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Schaen‐Heacock NE, Rowe LM, Ciucci MR, Russell JA. Effects of chemoradiation and tongue exercise on swallow biomechanics and bolus kinematics. Head Neck 2025; 47:355-370. [PMID: 39150237 PMCID: PMC11635752 DOI: 10.1002/hed.27899] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/26/2023] [Revised: 06/20/2024] [Accepted: 07/18/2024] [Indexed: 08/17/2024] Open
Abstract
BACKGROUND Common treatments for head and neck cancer (radiation and chemotherapy) can lead to dysphagia; tongue exercise is a common intervention. This study aimed to assess swallow biomechanics and bolus kinematics using a well-established rat model of radiation or chemoradiation treatment to the tongue base, with or without tongue exercise intervention. METHODS Pre- and post-treatment videofluoroscopy was conducted on 32 male Sprague-Dawley rats treated with radiation/chemoradiation and exercise/no exercise. Rats in the exercise groups completed a progressive resistance tongue training paradigm. Swallow biomechanics, bolus kinematics, jaw opening, and post-swallow respiration were assessed. RESULTS Both treatments impacted outcome measures; the addition of exercise intervention showed benefit for some measures, particularly in rats treated with radiation, vs. chemoradiation. CONCLUSIONS Radiation and chemoradiation can significantly affect aspects of deglutition; combined treatment may result in worse outcomes. Tongue exercise intervention can mitigate deficits; more intensive intervention may be warranted in proportion to combined treatment.
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Affiliation(s)
- Nicole E. Schaen‐Heacock
- Department of Communication Sciences and DisordersUniversity of Wisconsin‐MadisonMadisonWisconsinUSA
- Division of Otolaryngology, Department of SurgeryUniversity of Wisconsin‐MadisonMadisonWisconsinUSA
| | - Linda M. Rowe
- Department of Communication Sciences and DisordersUniversity of Wisconsin‐MadisonMadisonWisconsinUSA
- Division of Otolaryngology, Department of SurgeryUniversity of Wisconsin‐MadisonMadisonWisconsinUSA
| | - Michelle R. Ciucci
- Department of Communication Sciences and DisordersUniversity of Wisconsin‐MadisonMadisonWisconsinUSA
- Division of Otolaryngology, Department of SurgeryUniversity of Wisconsin‐MadisonMadisonWisconsinUSA
- Neuroscience Training ProgramUniversity of Wisconsin‐MadisonMadisonWisconsinUSA
| | - John A. Russell
- Division of Otolaryngology, Department of SurgeryUniversity of Wisconsin‐MadisonMadisonWisconsinUSA
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Leonard R, Miles A, Bakker L, Allen J. A Novel Quantitative Measure of Pharyngeal Shortening. Laryngoscope 2024; 134:2121-2126. [PMID: 37916781 DOI: 10.1002/lary.31149] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/28/2023] [Revised: 10/10/2023] [Accepted: 10/17/2023] [Indexed: 11/03/2023]
Abstract
BACKGROUND Little is known about pharyngeal shortening (PShort) during swallowing. This observational study measured PShort during swallowing in healthy adults and compared it to patients with swallowing impairments of different aetiologies. METHODS 275 healthy volunteers (19-99 years) and 75 dysphagic patients (25 with head and neck cancer, 25 with Parkinson's, 25 with stroke) underwent videofluoroscopy. A novel quantitative measure of PShort for 1, 3, and 20 mL thin liquid barium and 3 mL paste boli was determined and compared across age, sex, bolus type and patient cohort. RESULTS PShort ranged from 1.05 to 4.41 cm across bolus types with larger displacements for 20 mL (M: 2.52 cm) and paste (M: 2.43 cm) compared with 1 mL (M: 2.36 cm) and 3 mL (M: 2.41 cm). PShort correlated with sex, height, and cohort but not age. Inter-rater reliability for three raters was substantial (intraclass correlation >0.80). CONCLUSIONS This novel fluoroscopic measure of PShort is reliable and demonstrates quantitative changes in vertical pharyngeal displacement in healthy and swallow-impaired adults related to sex, size, and bolus type. LEVEL OF EVIDENCE 3 Laryngoscope, 134:2121-2126, 2024.
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Affiliation(s)
- Rebecca Leonard
- Department of Otolaryngology, University California, Davis, Davis, California, USA
| | - Anna Miles
- Department of Speech Science, The University of Auckland, Auckland, New Zealand
| | - Lise Bakker
- Department of Speech Science, The University of Auckland, Auckland, New Zealand
| | - Jacqueline Allen
- Department of Surgery, The University of Auckland, Auckland, New Zealand
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Randall DR, Young-Speirs M, Walker K. Association of the "Jet Phenomenon" with Positive Symptom Outcome Following Surgical Treatment of Cricopharyngeus Muscle Dysfunction. Dysphagia 2023; 38:1440-1446. [PMID: 37093277 DOI: 10.1007/s00455-023-10573-2] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/21/2022] [Accepted: 03/31/2023] [Indexed: 04/25/2023]
Abstract
OBJECTIVES Cricopharyngeus muscle dysfunction (CPMD) is a common cause for progressive dysphagia and can lead to dietary restriction, reduced nutrition, weight loss, and pneumonia. Controversy exists whether CPMD is best managed with primary surgical treatment of the cricopharyngeus muscle and who represents a good surgical candidate. METHODS Retrospective review of patients diagnosed with CPMD who underwent surgical treatment were evaluated through prospectively collected pre- and postoperative Eating Assessment Tool-10 (EAT-10) and Functional Oral Intake Scale (FOIS). Videofluoroscopic swallowing studies (VFSS) were reviewed for presence or absence of a high-pressure barium stream through the upper esophageal sphincter, termed the jet phenomenon (JP). RESULTS We identified 42 patients with CPMD who underwent surgical treatment and had serial Eating Assessment Tool (EAT-10) measures obtained pre- and postoperatively. Mean EAT-10 scores improved by 12.1 points (95%CI = 8.6-15.6), p < 0.0001. There was a significantly greater improvement among patients with JP (|∆EAT-10|= 17.0, 95%CI = 12.5-21.4) compared to those without (|∆EAT-10|= 6.2, 95%CI = 1.6-10.8), p = 0.0013. Patients with JP also showed improved FOIS score (p = 0.0023) while those without JP did not. CONCLUSION This study provides the initial report on the utility of JP as a VFSS feature that is strongly associated with improved outcomes following surgical treatment of CPMD. Further work determining the physiologic correlates responsible for JP will help clarify its predictive capabilities. LEVEL OF EVIDENCE Level 3.
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Affiliation(s)
- Derrick R Randall
- Section of Otolaryngology-Head & Neck Surgery, Department of Surgery, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
- Peter Lougheed Centre, Outpatient Dysphagia Clinic, Calgary, AB, Canada.
| | | | - Kim Walker
- Peter Lougheed Centre, Outpatient Dysphagia Clinic, Calgary, AB, Canada
- Speech Language Pathology, Department of Allied Health, South Health Campus, Calgary, AB, Canada
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Feng HY, Zhang PP, Wang XW. Presbyphagia: Dysphagia in the elderly. World J Clin Cases 2023; 11:2363-2373. [PMID: 37123321 PMCID: PMC10131003 DOI: 10.12998/wjcc.v11.i11.2363] [Citation(s) in RCA: 14] [Impact Index Per Article: 7.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/17/2023] [Revised: 02/08/2023] [Accepted: 03/22/2023] [Indexed: 04/06/2023] Open
Abstract
Dysphagia has been classified as a “geriatric syndrome” and can lead to serious complications that result in a tremendous burden on population health and healthcare resources worldwide. A characteristic age-related change in swallowing is defined as “presbyphagia.” Medical imaging has shown some changes that seriously affect the safety and efficacy of swallowing. However, there is a general lack of awareness of the effects of aging on swallowing function and a belief that these changes are part of normal aging. Our review provides an overview of presbyphagia, which has been a neglected health problem for a long time. Attention and awareness of dysphagia in the elderly population should be strengthened, and targeted intervention measures should be actively implemented.
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Affiliation(s)
- Hai-Yang Feng
- School of Rehabilitation Medicine, Weifang Medical University, Weifang 261021, Shandong Province, China
| | - Ping-Ping Zhang
- School of Rehabilitation Medicine, Weifang Medical University, Weifang 261021, Shandong Province, China
| | - Xiao-Wen Wang
- School of Rehabilitation Medicine, Weifang Medical University, Weifang 261021, Shandong Province, China
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Jijakli A, Borders JC, Gottlieb A, Ramirez E, Leonard R, Langmore SE, Murray J, Pisegna JM. Absent epiglottic inversion as seen on flexible endoscopic evaluations of swallowing (FEES) is associated with a gestalt reduction in swallowing mechanics. Am J Otolaryngol 2023; 44:103757. [PMID: 36753976 DOI: 10.1016/j.amjoto.2022.103757] [Citation(s) in RCA: 4] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/04/2022] [Accepted: 12/18/2022] [Indexed: 01/26/2023]
Abstract
PURPOSE Epiglottic inversion, which provides one layer of the requisite protection of the airway during swallowing, is dependent on a number of biomechanical forces. The aim of this study was to examine the association between swallowing mechanics, as visualized during a Modified Barium Swallow (MBS) exam, and the rating of epiglottic inversion as seen on Flexible Endoscopic Evaluation of Swallowing (FEES). METHODS This study analyzed twenty-five adult outpatients referred for a simultaneous FEES/MBS exams. Each participant swallowed a 5 mL thin liquid bolus, which was the bolus size analyzed for this study's question. Epiglottic inversion, as seen on FEES, was rated by three independent raters. Additionally, twelve swallowing landmarks tracked the shape change of each participant's swallow on the MBS video using a MatLab-specific tracking tool. Analyses were run to determine mean differences in swallowing shape change between the swallows across 3 groups: complete, reduced, and absent epiglottic inversion, as seen on FEES. Using a Computerized Analysis of Swallowing Mechanics (CASM), canonical variate analyses and discriminant function testing were carried out. Other swallowing mechanics were also analyzed for kinematic movements to isolate the function of the hyoid and larynx. A two-sample t-test was conducted to compare mean hyolaryngeal movement between complete and incomplete epiglottic inversion groups. RESULTS Overall swallowing shape changes were statistically significantly different between the absent, reduced, and complete epiglottic inversion groups on FEES. Canonical variate analyses revealed a significant overall effect of shape change between the groups (eigenvalue = 2.46, p < 0.0001). However, no statistically significant differences were found on hyoid excursion (p = 0.37) and laryngeal elevation (p = 0.06) kinematic measurements between patients with complete and incomplete epiglottic inversion on FEES. CONCLUSION Epiglottic inversion on FEES is a valuable rating that infers reduced range of motion of structures that cannot be seen on FEES. This small sample of patients suggests that FEES ratings of absent epiglottic inversion may represent gestalt reduction in swallowing mechanics.
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Affiliation(s)
- Amr Jijakli
- Boston University School of Public Health, Boston, MA, United States of America
| | - James C Borders
- Department of Otolaryngology, Boston Medical Center, Boston, MA, United States of America
| | - Amy Gottlieb
- Department of Otolaryngology, Boston Medical Center, Boston, MA, United States of America; Boston University Chobanian & Avedisian School of Medicine, Boston, MA, United States of America
| | - Emily Ramirez
- Boston University School of Public Health, Boston, MA, United States of America
| | - Rebecca Leonard
- University of California at Davis, Davis, CA, United States of America
| | - Susan E Langmore
- Boston University Chobanian & Avedisian School of Medicine, Boston, MA, United States of America
| | - Joseph Murray
- VA Ann Arbor Health Care System, Ann Arbor, MI, United States of America
| | - Jessica M Pisegna
- Department of Otolaryngology, Boston Medical Center, Boston, MA, United States of America; Boston University Chobanian & Avedisian School of Medicine, Boston, MA, United States of America.
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Nakamura T, Kita Y, Fujimoto J, Ayuzawa K, Ozawa H. Hyoid bone movement during swallowing and mechanism of pharyngeal residue in patients with profound intellectual and multiple disabilities. Int J Pediatr Otorhinolaryngol 2021; 149:110849. [PMID: 34329832 DOI: 10.1016/j.ijporl.2021.110849] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 02/11/2021] [Revised: 06/22/2021] [Accepted: 07/18/2021] [Indexed: 10/20/2022]
Abstract
OBJECTIVES Dysphagia is linked to mortality risk among patients with profound intellectual and multiple disabilities (PIMD); the present study therefore aimed to clarify the characteristics of hyoid movements during swallowing and to examine the mechanism of dysphagia in patients with PIMD. METHODS A retrospective video fluoroscopic swallowing study was conducted on 43 patients with PIMD (mean age = 25.4; 25 males, 18 females) and 24 healthy adults (mean age = 44.3; 16 males, 8 females). The movements of the hyoid bone and mandible were tracked frame by frame in the video footage, and their range of movements and trajectories were analyzed. RESULTS Most patients showed atypical movement trajectories of the hyoid, such as insufficient anterior movement and increased range of mandibular downward movement, compared with normal adults. Moreover, the mechanism of dysphagia was revealed by structural equation modeling, indicating that insufficient anterior movement could lead to pharyngeal residue in the pyriform sinus. CONCLUSION The insufficient anterior movement of the hyoid could be caused by weak ventral suprahyoid muscles and atypical head and neck posture characteristic of patients with PIMD. It may be useful to predict pharyngeal residue from the range of hyoid movements and trajectories for the prevention of aspiration.
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Affiliation(s)
- Tatsuya Nakamura
- Department of Rehabilitation, Shimada Ryoiku Medical Center Hachioji for Challenged Children, Japan.
| | - Yosuke Kita
- Mori Arinori Center for Higher Education and Global Mobility, Hitotsubashi University, Japan; Cognitive Brain Research Unit, Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Japan
| | - Junpei Fujimoto
- Department of Rehabilitation, Shimada Ryoiku Medical Center Hachioji for Challenged Children, Japan
| | - Koichi Ayuzawa
- Department of Rehabilitation, Shimada Ryoiku Medical Center Hachioji for Challenged Children, Japan
| | - Hiroshi Ozawa
- Department of Pediatrics, Shimada Ryoiku Medical Center Hachioji for Challenged Children, Japan
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Mehraban-Far S, Alrassi J, Patel R, Ahmad V, Browne N, Lam W, Jiang Y, Barber N, Mortensen M. Dysphagia in the elderly population: A Videofluoroscopic study. Am J Otolaryngol 2021; 42:102854. [PMID: 33482586 DOI: 10.1016/j.amjoto.2020.102854] [Citation(s) in RCA: 13] [Impact Index Per Article: 3.3] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/06/2020] [Revised: 11/22/2020] [Accepted: 12/22/2020] [Indexed: 11/20/2022]
Abstract
OBJECTIVE To examine the impact of age and underlying comorbid conditions on swallowing in elderly patients with dysphagia. METHODS Charts of consecutive patients aged >64 studied by Videofluoroscopic swallowing study (VFSS) between 2010 and 2018 at our institution were reviewed (n = 731). Patients were categorized based on age into young old (aged 65-74), older old (aged 75-84) and oldest old (aged 85+). The underlying comorbidities and VFSS results were compared between different age groups. RESULTS Dysphagia was more likely to be caused by presbyphagia (p < 0.01) and dementia (p < 0.0001) in the oldest old, whereas, head and neck cancers (p < 0.0001) were more common in the young old cohort. In the absence of organic disease (e.g. cancer, stroke, dementia), aging was associated with prolonged oral transit time (OTT) (p < 0.05) and aspiration after swallow (p < 0.05). Compared to those with presbyphagia, patients with organic disease were more likely to have delayed pharyngeal swallow response (p < 0.05) and aspiration during swallow (p < 0.005). CONCLUSION There are significant differences in the etiology of dysphagia between different age cohorts amongst the dysphagic elderly population. In addition, organic diseases affect swallowing differently than does mere aging. The rate of prolonged OTT and post-swallow aspiration increase with aging in patients with presbyphagia, likely due to age-related sarcopenia of the swallowing muscles. Whereas, those with organic diseases have a higher rate of delayed pharyngeal swallow response and aspiration during swallow, likely due to sensorineural impairment. Thus, it is important to view the elderly as a heterogeneous group when evaluating patients with dysphagia.
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Affiliation(s)
- Sina Mehraban-Far
- Stony Brook University Hospital, Department of Surgery, Stony Brook, NY, USA.
| | - James Alrassi
- SUNY Downstate Health Sciences University, Department of Otolaryngology, Brooklyn, NY, USA
| | - Rushil Patel
- Stony Brook University Hospital, Department of Surgery, Stony Brook, NY, USA
| | - Verdah Ahmad
- Stony Brook University Hospital, Department of Surgery, Stony Brook, NY, USA
| | - Nicholas Browne
- Stony Brook University Hospital, Department of Surgery, Stony Brook, NY, USA
| | - Wai Lam
- Stony Brook University Hospital, Department of Surgery, Stony Brook, NY, USA
| | - Yujie Jiang
- Stony Brook University Hospital, Department of Surgery, Stony Brook, NY, USA
| | - Nathaniel Barber
- Stony Brook University Hospital, Department of Surgery, Stony Brook, NY, USA
| | - Melissa Mortensen
- Albany Medical College, Department of Otolaryngology, Albany, NY, USA
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Dietsch AM, Westemeyer RM, Pearson WG, Schultz DH. Genetic Taster Status as a Mediator of Neural Activity and Swallowing Mechanics in Healthy Adults. Front Neurosci 2019; 13:1328. [PMID: 31920497 PMCID: PMC6927995 DOI: 10.3389/fnins.2019.01328] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/31/2019] [Accepted: 11/26/2019] [Indexed: 01/05/2023] Open
Abstract
As part of a larger study examining relationships between taste properties and swallowing, we assessed the influence of genetic taster status (GTS) on measures of brain activity and swallowing physiology during taste stimulation in healthy men and women. Twenty-one participants underwent videofluoroscopic swallowing study (VFSS) and functional magnetic resonance imaging (fMRI) during trials of high-intensity taste stimuli. The precisely formulated mixtures included sour, sweet-sour, lemon, and orange taste profiles and unflavored controls. Swallowing physiology was characterized via computational analysis of swallowing mechanics plus other kinematic and temporal measures, all extracted from VFSS recordings. Whole-brain analysis of fMRI data assessed blood oxygen responses to neural activity associated with taste stimulation. Swallowing morphometry, kinematics, temporal measures, and neuroimaging analysis revealed differential responses by GTS. Supertasters exhibited increased amplitude of most pharyngeal movements, and decreased activity in the primary somatosensory cortex compared to nontasters and midtasters. These preliminary findings suggest baseline differences in swallowing physiology and the associated neural underpinnings associated with GTS. Given the potential implications for dysphagia risk and recovery patterns, GTS should be included as a relevant variable in future research regarding swallowing function and dysfunction.
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Affiliation(s)
- Angela M Dietsch
- Department of Special Education and Communication Disorders, University of Nebraska-Lincoln, Lincoln, NE, United States.,Center for Brain, Biology and Behavior, University of Nebraska-Lincoln, Lincoln, NE, United States
| | - Ross M Westemeyer
- Department of Special Education and Communication Disorders, University of Nebraska-Lincoln, Lincoln, NE, United States
| | - William G Pearson
- Department of Cellular Biology & Anatomy, Medical College of Georgia, Augusta University, Augusta, GA, United States
| | - Douglas H Schultz
- Center for Brain, Biology and Behavior, University of Nebraska-Lincoln, Lincoln, NE, United States
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