• Breast surgery
• Breast tumours
• Randomized Controlled Trial
• eHealth

• Humans
• Female
• Breast Neoplasms/therapy
• Breast Neoplasms/psychology
• Telemedicine
• COVID-19/epidemiology
• Randomized Controlled Trials as Topic
• Patient Reported Outcome Measures
• SARS-CoV-2
• Mobile Applications
• Ontario
• Quality of Life
• Fitness Trackers
• Patient Participation

• Innovation Fund of the Alternative Funding Plan for the Academic Health Sciences Centre of Ontario (AFP)
• The Princess Margaret Cancer Foundation
• Canadian Institute of Health Research

• Humans
• Male
• Radiosurgery/adverse effects
• Prostatic Neoplasms/pathology
• Prostatic Neoplasms/therapy
• Prostatic Neoplasms/radiotherapy
• Prostatic Neoplasms/drug therapy
• Prostatic Neoplasms/mortality
• Aged
• Androgen Antagonists/therapeutic use
• Androgen Antagonists/adverse effects
• Middle Aged
• Neoplasm Recurrence, Local/pathology
• Neoplasm Recurrence, Local/therapy
• Neoplasm Recurrence, Local/radiotherapy
• Aged, 80 and over
• Progression-Free Survival
• Combined Modality Therapy
• Prostate-Specific Antigen/blood
• Bone Neoplasms/secondary

• anxiety
• cancer
• coping with stress
• emotional control
• health
• oncology
• psycho‐oncology

• Humans
• Neoplasms/psychology
• Female
• Male
• Anxiety/psychology
• Stress, Psychological/psychology
• Middle Aged
• Emotional Regulation
• Aged
• Adult
• Emotions
• Surveys and Questionnaires

• Humans
• Lung Neoplasms/diagnosis
• Early Detection of Cancer
• Follow-Up Studies
• Prospective Studies
• Pilot Projects
• Patient Reported Outcome Measures
• Mass Screening/methods

• American Lung Association

• Bilateral prophylactic mastectomy
• Breast reconstruction
• Health-related quality of life
• Hereditary breast cancer
• Patient-reported outcomes
• Satisfaction

• Female
• Humans
• Mastectomy/methods
• Prophylactic Mastectomy/methods
• Breast Neoplasms/prevention & control
• Breast Neoplasms/surgery
• Quality of Life
• Mammaplasty/methods
• Patient Satisfaction
• Patient Reported Outcome Measures

• Adult
• Aged
• Aged, 80 and over
• Female
• Humans
• Middle Aged
• Young Adult
• Counseling
• Genetic Counseling/methods
• Genetic Testing/statistics & numerical data
• Ovarian Neoplasms/genetics
• Rosaniline Dyes

• Humans
• Cancer Survivors
• Chronic Pain
• Catastrophization/etiology
• Catastrophization/psychology
• Neoplasms/complications

• F31 NR019929 NINR NIH HHS

• COVID-19/prevention and control
• health care personnel
• intensive care units
• pediatric
• visitors to patients

• Child
• Humans
• Female
• Male
• Cross-Sectional Studies
• COVID-19
• Canada
• Intensive Care Units, Pediatric
• Surveys and Questionnaires
• Intensive Care Units
• Stress, Psychological/epidemiology

• 1025925 IWK Health Centre
• 174916 Canadian Institutes for Health Research

Dry eye is a disorder of tear film and ocular surface characterized by ocular discomforts. It is associated with multiple causes and sometimes intractable. We investigated the effect of oral multivitamin supplementation (MVG) on dry eyes. Tear break-up time (TBUT), fluorescein ocular surface staining score, and tear secretion Schirmer test were measured in dry eye patients refractory to conventional topical treatment. The ocular surface disease index (OSDI), visual analog pain score (VAS), and modified standardized patient evaluation of eye dryness questionnaire were analyzed. In total, 42 eyes of 42 patients were included. TBUT increased at 1 and 3 months compared to baseline (p < 0.05). OSDI decreased at 1 and 3 months compared to baseline (p < 0.05). VAS score, impact on life, and frequency of total symptoms decreased at 3 months compared to baseline (p < 0.05). Oral administration of MVG, a vitamin complex formulation, was effective in stabilizing tear stability and alleviating symptoms in patients with intractable dry eye. Thus, it may be a viable treatment option for intractable dry eye.

• Hallym University
• Hallym University Medical Center

• cancer
• depression
• inflammation
• resilience
• stress

• Breast Neoplasms/complications
• Breast Neoplasms/psychology
• Cancer Survivors/psychology
• Depression/psychology
• Female
• Humans
• Inflammation/complications
• Longitudinal Studies
• Prospective Studies

• K08 MH112773 NIMH NIH HHS
• P30 CA016042 NCI NIH HHS
• R01 CA160427 NCI NIH HHS
• T32 MH015750 NIMH NIH HHS
• National Institute of Mental Health
• National Cancer Institute

The ongoing coronavirus disease 2019 (COVID-19) pandemic infiltrates every aspect of our life, including the psychological impact. China has experienced the first wave of this epidemic, and it is now affecting the global population.

This study aimed to investigate the prevalence and associated factors of post-traumatic stress disorder (PTSD) among the general Chinese population.

A detailed questionnaire, comprising of 38 questions designed in both English and Chinese, was developed. The survey was conducted via WeChat, a multi-purpose messaging, social media, and mobile payment app, which is widely used by the Chinese population.

In total, 1082 individuals from 31 provinces, autonomous regions, and municipalities participated in the survey by filling the questionnaires through the WeChat app. 97.8% of the participants had an Impact of Event-Scale-Revised (IES-R) total score above 20, which is an indicator of PTSD. The IES-R total and all the three subscales, including intrusion, avoidance, and hyperarousal, are significantly correlated with age. In addition, age, profession, marital status, and level of education are significantly correlated with the degree of PTSD symptoms.

The COVID-19 epidemic has widely caused PTSD among the general Chinese population. These results bear important implications for regions struggling with the pandemic to implement effective interventions to cope with these mental health problems.

• COVID-19
• Post-traumatic stress disorder
• Impact of Event-Scale-Revised
• China

• COVID-19
• Iran
• depression
• financial distress
• social support
• spiritual well-being
• stress

During, shortly after, and sometimes for years after hematopoietic stem cell transplant, a large proportion of hematological cancer patients undergoing transplant report significant physical and psychological symptoms and reduced health-related quality of life. To address these survivorship problems, we developed a low-burden, brief psychological intervention called expressive helping that includes two theory- and evidence-based components designed to work together synergistically: emotionally expressive writing and peer support writing. Building on evidence from a prior randomized control trial showing reductions in physical symptoms and distress in long-term transplant survivors with persistent survivorship problems, the Writing for Insight, Strength, and Ease (WISE) trial will evaluate the efficacy of expressive helping when used during transplant and in the early post-transplant period, when symptoms peak, and when intervention could prevent development of persistent symptoms.

WISE is a multi-site, two-arm randomized controlled efficacy trial. Adult hematological cancer patients scheduled for a hematopoietic stem cell transplant will complete baseline measures and then, after hospitalization but prior to transplant, they will be randomized to complete either expressive helping or a time and attention “neutral writing” task. Both expressive helping and neutral writing involve four brief writing sessions, beginning immediately after randomization and ending approximately 4 weeks after hospital discharge. Measures of symptom burden (primary outcome), distress, health-related quality of life, and fatigue (secondary outcomes) will be administered in seven assessments coinciding with medically relevant time points from baseline and to a year post-intervention.

The steady and continuing increase in use of stem cell transplantation has created growing need for efficacious, accessible interventions to reduce the short- and long-term negative physical and psychosocial effects of this challenging but potentially life-saving treatment. Expressive helping is a psychological intervention that was designed to fill this gap. It has been shown to be efficacious in long-term transplant survivors but could have even greater impact if it is capable of reducing symptoms during and soon after transplant. The WISE study will evaluate these benefits in a rigorous randomized controlled trial.

Clinicaltrial.govNCT03800758. Registered January 11, 2019

• Cancer survivors
• Expressive writing
• Hematopoietic stem cell transplant
• Patient-reported outcomes
• Peer support
• Psychological intervention
• Randomized controlled trial

• Breast cancer
• Distress
• Health disparities
• Race

• COVID-19
• perceived scale
• psychometric properties
• stress

Lockdown has been enforced globally to curb the spread of SARS-CoV-2. Patients with uncontrolled asthma are at risk of severe illness from COVID-19, highlighting the priority of adequate asthma control during the pandemic. Staying indoors exposes asthmatics to indoor asthma triggers, including disinfectants used for limiting the virus spread, in addition to psychological stresses of the pandemic which represent crucial contributors to loss of asthma control. Elective medical care, curtailed by the lockdown procedures, compromises adequate asthma follow up. The current study evaluated the effect of COVID-19 lockdown on the level of asthma control and mental health of bronchial asthma patients. The study included 264 bronchial asthma patients, aged 12 years and older, who responded to an online questionnaire including the asthma control test to evaluate asthma control in the preceding 4 weeks. Anxiety and depression scores and the impact of event scale were also provided.

Seventy percent of asthmatics had uncontrolled asthma, and disinfectant use was associated with perceived increase in asthma symptoms in 77.7%. Anxiety and depression were associated with uncontrolled asthma in 50% of participants, suggesting a possible psychological impact on asthma patients.

During lockdown, asthma patients participating in the study had significantly uncontrolled disease and associated anxiety and depression. Since regular follow-up of asthma patients is cornerstone to adequate asthma control, alternative methods of medical care for asthma patients during lockdown are warranted, and particular need for mental health support ought to be provided as a continuum to adequate asthma control.

• 5-HTTLPR polymorphism
• breast cancer
• post-traumatic stress disorder
• post-traumatic stress symptoms
• serotonine transporter

• Avoidance
• Cancer survivors
• Cancer-related distress
• Inflammation
• Intrusive thoughts

• endoscopic ultrasound
• pancreatic cancer
• screening

• Adjuvant therapy
• Breast cancer
• Patients’ preferences

• Antineoplastic Agents, Hormonal/adverse effects
• Antineoplastic Combined Chemotherapy Protocols
• Breast Neoplasms/drug therapy
• Chemotherapy, Adjuvant
• Child
• Female
• Humans
• Patient Preference
• Survival Rate

Keratoconjunctivitis sicca (KCS) or dry eye is a disease characterized by ocular surface symptoms. This study aimed to investigate the effectiveness of oral choline alfoscerate (CA) administration as a treatment for KCS. The medical records of dry eye patients who were refractory to topical eyedrops and then took oral CA were reviewed. Results of tear break-up time (TBUT), fluorescein ocular surface staining score (FSS), and tear secretion by the Schirmer test (STT) were analyzed. The results of the ocular surface disease index (OSDI), visual analog pain score (VAS), reporting of the severity and frequency of symptoms, and the modified Standardized Patient Evaluation of Eye Dryness (SPEED) questionnaire were also analyzed. The records of 47 patients were analyzed for this study. The mean age was 62.8 ± 9.3 years, and the patients included 9 males and 38 females. TBUT, OSDI, and VAS significantly improved after CA administration compared to before (p < 0.05, paired t-test). After CA administration, symptom frequency and impact on life improved (p < 0.05, paired t-test). No significant change in photophobia or FSS was identified. In conclusion, oral CA administration was effective in improving tear stability and alleviating symptoms of KCS.

• choline alfoscerate
• dry eye symptoms
• keratoconjunctivitis sicca
• tear break-up time

• Critical events
• Effort-recovery model
• Emotional demands
• Job demands-resources model
• [Leisure Activities]
• [Nursing Staff, Hospital]
• [Stress Disorders, Post-Traumatic]
• [aggression]
• [burnout, professional]
• [emergency service, hospital]

• Adaptation, Psychological
• Adult
• Attitude of Health Personnel
• Burnout, Professional/prevention & control
• Burnout, Professional/psychology
• Cross-Sectional Studies
• Emergency Nursing/methods
• Emergency Nursing/statistics & numerical data
• Female
• Humans
• Job Satisfaction
• Leisure Activities/psychology
• Male
• Middle Aged
• Netherlands
• Nurses/psychology
• Occupational Stress/complications
• Occupational Stress/psychology
• Occupational Stress/therapy
• Surveys and Questionnaires
• Workplace/psychology
• Workplace/standards

Routine screening for ovarian cancer (OC) can yield an abnormal result later deemed benign. Such false positive (FP) results have been shown to trigger distress, which generally resolves over time. However, women might differ in the trajectory of the distress experience. Women participating in a routine OC screening program (n = 373) who received an abnormal screening result completed a baseline assessment prior to a follow-up screening test to clarify the nature of their abnormal result. All women were subsequently informed that no malignancy was present, and follow-up assessments were completed one and four months post-baseline. Demographic, clinical, dispositional (optimism, monitoring), and social environmental (social constraint, social support) variables were assessed at baseline. OC-specific distress was assessed at all three assessments. Trajectory analyses identified three distress trajectories differing in the baseline level of distress. A high decreasing trajectory, representing about 25% of women, was characterized by high levels of distress at baseline with distress declining over time, but still elevated at four-month follow-up. In contrast, a no distress trajectory group, representing about 30% of women, was characterized by essentially no distress at any time point. Principal risk factors for membership in the high decreasing trajectory group included a family history of OC, lower dispositional optimism, and greater social constraint. These risk factors could be used to target resources efficiently towards managing women at risk for potentially clinically-significant distress after receipt of an FP OC screening test.

• adjustment
• distress
• ovarian cancer
• screening
• trajectory analysis

• CA84036 NCI NIH HHS

Studies have consistently indicated that the majority of individuals meeting the US Prevention Services Task Force guidelines for genetic testing have not had genetic counseling or testing. Despite increased availability and lower costs of multiplex cancer gene panels, there remains a gap in genetics services that has not been addressed by the current care delivery models. Lower cost of DNA sequencing with online patient-initiated ordering could increase test availability, but the ideal quantity and delivery method of patient education is not known. We hypothesized that online genetic education and testing with access to board certified genetic counselors could improve access to genetic testing while maintaining test quality and clinical utility. The MAGENTA (MAking GENetic Testing Accessible) trial is a nationwide randomized study designed to compare the effectiveness of online genetic education with pre- and post-test telephone genetic counseling to three potentially more accessible alternative approaches: online genetic education with optional telephone counseling, online genetic education with required pre-test telephone genetic counseling, and online genetic education with required post-test telephone genetic counseling.

3000 women nationwide will undergo genetic testing for 19 hereditary cancer genes. This is a randomized four-arm non-inferiority study with equal randomization. The four study arms were selected to independently assess the delivery of genetic information both before and after genetic testing (pre-test and post-test) by either requiring telephone genetic counseling or providing only online education with optional telephone counseling. Patients have post-test telephone counseling when testing positive for a pathogenic inherited mutation in all four arms. Surveys measuring psychological, behavioral and cognitive state are completed online at baseline, 3 months, 12 months and 24 months post-results disclosure. The primary study outcome is cancer-risk distress at 3 months post-result disclosure.

This trial will assess the use of a genetic service model using online access and electronic education, while evaluating the need for personal pre- and post-test genetic counseling. Data from this study may lead to increased options for delivery of genetic testing and possibly increase access to genetic testing. Identifying more individuals with inherited cancer susceptibility will allow targeted cancer prevention.

Clinicaltrials.gov: NCT02993068 (registered December 14, 2016).

• Genetic counseling
• Genetic testing
• Hereditary cancer
• Ovarian cancer

• cancer
• emotional distress
• metacognitive therapy
• open trial
• survivors

• Cancer disparities
• Masculinity
• Psychological distress
• Restrictive emotionality
• Social constraints

• Adult
• Aged
• Depression/psychology
• Emotions
• Humans
• Male
• Masculinity
• Men/psychology
• Middle Aged
• Neoplasms, Germ Cell and Embryonal/psychology
• Prostatic Neoplasms/psychology
• Social Norms
• Testicular Neoplasms/psychology
• Young Adult

• SC1 CA187494 NCI NIH HHS
• T32 MH015750 NIMH NIH HHS

• APIM
• breast cancer
• dyads
• emotional distress
• oncology
• partners
• post-traumatic growth
• spirituality