- Student Scientific Association, Department of Physical Education and Sport, Wroclaw Medical University, 51-601 Wroclaw, Poland
| | - Andrzej Wasilewski
- Student Scientific Association, Department of Physical Education and Sport, Wroclaw Medical University, 51-601 Wroclaw, Poland
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Clifford R, Munro D, Dochtermann D, Devineni P, Pyarajan S, Telese F, Palmer AA, Mohammadi P, Friedman R. Genome-Wide Association Study of Chronic Dizziness in the Elderly Identifies Loci Implicating MLLT10, BPTF, LINC01224, and ROS1. J Assoc Res Otolaryngol 2023; 24:575-591. [PMID: 38036714 PMCID: PMC10752854 DOI: 10.1007/s10162-023-00917-y] [Citation(s) in RCA: 2] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/06/2023] [Accepted: 11/12/2023] [Indexed: 12/02/2023] Open
Abstract
PURPOSE Chronic age-related imbalance is a common cause of falls and subsequent death in the elderly and can arise from dysfunction of the vestibular system, an elegant neuroanatomical group of pathways that mediates human perception of acceleration, gravity, and angular head motion. Studies indicate that 27-46% of the risk of age-related chronic imbalance is genetic; nevertheless, the underlying genes remain unknown. METHODS The cohort consisted of 50,339 cases and 366,900 controls in the Million Veteran Program. The phenotype comprised cases with two ICD diagnoses of vertigo or dizziness at least 6 months apart, excluding acute or recurrent vertiginous syndromes and other non-vestibular disorders. Genome-wide association studies were performed as individual logistic regressions on European, African American, and Hispanic ancestries followed by trans-ancestry meta-analysis. Downstream analysis included case-case-GWAS, fine mapping, probabilistic colocalization of significant variants and genes with eQTLs, and functional analysis of significant hits. RESULTS Two significant loci were identified in Europeans, another in the Hispanic population, and two additional in trans-ancestry meta-analysis, including three novel loci. Fine mapping revealed credible sets of intronic single nucleotide polymorphisms (SNPs) in MLLT10 - a histone methyl transferase cofactor, BPTF - a subunit of a nucleosome remodeling complex implicated in neurodevelopment, and LINC01224 - a proto-oncogene receptor tyrosine kinase. CONCLUSION Despite the difficulties of phenotyping the nature of chronic imbalance, we replicated two loci from previous vertigo GWAS studies and identified three novel loci. Findings suggest candidates for further study and ultimate treatment of this common elderly disorder.
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Affiliation(s)
- Royce Clifford
- Department of Otolaryngology-Head and Neck Surgery, University of California San Diego, La Jolla, CA, 92093, USA.
- Research Dept, Veteran Administration Hospitals, San Diego, CA, 92161, USA.
| | - Daniel Munro
- Dept. of Psychiatry, University of California San Diego, La Jolla, CA, 92093, USA
- Dept. of Integrative Structural and Computational Biology, Scripps Research, La Jolla, CA, 92093, USA
| | - Daniel Dochtermann
- Veterans Administrations Hospitals, Million Veteran Program, Boston, MA, 02130, USA
| | - Poornima Devineni
- Veterans Administrations Hospitals, Million Veteran Program, Boston, MA, 02130, USA
| | - Saiju Pyarajan
- Veterans Administrations Hospitals, Million Veteran Program, Boston, MA, 02130, USA
| | - Francesca Telese
- Dept. of Psychiatry, University of California San Diego, La Jolla, CA, 92093, USA
| | - Abraham A Palmer
- Dept. of Psychiatry, University of California San Diego, La Jolla, CA, 92093, USA
- Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, 92093, USA
| | - Pejman Mohammadi
- Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA, 98101, USA
- Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, 98195, USA
| | - Rick Friedman
- Department of Otolaryngology-Head and Neck Surgery, University of California San Diego, La Jolla, CA, 92093, USA
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Zheng R, Yu M, Huang L, Wang F, Gao B, Fu D, Zhu J, Liu G. Effect of intergenerational exchange patterns and intergenerational relationship quality on depressive symptoms in the elderly: An empirical study on CHARLS data. Front Public Health 2022; 10:1009781. [PMID: 36262237 PMCID: PMC9574018 DOI: 10.3389/fpubh.2022.1009781] [Citation(s) in RCA: 15] [Impact Index Per Article: 5.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/02/2022] [Accepted: 09/16/2022] [Indexed: 01/27/2023] Open
Abstract
Background As the population ages with fewer children, depression symptoms are increasing among the elderly who lack companionship. Intergenerational support is closely related to depression in the elderly; hence how the behavioral patterns and emotional quality of intergenerational support affect depressive symptoms in the elderly should be further explored. Objective To study the effects of intergenerational exchange patterns and intergenerational relationship quality on depressive symptoms in the elderly. Methods A total of 8,015 people over 60 years old in CHARLS in 2018 were selected as the object of this study. First, the correlation between demographics, economic conditions, health status, intergenerational support patterns, intergenerational relationship quality, and depressive symptoms in the elderly were analyzed. Three regression analysis models were established to analyze the relationship between control variables, intergenerational support patterns, intergenerational relationship quality, and depressive symptoms in the elderly. Results: Among the intergenerational economic, care, and emotional exchange modes, the risk of depressive symptoms in the elderly in the mutual support group was 31.8, 38.4, and 25.5% lower than that in the non-communication group. Compared with the elderly with very poor intergenerational relationship quality, the elderly with good, very good, and excellent intergenerational relationship quality had 74.5, 84.0, and 85.6% lower risk of depressive symptoms. Discussion Different cultural backgrounds also affect intergenerational exchange patterns and depression in the elderly. During the study of depressive symptoms, two aspects relating to intergenerational support should be considered behaviorally and emotionally: the intergenerational exchange model and the intergenerational relationship quality. As depression in the elderly is affected by multiple factors, the participation and joint efforts of the whole society are required to reduce depressive symptoms in the elderly and realize active aging. Conclusion The intergenerational exchange pattern of mutual support and the higher quality of the intergenerational relationship can significantly reduce the depressive symptoms of the elderly.
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Affiliation(s)
- Ranran Zheng
- School of Public Health and Management, Wenzhou Medical University, Wenzhou, China
| | - Mingyang Yu
- Integrated Office of Party and Government, First Affiliated Hospital Zhejiang Chinese Medicine University, Hangzhou, China
| | - Li Huang
- School of Public Health and Management, Wenzhou Medical University, Wenzhou, China
| | - Fang Wang
- School of Public Health and Management, Wenzhou Medical University, Wenzhou, China
| | - Baizhi Gao
- School of Public Health and Management, Wenzhou Medical University, Wenzhou, China
| | - Duanduan Fu
- School of Public Health and Management, Wenzhou Medical University, Wenzhou, China
| | - Jinghui Zhu
- School of Public Health and Management, Wenzhou Medical University, Wenzhou, China,*Correspondence: Jinghui Zhu
| | - Guilin Liu
- School of Public Health and Management, Wenzhou Medical University, Wenzhou, China,Guilin Liu
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Construction of a Physical and Medical Care Integrated Model for the Elderly in the Community Based on Artificial Intelligence and Machine Learning. JOURNAL OF HEALTHCARE ENGINEERING 2022; 2022:3678577. [PMID: 35251565 PMCID: PMC8896920 DOI: 10.1155/2022/3678577] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 11/26/2021] [Revised: 01/12/2022] [Accepted: 01/17/2022] [Indexed: 11/17/2022]
Abstract
With the increasingly serious population aging, economic system transformation, and social transformation, the elderly have an increasingly strong demand for the elderly care service industry, but the development of China’s elderly care service industry started late, and there are still many problems. For how to build a better elderly care service model, under the current situation of shortage of elderly care resources, community elderly care may become a solution. By analyzing the status quo, existing problems and development trends of home-based care services in Hangzhou’s community, and learning from foreign experience, it explores the establishment of a “integrated physical, medical, and nursing care” community health management model for the elderly and provides a perfect solution for the development of Hangzhou’s community elderly care services countermeasures and suggestions for mode operation. Based on the evaluation, problem analysis, and empirical research on the current situation of home care services in Hangzhou communities, this paper draws on relatively mature community care practices, proposes to build a community elderly health management model that combines medical care and care, and improves and innovates the overall design and medical care of the elderly service model measures for the health management of the elderly in the integrated community. The experimental results of this study show that, according to the demand for elderly care services, elderly people in need of care account for 86.6%, 79.5%, and 68.4% of the elderly population, especially in the areas of medical care, life care, and housekeeping services.
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Jia YH, Ye ZH. Impress of intergenerational emotional support on the depression in non-cohabiting parents. World J Clin Cases 2019; 7:3407-3418. [PMID: 31750325 PMCID: PMC6854408 DOI: 10.12998/wjcc.v7.i21.3407] [Citation(s) in RCA: 9] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 05/22/2019] [Revised: 09/21/2019] [Accepted: 10/05/2019] [Indexed: 02/05/2023] Open
Abstract
BACKGROUND Mental health is one of the important dimensions of health, while depression is an important indicator of mental health evaluation.
AIM To investigate the association between intergenerational emotional support and depression of non-cohabiting parents (≥ 45 years old) in China.
METHODS We used the fourth wave data from the China Health and Retirement Longitudinal Study (2015). The data was made up of ten main modules, the associated two datasets, and five constructed datasets. The first step is to select the corresponding module data according to the purpose of this study. Moreover, the data of the six modules are integrated by the unique ID code and we choose depression and non-cohabiting items as the selection conditions. 4810 samples were selected, which mainly included data on intergenerational emotional support and the individual scores on depressive symptoms.
RESULTS The average age of 4810 respondents was (60.56 ± 14.613) years old. Females were accounted for more than half of the samples (52.6%). 74.0% respondents from rural areas and approximately 63.3% of the participants had a chronic disease. The mean value of the CESD-10 score was 13.06 (SD5.225). Both faces to face and phone contacts were protective factors on depression symptoms in the mid-aged and seniors in China (P < 0.05). In terms of the frequency of face to face contact, the more frequently you met your parents, the lower your parents' depressive score was. Also, phone contact variable results are displayed as a positive correlation completely between inter-generational contacts from children and depressive symptoms in non-cohabiting parents in China. Children’s education level and income level were also reducing the risk of depression in non-cohabiting parents. However, gender, children’s numerous, chronic disease and chronic disease number were the risk factors.
CONCLUSION Intergenerational emotional support is associated with depressive symptoms in non-cohabiting parents in China. However, the relationship was also affected by other variables.
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Affiliation(s)
- Yun-Hua Jia
- Department of Nursing, Affiliated Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, Zhejiang Province, China
- School of Medicine, Zhejiang University City College, Hangzhou 310015, Zhejiang Province, China
| | - Zhi-Hong Ye
- Department of Nursing, Affiliated Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, Zhejiang Province, China
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