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Sun J, Brooks EC, Houshyar Y, Connor SJ, Paven G, Grimm MC, Hold GL. Unravelling the Relationship Between Obesity and Inflammatory Bowel Disease. Inflamm Bowel Dis 2025:izaf098. [PMID: 40397482 DOI: 10.1093/ibd/izaf098] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/12/2024] [Indexed: 05/22/2025]
Abstract
Mirroring the global obesity epidemic, obesity rates in inflammatory bowel disease (IBD) patients is rising. Several epidemiological studies propose that 15%-40% of adult patients with IBD are obese, and an additional 25%-40% fall into the overweight category. This article examines the pathophysiologic relationship between obesity and IBD concerning the role of visceral adipose tissue, microbiota shifts, dietary patterns, and hunger hormone changes. Additionally, increasing evidence is demonstrating the negative impact that obesity is having on disease course and quality of life in patients with IBD. Obesity has been demonstrated to be associated with an attenuated response to immunomodulators and biological agents, as well as higher rates of peri-operative surgical complications. A better understanding of the relationship between obesity and IBD can be applied to clinical decision-making in personalizing treatment plans, promoting weight loss in patients with obesity, and identifying areas of future research.
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Affiliation(s)
- Jessica Sun
- Microbiome Research Centre, School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia
- Prince of Wales Hospital, South Eastern Sydney Local Health District, Sydney, NSW, Australia
| | - Ella C Brooks
- Microbiome Research Centre, School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia
| | - Yashar Houshyar
- Microbiome Research Centre, School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia
- St. George and Sutherland Clinical Campuses, University of New South Wales, Sydney, NSW, Australia
| | - Susan J Connor
- Department of Gastroenterology and Hepatology, Liverpool Hospital, Liverpool, NSW 2170, Australia
| | - Gokulan Paven
- St. George and Sutherland Clinical Campuses, University of New South Wales, Sydney, NSW, Australia
| | - Michael C Grimm
- Microbiome Research Centre, School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia
- St. George and Sutherland Clinical Campuses, University of New South Wales, Sydney, NSW, Australia
| | - Georgina L Hold
- Microbiome Research Centre, School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia
- St. George and Sutherland Clinical Campuses, University of New South Wales, Sydney, NSW, Australia
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Boisen EB, Cawson M, de Fries Jensen L, Mealing S, van Hest N. Cost-Effectiveness of a Digital Leakage Notification System (Heylo™) for People with Ileostomies or Colostomies in the United Kingdom. PHARMACOECONOMICS 2025:10.1007/s40273-025-01498-9. [PMID: 40329061 DOI: 10.1007/s40273-025-01498-9] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Subscribe] [Scholar Register] [Accepted: 04/06/2025] [Indexed: 05/08/2025]
Abstract
BACKGROUND People with stomas report a substantial negative impact of stomal effluent leaking outside the ostomy baseplate and subsequent complications in their professional and social lives, causing immense worry. However, many patients are not able to recognize leakages in a timely manner. We conducted a cost-effectiveness study to evaluate the impact of a digital leakage notification system (DLNS) to reduce leakages outside the baseplate (LOB) and worry about leakage for people with intestinal stomas from a UK National Health Service and Personal Social Services perspective. METHODS A Markov model for ostomy care was used to compare health-related quality of life and costs for adults with ileostomies or colostomies using UK standard of care ostomy products with the DLNS (intervention) or without the DLNS (comparator). The base case model used a 3-year time horizon with 1-week cycles and an annual 3.5% discounting of utilities and costs. Patients in all health states experience LOB events and/or worry about leakage as events associated with one-time utility decrements and costs of additional healthcare provider visits and ostomy product use. Probabilities of LOB (DLNS, 46.5%; comparator, 78.6%) and worry about leakage (DLNS, 39.1%; comparator, 78.6%) were based on clinical trial results. Peristomal skin complications were included in the model with the same probabilities of occurrence in the intervention and comparator arms. Sensitivity and scenario analyses were performed to test the robustness of the base case model assumptions. RESULTS In the base case analysis, the DLNS arm had 49.81 fewer LOB events per person than the comparator arm, resulting in 0.309 incremental quality-adjusted life-years (QALYs) and cost savings of British Pound Sterling (GBP) £1703 per person over 3 years (2023/2024 costing year). The DLNS arm had 56.98 fewer worry about leakage events per person, resulting in cost savings of £403 per person. Total costs and QALYs were £18,600 and 1.818 for the intervention arm, respectively, and £18,566 and 1.509 for the comparator arm. Overall, the DLNS provided 0.309 incremental QALYs at an incremental cost of £34 versus the comparator arm for an incremental cost-effectiveness ratio of £110/QALY gained, well below a willingness-to-pay threshold of £20,000/QALY. Sensitivity analyses showed the DLNS was cost-effective in 97.6% of simulations. CONCLUSIONS This analysis suggests that the DLNS added to standard of care ostomy products is a cost-effective intervention to help prevent LOB events and reduce worry about leakage for people with stomas in the UK. Results of the present study suggest that timely awareness of leakage has a positive impact on the health-related quality of life of people with stomas and on the direct costs of stoma management in the UK.
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Ma LL, Zhang YJ, Zhuang HR, Jiang H. Risk Prediction Model of Peristomal Skin Complications Among Patients with Colorectal Cancer and an Ostomy: A Cross-sectional Study in Shanghai, China. Adv Skin Wound Care 2025; 38:133-141. [PMID: 39874423 DOI: 10.1097/asw.0000000000000245] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/30/2025]
Abstract
OBJECTIVE To analyze the risk factors for peristomal skin complications (PSCs) in patients with colorectal cancer and an ostomy, construct a prediction model, and verify its effectiveness. METHODS In this cross-sectional study, researchers recruited 265 patients with an ostomy at the stoma clinic of a tertiary hospital, from May 2022 to August 2023. Patients were divided into two groups: complications group (n = 81) and no complications group (n = 184). Researchers constructed a logistic regression prediction model using univariate and multivariate analyses. From May 2023 to August 2023, a validation group of 135 patients with an ostomy was selected for external validation of the model. RESULTS The incidence of PSCs was 30.57% in the modeling group and 30.37% in the validation group. The predictor variables were preoperative and postoperative health education, tumor therapy within 3 months, preoperative stoma positioning, stoma height, stoma type, and excrement state. The Hosmer-Lemeshow test yielded a P value of .513, the area under the receiver operating characteristic curve was 0.872, the Youden index was 0.561, and the sensitivity and specificity were 0.827 and 0.734. For external validation, the Hosmer-Lemeshow test yielded a P value of .835, the area under the receiver operating characteristic curve was 0.887, and the sensitivity and specificity were 0.905 and 0.720, respectively. CONCLUSIONS The prediction model demonstrates good predictive efficacy and can serve as a reference for clinical caregivers in identifying patients at high risk of PSCs.
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Affiliation(s)
- Li-Li Ma
- Li-li Ma, MSc, RN, is PhD Candidate, Medical College, Tongji University, Shanghai, Chinaï¼Department of Nursing, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China. Ya-juan Zhang, MSc, RN, is Head Nurse, Department of Nursing, Shanghai Sixth People's Hospital, School of Medicine, Jiao Tong University, Shanghai. Hui-ren Zhuang, MSc, RN, is Department Head Nursing, Department of Nursing, Shanghai East Hospital, School of Medicine, Tongji University. Hui Jiang, PhD, RN, is Nursing Director, Department of Nursing, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University. Acknowledgments: The authors express their gratitude to all the participants who were involved in this study. The authors have disclosed no financial relationships related to this article. Submitted November 14, 2023; accepted in revised form January 23, 2024
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Maeng D, Hoffman RL, Sun V, Sticca RP, Krouse RS. Post-surgical acute care utilization and cost of care among cancer survivors with an ostomy: Findings from three large hospital systems in the United States. J Cancer Policy 2025; 43:100534. [PMID: 39657389 PMCID: PMC11890926 DOI: 10.1016/j.jcpo.2024.100534] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/31/2024] [Revised: 12/05/2024] [Accepted: 12/08/2024] [Indexed: 12/12/2024]
Abstract
PURPOSE To describe patterns of 6-month total cost of care and acute care utilization among cancer survivors who received ostomy surgeries in 3 large hospital systems in the United States between 2018 and 2022 and to identify reasons for acute care utilization. METHODS A retrospective cohort study using electronic medical records and the corresponding hospital revenue data obtained from 3 geographically diverse hospital systems in the United States was performed. 6-month all-cause post-surgical encounters subsequent to respective ostomy surgery dates were included. Clinical reasons for acute care utilization were captured and examined via available diagnosis codes. RESULTS Mean six-month total cost of care per patient varied greatly by hospital and by payer type, ranging between $18,000 and $80,000. Inpatient care was the largest driver of these cost, accounting for 70 % of the total cost of care. In the sample, 56 % of the patients experienced one or more post-surgical inpatient admissions over a six-month period. Moreover, 26 % of the acute care events were associated with primary or secondary diagnosis codes potentially attributable to post-surgical ostomy-related complications, accounting for approximately 18 % of the total cost. Patients who received urostomy and/or had metastatic cancer had higher rates of acute care utilization, although statistical significances were not achieved. CONCLUSION The results are indicative of significant financial burdens as well as morbidities associated with post-surgical ostomy care that are common across hospital systems. Some of these cost burdens are potentially avoidable with improved ostomy follow-up care.
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Affiliation(s)
- Daniel Maeng
- Department of Psychiatry, University of Rochester Medical Center, Box PSYCH 300 Crittenden Blvd Rochester, NY 14642, United States.
| | - Rebecca L Hoffman
- Division of Colorectal Surgery, Geisinger Medical Center, United States
| | - Virginia Sun
- Department of Population Sciences, City of Hope, United States
| | - Robert P Sticca
- Department of Surgery, University of North Dakota School of Medicine & Health Sciences, United States
| | - Robert S Krouse
- Department of Surgery, University of Pennsylvania, United States
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Cai L, Qiu G, Jiang Z, Zhao P, Zheng Z, Zhu M, Han S, Chen N, Liao X, Che X, Li X, Fan L. Linea alba support method of prophylactic loop ileostomy via lower abdominal midline incision for rectal cancer: a retrospective cohort study. Surg Endosc 2025; 39:1351-1361. [PMID: 39762610 DOI: 10.1007/s00464-024-11493-4] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/24/2024] [Accepted: 12/08/2024] [Indexed: 02/06/2025]
Abstract
BACKGROUND The traditional method of prophylactic loop ileostomy is time-consuming and prone to complications like stoma stenosis, peristomal adhesions, or dermatitis. The aim of this study is to evaluate the clinical application value and potential benefits of a novel approach named linea alba support method (LASM) of prophylactic loop ileostomy via lower abdominal midline incision. METHODS The clinical data of rectal cancer patients admitted to the General Surgery Department of the First Affiliated Hospital of Xi'an Jiaotong University between January 2021 and December 2023 were retrospectively analyzed. The patients were divided into two groups based on different methods for prophylactic loop ileostomy they received, and clinical outcomes were further compared between the two groups. RESULTS A total of 102 patients, including 48 patients underwent LASM (LASM group) and 54 patients underwent traditional method (TM group) were included in this study. The LASM group exhibited significantly shorter operative time (201.8 vs. 223.0 min, p = 0.011), ileostomy time (10 vs. 22 min, p < 0.001), the length of postoperative visual incision (5 vs. 8 cm, p < 0.001), and operative time of stoma closure (75 vs. 90 min, p < 0.001) compared to the TM group. There were no significant differences between the two groups in postoperative complications and stoma-related complications. In addition, LASM was an independent influencing factor for shorter operative time of ileostomy. CONCLUSION LASM of prophylactic loop ileostomy via lower abdominal midline incision, seamlessly integrating simplicity, safety, and exceptional cosmetic outcomes, merits extensive promotion and adoption.
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Affiliation(s)
- Lindi Cai
- Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta West Road, Xi'an, 710061, Shaanxi, China
| | - Guanglin Qiu
- Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta West Road, Xi'an, 710061, Shaanxi, China
| | - Zhengdong Jiang
- Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta West Road, Xi'an, 710061, Shaanxi, China
| | - Pengwei Zhao
- Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta West Road, Xi'an, 710061, Shaanxi, China
| | - Zhongqiang Zheng
- Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta West Road, Xi'an, 710061, Shaanxi, China
| | - Mengke Zhu
- Department of Pathology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China
| | - Shangning Han
- Department of General Surgery, Honghui Hospital, Xi'an, 710054, Shaanxi, China
| | - Ni Chen
- Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta West Road, Xi'an, 710061, Shaanxi, China
| | - Xinhua Liao
- Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta West Road, Xi'an, 710061, Shaanxi, China
| | - Xiangming Che
- Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta West Road, Xi'an, 710061, Shaanxi, China
| | - Xuqi Li
- Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta West Road, Xi'an, 710061, Shaanxi, China.
| | - Lin Fan
- Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta West Road, Xi'an, 710061, Shaanxi, China.
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Liu Y, Li H, Wu JJ, Ye JH. Risk factors and risk prediction model for mucocutaneous separation in enterostomy patients: A single center experience. World J Clin Cases 2024; 12:6620-6628. [PMID: 39600483 PMCID: PMC11514340 DOI: 10.12998/wjcc.v12.i33.6620] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 05/20/2024] [Revised: 09/05/2024] [Accepted: 09/11/2024] [Indexed: 09/27/2024] Open
Abstract
BACKGROUND Mucocutaneous separation (MCS) is a common postoperative complication in enterostomy patients, potentially leading to significant morbidity. Early identification of risk factors is crucial for preventing this condition. However, predictive models for MCS remain underdeveloped. AIM To construct a risk prediction model for MCS in enterostomy patients and assess its clinical predictive accuracy. METHODS A total of 492 patients who underwent enterostomy from January 2019 to March 2023 were included in the study. Patients were divided into two groups, the MCS group (n = 110), and the non-MCS (n = 382) based on the occurrence of MCS within the first 3 weeks after surgery. Univariate and multivariate analyses were used to identify the independent predictive factors of MCS and the model constructed. Receiver operating characteristic curve analysis was used to assess the model's performance. RESULTS The postoperative MCS incidence rate was 22.4%. Suture dislodgement (P < 0.0001), serum albumin level (P < 0.0001), body mass index (BMI) (P = 0.0006), hemoglobin level (P = 0.0409), intestinal rapture (P = 0.0043), incision infection (P < 0.0001), neoadjuvant therapy (P = 0.0432), stoma site (P = 0.0028) and elevated intra-abdominal pressure (P = 0.0395) were potential predictive factors of MCS. Suture dislodgement [P < 0.0001, OR: 28.0075 95%CI: (11.0901-82.1751)], serum albumin level (P = 0.0008, OR: 0.3504, 95%CI: [0.1902-0.6485]), BMI [P = 0.0045, OR: 2.1361, 95%CI: (1.2660-3.6235)], hemoglobin level [P = 0.0269, OR: 0.5164, 95%CI: (0.2881-0.9324)], intestinal rapture [P = 0.0351, OR: 3.0694, 95%CI: (1.0482-8.5558)], incision infection [P = 0.0179, OR: 0.2885, 95%CI: (0.0950-0.7624)] and neoadjuvant therapy [P = 0.0112, OR: 1.9769, 95%CI: (1.1718-3.3690)] were independent predictive factors and included in the model. The model had an area under the curve of 0.827 and good clinical utility on decision curve analysis. CONCLUSION The mucocutaneous separation prediction model constructed in this study has good predictive performance and can provide a reference for early warning of mucocutaneous separation in enterostomy patients.
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Affiliation(s)
- Yun Liu
- Department of Reconstructive, Hand and Plastic Surgery, Zhejiang Chinese Medical University, Lishui Central Hospital, 289 Kuocang Road, Liandu District, Lishui 323000, Zhejiang Province, China
| | - Hong Li
- Department of Reconstructive, Hand and Plastic Surgery, Zhejiang Chinese Medical University, Lishui Central Hospital, 289 Kuocang Road, Liandu District, Lishui 323000, Zhejiang Province, China
| | - Jin-Jing Wu
- Department of Reconstructive, Hand and Plastic Surgery, Zhejiang Chinese Medical University, Lishui Central Hospital, 289 Kuocang Road, Liandu District, Lishui 323000, Zhejiang Province, China
| | - Jian-Hong Ye
- Department of Operation Room, Zhejiang Chinese Medical University, Lishui Central Hospital, 289 Kuocang Road, Liandu District, Lishui 323000, Zhejiang Province, China
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Gouvas N, Manatakis D, Agalianos C, Dimitriou N, Baloyiannis I, Tzovaras G, Xynos E. Defunctioning Ileostomy After Low Anterior Resection of Rectum: Morbidity Related to Fashioning and Closure. MEDICINA (KAUNAS, LITHUANIA) 2024; 60:1864. [PMID: 39597049 PMCID: PMC11596492 DOI: 10.3390/medicina60111864] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 08/24/2024] [Revised: 09/21/2024] [Accepted: 11/06/2024] [Indexed: 11/29/2024]
Abstract
Background and Objectives: The aim of this study was to assess any predisposing factors to the morbidity of fashioning and reversal of diverting ileostomy in a prospective cohort of patients who have undergone TME and low colo-rectal or colo-anal anastomosis for rectal cancer. Materials and Methods: Consecutive patients with rectal cancer undergoing low anterior resection and a defunctioning loop ileostomy in three surgical units from 2016 to 2020 were included in the study and retrospectively analyzed. Results: One hundred eighty-two patients from three centres were included. Ileostomy-related mortality was 0.5%, attributed to renal failure.. Ileostomy-related morbidity was 46%. Postoperative ileus was seen in 37.4%, and dehydration in 18.8% of the patients. The readmission rate for ileostomy-related reasons was 15.4%. Stoma care was problematic in 15.7% or poor in 7% of the cases. Advanced age, male gender and obesity were independent risk factors for ileostomy-related morbidity. Ileostomy was reversed in 165 patients. The morbidity in 165 patients was 16%. Ileus was seen in 10.3%, anastomotic leak in 4.8% and wound infection in 12.7% of the cases. One patient died because of an anastomotic leak. No predisposing factors that affect the outcomes of ileostomy closure were identified. Conclusions: Diverting ileostomy-related morbidity is high. Life threatening dehydration and renal failure from ileus is more commonly seen in elderly, male and obese patients and should be anticipated. Ileostomy closure-related morbidity is low.
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Affiliation(s)
- Nikolaos Gouvas
- Department of General Surgery, Medical School, University of Cyprus, Nicosia 2404, Cyprus;
| | - Dimitrios Manatakis
- Department of General Surgery, Naval & Veterans Hospital, 11521 Athens, Greece;
| | - Christos Agalianos
- Department of General Surgery, Naval & Veterans Hospital, 73200 Chania, Greece;
| | - Nikoletta Dimitriou
- Department of General Surgery, Medical School, University of Cyprus, Nicosia 2404, Cyprus;
| | - Ioannis Baloyiannis
- Department of General Surgery, University Hospital of Larissa, 41334 Larisa, Greece; (I.B.); (G.T.)
| | - George Tzovaras
- Department of General Surgery, University Hospital of Larissa, 41334 Larisa, Greece; (I.B.); (G.T.)
| | - Evangelos Xynos
- Department of General Surgery, Creta Interclinic Hospital, 71304 Heraklion, Greece;
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Dietmaier L, Summa S, Ronicke M, Erfurt-Berge C. Peristomal skin lesions - identifying patients at risk. ZEITSCHRIFT FUR GASTROENTEROLOGIE 2024; 62:1924-1930. [PMID: 39074813 DOI: 10.1055/a-2360-5099] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 07/31/2024]
Abstract
BACKGROUND AND OBJECTIVES Diagnosis and therapy of peristomal skin lesions are challenging for the majority of therapists. Established diagnostic tools have not yet been validated. Our objective was to outline the spectrum of and to identify risk factors for skin lesions in ostomy patients. A focus was set on peristomal ulcerations and their differentiation as peristomal pyoderma gangrenosum. METHODS In a retrospective analysis, frequency and character of peristomal skin lesions in patients presenting at two departments were analysed. Patients suffering from peristomal ulcerations were subjected to a more detailed analysis including application of the PARACELSUS score. RESULTS A total of 565 patients with ostomy were analysed; 40.2% (n = 227) presented with peristomal skin lesions. Moisture-associated skin damage (27.9%) was the most common, while ulcerations (21.9%) and eczematous skin alterations (19.1%) were seen with comparable frequency. Peristomal pyoderma gangrenosum was diagnosed in 7.9% of all observed peristomal lesions. Among patients with inflammatory bowel disease (n = 98), peristomal ulcerations were the leading finding (35.7%), and pyoderma gangrenosum was more frequent in these patients (16.3%). CONCLUSIONS It is necessary to assess and classify peristomal skin lesions. Further studies for the validation of different scores or the development of diagnostic tools are needed.
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Affiliation(s)
- Louisa Dietmaier
- Klinik für Allgemeine Innere Medizin und Geriatrie, Krankenhaus der Barmherzigen Bürder, Regensburg, Germany
| | - Scarlett Summa
- Department of Surgery, Section of Coloproctology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Uniklinikum Erlangen, Erlangen, Germany
| | - Moritz Ronicke
- Department of Dermatology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Uniklinikum Erlangen, Erlangen, Germany
| | - Cornelia Erfurt-Berge
- Department of Dermatology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Uniklinikum Erlangen, Erlangen, Germany
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Mahmoud M, Syn WK. Impact of Obesity and Metabolic Syndrome on IBD Outcomes. Dig Dis Sci 2024; 69:2741-2753. [PMID: 38864929 DOI: 10.1007/s10620-024-08504-8] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/04/2023] [Accepted: 05/14/2024] [Indexed: 06/13/2024]
Abstract
PURPOSE OF REVIEW The recent surge in inflammatory bowel disease (IBD) cases has paralleled a significant rise in obesity and metabolic comorbidities rates. In this article, we explore the potential influence of obesity and associated metabolic comorbidities on disease progression, complications, treatment response, surgical outcomes, health economics, and the potential impact of obesity treatment on the course of IBD. FINDINGS Contrary to visceral adiposity, obesity does not consistently result in an increased risk of IBD-related complications. Patients with IBD have a higher risk of acute arterial events, likely linked to systemic inflammation. Substantial evidence suggests that obesity has a negative impact on the response to IBD treatment, with this effect being most thoroughly studied in biologics and immunomodulators. The rates of overall complications and post-operative infections are higher in patients who are obese. There are limited but promising data regarding the impact of weight loss techniques, including exercise, medications, and bariatric interventions, on the outcomes in IBD. Both obesity and diabetes have adverse effects on the overall quality of life and place an increased financial burden on the IBD population. A growing body of evidence indicates a connection between obesity and associated metabolic comorbidities and negative outcomes in IBD, yet further efforts are required to fully understand this relationship.
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Affiliation(s)
- Maya Mahmoud
- Department of Internal Medicine, Saint Louis University, St Louis, MO, USA
| | - Wing-Kin Syn
- Division of Gastroenterology & Hepatology, Department of Internal Medicine, Saint Louis University, St. Louis, MO, USA.
- Department of Physiology, Faculty of Medicine and Nursing, University of Basque Country UPV/EHU, Vizcaya, Spain.
- James F. King Chair in Gastroenterology, Division of Gastroenterology and Hepatology, Liver Center, Metabolic & Nutrition Institute, Research Track Fellowship, Saint Louis University School of Medicine, St. Louis, MO, USA.
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Merritt C, Maldonado P. Management of the Difficult Stoma. Surg Clin North Am 2024; 104:579-593. [PMID: 38677822 DOI: 10.1016/j.suc.2023.11.008] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 04/29/2024]
Abstract
Fecal ostomy creation is a commonly performed procedure with many indications. Better outcomes occur when preoperative patient education and stoma site marking are provided. Despite a seemingly simple operation, ostomy creation is often difficult and complications are common. Certain risk factors, particularly obesity, are strongly associated with stoma-related complications. The ability to optimize the ostomy and stoma in the operating room and to troubleshoot frequently encountered post-operative stoma-related issues are critical skills for surgeons and ostomy nurses alike.
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Affiliation(s)
- Clay Merritt
- Department of Colon and Rectal Surgery, Alexander T. Augusta Military Medical Center, 9300 DeWitt Loop, Sunrise Pavilion, 2nd Floor, General Surgery Reception Desk, Fort Belvoir, VA 22060, USA.
| | - Paola Maldonado
- Wound Care Clinic, Alexander T. Augusta Military Medical Center, 9300 DeWitt Loop, Sunrise Pavilion, 2nd Floor, General Surgery Reception Desk, Fort Belvoir, VA 22060, USA
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MacDonald S, Wong LS, Ng HJ, Hastings C, Ross I, Quasim T, Moug S. Postoperative outcomes and identification of risk factors for complications after emergency intestinal stoma surgery - a multicentre retrospective study. Colorectal Dis 2024; 26:994-1003. [PMID: 38499914 DOI: 10.1111/codi.16947] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 08/14/2023] [Revised: 11/29/2023] [Accepted: 02/20/2024] [Indexed: 03/20/2024]
Abstract
AIM Approximately 4000 patients in the UK have an emergency intestinal stoma formed each year. Stoma-related complications (SRCs) are heterogeneous but have previously been subcategorized into early or late SRCs, with early SRCs generally occurring within 30 days postoperatively. Early SRCs include skin excoriation, stoma necrosis and high output, while late SRCs include parastomal hernia, retraction and prolapse. There is a paucity of research on specific risk factors within the emergency cohort for development of SRCs. This paper aims to describe the incidence of SRCs after emergency intestinal surgery and to identify potential risk factors for SRCs within this cohort. METHOD Consecutive patients undergoing emergency formation of an intestinal stoma (colostomy, ileostomy or jejunostomy) were identified prospectively from across three acute hospital sites over a 3-year period from the ELLSA (Emergency Laparotomy and Laparoscopic Scottish Audit) database. All patients were followed up for a minimum of 1 year. A multivariate logistic regression model was used to identify risk factors for early and late SRCs. RESULTS A total of 455 patients were included (median follow-up 19 months, median age 64 years, male:female 0.52, 56.7% ileostomies). Early SRCs were experienced by 54.1% of patients, while 51% experienced late SRCs. A total of 219 patients (48.1%) had their stoma sited preoperatively. Risk factors for early SRCs included end ileostomy formation [OR 3.51 (2.24-5.49), p < 0.001], while preoperative stoma siting was found to be protective [OR 0.53 (0.35-0.83), p = 0.005]. Patient obesity [OR 3.11 (1.92-5.03), p < 0.001] and reoperation for complications following elective surgery [OR 4.18 (2.01-8.69), p < 0.001] were risk factors for late SRCs. CONCLUSION Stoma-related complications after emergency surgery are common. Preoperative stoma siting is the only truly modifiable risk factor to reduce SRCs, and further research should be aimed at methods of improving the frequency and accuracy of this in the emergency setting.
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Affiliation(s)
- Scott MacDonald
- Department of Surgery, Royal Alexandra Hospital, Paisley, UK
| | - Li-Siang Wong
- Department of Surgery, Royal Alexandra Hospital, Paisley, UK
| | - Hwei Jene Ng
- Department of Surgery, Royal Alexandra Hospital, Paisley, UK
| | - Claire Hastings
- Department of Surgery, Royal Alexandra Hospital, Paisley, UK
| | - Immogen Ross
- Department of Surgery, Royal Alexandra Hospital, Paisley, UK
| | - Tara Quasim
- Department of Anaesthesia, Pain and Critical Care, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK
| | - Susan Moug
- Department of Surgery, Royal Alexandra Hospital, Paisley, UK
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12
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Bavikatte A. Enhancing Stoma Care Education for Junior Doctors: A Comprehensive Teaching Series. Cureus 2024; 16:e58014. [PMID: 38606025 PMCID: PMC11007581 DOI: 10.7759/cureus.58014] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 04/11/2024] [Indexed: 04/13/2024] Open
Abstract
Introduction Colorectal stomas are prevalent in surgical wards and demand careful medical attention, particularly in stoma management. Junior doctors play a vital role in this care, but their limited exposure and training may hinder their ability, impacting patient care. Given the dearth of literature, we aimed to assess junior doctors' stoma care knowledge and the efficacy of a specialized teaching course in boosting their confidence and skills. Methods The research, conducted at the West Suffolk Hospital NHS Trust in the UK, engaged 60 junior doctors, predominantly from Foundation Year 1 and Year 2, from August 2021 to December 2022. To ensure effective management and assessment, participants were divided into four groups, each comprising 15 doctors. A pivotal aspect of the study was implementing a structured stoma teaching series delivered by a panel of seasoned surgical experts. This series, conducted every Friday for three weeks, comprehensively covered all facets of stoma care. Both before and after the teaching series, assessments were administered to measure the impact of this educational intervention on the participants' understanding of stomas. The study meticulously adhered to ethical guidelines, with all participants providing informed consent, and measures were implemented to guarantee anonymity, thus safeguarding the privacy and confidentiality of all individuals involved. The primary objective of this investigation was to evaluate the efficacy of the stoma teaching series in augmenting the knowledge and comprehension of stomas among junior doctors. The findings of this study hold significant potential in guiding healthcare professionals toward developing more efficacious stoma education programs, ultimately leading to improved patient care outcomes. Results The study involved 60 junior doctors categorized into four groups from August 2021 to December 2022. It aimed to assess their understanding of colorectal stomas, focusing on complications and their knowledge about stoma appliances and care nurses. A questionnaire was used to evaluate their knowledge in these areas at the start of their surgical rotation, which showed significant knowledge gaps among participants. Of the 60 participants, 48 (80%) expressed slight or no confidence in basic stoma care, while 54 (90%) admitted unfamiliar with managing stoma complications. Astonishingly, all 60 (100%) participants lacked awareness of fundamental stoma care concepts. Significant improvements were observed following a comprehensive stoma teaching series covering basic stoma knowledge, its complications and management, and practical stoma care. Feedback from the course revealed positive outcomes, with 54 (87%) doctors feeling confident or very confident in basic stoma knowledge and 48 (80%) reporting increased familiarity with managing stoma complications. Remarkably, all 60 (100%) doctors indicated comfort with stoma care concepts after the sessions. Participants emphasized the course's value in medical education and professional development, citing enhanced practical skills such as communication and teamwork. Conclusion Our study revealed junior doctors' limited stoma knowledge, emphasizing the need for a dedicated teaching program that significantly improves their understanding. Focused stoma education is vital for junior doctors to deliver optimal patient care, necessitating hospitals to promote awareness for improved patient outcomes.
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Affiliation(s)
- Akshay Bavikatte
- General and Colorectal Surgery, West Suffolk Hospital NHS Trust, Bury St Edmunds, GBR
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13
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Øresland T, Schultz JK. Stoma formation: An underestimated challenge in emergency surgery. Scand J Surg 2024; 113:60-61. [PMID: 38439209 DOI: 10.1177/14574969241234987] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 03/06/2024]
Affiliation(s)
- Tom Øresland
- Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway
| | - Johannes Kurt Schultz
- Department of Pediatric and Gastrointestinal surgery, Oslo University Hospital, 0424 Oslo, Norway
- Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway
- Department of Gastrointestinal Surgery, Akershus University Hospital, Lørenskog, Norway
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14
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Burghgraef TA, Geitenbeek RTJ, Broekman M, Hol JC, Hompes R, Consten ECJ. Permanent stoma rate and long-term stoma complications in laparoscopic, robot-assisted, and transanal total mesorectal excisions: a retrospective cohort study. Surg Endosc 2024; 38:105-115. [PMID: 37932600 PMCID: PMC10776460 DOI: 10.1007/s00464-023-10517-9] [Citation(s) in RCA: 7] [Impact Index Per Article: 7.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/26/2023] [Accepted: 10/08/2023] [Indexed: 11/08/2023]
Abstract
BACKGROUND The surgical resection of rectal carcinoma is associated with a high risk of permanent stoma rate. Primary anastomosis rate is suggested to be higher in robot-assisted and transanal total mesorectal excision, but permanent stoma rate is unknown. METHODS Patients undergoing total mesorectal excision for MRI-defined rectal cancer between 2015 and 2017 in 11 centers highly experienced in laparoscopic, robot-assisted or transanal total mesorectal excision were included in this retrospective study. Permanent stoma rate, stoma-related complications, readmissions, and reoperations were registered. A multivariable regression analysis was performed for permanent stoma rate, stoma-related complications, and stoma-related reoperations. RESULTS In total, 1198 patients were included. Permanent stoma rate after low anterior resection (with anastomosis or with an end colostomy) was 40.1% in patients undergoing laparoscopic surgery, 21.3% in patients undergoing robot-assisted surgery, and 25.6% in patients undergoing transanal surgery (P < 0.001). Permanent stoma rate after low anterior resection with an anastomosis was 17.3%, 11.8%, and 15.1%, respectively. The robot-assisted and transanal techniques were independently associated with a reduction in permanent stoma rate in patients who underwent a low anterior resection (with anastomosis or with an end colostomy) (OR 0.39 [95% CI 0.25, 0.59] and OR 0.35 [95% CI 0.22, 0.55]), while this was not seen in patients who underwent a restorative low anterior resection. 45.4% of the patients who had a stoma experienced stoma-related complications, 4.0% were at least once readmitted, and 8.9% underwent at least one reoperation. CONCLUSIONS The robot-assisted and transanal techniques are associated with a lower permanent stoma rate in patients who underwent a low anterior resection.
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Affiliation(s)
- T A Burghgraef
- Department of Surgery, Meander Medical Center, Maatweg 3, 3813 TZ, Amersfoort, The Netherlands.
- Department of Surgery, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands.
| | - R T J Geitenbeek
- Department of Surgery, Meander Medical Center, Maatweg 3, 3813 TZ, Amersfoort, The Netherlands
- Department of Surgery, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands
| | - M Broekman
- Department of Surgery, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands
| | - J C Hol
- Department of Surgery, Amsterdam UMC, VUmc, Amsterdam, The Netherlands
| | - R Hompes
- Department of Surgery, Amsterdam UMC, AMC, Amsterdam, The Netherlands
| | - E C J Consten
- Department of Surgery, Meander Medical Center, Maatweg 3, 3813 TZ, Amersfoort, The Netherlands
- Department of Surgery, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands
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15
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Fujimoto N, Ogino T, Miyoshi N, Uemura M, Doki Y, Eguchi H. Avoiding stoma creation due to super-morbid obesity: A report of two surgical cases of colorectal cancer. Int J Surg Case Rep 2024; 114:109171. [PMID: 38113563 PMCID: PMC10772238 DOI: 10.1016/j.ijscr.2023.109171] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/08/2023] [Revised: 12/09/2023] [Accepted: 12/11/2023] [Indexed: 12/21/2023] Open
Abstract
INTRODUCTION A stoma is commonly created in patients with a high risk of anastomotic leakage. However, patients with obesity have a higher incidence of stoma-related complications, and the decision to create a stoma should be carefully considered. We report two cases of patients with colorectal cancer and super-morbid obesity wherein stoma creation was avoided. PRESENTATION OF CASES Case 1 involved a 52-year-old male patient with a body mass index (BMI) of 41.8 kg/m2 who underwent a robotic-assisted laparoscopic low anterior resection after neoadjuvant chemotherapy for lower rectal cancer. Although temporary diverting ileostomy was initially considered, stoma creation was skipped intraoperatively, considering the complication risk-benefit ratio. Case 2 involved a 42-year-old female patient with a BMI of 64 kg/m2 who underwent open partial non-curative colon resection for descending colon cancer complicated by colonic perforation and abscess formation. The patient was considered to be at high risk of stoma-related complications due to high mobility of the subcutaneous fat of abdominal wall; therefore, we decided not to create a stoma preoperatively. DISCUSSION Considering the high risk of stoma-associated complications, avoiding stoma creation and implementing preventive measures against potential complications are alternative options for patients with super-morbid obesity. CONCLUSION We present our experience two cases in which stoma creation was avoided for super-morbid obese patients with BMI over 40.
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Affiliation(s)
- Naoto Fujimoto
- Department of Gastroenterological Surgery, Graduate school of medicine, Osaka University, Suita, Osaka, Japan
| | - Takayuki Ogino
- Department of Gastroenterological Surgery, Graduate school of medicine, Osaka University, Suita, Osaka, Japan; Therapeutics for Inflammatory Bowel Diseases, Graduate school of medicine, Osaka University, Suita, Osaka, Japan.
| | - Norikatsu Miyoshi
- Department of Gastroenterological Surgery, Graduate school of medicine, Osaka University, Suita, Osaka, Japan
| | - Mamoru Uemura
- Department of Gastroenterological Surgery, Graduate school of medicine, Osaka University, Suita, Osaka, Japan
| | - Yuichiro Doki
- Department of Gastroenterological Surgery, Graduate school of medicine, Osaka University, Suita, Osaka, Japan
| | - Hidetoshi Eguchi
- Department of Gastroenterological Surgery, Graduate school of medicine, Osaka University, Suita, Osaka, Japan
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Mthombeni F, Cawson M, Chan G, Boisen EB, Rethmeier LO, Pearson-Stuttard J. The economic burden of stomas in the UK: a retrospective observational study of health records and hospital encounters. BRITISH JOURNAL OF NURSING (MARK ALLEN PUBLISHING) 2023; 32:S12-S20. [PMID: 38060389 DOI: 10.12968/bjon.2023.32.22.s12] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 12/18/2023]
Abstract
BACKGROUND Stomas divert waste from the small intestine (ileostomy), large intestine (colostomy) or ureters (urostomy), and complications are common. AIMS This study evaluated healthcare resource utilisation (HCRU) and costs of stomas from a UK perspective. METHODS This was a retrospective observational study of adults with new stomas (New Stoma Group) or new/existing stomas and >6 months of follow-up (Established Stoma Group) using health records linked with hospital encounters (January 2009-December 2018). Age- and sex-matched controls were identified for each stoma case (1:50). FINDINGS Both the New (n=8533) and Established (n=9397) stoma groups had significantly higher HCRU (all P<0.0001) and associated costs (all P<0.01), driven by inpatient admissions. New Stoma Group: colostomy versus controls, £3227 versus £99 per person; ileostomy, £2576 versus £78 per person; and urostomy, £2850 versus £110 per person (all P<0.0001). Findings were similar in the Established Stoma Group. CONCLUSION Stomas are associated with a substantial economic burden in the UK driven by hospital care. (Supplementary data tables can be obtained from the authors.).
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Affiliation(s)
| | | | - Gerald Chan
- Health Economics Manager, Coloplast Ltd, Peterborough
| | - Esben Bo Boisen
- Health Economics Manager, Coloplast A/S, Humblebaek, Denmark
| | | | - Jonathan Pearson-Stuttard
- Health Economics Manager, Health Analytics, Lane Clark & Peacock LLP, London, Northumbria Healthcare NHS Foundation Trust, and School of Public Health, Imperial College London
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17
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Näverlo S, Strigård K, Gunnarsson U, Edin-Liljegren A. Patients' experiences of living with a stoma in rural areas in Northern Sweden. Int J Circumpolar Health 2023; 82:2221767. [PMID: 37300840 PMCID: PMC10259297 DOI: 10.1080/22423982.2023.2221767] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/06/2023] [Revised: 05/31/2023] [Accepted: 06/01/2023] [Indexed: 06/12/2023] Open
Abstract
Introduction: Stoma complications are common and interfere with many aspects of everyday life. Stoma problems are usually managed by a specialised stoma nurse, a service not present in the rural areas of South Lapland in Sweden. The aim of this study was to describe how stoma patients in rural areas experience living with a stoma.Methods: A qualitative descriptive study with semi-structured interviews were conducted with 17 stoma patients living in rural municipalities and who received a part of their care at the local cottage hospital. Qualitative content analysis was employed.Results: Initially, the stoma was experienced as very depressing. Participants had difficulties in properly managing the dressing. Over time they learned how to properly care for their stoma, making their life easier. Both satisfaction and dissatisfaction with the healthcare were experienced. Those who were dissatisfied expressed a lack of competence in dealing with stoma-related problems.Conclusions: Living with a stoma in a rural area in northern Sweden is experienced as a learning process and acceptance of the stoma's existence is important. This study emphasises the need for increased knowledge of stoma-related problems in rural primary healthcare in order to help patients cope with everyday life.
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Affiliation(s)
- Simon Näverlo
- Department of Surgical and Perioperative Sciences, Surgery, Umeå University, Umeå, Sweden
| | - Karin Strigård
- Department of Surgical and Perioperative Sciences, Surgery, Umeå University, Umeå, Sweden
| | - Ulf Gunnarsson
- Department of Surgical and Perioperative Sciences, Surgery, Umeå University, Umeå, Sweden
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Ota E, Hiyoshi Y, Matsuura N, Ishikawa K, Fujinami F, Mukai T, Yamaguchi T, Nagasaki T, Akiyoshi T, Fukunaga Y. Standardization of preoperative stoma site marking and its utility for preventing stoma leakage: a retrospective study of 519 patients who underwent laparoscopic/robotic rectal cancer surgery. Tech Coloproctol 2023; 27:1387-1392. [PMID: 37358669 DOI: 10.1007/s10151-023-02839-6] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 04/23/2023] [Accepted: 06/17/2023] [Indexed: 06/27/2023]
Abstract
PURPOSE Stoma site marking is an important preoperative intervention for preventing various stoma-associated complications. In our institution, standardized stoma site marking is routinely performed before rectal cancer surgery with stoma creation, and various stoma-associated factors are recorded in the ostomy-record template. The present study investigated risk factors for stoma leakage. METHODS Our stoma site marking is standardized so that it can be performed by non-stoma specialists. To identify risk factors of stoma leakage at 3 months after surgery, various preoperative factors associated with stoma site marking in our ostomy-record template were retrospectively analyzed in 519 patients who underwent rectal cancer surgery with stoma creation from 2015 to 2020. RESULTS Stoma leakage was seen in 35 of the 519 patients (6.7%). The distance between the stoma site marking and the umbilicus was less than 60 mm in 27 of the 35 patients (77%) who experienced stoma leakage, so a distance of less than 60 mm was identified as an independent risk factor for stoma leakage. Aside from preoperative factors, stoma leakage was also caused by postoperative skin wrinkles or surgical scars near the stoma site in 8 of 35 patients (23%). CONCLUSION Preoperative standardized stoma site marking is necessary to achieve reliable marking that is easy to perform. To reduce the risk of stoma leakage, a distance of 60 mm or more between the stoma site marking and the umbilicus is ideal, and surgeons need to contrive ways to keep surgical scars away from the stoma site.
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Affiliation(s)
- E Ota
- Gastroenterological Center, Department of Gastroenterological Surgery, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan
| | - Y Hiyoshi
- Gastroenterological Center, Department of Gastroenterological Surgery, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan.
| | - N Matsuura
- Gastroenterological Center, Department of Wound, Ostomy and Continence (WOC) Nursing, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan
| | - K Ishikawa
- Gastroenterological Center, Department of Wound, Ostomy and Continence (WOC) Nursing, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan
| | - F Fujinami
- Gastroenterological Center, Department of Wound, Ostomy and Continence (WOC) Nursing, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan
| | - T Mukai
- Gastroenterological Center, Department of Gastroenterological Surgery, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan
| | - T Yamaguchi
- Gastroenterological Center, Department of Gastroenterological Surgery, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan
| | - T Nagasaki
- Gastroenterological Center, Department of Gastroenterological Surgery, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan
| | - T Akiyoshi
- Gastroenterological Center, Department of Gastroenterological Surgery, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan
| | - Y Fukunaga
- Gastroenterological Center, Department of Gastroenterological Surgery, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan
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Parini D, Bondurri A, Ferrara F, Rizzo G, Pata F, Veltri M, Forni C, Coccolini F, Biffl WL, Sartelli M, Kluger Y, Ansaloni L, Moore E, Catena F, Danelli P. Surgical management of ostomy complications: a MISSTO-WSES mapping review. World J Emerg Surg 2023; 18:48. [PMID: 37817218 PMCID: PMC10563348 DOI: 10.1186/s13017-023-00516-5] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/19/2023] [Accepted: 09/09/2023] [Indexed: 10/12/2023] Open
Abstract
BACKGROUND The creation of an ileostomy or colostomy is a common surgical event, both in elective and in emergency context. The main aim of stoma creation is to prevent postoperative complications, such as the anastomotic leak. However, stoma-related complications can also occur and their morbidity is not negligible, with a rate from 20 to 70%. Most stomal complications are managed conservatively, but, when this approach is not resolutive, surgical treatment becomes necessary. The aim of this mapping review is to get a comprehensive overview on the incidence, the risk factors, and the management of the main early and late ostomy complications: stoma necrosis, mucocutaneous separation, stoma retraction, stoma prolapse, parastomal hernia, stoma stenosis, and stoma bleeding. MATERIAL AND METHODS A complete literature research in principal databases (PUBMED, EMBASE, SCOPUS and COCHRANE) was performed by Multidisciplinary Italian Study group for STOmas (MISSTO) for each topic, with no language restriction and limited to the years 2011-2021. An international expert panel, from MISSTO and World Society of Emergency Surgery (WSES), subsequently reviewed the different issues, endorsed the project, and approved the final manuscript. CONCLUSION Stoma-related complications are common and require a step-up management, from conservative stoma care to surgical stoma revision. A study of literature evidence in clinical practice for stoma creation and an improved management of stoma-related complications could significantly increase the quality of life of patients with ostomy. Solid evidence from the literature about the correct management is lacking, and an international consensus is needed to draw up new guidelines on this subject.
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Affiliation(s)
- Dario Parini
- General Surgery Department, Santa Maria della Misericordia Hospital, Rovigo, Italy
| | - Andrea Bondurri
- General Surgery Department, Luigi Sacco University Hospital, ASST Fatebenefratelli-Sacco, Milano, Italy.
| | - Francesco Ferrara
- Department of Surgical, Oncological and Stomatological Sciences, University of Palermo, Palermo, Italy
| | - Gianluca Rizzo
- Digestive and Colorectal Unit, Fatebenefratelli Isola Tiberina Gemelli Isola Hospital, Università Cattolica del Sacro Cuore, Roma, Italy
| | - Francesco Pata
- Department of Pharmacy, Health and Nutricional Sciences, University of Calabria, Cosenza, Italy
- Department of Surgery, Nicola Giannettasio Hospital, Corigliano-Rossano, Italy
| | - Marco Veltri
- General Surgery Unit, San Jacopo Hospital, Pistoia, Italy
| | - Cristiana Forni
- Nursing and allied profession research Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
| | - Federico Coccolini
- General, Emergency and Trauma Surgery Department, Pisa University Hospital, Pisa, Italy
| | - Walt L Biffl
- Trauma/Acute Care Surgery, Scripps Clinic Medical Group, La Jolla, CA, USA
| | | | - Yoram Kluger
- Division of General Surgery, Rambam Health Care Campus, Haifa, Israel
| | - Luca Ansaloni
- General Surgery Department, Pavia University Hospital, Pavia, Italy
| | - Ernest Moore
- E. Moore Shock and Trauma Centre, Denver, CO, USA
| | - Fausto Catena
- General, Emergency and Trauma Surgery Department, Bufalini Hospital, Cesena, Italy
| | - Piergiorgio Danelli
- General Surgery Department, Luigi Sacco University Hospital, ASST Fatebenefratelli-Sacco, Milano, Italy
- Department of Biomedical and Clinical Sciences "Luigi Sacco", University of Milan, Milano, Italy
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Manole TE, Daniel I, Alexandra B, Dan PN, Andronic O. Risk Factors for the Development of Parastomal Hernia: A Narrative Review. SAUDI JOURNAL OF MEDICINE & MEDICAL SCIENCES 2023; 11:187-192. [PMID: 37533654 PMCID: PMC10393091 DOI: 10.4103/sjmms.sjmms_235_22] [Citation(s) in RCA: 5] [Impact Index Per Article: 2.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Subscribe] [Scholar Register] [Received: 05/18/2022] [Revised: 03/13/2023] [Accepted: 06/07/2023] [Indexed: 08/04/2023]
Abstract
Parastomal hernia is one of the most common late complications after stoma formation, significantly decreasing patient's quality of life and negatively impacting body image and physical functioning. Progress has been made regarding the surgical technique of stoma creation in different categories of patients, but a better understanding of the risk factors is crucial in reducing the likeliness of parastomal hernia formation and in helping develop risk stratification strategies for pre-and post-operation management. However, currently there is limited consensus on the associated risk factors. Accordingly, for this narrative review, the authors conducted a literature review through three databases (PubMed, Web of Science, and Scopus) and categorized the identified risk factors into the following three categories: patient-, surgery-, and disease-related. Within these categories, the following 10 risk factors were identified and discussed: age, gender, waist circumference, type of ostomy, laparoscopic approach, aperture size >3 cm, stoma not passing through the middle of rectus abdominis muscle, BMI >25 kg/m2, altered collagen metabolism, and diabetes.
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Affiliation(s)
- Teodora Elena Manole
- Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
| | - Ion Daniel
- Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
- IIIrd Department of General Surgery, University Emergency Hospital of Bucharest, Bucharest, Romania
| | - Bolocan Alexandra
- Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
- IIIrd Department of General Surgery, University Emergency Hospital of Bucharest, Bucharest, Romania
| | - Păduraru N. Dan
- Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
- IIIrd Department of General Surgery, University Emergency Hospital of Bucharest, Bucharest, Romania
| | - Octavian Andronic
- Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
- IIIrd Department of General Surgery, University Emergency Hospital of Bucharest, Bucharest, Romania
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Garoufalia Z, Mavrantonis S, Emile SH, Gefen R, Horesh N, Freund MR, Wexner SD. Surgical treatment of stomal prolapse: A systematic review and meta-analysis of the literature. Colorectal Dis 2023; 25:1128-1134. [PMID: 36965087 DOI: 10.1111/codi.16548] [Citation(s) in RCA: 3] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 12/19/2022] [Revised: 02/14/2023] [Accepted: 02/16/2023] [Indexed: 03/27/2023]
Abstract
AIM This study aimed to assess success, recurrence, and overall complication rates among different surgical procedures for stomal prolapse. METHODS This study was a PRISMA-compliant systematic review. PubMed, Scopus, and Google Scholar were searched until March 2022. Studies that assessed surgical treatments of stomal prolapse in adults were included. The primary outcome was recurrence of stomal prolapse and the secondary outcome was 30-day complications. A random-effect meta-analysis was used to estimate the weighted mean rates of recurrence. RESULTS Six studies published (111 patients; 103 males) were included. 52 (46.8%) patients had end colostomies, 35 (31.5%) had loop colostomies. Seven procedures were assessed and included local stoma reconstruction (40%), stapled local repair (27%), modified Altemeier technique (10%), mesh strip repair (9%), stoma relocation (6%) redo laparotomy repair (5%), and colectomy and end ileostomy (3%). The weighted mean recurrence rate after local stoma reconstruction was 37.2% (95% CI: -1.8 to 76.3), higher than that after the stapled local repair technique (14.9%; 95% CI: 1.7-28.2). The crude recurrence rate of the modified Altemeier technique was 20%, and of stoma relocation was 66.6%. No recurrence was detected after the mesh strip technique (n = 10). The median follow-up ranged between 7 months and 2.5 years. CONCLUSION Several surgical techniques are available to treat stomal prolapse. Local stoma reconstruction may be associated with high rates of recurrence while the stapled local repair and modified Altemeier procedure has relatively low recurrence. Further larger studies are needed to compare the efficacy of these techniques.
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Affiliation(s)
- Zoe Garoufalia
- Ellen Leifer Shulman and Steven Shulman Digestive Disease Center, Cleveland Clinic Florida, Weston, Florida, USA
| | | | - Sameh Hany Emile
- Ellen Leifer Shulman and Steven Shulman Digestive Disease Center, Cleveland Clinic Florida, Weston, Florida, USA
- Colorectal Surgery Unit, General Surgery Department, Mansoura University Hospitals, Mansoura, Egypt
| | - Rachel Gefen
- Ellen Leifer Shulman and Steven Shulman Digestive Disease Center, Cleveland Clinic Florida, Weston, Florida, USA
- Department of General Surgery, Faculty of Medicine, Hadassah Medical Organization, Hebrew University of Jerusalem, Jerusalem, Israel
| | - Nir Horesh
- Ellen Leifer Shulman and Steven Shulman Digestive Disease Center, Cleveland Clinic Florida, Weston, Florida, USA
- Department of Surgery and Transplantations, Sheba Medical Center, Ramat Gan, Israel
| | - Michael R Freund
- Ellen Leifer Shulman and Steven Shulman Digestive Disease Center, Cleveland Clinic Florida, Weston, Florida, USA
- Department of General Surgery, Shaare Zedek Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel
| | - Steven D Wexner
- Ellen Leifer Shulman and Steven Shulman Digestive Disease Center, Cleveland Clinic Florida, Weston, Florida, USA
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22
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Gillet J, Morgado L, Hamy A, Casa C, Mucci S, Drissi F, Le Naoures P, Hamel JF, Venara A. Does stoma modify compliance with enhanced recovery after surgery programs? Results of a cohort study. Int J Colorectal Dis 2023; 38:100. [PMID: 37067607 DOI: 10.1007/s00384-023-04396-8] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Accepted: 04/03/2023] [Indexed: 04/18/2023]
Abstract
PURPOSE Few studies have focused on enhanced recovery programs (ERPs) in patients who have received a stoma after colorectal surgery. The objective of the study was to compare ERP compliant patients who have not received a stoma, those who received a colostomy, and those who received an ileostomy. METHODS This study used data that had been prospectively collected as part of the ERP audit performed through the Groupe francophone de Réhabilitation Améliorée après Chirurgie [Francophone Group for Enhanced Recovery after Surgery] over a 4-year period. All patients who had undergone colorectal surgery were included and separated into three groups (no stoma, ileostomy, and colostomy). The primary outcome was ERP compliance, calculated through the use of 16 tracer items. RESULTS Of the 422 recruited patients, 317 had not received a stoma (75.12%), 59 had an ileostomy (13.98%), and 46 had a colostomy (10.90%). ERP compliance was 73% in the non-stoma group, 66.6% in the ileostomy group, and 66% in the colostomy group (p < 0.001). Multivariate analysis showed that patients from the ileostomy group had a higher risk of bowel preparation [OR = 9.1; 95% CI = 1.16-71.65] and of maintaining their urinary catheter [OR = 0.3; 95% CI = 0.14-0.81] than the group which did not receive a stoma. Patients from the colostomy group required significantly more drainage than those in the non-stoma group (OR = 4.3; 95% CI = 1.33-14.02). CONCLUSION ERP is feasible in colorectal surgery in the context of stomas, but in case of ileostomy protecting a rectal surgery, the audit system must be adapted to the protocols in use in the departments.
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Affiliation(s)
- J Gillet
- Department of Digestive Surgery, University Hospital of Angers, 4 Rue Larrey, Angers, 49933 Cedex 9, France
| | - L Morgado
- Department of Digestive Surgery, University Hospital of Angers, 4 Rue Larrey, Angers, 49933 Cedex 9, France
| | - A Hamy
- Department of Digestive Surgery, University Hospital of Angers, 4 Rue Larrey, Angers, 49933 Cedex 9, France
- Faculty of Health, Department of Medicine, University of Angers, Angers, France
- IHFIH, UPRES, University of Angers, Angers, EA, 3859, France
| | - C Casa
- Department of Digestive Surgery, University Hospital of Angers, 4 Rue Larrey, Angers, 49933 Cedex 9, France
| | - S Mucci
- Department of Digestive Surgery, University Hospital of Angers, 4 Rue Larrey, Angers, 49933 Cedex 9, France
| | - F Drissi
- The Enteric Nervous System in Gut and Brain Disorders, Université de Nantes, INSERM, TENS, 44000, Nantes, IMAD, France
- Department of Digestive Surgery, University Hospital of Nantes, Rue Alexis Ricordeau, Nantes, 44000, France
| | - P Le Naoures
- Department of Digestive Surgery, University Hospital of Angers, 4 Rue Larrey, Angers, 49933 Cedex 9, France
| | - J F Hamel
- Department of Biostatistics, La Maison de la Recherche, University Hospital of Angers, 4 Rue Larrey, Angers, 49933 Cedex 9, France
| | - A Venara
- Department of Digestive Surgery, University Hospital of Angers, 4 Rue Larrey, Angers, 49933 Cedex 9, France.
- Faculty of Health, Department of Medicine, University of Angers, Angers, France.
- IHFIH, UPRES, University of Angers, Angers, EA, 3859, France.
- The Enteric Nervous System in Gut and Brain Disorders, Université de Nantes, INSERM, TENS, 44000, Nantes, IMAD, France.
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23
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Patient Education for Stoma Patients. SEMINARS IN COLON AND RECTAL SURGERY 2023. [DOI: 10.1016/j.scrs.2023.100952] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 03/17/2023]
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24
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Modified Primary Anastomosis Using an Intestinal Internal Drainage Tube for Crohn's Disease: A Pilot Study. J Clin Med 2023; 12:jcm12010364. [PMID: 36615164 PMCID: PMC9821564 DOI: 10.3390/jcm12010364] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/29/2022] [Revised: 12/24/2022] [Accepted: 12/29/2022] [Indexed: 01/04/2023] Open
Abstract
PURPOSE Surgical treatment is an important part of the management of Crohn's disease (CD). However, the current recommended staged procedures require two operations, with long hospital stays and high costs, while traditional primary anastomosis has a high risk of complications. Therefore, the aim of this study was to compare the clinical efficacy and safety of modified primary anastomosis using intestinal internal drainage tubes for CD. METHODS In this study, emergency and nonemergency CD patients were included separately. Then, the patients were divided into three subgroups: patients with intestinal internal drainage tubes (modified primary anastomosis), staged procedures, and traditional primary anastomosis. The main outcomes were the number of hospitalizations, length and cost of the first hospital stay, length and cost of total hospital stays, and complications. RESULTS The outcomes of the three subgroups of emergency CD patients were not significantly different. For nonemergency CD patients, patients with intestinal internal drainage tubes had shorter total hospital stays and fewer hospitalizations compared with the staged procedures subgroup, while no significant differences in any outcomes were observed between the modified and traditional primary anastomosis subgroups. CONCLUSIONS For emergency CD patients, no significant advantage in terms of the main outcomes was observed for modified primary anastomosis. For nonemergency CD patients, modified primary anastomosis reduced the length of total hospital stays and hospitalizations compared with staged procedures. The placement of intestinal internal drainage tubes allows some patients who cannot undergo primary anastomosis to undergo it, which is a modification of traditional primary anastomosis.
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25
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Ambe PC, Kugler CM, Breuing J, Grohmann E, Friedel J, Hess S, Pieper D. The effect of preoperative stoma site marking on risk of stoma-related complications in patients with intestinal ostomy - A systematic review and meta-analysis. Colorectal Dis 2022; 24:904-917. [PMID: 35297146 DOI: 10.1111/codi.16118] [Citation(s) in RCA: 14] [Impact Index Per Article: 4.7] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 12/09/2021] [Revised: 02/15/2022] [Accepted: 03/08/2022] [Indexed: 12/12/2022]
Abstract
AIM This systematic review and meta-analysis aimed to investigate the effect of preoperative stoma site marking on stoma-related complications in patients with intestinal ostomy. METHODS MEDLINE, Embase, CENTRAL, CINHAL, and Google Scholar were searched up to August 2021 for randomised controlled trials (RCTs) and nonrandomised studies of interventions (NRSI) that involved patients with intestinal ostomies comparing preoperative stoma site marking to no marking and which reported at least one patient-relevant outcome. Outcomes were prioritised by stakeholder involvement. Random-effects meta-analyses produced odds ratios (ORs) or standardised mean differences (SMD) and 95% confidence intervals (CIs). The ROBINS-I tool and the GRADE approach were used to assess the risk of bias and certainty of evidence, respectively. RESULTS This review included two RCTs and 25 NRSI. The risk of bias was high in RCTs and serious to critical in NRSI. Although preoperative site marking reduced stoma-related complications (OR: 0.45, 95% CI: [0.31-0.65]), dependence on professional or unprofessional care (narrative synthesis), and increased health-related quality of life (SMD: 1.13 [0.38-1.88]), the evidence is very uncertain. Preoperative site marking may probably reduce leakage (OR: 0.14 [0.06-0.37]) and may decrease dermatological complications (OR: 0.38 [0.29-0.50]) and surgical revision (OR: 0.09 [0.02-0.49]). The confidence in the cumulative evidence was moderate to very low. CONCLUSION Despite low quality evidence, preoperative stoma site marking can prevent stoma-related complications and should be performed in patients undergoing gastrointestinal surgery given that this intervention poses no harm to patients.
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Affiliation(s)
- Peter C Ambe
- GFO Kliniken Rhein-Berg, Vinzenz Pallotti Hospital, Bergisch Gladbach, Germany.,Department of Health, Witten/Herdecke University, Witten, Germany
| | | | - Jessica Breuing
- Institute for Research in Operative Medicine, Witten/Herdecke University, Witten, Germany
| | | | - Julia Friedel
- Institute for Research in Operative Medicine, Witten/Herdecke University, Witten, Germany.,University of Cologne, Cologne, Germany
| | - Simone Hess
- Institute for Research in Operative Medicine, Witten/Herdecke University, Witten, Germany
| | - Dawid Pieper
- Institute for Research in Operative Medicine, Witten/Herdecke University, Witten, Germany
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26
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Dellafiore F, Caruso R, Bonavina L, Udugampolage NS, Villa G, Russo S, Vangone I, BaronI I, Di Pasquale C, Nania T, Manara DF, Arrigoni C. Risk factors and pooled incidence of intestinal stoma complications: systematic review and Meta-analysis. Curr Med Res Opin 2022; 38:1103-1113. [PMID: 35608158 DOI: 10.1080/03007995.2022.2081455] [Citation(s) in RCA: 8] [Impact Index Per Article: 2.7] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 11/03/2022]
Abstract
OBJECTIVE The present systematic review aimed to identify, critically assess and summarize which risk factors might determine the onset of ostomy complications, describing a pooled incidence and stratified incidences by each identified risk factor. METHODS A systematic literature review with a meta-analysis of observational studies was performed by following the PRISMA statement and flow chart. The quality assessment of the included articles was performed through the Newcastle-Ottawa Scale (NOS). RESULTS Sixteen articles published between 1990 and 2018 focused on the risk factors related to intestinal stomal complications, and the performed analysis led to identifying influenceable and non-influenceable risk factors. The median of the NOS evaluation was 6 (IQR = 5.75-6). Among 10,520 included patients, the pooled incidence of stomal complications was 35%, ranging from 9% to 63%, regardless of the nature of the complications. Analysis of the sub-groups highlighted obesity and ostomy surgery performed via laparoscopy or emergency conditions have significant incidences, respectively, of 66% and 68%. CONCLUSIONS The pooled incidence of stomal complications requires greater attention for its relevant epidemiology. From the clinical point of view, patients with obesity and chronic conditions require more attention to prevent complications, possibly employing accurate educational interventions to enhance proper stoma management.
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Affiliation(s)
- Federica Dellafiore
- Department of Public Health, Experimental and Forensic Medicine, Section of Hygiene, University of Pavia, Pavia, Italy
| | - Rosario Caruso
- Health Professions Research and Development Unit, IRCCS Policlinico San Donato, Milan, Italy
- Department of Biomedical Sciences for Health, University of Milan, Milan, Italy
| | - Luigi Bonavina
- Department of Biomedical Sciences for Health, University of Milan, Milan, Italy
- Division of General Surgery, IRCCS Policlinico San Donato, San Donato Milanese, Italy
| | | | - Giulia Villa
- Center for Nursing Research and Innovation, Vita-Salute San Raffaele University, Milan, Italy
| | - Sara Russo
- ItalyVascular Surgery Unit, IRCCS Policlinic San Matteo Foundation, Nursing degree course, University of Pavia, section Istituti Clinici di Pavia e Vigevano S.p.A., Pavia, Italy
| | - Ida Vangone
- Department of Oncology and Hematology-Oncology, Istituto Europeo Oncologia, Milan, Italy
| | - Irene BaronI
- Health Professions Research and Development Unit, IRCCS Policlinico San Donato, Milan, Italy
| | | | - Tiziana Nania
- Health Professions Research and Development Unit, IRCCS Policlinico San Donato, Milan, Italy
| | - Duilio F Manara
- Center for Nursing Research and Innovation, Vita-Salute San Raffaele University, Milan, Italy
| | - Cristina Arrigoni
- Department of Public Health, Experimental and Forensic Medicine, Section of Hygiene, University of Pavia, Pavia, Italy
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27
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Huisman JF, de Haas JWA, Brohet RM, Vleggaar FP, de Vos Tot Nederveen Cappel WH, van Westreenen HL. Clinical outcome of decompressing colostomy for acute left-sided colorectal obstruction: a consecutive series of 100 patients. Scand J Gastroenterol 2022; 57:757-762. [PMID: 35060822 DOI: 10.1080/00365521.2022.2029557] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/20/2021] [Revised: 01/05/2022] [Accepted: 01/07/2022] [Indexed: 02/04/2023]
Abstract
PURPOSE Aim of our study was to evaluate the outcomes of a consecutive series of patients who were treated with a decompressing colostomy (DC) for acute left-sided colorectal obstruction. METHOD A consecutive series of 100 patients with acute left-sided colorectal obstruction who underwent DC from January 2015 to August 2020 was retrospectively analyzed. Demographic characteristics, etiology of the obstruction, postoperative morbidity- and mortality rates, DC-related complication and stoma reversal rates were evaluated. RESULTS Of the 100 included patients, 64 had malignant- and 36 had benign obstruction. The mean age was 69 years, 42% was male, and the ASA score was 2. Morbidity and mortality rates after DC construction were 20 and 2%, respectively. In 39% of the patients, DC ended up as a permanent stoma and in 61% as bridge to surgery (BtS). DC related complication rate was 32%, with a re-intervention rate of 9%. Elective colorectal resection was performed in 59 cases (59%) with subsequent postoperative morbidity rate of 20%. Stoma reversal rate was 77% for the patients who underwent DC as BtS. Stoma reversal was performed in 66% of the patients with benign obstruction and in 36% for oncological obstruction. CONCLUSION DC as bridge to possible elective resection for acute left-sided colorectal obstruction is an effective strategy with low morbidity and mortality rates and a high stoma reversal rate, especially for benign obstruction. However, DC is less appropriate for patients in whom DC turns out to be a permanent stoma due to a relatively high stoma related complications.
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Affiliation(s)
- Jelle F Huisman
- Department of Gastroenterology and Hepatology, Isala Hospital, Zwolle, The Netherlands
| | - Job W A de Haas
- Department of Surgery, Isala Hospital, Zwolle, The Netherlands
| | - Richard M Brohet
- Department of Epidemiology and Statistics, Isala Hospital, Zwolle, The Netherlands
| | - Frank P Vleggaar
- Department of Gastroenterology and Hepatology, UMC, Utrecht, The Netherlands
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28
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Babakhanlou R, Larkin K, Hita AG, Stroh J, Yeung SC. Stoma-related complications and emergencies. Int J Emerg Med 2022; 15:17. [PMID: 35534817 PMCID: PMC9082897 DOI: 10.1186/s12245-022-00421-9] [Citation(s) in RCA: 25] [Impact Index Per Article: 8.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/15/2022] [Accepted: 04/29/2022] [Indexed: 11/10/2022] Open
Abstract
AbstractStoma creations are common procedures in surgical specialties. They can be created either as a temporary or a permanent measure. Despite advancements in surgical technique and stoma care, complications are common. Patients experiencing stoma-related complications often present to the emergency department. Emergency physicians are not expected to be stoma experts, yet they are often the first point of contact for patients experiencing stoma-related complications. Accordingly, emergency physicians should be familiar with the types of stomas and complications and emergencies associated with them so that they can appropriately address the problems related to stomas. This article will provide a review of emergencies and complications associated with ileostomies, colostomies, and urostomies.
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29
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Colwell JC, Stoia Davis J, Emodi K, Fellows J, Mahoney M, McDade B, Porten S, Raskin E, Sims T, Norman H, Kelly MT, Gray M. Use of a Convex Pouching System in the Postoperative Period: A National Consensus. J Wound Ostomy Continence Nurs 2022; 49:240-246. [PMID: 35523239 PMCID: PMC9093727 DOI: 10.1097/won.0000000000000874] [Citation(s) in RCA: 8] [Impact Index Per Article: 2.7] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/26/2022]
Abstract
Convex pouching systems have been available for ostomy patients for decades; however, controversy remains over the use of convexity in the postoperative period. A group of 10 nurses and physicians with expertise caring for patients with an ostomy completed a scoping review identifying research-based evidence and gaps in our knowledge of the safety and effectiveness related to the use of a convex pouching system following ostomy surgery. Results of this scoping review demonstrated the need for a structured consensus to define best practices when selecting a pouching system that provides a secure and reliable seal around the stoma, avoids undermining and leakage of effluent from the pouching system, and contributes to optimal health-related quality of life for patients following ostomy surgery. The expert panel reached consensus on 8 statements for the use of convex products immediately after surgery and throughout the first 6 months after stoma creation, as well as describing goals in choosing the best pouching system for the patient with an ostomy.
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Affiliation(s)
- Janice C. Colwell
- Correspondence: Janice C. Colwell, MS, APRN, CWOCN, FAAN, Department of General Surgery, University of Chicago Medicine, 1335 S. Prairie Ave, Chicago, IL 60605 ()
| | - Janet Stoia Davis
- Janice C. Colwell, MS, APRN, CWOCN, FAAN, Department of General Surgery, University of Chicago Medicine, Chicago, Illinois
- Janet Stoia Davis, RN, CWOCN, FCN, Stoia Consultants, Riverside, California
- Krisztina Emodi, NP-C, MPH, CNS, University of California San Francisco
- Jane Fellows, MSN, RN-CNS, COCN-AP, Duke University, Durham, North Carolina
- Mary Mahoney, MSN, RN, CWOCN, CFCN, UnityPoint at Home, Urbandale, Iowa
- Bethany McDade, MS, AGPCNP-BC, CWON, Beaumont Health, Southfield, Michigan
- Sima Porten, MD, University of California San Francisco
- Elizabeth Raskin, MD, University of California, Davis
- Terran Sims, MSN, ACNP-C, University of Virginia, Charlottesville
- Holly Norman, PhD, MBA, Coloplast, Minneapolis, Minnesota
- Matthew T. Kelly, PhD, Coloplast, Minneapolis, Minnesota
- Mikel Gray, PhD, RN, FNP, PNP, CUNP, CCCN, FAANP, FAAN, Department of Urology, University of Virginia, Charlottesville
| | - Krisztina Emodi
- Janice C. Colwell, MS, APRN, CWOCN, FAAN, Department of General Surgery, University of Chicago Medicine, Chicago, Illinois
- Janet Stoia Davis, RN, CWOCN, FCN, Stoia Consultants, Riverside, California
- Krisztina Emodi, NP-C, MPH, CNS, University of California San Francisco
- Jane Fellows, MSN, RN-CNS, COCN-AP, Duke University, Durham, North Carolina
- Mary Mahoney, MSN, RN, CWOCN, CFCN, UnityPoint at Home, Urbandale, Iowa
- Bethany McDade, MS, AGPCNP-BC, CWON, Beaumont Health, Southfield, Michigan
- Sima Porten, MD, University of California San Francisco
- Elizabeth Raskin, MD, University of California, Davis
- Terran Sims, MSN, ACNP-C, University of Virginia, Charlottesville
- Holly Norman, PhD, MBA, Coloplast, Minneapolis, Minnesota
- Matthew T. Kelly, PhD, Coloplast, Minneapolis, Minnesota
- Mikel Gray, PhD, RN, FNP, PNP, CUNP, CCCN, FAANP, FAAN, Department of Urology, University of Virginia, Charlottesville
| | - Jane Fellows
- Janice C. Colwell, MS, APRN, CWOCN, FAAN, Department of General Surgery, University of Chicago Medicine, Chicago, Illinois
- Janet Stoia Davis, RN, CWOCN, FCN, Stoia Consultants, Riverside, California
- Krisztina Emodi, NP-C, MPH, CNS, University of California San Francisco
- Jane Fellows, MSN, RN-CNS, COCN-AP, Duke University, Durham, North Carolina
- Mary Mahoney, MSN, RN, CWOCN, CFCN, UnityPoint at Home, Urbandale, Iowa
- Bethany McDade, MS, AGPCNP-BC, CWON, Beaumont Health, Southfield, Michigan
- Sima Porten, MD, University of California San Francisco
- Elizabeth Raskin, MD, University of California, Davis
- Terran Sims, MSN, ACNP-C, University of Virginia, Charlottesville
- Holly Norman, PhD, MBA, Coloplast, Minneapolis, Minnesota
- Matthew T. Kelly, PhD, Coloplast, Minneapolis, Minnesota
- Mikel Gray, PhD, RN, FNP, PNP, CUNP, CCCN, FAANP, FAAN, Department of Urology, University of Virginia, Charlottesville
| | - Mary Mahoney
- Janice C. Colwell, MS, APRN, CWOCN, FAAN, Department of General Surgery, University of Chicago Medicine, Chicago, Illinois
- Janet Stoia Davis, RN, CWOCN, FCN, Stoia Consultants, Riverside, California
- Krisztina Emodi, NP-C, MPH, CNS, University of California San Francisco
- Jane Fellows, MSN, RN-CNS, COCN-AP, Duke University, Durham, North Carolina
- Mary Mahoney, MSN, RN, CWOCN, CFCN, UnityPoint at Home, Urbandale, Iowa
- Bethany McDade, MS, AGPCNP-BC, CWON, Beaumont Health, Southfield, Michigan
- Sima Porten, MD, University of California San Francisco
- Elizabeth Raskin, MD, University of California, Davis
- Terran Sims, MSN, ACNP-C, University of Virginia, Charlottesville
- Holly Norman, PhD, MBA, Coloplast, Minneapolis, Minnesota
- Matthew T. Kelly, PhD, Coloplast, Minneapolis, Minnesota
- Mikel Gray, PhD, RN, FNP, PNP, CUNP, CCCN, FAANP, FAAN, Department of Urology, University of Virginia, Charlottesville
| | - Bethany McDade
- Janice C. Colwell, MS, APRN, CWOCN, FAAN, Department of General Surgery, University of Chicago Medicine, Chicago, Illinois
- Janet Stoia Davis, RN, CWOCN, FCN, Stoia Consultants, Riverside, California
- Krisztina Emodi, NP-C, MPH, CNS, University of California San Francisco
- Jane Fellows, MSN, RN-CNS, COCN-AP, Duke University, Durham, North Carolina
- Mary Mahoney, MSN, RN, CWOCN, CFCN, UnityPoint at Home, Urbandale, Iowa
- Bethany McDade, MS, AGPCNP-BC, CWON, Beaumont Health, Southfield, Michigan
- Sima Porten, MD, University of California San Francisco
- Elizabeth Raskin, MD, University of California, Davis
- Terran Sims, MSN, ACNP-C, University of Virginia, Charlottesville
- Holly Norman, PhD, MBA, Coloplast, Minneapolis, Minnesota
- Matthew T. Kelly, PhD, Coloplast, Minneapolis, Minnesota
- Mikel Gray, PhD, RN, FNP, PNP, CUNP, CCCN, FAANP, FAAN, Department of Urology, University of Virginia, Charlottesville
| | - Sima Porten
- Janice C. Colwell, MS, APRN, CWOCN, FAAN, Department of General Surgery, University of Chicago Medicine, Chicago, Illinois
- Janet Stoia Davis, RN, CWOCN, FCN, Stoia Consultants, Riverside, California
- Krisztina Emodi, NP-C, MPH, CNS, University of California San Francisco
- Jane Fellows, MSN, RN-CNS, COCN-AP, Duke University, Durham, North Carolina
- Mary Mahoney, MSN, RN, CWOCN, CFCN, UnityPoint at Home, Urbandale, Iowa
- Bethany McDade, MS, AGPCNP-BC, CWON, Beaumont Health, Southfield, Michigan
- Sima Porten, MD, University of California San Francisco
- Elizabeth Raskin, MD, University of California, Davis
- Terran Sims, MSN, ACNP-C, University of Virginia, Charlottesville
- Holly Norman, PhD, MBA, Coloplast, Minneapolis, Minnesota
- Matthew T. Kelly, PhD, Coloplast, Minneapolis, Minnesota
- Mikel Gray, PhD, RN, FNP, PNP, CUNP, CCCN, FAANP, FAAN, Department of Urology, University of Virginia, Charlottesville
| | - Elizabeth Raskin
- Janice C. Colwell, MS, APRN, CWOCN, FAAN, Department of General Surgery, University of Chicago Medicine, Chicago, Illinois
- Janet Stoia Davis, RN, CWOCN, FCN, Stoia Consultants, Riverside, California
- Krisztina Emodi, NP-C, MPH, CNS, University of California San Francisco
- Jane Fellows, MSN, RN-CNS, COCN-AP, Duke University, Durham, North Carolina
- Mary Mahoney, MSN, RN, CWOCN, CFCN, UnityPoint at Home, Urbandale, Iowa
- Bethany McDade, MS, AGPCNP-BC, CWON, Beaumont Health, Southfield, Michigan
- Sima Porten, MD, University of California San Francisco
- Elizabeth Raskin, MD, University of California, Davis
- Terran Sims, MSN, ACNP-C, University of Virginia, Charlottesville
- Holly Norman, PhD, MBA, Coloplast, Minneapolis, Minnesota
- Matthew T. Kelly, PhD, Coloplast, Minneapolis, Minnesota
- Mikel Gray, PhD, RN, FNP, PNP, CUNP, CCCN, FAANP, FAAN, Department of Urology, University of Virginia, Charlottesville
| | - Terran Sims
- Janice C. Colwell, MS, APRN, CWOCN, FAAN, Department of General Surgery, University of Chicago Medicine, Chicago, Illinois
- Janet Stoia Davis, RN, CWOCN, FCN, Stoia Consultants, Riverside, California
- Krisztina Emodi, NP-C, MPH, CNS, University of California San Francisco
- Jane Fellows, MSN, RN-CNS, COCN-AP, Duke University, Durham, North Carolina
- Mary Mahoney, MSN, RN, CWOCN, CFCN, UnityPoint at Home, Urbandale, Iowa
- Bethany McDade, MS, AGPCNP-BC, CWON, Beaumont Health, Southfield, Michigan
- Sima Porten, MD, University of California San Francisco
- Elizabeth Raskin, MD, University of California, Davis
- Terran Sims, MSN, ACNP-C, University of Virginia, Charlottesville
- Holly Norman, PhD, MBA, Coloplast, Minneapolis, Minnesota
- Matthew T. Kelly, PhD, Coloplast, Minneapolis, Minnesota
- Mikel Gray, PhD, RN, FNP, PNP, CUNP, CCCN, FAANP, FAAN, Department of Urology, University of Virginia, Charlottesville
| | - Holly Norman
- Janice C. Colwell, MS, APRN, CWOCN, FAAN, Department of General Surgery, University of Chicago Medicine, Chicago, Illinois
- Janet Stoia Davis, RN, CWOCN, FCN, Stoia Consultants, Riverside, California
- Krisztina Emodi, NP-C, MPH, CNS, University of California San Francisco
- Jane Fellows, MSN, RN-CNS, COCN-AP, Duke University, Durham, North Carolina
- Mary Mahoney, MSN, RN, CWOCN, CFCN, UnityPoint at Home, Urbandale, Iowa
- Bethany McDade, MS, AGPCNP-BC, CWON, Beaumont Health, Southfield, Michigan
- Sima Porten, MD, University of California San Francisco
- Elizabeth Raskin, MD, University of California, Davis
- Terran Sims, MSN, ACNP-C, University of Virginia, Charlottesville
- Holly Norman, PhD, MBA, Coloplast, Minneapolis, Minnesota
- Matthew T. Kelly, PhD, Coloplast, Minneapolis, Minnesota
- Mikel Gray, PhD, RN, FNP, PNP, CUNP, CCCN, FAANP, FAAN, Department of Urology, University of Virginia, Charlottesville
| | - Matthew T. Kelly
- Janice C. Colwell, MS, APRN, CWOCN, FAAN, Department of General Surgery, University of Chicago Medicine, Chicago, Illinois
- Janet Stoia Davis, RN, CWOCN, FCN, Stoia Consultants, Riverside, California
- Krisztina Emodi, NP-C, MPH, CNS, University of California San Francisco
- Jane Fellows, MSN, RN-CNS, COCN-AP, Duke University, Durham, North Carolina
- Mary Mahoney, MSN, RN, CWOCN, CFCN, UnityPoint at Home, Urbandale, Iowa
- Bethany McDade, MS, AGPCNP-BC, CWON, Beaumont Health, Southfield, Michigan
- Sima Porten, MD, University of California San Francisco
- Elizabeth Raskin, MD, University of California, Davis
- Terran Sims, MSN, ACNP-C, University of Virginia, Charlottesville
- Holly Norman, PhD, MBA, Coloplast, Minneapolis, Minnesota
- Matthew T. Kelly, PhD, Coloplast, Minneapolis, Minnesota
- Mikel Gray, PhD, RN, FNP, PNP, CUNP, CCCN, FAANP, FAAN, Department of Urology, University of Virginia, Charlottesville
| | - Mikel Gray
- Janice C. Colwell, MS, APRN, CWOCN, FAAN, Department of General Surgery, University of Chicago Medicine, Chicago, Illinois
- Janet Stoia Davis, RN, CWOCN, FCN, Stoia Consultants, Riverside, California
- Krisztina Emodi, NP-C, MPH, CNS, University of California San Francisco
- Jane Fellows, MSN, RN-CNS, COCN-AP, Duke University, Durham, North Carolina
- Mary Mahoney, MSN, RN, CWOCN, CFCN, UnityPoint at Home, Urbandale, Iowa
- Bethany McDade, MS, AGPCNP-BC, CWON, Beaumont Health, Southfield, Michigan
- Sima Porten, MD, University of California San Francisco
- Elizabeth Raskin, MD, University of California, Davis
- Terran Sims, MSN, ACNP-C, University of Virginia, Charlottesville
- Holly Norman, PhD, MBA, Coloplast, Minneapolis, Minnesota
- Matthew T. Kelly, PhD, Coloplast, Minneapolis, Minnesota
- Mikel Gray, PhD, RN, FNP, PNP, CUNP, CCCN, FAANP, FAAN, Department of Urology, University of Virginia, Charlottesville
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Luo J, Singh D, Zhang F, Yang X, Zha X, Jiang H, Yang L, Yang H. Comparison of the extraperitoneal and transperitoneal routes for permanent colostomy: a meta-analysis with RCTs and systematic review. World J Surg Oncol 2022; 20:82. [PMID: 35279174 PMCID: PMC8918274 DOI: 10.1186/s12957-022-02547-9] [Citation(s) in RCA: 9] [Impact Index Per Article: 3.0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/29/2021] [Accepted: 03/01/2022] [Indexed: 11/10/2022] Open
Abstract
Aim To assess the efficacy of extraperitoneal colostomy (EPC) in preventing stoma-related complications. Background Transperitoneal colostomy (TPC) is a widely used surgical approach. However, TPCs have been reported to have increased risks of stoma-related complications, such as parastomal hernias, stomal retraction, and stomal prolapse. The purpose of EPC is to reduce these complications. However, there is still a lack of evidence-based studies. Materials and methods MEDLINE, EMBASE, Web of Science, Scopus, MOOSE, PubMed, Google Scholar, Baidu Scholar, and the Cochrane Library were searched to conduct a systematic review and meta-analysis with RCTs. The meta-analysis was performed with RevMan 5.4 software. Results This study included 5 eligible RCTs. Compared with the TPC group, the EPC group had lower incidence rates of parastomal hernias (RR, 0.14; 95% CI, 0.04–0.52, P = 0.003, I2 = 0%) and stomatal prolapse (RR, 0.27; 95% CI, 0.08–0.95, P = 0.04, I2 = 0%), but a higher rate of defecation sensation (RR, 3.51; 95% CI, 2.47–5.0, P < 0.00001, I2 = 37%). No statistically significant differences were observed in stoma retraction, colostomy construction time, stoma ischemia, or stoma necrosis. Conclusion Extraperitoneal colostomies are associated with lower rates of postoperative complications than transperitoneal colostomies. A randomized controlled trial meta-analysis found that permanent colostomies after abdominoperineal resection resulted in better outcomes.
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Zahia S, Garcia-Zapirain B, Anakabe J, Ander J, Jossa Bastidas O, Loizate Totoricagüena A. A Comparative Study between Scanning Devices for 3D Printing of Personalized Ostomy Patches. SENSORS (BASEL, SWITZERLAND) 2022; 22:560. [PMID: 35062521 PMCID: PMC8780182 DOI: 10.3390/s22020560] [Citation(s) in RCA: 8] [Impact Index Per Article: 2.7] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Figures] [Subscribe] [Scholar Register] [Received: 11/28/2021] [Revised: 01/06/2022] [Accepted: 01/07/2022] [Indexed: 06/14/2023]
Abstract
This papers presents a comparative study of three different 3D scanning modalities to acquire 3D meshes of stoma barrier rings from ostomized patients. Computerized Tomography and Structured light scanning methods were the digitization technologies studied in this research. Among the Structured Light systems, the Go!Scan 20 and the Structure Sensor were chosen as the handheld 3D scanners. Nineteen ostomized patients took part in this study, starting from the 3D scans acquisition until the printed ostomy patches validation. 3D mesh processing, mesh generation and 3D mesh comparison was carried out using commercial softwares. The results of the presented study show that the Structure Sensor, which is the low cost structured light 3D sensor, has a great potential for such applications. This study also discusses the benefits and reliability of low-cost structured light systems.
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Affiliation(s)
- Sofia Zahia
- eVIDA Research Group, University of Deusto, 48007 Bilbao, Spain; (B.G.-Z.); (O.J.B.)
| | | | - Jon Anakabe
- LEARTIKER S.COOP, 48270 Markina, Spain; (J.A.); (J.A.)
| | - Joan Ander
- LEARTIKER S.COOP, 48270 Markina, Spain; (J.A.); (J.A.)
| | - Oscar Jossa Bastidas
- eVIDA Research Group, University of Deusto, 48007 Bilbao, Spain; (B.G.-Z.); (O.J.B.)
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Pandiaraja J, Chakkarapani R, Arumugam S. A study on patterns, indications, and complications of an enteric stoma. J Family Med Prim Care 2021; 10:3277-3282. [PMID: 34760744 PMCID: PMC8565109 DOI: 10.4103/jfmpc.jfmpc_123_21] [Citation(s) in RCA: 10] [Impact Index Per Article: 2.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/18/2021] [Accepted: 07/01/2021] [Indexed: 11/15/2022] Open
Abstract
Introduction: Stoma could be a surgically created opening within the abdominal wall. The main purpose of the stoma is to divert the excreta off from the distal intestinal loops to relieve an obstruction or protect anastomosis. The indications for stoma creation are intestinal obstruction due to benign or malignant tumors, perforation peritonitis, inflammatory bowel disease, colorectal malignancies, and anorectal malformations. Aim of the study: The study aimed to identify the patterns, indications, and complications that occur following the creation of enteric stomas. Materials and Methods: It is a prospective observational study conducted from May 2012 to October 2015 on a hundred patients, who were admitted in the department of general surgery, surgical gastroenterology, and pediatric surgery, Government Stanley Medical College and Hospital. The sampling method followed here is the non-probability convenience sampling technique. The data is collected from all the patients who come under the inclusion criteria. Results: Of 100 patients, the majority of the patients belonged to 26–35 years and 46–55 years (n = 25). Based on the study, loop colostomy is more common with age less than one year and loop ileostomy is more common in 26–55 years. The foremost common indication of an enteric stoma is a gastrointestinal malignancy (25%) followed by abdominal trauma (22%). In our study, an ileostomy (80%) is the most common type of stoma created followed by colostomy. Within the ileostomy, loop ileostomy is the more common (60%) followed by end ileostomy (20%). Among the complications related to an enteric stoma, skin excoriation (54.4%) is most common followed by surgical site infections (8.5%). Conclusion: Our study shows stoma creation is higher in the adult and old age group, mostly done as an emergency procedure compared to an elective procedure. So, better preoperative planning in both emergency and elective settings can reduce the number of stoma and its related complications. The duration of hospital stay is higher in stoma patients. So, the reduction in stoma creation leads to a reduction in complication, duration of hospital stays and indirectly reduces expenditure related to it. In our study, most of the stoma is created for obstruction in malignancy and perforation in trauma patients. From our study, we can observe early diagnosis of intestinal malignancy with a well-planned elective procedure or bride procedure like colonic stenting in malignant obstruction can reduce the number of stoma creation. Skin excoriation is the most complication followed by surgical site infections. These complications can be reduced by better postoperative stoma care and early reversal of stoma.
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Affiliation(s)
- Jayabal Pandiaraja
- Department of General Surgery, Appasamy Hospital, Chennai, Tamilnadu, India
| | - Rajesh Chakkarapani
- Department of General Surgery, Melmaruvathur Adhiparasakthi Institute of Medical Science and Research, Melmaruvathur, Tamilnadu, India
| | - Shalini Arumugam
- Department of Community Medicine, ACS Medical College and Hospital, Chennai, Tamilnadu, India
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Sandberg S, Asplund D, Bock D, Ehrencrona C, Ohlsson B, Park J, Rosenberg J, Smedh K, Walming S, Angenete E. Predicting life with a permanent end colostomy: A prospective study on function, bother and acceptance. Colorectal Dis 2021; 23:2681-2689. [PMID: 34314553 DOI: 10.1111/codi.15842] [Citation(s) in RCA: 6] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 03/03/2021] [Revised: 06/22/2021] [Accepted: 07/07/2021] [Indexed: 01/31/2023]
Abstract
AIM The factors that influence a patient's experience of a colostomy are not known. The aim of this study was to characterise stoma function, stoma-related bother and acceptance among patients operated for rectal cancer and to investigate if there were any preoperative personal factors with predictive impact on long-term stoma-related bother. METHODS The QoLiRECT (Quality of Life in RECTal cancer) study is a prospective multicentre study of patients with rectal cancer. This was a subgroup analysis of patients with a permanent colostomy with a 2-year follow-up. Penalised regression models with shrinkage estimation were used to predict the 1-and 2-year bother using baseline data. The predictive value and the importance of the included variables were evaluated using bootstrap resampling techniques. RESULTS A total of 379 patients were included. Overall stoma acceptance was high and a majority of patients were not bothered by their stoma; 77% and 83% at 1 and 2 years, respectively. The subgroup of patients with stoma-related bother had a high prevalence of difficulties, especially fear of leakage, and a low stoma acceptance in daily life. Both clinical and personal factors were associated with stoma-related bother. The most important factors were quality of life and physical health, but the prediction accuracy was low. CONCLUSIONS Stoma-related bother was associated with overall stoma dysfunction. As stoma-related bother is a multifactorial problem, it was not possible to predict which patients will experience stoma-related bother. It is therefore of importance to prevent stoma-related symptoms and optimise stoma function to reduce long-term bother and increase stoma acceptance.
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Affiliation(s)
- Sofia Sandberg
- Department of Surgery, SSORG - Scandinavian Surgical Outcomes Research Group, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.,Department of Surgery, Region Västra Götaland, Sahlgrenska University Hospital/Östra, Gothenburg, Sweden
| | - Dan Asplund
- Department of Surgery, SSORG - Scandinavian Surgical Outcomes Research Group, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.,Department of Surgery, Region Västra Götaland, Sahlgrenska University Hospital/Östra, Gothenburg, Sweden
| | - David Bock
- Department of Surgery, SSORG - Scandinavian Surgical Outcomes Research Group, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
| | - Carolina Ehrencrona
- Department of Surgery, SSORG - Scandinavian Surgical Outcomes Research Group, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
| | - Björn Ohlsson
- Department of Surgery, Blekinge Hospital, Karlshamn, Sweden
| | - Jennifer Park
- Department of Surgery, SSORG - Scandinavian Surgical Outcomes Research Group, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.,Department of Surgery, Region Västra Götaland, Sahlgrenska University Hospital/Östra, Gothenburg, Sweden
| | - Jacob Rosenberg
- Department of Surgery, Herlev Hospital, University of Copenhagen, Herlev, Denmark
| | - Kenneth Smedh
- Department of Surgery, Västmanlands Hospital, Västerås, Sweden
| | - Sofie Walming
- Department of Surgery, SSORG - Scandinavian Surgical Outcomes Research Group, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.,Department of Surgery, Helsingborg Hospital, Helsingborg, Sweden
| | - Eva Angenete
- Department of Surgery, SSORG - Scandinavian Surgical Outcomes Research Group, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.,Department of Surgery, Region Västra Götaland, Sahlgrenska University Hospital/Östra, Gothenburg, Sweden
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Modified Stapled Mesh Stoma Reinforcement Technique (SMART) for parastomal hernias, with video. J Visc Surg 2021; 159:77-79. [PMID: 34561190 DOI: 10.1016/j.jviscsurg.2021.08.007] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/23/2022]
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Huang Y, Chen H, Zheng Q, Lin X, Zhu G, Wang J, Huang C, Ye J. Abdominal Oblique Internal and External Muscles Gap Colostomy for Lower Incidence of Parastomal Hernia and Higher Quality of Life: A Retrospective Cohort Study. World J Surg 2021; 45:3623-3632. [PMID: 34494162 DOI: 10.1007/s00268-021-06294-y] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 08/07/2021] [Indexed: 11/26/2022]
Abstract
BACKGROUND Parastomal hernia and fecal incontinence cause severe distress to the rectal cancer patients with stoma after abdominoperineal resection. We attempted a new colostomy technique through the gap between the abdominal oblique internal and external muscles to prevent parastomal hernia and improve quality of life. METHODS This cohort study retrospectively examined clinical data from a total of 114 consecutive rectal cancer patients who underwent laparoscopic abdominoperineal resection in our center from March 2016 to March 2018 after propensity score matching. Group A included 57 patients who underwent colostomy through the gap between the abdominal oblique internal and oblique external muscles, while group B included 57 patients who underwent extraperitoneal colostomy. Patients' quality of life was evaluated using Fecal Incontinence Quality of Life (FIQL) Scale. RESULTS Group A had a lower incidence of parastomal hernia (0% vs. 15.7%, p = 0.004) and higher quality of life, especially in lifestyle, coping/behavior and embarrassment domains (all p values < 0.05) than group B both during the follow-up period. The incidence of other outcomes did not differ between the groups. CONCLUSIONS Colostomy through the gap between the abdominal oblique internal and oblique external muscle is a new technique showing both safety and effectiveness for preventing parastomal hernia and improving quality of life after laparoscopic abdominoperineal resection.
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Affiliation(s)
- Yongjian Huang
- Department of Gastrointestinal Surgery 2 Section, The First Affiliated Hospital of Fujian Medical University, 20th, Chazhong Road, Fuzhou, 350005, China
- Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fuzhou, 350000, China
| | - Hengkai Chen
- Department of Gastrointestinal Surgery 2 Section, The First Affiliated Hospital of Fujian Medical University, 20th, Chazhong Road, Fuzhou, 350005, China
- Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fuzhou, 350000, China
| | - Qiajun Zheng
- Department of Gastrointestinal Surgery 2 Section, The First Affiliated Hospital of Fujian Medical University, 20th, Chazhong Road, Fuzhou, 350005, China
- Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fuzhou, 350000, China
| | - Xiaohan Lin
- Department of Gastrointestinal Surgery 2 Section, The First Affiliated Hospital of Fujian Medical University, 20th, Chazhong Road, Fuzhou, 350005, China
- Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fuzhou, 350000, China
| | - Guangwei Zhu
- Department of Gastrointestinal Surgery 2 Section, The First Affiliated Hospital of Fujian Medical University, 20th, Chazhong Road, Fuzhou, 350005, China
- Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fuzhou, 350000, China
| | - Jinzhou Wang
- Department of Gastrointestinal Surgery 2 Section, The First Affiliated Hospital of Fujian Medical University, 20th, Chazhong Road, Fuzhou, 350005, China
- Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fuzhou, 350000, China
| | - Changli Huang
- Department of Gastrointestinal Surgery 2 Section, The First Affiliated Hospital of Fujian Medical University, 20th, Chazhong Road, Fuzhou, 350005, China
- Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fuzhou, 350000, China
| | - Jianxin Ye
- Department of Gastrointestinal Surgery 2 Section, The First Affiliated Hospital of Fujian Medical University, 20th, Chazhong Road, Fuzhou, 350005, China.
- Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fuzhou, 350000, China.
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Zelga P, Kluska P, Zelga M, Piasecka-Zelga J, Dziki A. Patient-Related Factors Associated With Stoma and Peristomal Complications Following Fecal Ostomy Surgery: A Scoping Review. J Wound Ostomy Continence Nurs 2021; 48:415-430. [PMID: 34495932 DOI: 10.1097/won.0000000000000796] [Citation(s) in RCA: 30] [Impact Index Per Article: 7.5] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/06/2023]
Abstract
PURPOSE Ostomy creation is often an integral part of the surgical management of various diseases including colorectal malignancies and inflammatory bowel disease. Stoma and peristomal complications may occur in up to 70% of patients following ostomy surgery. The aim of this scoping literature review was to synthesize evidence on the risk factors for developing complications following creation of a fecal ostomy. DESIGN Scoping literature review. SEARCH STRATEGY Two independent researchers completed a search of the online bibliographic databases PubMed, MEDLINE, Cochrane, Google Scholar, and EMBASE for all articles published between January 1980 and December 2018. The search comprised multiple elements including systematic literature reviews with meta-analysis of pooled findings, randomized controlled trials, cohort studies, observational studies, other types of review articles, and multiple case reports. We screened 307 unique titles and abstracts; 68 articles met our eligibility criteria for inclusion. The methodological rigor of study quality included in our scoping review was variable. FINDINGS/CONCLUSIONS We identified 6 risk factors associated with an increased likelihood of stoma or peristomal complications (1) age more than 65 years; (2) female sex; (3) body mass index more than 25; (4) diabetes mellitus as a comorbid condition; (5) abdominal malignancy as the underlying reason for ostomy surgery; and (6) lack of preoperative stoma site marking and WOC/ostomy nurse specialist care prior to stoma surgery. We also found evidence that persons with a colostomy are at a higher risk for prolapse and parastomal hernia. IMPLICATIONS Health care professionals should consider these risk factors when caring for patients undergoing fecal ostomy surgery and manage modifiable factors whenever possible. For example, preoperative stoma site marking by an ostomy nurse or surgeon familiar with this task, along with careful perioperative ostomy care and education of the patient by an ostomy nurse specialist, are essential to reduce the risk of modifiable risk factors related to creation of a fecal ostomy.
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Affiliation(s)
- Piotr Zelga
- Piotr Zelga, MD, PhD, Department of General and Colorectal Surgery, Medical University of Lodz, Lodz, Poland
- Piotr Kluska, MD, Department of General and Colorectal Surgery, Medical University of Lodz, Lodz, Poland
- Marta Zelga, MD, Department of Pediatric Surgery, Urology and Transplantology, Polish Mother's Memorial Hospital Research Institute, Lodz, Poland
- Joanna Piasecka-Zelga, PhD, Research Laboratory for Medicine and Veterinary Products in the GMP Quality System, Nofer Institute of Occupational Medicine, Lodz, Poland
- Adam Dziki, MD, PhD, Department of General and Colorectal Surgery, Medical University of Lodz, Lodz, Poland
| | - Piotr Kluska
- Piotr Zelga, MD, PhD, Department of General and Colorectal Surgery, Medical University of Lodz, Lodz, Poland
- Piotr Kluska, MD, Department of General and Colorectal Surgery, Medical University of Lodz, Lodz, Poland
- Marta Zelga, MD, Department of Pediatric Surgery, Urology and Transplantology, Polish Mother's Memorial Hospital Research Institute, Lodz, Poland
- Joanna Piasecka-Zelga, PhD, Research Laboratory for Medicine and Veterinary Products in the GMP Quality System, Nofer Institute of Occupational Medicine, Lodz, Poland
- Adam Dziki, MD, PhD, Department of General and Colorectal Surgery, Medical University of Lodz, Lodz, Poland
| | - Marta Zelga
- Piotr Zelga, MD, PhD, Department of General and Colorectal Surgery, Medical University of Lodz, Lodz, Poland
- Piotr Kluska, MD, Department of General and Colorectal Surgery, Medical University of Lodz, Lodz, Poland
- Marta Zelga, MD, Department of Pediatric Surgery, Urology and Transplantology, Polish Mother's Memorial Hospital Research Institute, Lodz, Poland
- Joanna Piasecka-Zelga, PhD, Research Laboratory for Medicine and Veterinary Products in the GMP Quality System, Nofer Institute of Occupational Medicine, Lodz, Poland
- Adam Dziki, MD, PhD, Department of General and Colorectal Surgery, Medical University of Lodz, Lodz, Poland
| | - Joanna Piasecka-Zelga
- Piotr Zelga, MD, PhD, Department of General and Colorectal Surgery, Medical University of Lodz, Lodz, Poland
- Piotr Kluska, MD, Department of General and Colorectal Surgery, Medical University of Lodz, Lodz, Poland
- Marta Zelga, MD, Department of Pediatric Surgery, Urology and Transplantology, Polish Mother's Memorial Hospital Research Institute, Lodz, Poland
- Joanna Piasecka-Zelga, PhD, Research Laboratory for Medicine and Veterinary Products in the GMP Quality System, Nofer Institute of Occupational Medicine, Lodz, Poland
- Adam Dziki, MD, PhD, Department of General and Colorectal Surgery, Medical University of Lodz, Lodz, Poland
| | - Adam Dziki
- Piotr Zelga, MD, PhD, Department of General and Colorectal Surgery, Medical University of Lodz, Lodz, Poland
- Piotr Kluska, MD, Department of General and Colorectal Surgery, Medical University of Lodz, Lodz, Poland
- Marta Zelga, MD, Department of Pediatric Surgery, Urology and Transplantology, Polish Mother's Memorial Hospital Research Institute, Lodz, Poland
- Joanna Piasecka-Zelga, PhD, Research Laboratory for Medicine and Veterinary Products in the GMP Quality System, Nofer Institute of Occupational Medicine, Lodz, Poland
- Adam Dziki, MD, PhD, Department of General and Colorectal Surgery, Medical University of Lodz, Lodz, Poland
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Johnson AM, Loftus EV. Obesity in inflammatory bowel disease: A review of its role in the pathogenesis, natural history, and treatment of IBD. Saudi J Gastroenterol 2021; 27:183-190. [PMID: 34169900 PMCID: PMC8448008 DOI: 10.4103/sjg.sjg_30_21] [Citation(s) in RCA: 22] [Impact Index Per Article: 5.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 12/21/2022] Open
Abstract
In contrast to previous perceptions that inflammatory bowel disease (IBD) patients are generally malnourished and underweight, there is mounting evidence to suggest that rates of obesity in IBD now mirror that of the general population. IBD is an immune-mediated condition that appears to develop in individuals who have not only a genetic predisposition to immune dysregulation but also likely exposure to various environmental factors which further potentiate this risk. With the surge in obesity alongside the rising incidence of IBD, particularly in developing nations, the role that obesity may play, not only in the pathogenesis but also in the natural history of disease has become a topic of growing interest. Currently available data exploring obesity's impact on the natural history of IBD are largely conflicting, potentially limited by the use of body mass index as a surrogate measure of obesity at varying time points throughout the disease course. While there are pharmacokinetic data to suggest possible detrimental effects that obesity may have on the response to medical therapy, results in this realm are also inconsistent. Moreover, not only is it unclear whether weight loss improves IBD outcomes, little is known about the safety and efficacy of available weight-loss strategies in this population. For these reasons, it becomes increasingly important to further understand the nature of any interaction between obesity and IBD.
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Affiliation(s)
- Amanda M. Johnson
- Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street Southwest, Rochester, MN, USA,Address for correspondence: Dr. Amanda M. Johnson, Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street Southwest, Rochester, MN - 55905, USA. E-mail:
| | - Edward V. Loftus
- Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street Southwest, Rochester, MN, USA
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Kim YM, Jang HJ, Lee YJ. The effectiveness of preoperative stoma site marking on patient outcomes: A systematic review and meta-analysis. J Adv Nurs 2021; 77:4332-4346. [PMID: 34118170 DOI: 10.1111/jan.14915] [Citation(s) in RCA: 22] [Impact Index Per Article: 5.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/26/2021] [Revised: 04/03/2021] [Accepted: 05/08/2021] [Indexed: 01/23/2023]
Abstract
AIMS This study systematically reviews the literature regarding preoperative stoma site marking and discusses the effectiveness of the procedure on complication rates, self-care deficits and health-related quality of life (HRQOL). DESIGN Systematic review and meta-analysis. DATA SOURCE Our review was conducted following the PRISMA guidelines. PubMed, EMBASE, Cochrane and CINAHL databases were searched to obtain articles published in English. Articles were also retrieved from Korean databases as well. Our last search was conducted on 2 June 2019. REVIEW METHODS Two reviewers independently selected relevant studies, evaluated their methodological quality and extracted data. Experimental and observational studies were included. Our main focus was on complication rates, self-care deficits and HRQOL. We conducted meta-analysis using the statistical software spss 25.0 and Stata 13.0. RESULTS Of the 1,039 articles reviewed, 20 were included for review, and 19 were used for quantitative synthesis. Preoperative stoma site marking reduced complication rates (odds ratio [OR]: 0.47; 95% confidence interval [CI]: 0.36-0.62; I2 : 70.6%), lowered self-care deficits (OR: 0.34; 95% CI: 0.18-0.64; I2 : 0%), and increased HRQOL (standardized mean difference, 1.05; 95% CI: 0.70-1.40; I2 : 0%). Quality appraisal results for both the individual studies and the studies overall were excellent. The possibility of publication bias was low. CONCLUSIONS Our findings indicate that preoperative stoma site marking improves patient outcomes: stoma-related complication rates and self-care deficits decrease and HRQOL rises. For this reason, preoperative stoma site marking should be a mandatory procedure in clinical settings. The practice should also be supported by policymakers and healthcare expert associations. IMPACT Preoperative stoma site marking reduces overall complication rates by 53% and skin problems by 59%. Preoperative stoma site marking also improves self-care and health-related quality of life. We recommend that preoperative stoma site marking should be a mandatory procedure in clinical settings.
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Affiliation(s)
- Young Man Kim
- College of Nursing, Research Institute of Nursing Science, Jeonbuk National University, Jeonju-si, Jeollabuk-do, Republic of Korea
| | - Hyun Jin Jang
- Department of Nursing, Yonsei Cancer Center, Yonsei University Health System, Seoul, Republic of Korea.,Department of Nursing, Graduate School, Yonsei University, Seoul, Republic of Korea
| | - Yun Jin Lee
- Department of Nursing, Yonsei Cancer Center, Yonsei University Health System, Seoul, Republic of Korea.,College of Nursing, Yonsei University, Seoul, Republic of Korea
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Kugler CM, Breuing J, Rombey T, Hess S, Ambe P, Grohmann E, Pieper D. The effect of preoperative stoma site marking on risk of stoma-related complications in patients with intestinal ostomy-protocol of a systematic review and meta-analysis. Syst Rev 2021; 10:146. [PMID: 33980317 PMCID: PMC8117581 DOI: 10.1186/s13643-021-01684-8] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 03/02/2021] [Accepted: 04/22/2021] [Indexed: 11/18/2022] Open
Abstract
BACKGROUND An intestinal ostomy is an artificial bowel opening created on the skin. Procedure-related mortality is extremely rare. However, the presence of an ostomy may be associated with significant morbidity. Complications negatively affect the quality of life of ostomates. Preoperative stoma site marking can reduce stoma-related complications and is recommended by several guidelines. However, there is no consensus on the procedure and recommendations are based on low-quality evidence. The objective of the systematic review will be to investigate if preoperative stoma site marking compared to no preoperative marking in patients undergoing intestinal stoma surgery reduces or prevents the rate of stoma-related complications. METHODS We will include (cluster-) randomised controlled trials and cohort studies that involve patients with intestinal ostomies comparing preoperative stoma site marking to no preoperative marking and report at least one patient-relevant outcome. For study identification, we will systematically search MEDLINE/PubMed, EMBASE, CENTRAL and CINHAL as well as Google Scholar, trial registries, conference proceedings and reference lists. Additionally, we will contact experts in the field. Two reviewers will independently perform study selection and data extraction. Outcomes will be prioritised based on findings from telephone interviews with five ostomates and five ostomy and wound nurses prior to conducting the review. Outcomes may include but are not limited to stoma-related complications (infection, parastomal abscess, hernia, mucocutaneous separation, dermatological complications, stoma necrosis, stenosis, retraction and prolapse) or other patient-relevant postoperative endpoints (quality of life, revision rate, dependence on professional care, mortality, length of stay and readmission). We will use the ROBINS-I or the Cochrane risk of bias tool to assess the risk of bias of the included studies. We will perform a meta-analysis and assess the certainty of evidence using the GRADE approach. DISCUSSION With the results of the systematic review, we aim to provide information for future clinical guidelines and influence clinical routine with regard to preoperative stoma site marking in patients undergoing ostomy surgery. When the evidence of our systematic review is low, it would still be a useful basis for future clinical trials by identifying data gaps. SYSTEMATIC REVIEW REGISTRATION PROSPERO registration number: CRD42021226647.
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Affiliation(s)
- Charlotte Mareike Kugler
- Institute for Research in Operative Medicine, Witten/Herdecke University, Ostmerheimer Str. 200, 51109, Cologne, Germany.
| | - Jessica Breuing
- Institute for Research in Operative Medicine, Witten/Herdecke University, Ostmerheimer Str. 200, 51109, Cologne, Germany
| | - Tanja Rombey
- Institute for Research in Operative Medicine, Witten/Herdecke University, Ostmerheimer Str. 200, 51109, Cologne, Germany
| | - Simone Hess
- Institute for Research in Operative Medicine, Witten/Herdecke University, Ostmerheimer Str. 200, 51109, Cologne, Germany
| | - Peter Ambe
- GFO Kliniken Rhein-Berg, Vinzenz Pallotti Hospital, Bergisch Gladbach, Germany.,Department of Health, Witten/Herdecke University, Cologne, Germany
| | | | - Dawid Pieper
- Institute for Research in Operative Medicine, Witten/Herdecke University, Ostmerheimer Str. 200, 51109, Cologne, Germany
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Correa Marinez A, Bock D, Carlsson E, Petersén C, Erestam S, Kälebo P, Rosenberg J, Haglind E, Angenete E. Stoma-related complications: a report from the Stoma-Const randomized controlled trial. Colorectal Dis 2021; 23:1091-1101. [PMID: 33326678 DOI: 10.1111/codi.15494] [Citation(s) in RCA: 14] [Impact Index Per Article: 3.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 09/02/2020] [Revised: 12/07/2020] [Accepted: 12/08/2020] [Indexed: 12/07/2022]
Abstract
AIM The impact of construction techniques on the development of stoma complications is partly undiscovered. The aim of this paper was to report and analyse the impact of the three surgical techniques in a randomized controlled trial Stoma-Const on stoma-related complications as well as identifying risk factors and patient-reported stoma function as a planned secondary analysis. METHODS This was a randomized, multicenter trial where all patients scheduled to receive an end colostomy were invited to participate. Patients were randomized to one of three techniques for stoma construction; cruciate fascial incision, circular incision or prophylactic mesh. Stoma complications were assessed by a surgeon and stoma care nurses within 1 year postoperatively. RESULTS Two hundred and nine patients were randomized. Patient demographics were similar in all three groups. Data on stoma-related complications were available for analysis in 201 patients. A total of 127 patients (63%) developed some type of stoma complication within 1 year after surgery. The risk ratio (95% CI) for stoma complications was 0.93 (0.73; 1.2) between cruciate vs. circular incision groups and 1.02 (0.78; 1.34) between cruciate vs. mesh groups. There were no statistically significant differences between the groups regarding parastomal hernia rate and no risk factors could be identified. CONCLUSION This randomized trial confirmed a high prevalence of stoma-related complications but could not identify an impact of surgical technique or identify modifiable risk factors for stoma-related complications.
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Affiliation(s)
- Adiela Correa Marinez
- Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, Scandinavian Surgical Outcomes Research Group, University of Gothenburg, Gothenburg, Sweden.,Department of Surgery, Region Västra Götaland, Sahlgrenska University Hospital/Östra, Gothenburg, Sweden
| | - David Bock
- Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, Scandinavian Surgical Outcomes Research Group, University of Gothenburg, Gothenburg, Sweden
| | - Eva Carlsson
- Department of Surgery, Region Västra Götaland, Sahlgrenska University Hospital/Östra, Gothenburg, Sweden
| | - Charlotta Petersén
- Department of Surgery, Region Västra Götaland, Sahlgrenska University Hospital/Östra, Gothenburg, Sweden
| | - Sofia Erestam
- Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, Scandinavian Surgical Outcomes Research Group, University of Gothenburg, Gothenburg, Sweden
| | - Peter Kälebo
- Department of Radiology, Sahlgrenska University Hospital, Gothenburg, Sweden
| | - Jacob Rosenberg
- Department of Surgery, Herlev and Gentofte Hospital, University of Copenhagen, Herlev, Denmark
| | - Eva Haglind
- Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, Scandinavian Surgical Outcomes Research Group, University of Gothenburg, Gothenburg, Sweden.,Department of Surgery, Region Västra Götaland, Sahlgrenska University Hospital/Östra, Gothenburg, Sweden
| | - Eva Angenete
- Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, Scandinavian Surgical Outcomes Research Group, University of Gothenburg, Gothenburg, Sweden.,Department of Surgery, Region Västra Götaland, Sahlgrenska University Hospital/Östra, Gothenburg, Sweden
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Hashimoto H, Kaku-Ito Y, Furue M, Ito T. Mucosal Invasion, but Not Incomplete Excision, Has Negative Impact on Long-Term Survival in Patients With Extramammary Paget's Disease. Front Oncol 2021; 11:642919. [PMID: 33937045 PMCID: PMC8082157 DOI: 10.3389/fonc.2021.642919] [Citation(s) in RCA: 10] [Impact Index Per Article: 2.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/17/2020] [Accepted: 03/29/2021] [Indexed: 12/18/2022] Open
Abstract
Background Extramammary Paget’s disease (EMPD) sometimes spreads from the skin to mucosal areas, and curative surgical excision of these areas is challenging. The aim of this study is to analyze the impact of mucosal involvement and surgical treatment on the survival of patients with EMPD. Methods We conducted a retrospective review of 217 patients with EMPD. We also assessed the associations between tumor involvement in boundary areas (anal canal, external urethral meatus, vaginal introitus), prognostic factors, and survival in 198 patients treated with curative surgery. Results Of 217 patients, 75 (34.6%) had mucosal boundary area involvement. Lesions in these areas were associated with frequent lymphovascular invasion (p = 0.042), lymph node metastasis (p = 0.0002), incomplete excision (p < 0.0001), and locoregional recurrence (p < 0.0001). Boundary area involvement was an independent prognostic factor associated with disease-specific survival, per multivariate analysis (HR: 11.87, p = 0.027). Incomplete excision was not significantly correlated with disease-specific survival (HR: 1.05, p = 0.96). Conclusion Boundary area tumor involvement was a major risk factor for incomplete excision, local recurrence, and poor survival outcomes. However, incomplete removal of primary tumors was not significantly associated with poor prognosis. A less invasive surgical approach for preserving anogenital and urinary functions may be acceptable as the first-line treatment for resectable EMPD.
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Affiliation(s)
- Hiroki Hashimoto
- Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
| | - Yumiko Kaku-Ito
- Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
| | - Masutaka Furue
- Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
| | - Takamichi Ito
- Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
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Roveron G, Barbierato M, Rizzo G, Parini D, Bondurri A, Veltri M, Pata F, Cattaneo F, Tafuri A, Forni C, Ferrara F. Italian Guidelines for the Nursing Management of Enteral and Urinary Stomas in Adults: An Executive Summary. J Wound Ostomy Continence Nurs 2021; 48:137-147. [PMID: 33690248 DOI: 10.1097/won.0000000000000745] [Citation(s) in RCA: 8] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/26/2022]
Abstract
PURPOSE This article is an executive summary of Italian guidelines for nursing management of enteral and urinary ostomies in adults. METHODS Scoping review and generation of evidence and consensus-based clinical guidelines. SEARCH STRATEGY The Multidisciplinary Italian Study group for STOmas (MISSTO) was founded in 2018. This group created guidelines for management of enteral and urinary ostomies in adults based on a scoping review of the literature. The research included previous guidelines, systematic reviews, meta-analyses, randomized clinical trials, cohort studies, and case reports. Five main topics were identified: "stoma preparation," "stoma creation," "stoma complications," "stoma care," and "stoma reversal" (for enteral stomas)." All the studies were evaluated according to the GRADE system and AGREE II tool. Recommendations were elaborated in the form of statements, with an established grade of recommendation for each statement. For low levels of scientific evidence statements, a consensus conference composed of expert members of the major Italian scientific societies in the field of stoma management and care discussed, corrected, validated, or eliminated the statements. A final version of the guidelines with definitive recommendations was elaborated and prepared for publication. FINDINGS/CONCLUSIONS This document represents the first Italian guidelines on enteral and urinary stoma management to assist nurses caring for persons with an enteral or urinary ostomy.
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Affiliation(s)
- Gabriele Roveron
- Gabriele Roveron, RN, Ostomy and Pelvic Floor Rehabilitation Centre, S. Maria Della Misericordia Hospital, Rovigo, Italy
- Maria Barbierato, RN, Ostomy Centre, Azienda Ospedaliera di Padova, Padova, Italy
- Gianluca Rizzo, MD, Department of Surgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy
- Dario Parini, MD, General Surgery Unit, Santa Maria Della Misericordia Hospital, Rovigo, Italy
- Andrea Bondurri, MD , Department of General Surgery, Luigi Sacco University Hospital, ASST FBF-Sacco, Milan, Italy
- Marco Veltri, MD, General Surgery Unit, San Jacopo Hospital, Pistoia, Italy
- Francesco Pata, MD, General Surgery Unit, Nicola Giannettasio Hospital, Corigliano-Rossano, Italy
- Francesco Cattaneo, MD, Department of Oncological and Surgical Sciences, Urology Clinic, University of Padova, Italy
- Alessandro Tafuri, MD , Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata Verona, Verona Italy
- Cristiana Forni, RN , Nursing and Allied Profession Research Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
- Francesco Ferrara, MD, Department of Surgery, San Carlo Borromeo Hospital, ASST Santi Paolo e Carlo, Milan, Italy
| | - Maria Barbierato
- Gabriele Roveron, RN, Ostomy and Pelvic Floor Rehabilitation Centre, S. Maria Della Misericordia Hospital, Rovigo, Italy
- Maria Barbierato, RN, Ostomy Centre, Azienda Ospedaliera di Padova, Padova, Italy
- Gianluca Rizzo, MD, Department of Surgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy
- Dario Parini, MD, General Surgery Unit, Santa Maria Della Misericordia Hospital, Rovigo, Italy
- Andrea Bondurri, MD , Department of General Surgery, Luigi Sacco University Hospital, ASST FBF-Sacco, Milan, Italy
- Marco Veltri, MD, General Surgery Unit, San Jacopo Hospital, Pistoia, Italy
- Francesco Pata, MD, General Surgery Unit, Nicola Giannettasio Hospital, Corigliano-Rossano, Italy
- Francesco Cattaneo, MD, Department of Oncological and Surgical Sciences, Urology Clinic, University of Padova, Italy
- Alessandro Tafuri, MD , Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata Verona, Verona Italy
- Cristiana Forni, RN , Nursing and Allied Profession Research Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
- Francesco Ferrara, MD, Department of Surgery, San Carlo Borromeo Hospital, ASST Santi Paolo e Carlo, Milan, Italy
| | - Gianluca Rizzo
- Gabriele Roveron, RN, Ostomy and Pelvic Floor Rehabilitation Centre, S. Maria Della Misericordia Hospital, Rovigo, Italy
- Maria Barbierato, RN, Ostomy Centre, Azienda Ospedaliera di Padova, Padova, Italy
- Gianluca Rizzo, MD, Department of Surgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy
- Dario Parini, MD, General Surgery Unit, Santa Maria Della Misericordia Hospital, Rovigo, Italy
- Andrea Bondurri, MD , Department of General Surgery, Luigi Sacco University Hospital, ASST FBF-Sacco, Milan, Italy
- Marco Veltri, MD, General Surgery Unit, San Jacopo Hospital, Pistoia, Italy
- Francesco Pata, MD, General Surgery Unit, Nicola Giannettasio Hospital, Corigliano-Rossano, Italy
- Francesco Cattaneo, MD, Department of Oncological and Surgical Sciences, Urology Clinic, University of Padova, Italy
- Alessandro Tafuri, MD , Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata Verona, Verona Italy
- Cristiana Forni, RN , Nursing and Allied Profession Research Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
- Francesco Ferrara, MD, Department of Surgery, San Carlo Borromeo Hospital, ASST Santi Paolo e Carlo, Milan, Italy
| | - Dario Parini
- Gabriele Roveron, RN, Ostomy and Pelvic Floor Rehabilitation Centre, S. Maria Della Misericordia Hospital, Rovigo, Italy
- Maria Barbierato, RN, Ostomy Centre, Azienda Ospedaliera di Padova, Padova, Italy
- Gianluca Rizzo, MD, Department of Surgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy
- Dario Parini, MD, General Surgery Unit, Santa Maria Della Misericordia Hospital, Rovigo, Italy
- Andrea Bondurri, MD , Department of General Surgery, Luigi Sacco University Hospital, ASST FBF-Sacco, Milan, Italy
- Marco Veltri, MD, General Surgery Unit, San Jacopo Hospital, Pistoia, Italy
- Francesco Pata, MD, General Surgery Unit, Nicola Giannettasio Hospital, Corigliano-Rossano, Italy
- Francesco Cattaneo, MD, Department of Oncological and Surgical Sciences, Urology Clinic, University of Padova, Italy
- Alessandro Tafuri, MD , Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata Verona, Verona Italy
- Cristiana Forni, RN , Nursing and Allied Profession Research Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
- Francesco Ferrara, MD, Department of Surgery, San Carlo Borromeo Hospital, ASST Santi Paolo e Carlo, Milan, Italy
| | - Andrea Bondurri
- Gabriele Roveron, RN, Ostomy and Pelvic Floor Rehabilitation Centre, S. Maria Della Misericordia Hospital, Rovigo, Italy
- Maria Barbierato, RN, Ostomy Centre, Azienda Ospedaliera di Padova, Padova, Italy
- Gianluca Rizzo, MD, Department of Surgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy
- Dario Parini, MD, General Surgery Unit, Santa Maria Della Misericordia Hospital, Rovigo, Italy
- Andrea Bondurri, MD , Department of General Surgery, Luigi Sacco University Hospital, ASST FBF-Sacco, Milan, Italy
- Marco Veltri, MD, General Surgery Unit, San Jacopo Hospital, Pistoia, Italy
- Francesco Pata, MD, General Surgery Unit, Nicola Giannettasio Hospital, Corigliano-Rossano, Italy
- Francesco Cattaneo, MD, Department of Oncological and Surgical Sciences, Urology Clinic, University of Padova, Italy
- Alessandro Tafuri, MD , Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata Verona, Verona Italy
- Cristiana Forni, RN , Nursing and Allied Profession Research Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
- Francesco Ferrara, MD, Department of Surgery, San Carlo Borromeo Hospital, ASST Santi Paolo e Carlo, Milan, Italy
| | - Marco Veltri
- Gabriele Roveron, RN, Ostomy and Pelvic Floor Rehabilitation Centre, S. Maria Della Misericordia Hospital, Rovigo, Italy
- Maria Barbierato, RN, Ostomy Centre, Azienda Ospedaliera di Padova, Padova, Italy
- Gianluca Rizzo, MD, Department of Surgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy
- Dario Parini, MD, General Surgery Unit, Santa Maria Della Misericordia Hospital, Rovigo, Italy
- Andrea Bondurri, MD , Department of General Surgery, Luigi Sacco University Hospital, ASST FBF-Sacco, Milan, Italy
- Marco Veltri, MD, General Surgery Unit, San Jacopo Hospital, Pistoia, Italy
- Francesco Pata, MD, General Surgery Unit, Nicola Giannettasio Hospital, Corigliano-Rossano, Italy
- Francesco Cattaneo, MD, Department of Oncological and Surgical Sciences, Urology Clinic, University of Padova, Italy
- Alessandro Tafuri, MD , Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata Verona, Verona Italy
- Cristiana Forni, RN , Nursing and Allied Profession Research Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
- Francesco Ferrara, MD, Department of Surgery, San Carlo Borromeo Hospital, ASST Santi Paolo e Carlo, Milan, Italy
| | - Francesco Pata
- Gabriele Roveron, RN, Ostomy and Pelvic Floor Rehabilitation Centre, S. Maria Della Misericordia Hospital, Rovigo, Italy
- Maria Barbierato, RN, Ostomy Centre, Azienda Ospedaliera di Padova, Padova, Italy
- Gianluca Rizzo, MD, Department of Surgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy
- Dario Parini, MD, General Surgery Unit, Santa Maria Della Misericordia Hospital, Rovigo, Italy
- Andrea Bondurri, MD , Department of General Surgery, Luigi Sacco University Hospital, ASST FBF-Sacco, Milan, Italy
- Marco Veltri, MD, General Surgery Unit, San Jacopo Hospital, Pistoia, Italy
- Francesco Pata, MD, General Surgery Unit, Nicola Giannettasio Hospital, Corigliano-Rossano, Italy
- Francesco Cattaneo, MD, Department of Oncological and Surgical Sciences, Urology Clinic, University of Padova, Italy
- Alessandro Tafuri, MD , Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata Verona, Verona Italy
- Cristiana Forni, RN , Nursing and Allied Profession Research Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
- Francesco Ferrara, MD, Department of Surgery, San Carlo Borromeo Hospital, ASST Santi Paolo e Carlo, Milan, Italy
| | - Francesco Cattaneo
- Gabriele Roveron, RN, Ostomy and Pelvic Floor Rehabilitation Centre, S. Maria Della Misericordia Hospital, Rovigo, Italy
- Maria Barbierato, RN, Ostomy Centre, Azienda Ospedaliera di Padova, Padova, Italy
- Gianluca Rizzo, MD, Department of Surgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy
- Dario Parini, MD, General Surgery Unit, Santa Maria Della Misericordia Hospital, Rovigo, Italy
- Andrea Bondurri, MD , Department of General Surgery, Luigi Sacco University Hospital, ASST FBF-Sacco, Milan, Italy
- Marco Veltri, MD, General Surgery Unit, San Jacopo Hospital, Pistoia, Italy
- Francesco Pata, MD, General Surgery Unit, Nicola Giannettasio Hospital, Corigliano-Rossano, Italy
- Francesco Cattaneo, MD, Department of Oncological and Surgical Sciences, Urology Clinic, University of Padova, Italy
- Alessandro Tafuri, MD , Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata Verona, Verona Italy
- Cristiana Forni, RN , Nursing and Allied Profession Research Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
- Francesco Ferrara, MD, Department of Surgery, San Carlo Borromeo Hospital, ASST Santi Paolo e Carlo, Milan, Italy
| | - Alessandro Tafuri
- Gabriele Roveron, RN, Ostomy and Pelvic Floor Rehabilitation Centre, S. Maria Della Misericordia Hospital, Rovigo, Italy
- Maria Barbierato, RN, Ostomy Centre, Azienda Ospedaliera di Padova, Padova, Italy
- Gianluca Rizzo, MD, Department of Surgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy
- Dario Parini, MD, General Surgery Unit, Santa Maria Della Misericordia Hospital, Rovigo, Italy
- Andrea Bondurri, MD , Department of General Surgery, Luigi Sacco University Hospital, ASST FBF-Sacco, Milan, Italy
- Marco Veltri, MD, General Surgery Unit, San Jacopo Hospital, Pistoia, Italy
- Francesco Pata, MD, General Surgery Unit, Nicola Giannettasio Hospital, Corigliano-Rossano, Italy
- Francesco Cattaneo, MD, Department of Oncological and Surgical Sciences, Urology Clinic, University of Padova, Italy
- Alessandro Tafuri, MD , Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata Verona, Verona Italy
- Cristiana Forni, RN , Nursing and Allied Profession Research Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
- Francesco Ferrara, MD, Department of Surgery, San Carlo Borromeo Hospital, ASST Santi Paolo e Carlo, Milan, Italy
| | - Cristiana Forni
- Gabriele Roveron, RN, Ostomy and Pelvic Floor Rehabilitation Centre, S. Maria Della Misericordia Hospital, Rovigo, Italy
- Maria Barbierato, RN, Ostomy Centre, Azienda Ospedaliera di Padova, Padova, Italy
- Gianluca Rizzo, MD, Department of Surgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy
- Dario Parini, MD, General Surgery Unit, Santa Maria Della Misericordia Hospital, Rovigo, Italy
- Andrea Bondurri, MD , Department of General Surgery, Luigi Sacco University Hospital, ASST FBF-Sacco, Milan, Italy
- Marco Veltri, MD, General Surgery Unit, San Jacopo Hospital, Pistoia, Italy
- Francesco Pata, MD, General Surgery Unit, Nicola Giannettasio Hospital, Corigliano-Rossano, Italy
- Francesco Cattaneo, MD, Department of Oncological and Surgical Sciences, Urology Clinic, University of Padova, Italy
- Alessandro Tafuri, MD , Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata Verona, Verona Italy
- Cristiana Forni, RN , Nursing and Allied Profession Research Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
- Francesco Ferrara, MD, Department of Surgery, San Carlo Borromeo Hospital, ASST Santi Paolo e Carlo, Milan, Italy
| | - Francesco Ferrara
- Gabriele Roveron, RN, Ostomy and Pelvic Floor Rehabilitation Centre, S. Maria Della Misericordia Hospital, Rovigo, Italy
- Maria Barbierato, RN, Ostomy Centre, Azienda Ospedaliera di Padova, Padova, Italy
- Gianluca Rizzo, MD, Department of Surgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy
- Dario Parini, MD, General Surgery Unit, Santa Maria Della Misericordia Hospital, Rovigo, Italy
- Andrea Bondurri, MD , Department of General Surgery, Luigi Sacco University Hospital, ASST FBF-Sacco, Milan, Italy
- Marco Veltri, MD, General Surgery Unit, San Jacopo Hospital, Pistoia, Italy
- Francesco Pata, MD, General Surgery Unit, Nicola Giannettasio Hospital, Corigliano-Rossano, Italy
- Francesco Cattaneo, MD, Department of Oncological and Surgical Sciences, Urology Clinic, University of Padova, Italy
- Alessandro Tafuri, MD , Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata Verona, Verona Italy
- Cristiana Forni, RN , Nursing and Allied Profession Research Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
- Francesco Ferrara, MD, Department of Surgery, San Carlo Borromeo Hospital, ASST Santi Paolo e Carlo, Milan, Italy
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Hashmi ZG, Dalton MK, Sheikh SS, McCarty JC, Salim A, Haider AH. National estimates of intestinal ostomy creation and reversal for trauma. J Trauma Acute Care Surg 2021; 90:459-465. [PMID: 33617196 DOI: 10.1097/ta.0000000000003022] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/26/2022]
Abstract
BACKGROUND Intestinal ostomy creation after trauma is selectively indicated for destructive colon and rectal injuries. However, the nationwide rates of creation of ostomies for trauma and their reversal are not known. The objective of this study was to ascertain national estimates of trauma ostomy creation and reversal. METHODS Weighted analysis of Healthcare Cost and Utilization Project Nationwide Readmissions Database 2014 to 2015 was performed. Adult trauma patients (≥16 years) with a hollow viscus injury were included. Patients with preexisting ostomies and permanent ostomies and those who died within 48 hours of admission were excluded. Rates of ostomy creation and same admission ostomy reversal were calculated. Rates of postdischarge ostomy reversal were calculated using the Kaplan-Meier estimator. Multivariable Cox proportional hazards model was used to determine factors associated with postdischarge trauma ostomy reversal. RESULTS A total of 22,542 patients sustained a hollow viscus injury resulting in the creation of 2,145 ostomies (9.6%). The rate of same-admission ostomy reversal was 0.7% (n = 16). At 1, 3, 6, and 9 months, the cumulative stoma reversal rates were 0%, 7.6%, 31.0%, and 43.1%, respectively. The mean ± SD time from ostomy creation to reversal was 123 ± 6.7 days for those undergoing reversal. Injury Severity Score greater than 9 was significantly associated with ostomy nonreversal after discharge (hazard ratio, 0.41; 95% confidence interval, 0.26-0.66). Age, sex, insurance status, penetrating injury, Charlson Comorbidity Index, and hospital teaching status were not significantly associated with ostomy reversal. CONCLUSION The nationwide rate of ostomy creation after trauma is nearly 10%. At 6 months postinjury, only one third of patients had undergone ostomy reversal. Future study is needed to understand patient and provider-level factors associated with trauma ostomy reversal. LEVEL OF EVIDENCE Epidemiology, level III.
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Affiliation(s)
- Zain G Hashmi
- From the Center for Surgery and Public Health, Department of Surgery (Z.G.H., M.K.D., J.C.M., A.S., A.H.H.), Brigham and Women's Hospital, Harvard Medical School, Harvard T. H. Chan School of Public Health, Boston, Massachusetts; Department of Surgery (Z.G.H.), Sinai Hospital of Baltimore, Baltimore, Maryland; Department of Surgery (S.S.S.), University of Alabama at Birmingham, Birmingham, Alabama; Department of Surgery (J.C.M.), St. Elizabeth's Medical Center, Boston, Massachusetts; and Medical College (A.H.H.), Aga Khan University, Karachi, Pakistan
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Preoperative Stoma Site Marking Decreases Stoma and Peristomal Complications: A Meta-analysis. J Wound Ostomy Continence Nurs 2021; 47:249-256. [PMID: 32118803 DOI: 10.1097/won.0000000000000634] [Citation(s) in RCA: 35] [Impact Index Per Article: 8.8] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/11/2023]
Abstract
PURPOSE We systematically reviewed the literature in order to determine whether evidence indicated that preoperative stoma site marking reduces the occurrence of postoperative stoma and peristomal complications. DESIGN Systematic review with meta-analysis of pooled findings. SUBJECTS/SETTING We systematically reviewed 6 electronic databases including PubMed, MEDLINE, CINAHL, Cochrane Library for English language articles, along with the Airiti Library and Wanfang Data for Chinese articles for evidence related to the effects of stoma site marking on stoma and peristomal complications. We sought articles published from their inception to January 31, 2018. METHODS Ten studies that included 2109 participants, each comparing 2 groups of patients who did and did not undergo preoperative stoma site marking, were retrieved and analyzed. RESULTS In patients who underwent stoma site marking, the marking was associated with reduced stoma and peristomal complications in all stoma types (odds ratio [OR] = 0.52; 95% CI, 0.42-0.64; P < .001). Patients who underwent stoma and had fecal ostomies experienced fewer complications (OR = 0.34; 95% CI, 0.25-0.47; P < .001) than patients with unmarked stomas. In contrast, patients with urostomies did not experience fewer complications when compared to those with unmarked ostomies (OR = 0.531; 95% CI, 0.23-1.21; P = .132). Persons with fecal ostomies also had fewer hernias and peristomal skin complications (ORs = 0.25 and 0.30; 95% CIs, 0.09-0.71 and 0.20-0.44, respectively; both Ps < .001). The results revealed that stoma site marking was associated with reduced early and late stoma and peristomal complications (ORs = 0.76 and 0.38; 95% CIs, 0.61-0.94 and 0.32-0.46; P = .010 and P < .001, respectively). CONCLUSIONS Preoperative stoma site marking is associated with a reduced occurrence of stoma and peristomal complications and should be considered as a standard of preoperative care.
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Gialamas E, Meyer J, Abbassi Z, Popeskou S, Buchs NC, Ris F. The Use of a Stoma Rod/Bridge to Prevent Retraction: A Systematic Review. J Wound Ostomy Continence Nurs 2021; 48:39-43. [PMID: 33427808 DOI: 10.1097/won.0000000000000730] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/25/2022]
Abstract
PURPOSE We evaluated evidence related to the use of a rod (bridge) to prevent stoma retraction during loop ostomy construction. METHODS We completed a systematic review of the literature. We searched MEDLINE, EMBASE, and COCHRANE databases up to December 4, 2019. We posed the following question based on a PICO format. Do adult patients undergoing ostomy surgery experience less stomal retraction when compared to patients managed without placement of a stoma rod? FINDINGS Our initial search returned 182 articles; after reading studies in full, 5 articles were identified that collectively enrolled 1058 participants. Four studies were randomized controlled trials and one was a prospective cohort study. Meta-analysis could not be performed because of the small number of studies and the heterogeneity of outcomes measurements. The incidence of stoma retraction ranged between 0%-8% in patients managed with a rod and 0.78%-8.2% in patients with no rod. The number of reported adverse events was low. Placement of a stoma rod was associated with more adverse outcomes than in patients managed without a rod. Adverse events included local edema, stoma necrosis, skin necrosis, peristomal moisture-associated skin damage (irritant dermatitis), peristomal abscess, bleeding, and mucocutaneous separation. CONCLUSIONS Stoma rod does not seem to reduce the risk of stoma retraction and might result in other adverse events. IMPLICATIONS We recommend avoidance of stoma rod/bridge placement during ostomy surgery.
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Affiliation(s)
- Eleftherios Gialamas
- Eleftherios Gialamas, MD, Division of Digestive Surgery, University Hospitals of Geneva, Geneva, Switzerland; and Unit of Surgical Research, University of Geneva, Geneva, Switzerland
- Jeremy Meyer, MD, MD-PhD, Division of Digestive Surgery, University Hospitals of Geneva, Geneva, Switzerland; and Unit of Surgical Research, University of Geneva, Geneva, Switzerland
- Ziad Abbassi, MD, Division of Digestive Surgery, University Hospitals of Geneva, Geneva, Switzerland; and Unit of Surgical Research, University of Geneva, Geneva, Switzerland
- Sotirios Popeskou, MD, Division of Digestive Surgery, University Hospitals of Geneva, Geneva, Switzerland; and Unit of Surgical Research, University of Geneva, Geneva, Switzerland
- Nicolas Christian Buchs, MD, PD, Division of Digestive Surgery, University Hospitals of Geneva, Geneva, Switzerland; and Unit of Surgical Research, University of Geneva, Geneva, Switzerland
- Frédéric Ris, MD, PD, Division of Digestive Surgery, University Hospitals of Geneva, Geneva, Switzerland; and Unit of Surgical Research, University of Geneva, Geneva, Switzerland
| | - Jeremy Meyer
- Eleftherios Gialamas, MD, Division of Digestive Surgery, University Hospitals of Geneva, Geneva, Switzerland; and Unit of Surgical Research, University of Geneva, Geneva, Switzerland
- Jeremy Meyer, MD, MD-PhD, Division of Digestive Surgery, University Hospitals of Geneva, Geneva, Switzerland; and Unit of Surgical Research, University of Geneva, Geneva, Switzerland
- Ziad Abbassi, MD, Division of Digestive Surgery, University Hospitals of Geneva, Geneva, Switzerland; and Unit of Surgical Research, University of Geneva, Geneva, Switzerland
- Sotirios Popeskou, MD, Division of Digestive Surgery, University Hospitals of Geneva, Geneva, Switzerland; and Unit of Surgical Research, University of Geneva, Geneva, Switzerland
- Nicolas Christian Buchs, MD, PD, Division of Digestive Surgery, University Hospitals of Geneva, Geneva, Switzerland; and Unit of Surgical Research, University of Geneva, Geneva, Switzerland
- Frédéric Ris, MD, PD, Division of Digestive Surgery, University Hospitals of Geneva, Geneva, Switzerland; and Unit of Surgical Research, University of Geneva, Geneva, Switzerland
| | - Ziad Abbassi
- Eleftherios Gialamas, MD, Division of Digestive Surgery, University Hospitals of Geneva, Geneva, Switzerland; and Unit of Surgical Research, University of Geneva, Geneva, Switzerland
- Jeremy Meyer, MD, MD-PhD, Division of Digestive Surgery, University Hospitals of Geneva, Geneva, Switzerland; and Unit of Surgical Research, University of Geneva, Geneva, Switzerland
- Ziad Abbassi, MD, Division of Digestive Surgery, University Hospitals of Geneva, Geneva, Switzerland; and Unit of Surgical Research, University of Geneva, Geneva, Switzerland
- Sotirios Popeskou, MD, Division of Digestive Surgery, University Hospitals of Geneva, Geneva, Switzerland; and Unit of Surgical Research, University of Geneva, Geneva, Switzerland
- Nicolas Christian Buchs, MD, PD, Division of Digestive Surgery, University Hospitals of Geneva, Geneva, Switzerland; and Unit of Surgical Research, University of Geneva, Geneva, Switzerland
- Frédéric Ris, MD, PD, Division of Digestive Surgery, University Hospitals of Geneva, Geneva, Switzerland; and Unit of Surgical Research, University of Geneva, Geneva, Switzerland
| | - Sotirios Popeskou
- Eleftherios Gialamas, MD, Division of Digestive Surgery, University Hospitals of Geneva, Geneva, Switzerland; and Unit of Surgical Research, University of Geneva, Geneva, Switzerland
- Jeremy Meyer, MD, MD-PhD, Division of Digestive Surgery, University Hospitals of Geneva, Geneva, Switzerland; and Unit of Surgical Research, University of Geneva, Geneva, Switzerland
- Ziad Abbassi, MD, Division of Digestive Surgery, University Hospitals of Geneva, Geneva, Switzerland; and Unit of Surgical Research, University of Geneva, Geneva, Switzerland
- Sotirios Popeskou, MD, Division of Digestive Surgery, University Hospitals of Geneva, Geneva, Switzerland; and Unit of Surgical Research, University of Geneva, Geneva, Switzerland
- Nicolas Christian Buchs, MD, PD, Division of Digestive Surgery, University Hospitals of Geneva, Geneva, Switzerland; and Unit of Surgical Research, University of Geneva, Geneva, Switzerland
- Frédéric Ris, MD, PD, Division of Digestive Surgery, University Hospitals of Geneva, Geneva, Switzerland; and Unit of Surgical Research, University of Geneva, Geneva, Switzerland
| | - Nicolas Christian Buchs
- Eleftherios Gialamas, MD, Division of Digestive Surgery, University Hospitals of Geneva, Geneva, Switzerland; and Unit of Surgical Research, University of Geneva, Geneva, Switzerland
- Jeremy Meyer, MD, MD-PhD, Division of Digestive Surgery, University Hospitals of Geneva, Geneva, Switzerland; and Unit of Surgical Research, University of Geneva, Geneva, Switzerland
- Ziad Abbassi, MD, Division of Digestive Surgery, University Hospitals of Geneva, Geneva, Switzerland; and Unit of Surgical Research, University of Geneva, Geneva, Switzerland
- Sotirios Popeskou, MD, Division of Digestive Surgery, University Hospitals of Geneva, Geneva, Switzerland; and Unit of Surgical Research, University of Geneva, Geneva, Switzerland
- Nicolas Christian Buchs, MD, PD, Division of Digestive Surgery, University Hospitals of Geneva, Geneva, Switzerland; and Unit of Surgical Research, University of Geneva, Geneva, Switzerland
- Frédéric Ris, MD, PD, Division of Digestive Surgery, University Hospitals of Geneva, Geneva, Switzerland; and Unit of Surgical Research, University of Geneva, Geneva, Switzerland
| | - Frédéric Ris
- Eleftherios Gialamas, MD, Division of Digestive Surgery, University Hospitals of Geneva, Geneva, Switzerland; and Unit of Surgical Research, University of Geneva, Geneva, Switzerland
- Jeremy Meyer, MD, MD-PhD, Division of Digestive Surgery, University Hospitals of Geneva, Geneva, Switzerland; and Unit of Surgical Research, University of Geneva, Geneva, Switzerland
- Ziad Abbassi, MD, Division of Digestive Surgery, University Hospitals of Geneva, Geneva, Switzerland; and Unit of Surgical Research, University of Geneva, Geneva, Switzerland
- Sotirios Popeskou, MD, Division of Digestive Surgery, University Hospitals of Geneva, Geneva, Switzerland; and Unit of Surgical Research, University of Geneva, Geneva, Switzerland
- Nicolas Christian Buchs, MD, PD, Division of Digestive Surgery, University Hospitals of Geneva, Geneva, Switzerland; and Unit of Surgical Research, University of Geneva, Geneva, Switzerland
- Frédéric Ris, MD, PD, Division of Digestive Surgery, University Hospitals of Geneva, Geneva, Switzerland; and Unit of Surgical Research, University of Geneva, Geneva, Switzerland
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Shao W, Wang H, Chen Q, Zhao W, Gu Y, Feng G. Enhanced recovery after surgery nursing program, a protective factor for stoma-related complications in patients with low rectal cancer. BMC Surg 2020; 20:316. [PMID: 33276751 PMCID: PMC7716511 DOI: 10.1186/s12893-020-00978-3] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.6] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/08/2020] [Accepted: 11/22/2020] [Indexed: 01/04/2023] Open
Abstract
BACKGROUND This study aimed to investigate the association between enhanced recovery after surgery (ERAS) nursing program and stoma-related complications (SRCs) and prognosis in patients with low rectal cancer (LRC) undergoing abdominoperineal resection with sigmoidostomy. METHODS LRC patients who underwent elective abdominoperineal resection with sigmoidostomy between May 2016 and May 2019 were retrospectively enrolled. The occurrence of early major or minor SRCs (within postoperative 30 days) was set as the primary end-point. Clinicopathological variables and laboratory tests were compared between patients with or without SRCs. The univariate and multivariate logistic regression analyses were performed to investigate risk factors for SRCs. Hospitalization satisfaction-related and prognosis-related variables were compared between LRC patients with or without ERAS nursing program. RESULTS A total of 288 patients were enrolled and the incidence of SRCs was 26.7% (77/288). ERAS nursing program was the only independent risk factor for SRCs in LRC patients (OR 2.04, 95%CI 1.31-3.12, P = 0.016) by the multivariate logistic regression analysis. Moreover, ERAS nursing program was associated with higher hospitalization satisfaction rate, faster bowel function recovery, better psychological status, and higher quality of life. CONCLUSIONS ERAS nursing program was a protective factor for SRCs and associated with improved prognosis in LRC patients undergoing elective abdominoperineal resection with sigmoidostomy.
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Affiliation(s)
- Weiling Shao
- Department of General Surgery, Taizhou People's Hospital, Taizhou, China
| | - Honggang Wang
- Department of General Surgery, Taizhou People's Hospital, Taizhou, China
| | - Qun Chen
- Department of General Surgery, Taizhou People's Hospital, Taizhou, China
| | - Wen Zhao
- Department of General Surgery, Taizhou People's Hospital, Taizhou, China
| | - Yulian Gu
- Department of General Surgery, Taizhou People's Hospital, Taizhou, China
| | - Guoqin Feng
- Department of Nursing, Taizhou People's Hospital, No. 366 Taihu Road, Taizhou, 225300, Jiangsu Province, China.
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The European Hernia Society classification applied to the rare cases of parastomal hernia after ileal conduit urinary diversion: a retrospective cohort of 96 patients. Hernia 2020; 25:125-131. [PMID: 32495052 DOI: 10.1007/s10029-020-02230-6] [Citation(s) in RCA: 11] [Impact Index Per Article: 2.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/05/2020] [Accepted: 05/25/2020] [Indexed: 12/22/2022]
Abstract
INTRODUCTION To determine the incidence and classification of parastomal hernia (PH) following ileal conduit urinary diversion and to identify risk factors for PH development. METHODS We performed a retrospective review of our cystectomy database which includes benign and malignant cases from 2011-2016. Patients with an abdominal CT at 24 ± 2 months post-operation were included. PH were classified according to the European Hernia Society (EHS) system. Regression analyses were performed on variables associated with parastomal hernia. RESULTS A total of 96 patients were included in the study. The incidence of PH on CT is 20.2% at one year and 28.1% at two years. Using the EHS classification, the majority of PH was small (≤ 5 cm), but up to 50% were associated with a concomitant incisional hernia. On multivariable analysis, (C-index = 0.71), obesity was associated with a higher risk of PH (OR = 2.8, 95% CI 1.06-7.42, p = 0.04), whereas prior tobacco use was associated with a lower risk of PH at 2 years (OR = 0.23, 95% CI 0.09-0.63, p < 0.01). CONCLUSIONS Hernia after ileal conduit is common with radiographic rates approaching 30% at two years, with obesity being an independent risk factor. The relationship between prior tobacco use and a lower hernia rate may be limited to this study but presents an opportunity for future investigation. No difference in PH rates were observed between open and minimally invasive surgery and between intracorporeal and extracorporeal conduits.
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Nagayoshi K, Nagai S, Hisano K, Mizuuchi Y, Fujita H, Nakamura M. Atrophic change of the abdominal rectus muscle significantly influences the onset of parastomal hernias beyond existing risk factors after end colostomy. Hernia 2020; 25:141-148. [PMID: 32399627 DOI: 10.1007/s10029-020-02192-9] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.6] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/11/2019] [Accepted: 04/08/2020] [Indexed: 01/26/2023]
Abstract
PURPOSE To investigate optimal risk factors, including atrophy of the abdominal rectus muscle (ARM) for postoperative parastomal hernia (PH) in patients who underwent end colostomy at left lower quadrant. METHODS This single-institution retrospective study included 91 patients who underwent end colostomy between April 2004 and December 2015. The surgical and long-term outcomes among patients with or without PH were collected and compared. RESULTS Altogether, 22 (24.2%) patients had a PH including 15 (68.2%) patients with a simultaneous incisional hernia. Univariate analysis showed that older patients (71 ± 11.9 vs. 64 ± 12.2 years, p = 0.03) and those with higher body mass index (BMI) (23.8 ± 3.8 vs. 20.9 ± 3.3 kg/m2, p < 0.001) had a statistically significant relation with having PHs. Relative atrophy of left abdominal rectus muscle was more frequently found in patients with PH (ratio of left side/right side; caudal level and medial side: 0.66 vs. 0.92, p < 0.01, caudal level and lateral side: 0.95 vs. 1.03, p = 0.04). Multivariate analysis revealed that BMI > 25 kg/m2 [odds ratio (OR) 9.05, 95% confidence interval (CI) 2.06-39.76, p = 0.003] and atrophy of the left lower medial portion of the abdominal rectus muscle (OR 12.85, 95% CI 2.49-66.39, p = 0.002) were independent risk factors for PHs. Neither the laparoscopic approach nor the extraperitoneal route of the colostomy was proven to correlate with a lower rate of PHs. CONCLUSIONS High BMI and atrophic change of ARM were significantly associated with PH development. Surgical techniques for prevention of atrophic change of ARM are expected to reduce the incidence of PHs.
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Affiliation(s)
- K Nagayoshi
- Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan
| | - S Nagai
- Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan
| | - K Hisano
- Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan
| | - Y Mizuuchi
- Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan
| | - H Fujita
- Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan
| | - M Nakamura
- Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
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The Financial Impact of Living in Canada With an Ostomy: A Cross-sectional Survey. J Wound Ostomy Continence Nurs 2019; 46:505-512. [PMID: 31651800 DOI: 10.1097/won.0000000000000590] [Citation(s) in RCA: 12] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/26/2022]
Abstract
PURPOSE The aim of this study was to explore how living with an ostomy financially impacts Canadians. METHODS A descriptive, pan-Canadian, cross-sectional online and paper-based survey was conducted using a convenience sample. RESULTS Surveys were completed by 467 individuals. Seventy-six percent (n = 355) reported spending more than $1000 annually on ostomy supplies, with 58% (n = 271) paying partially out of pocket. Atlantic regions relied primarily on insurance (n = 81), and the central, prairies, and western regions used a combination of funding (provincial government funding and/or insurance) (n = 385) with no significant out-of-pocket funding differences between regions (χ = 18.267, P = .079). Fifteen percent (n = 70) reported frequent peristomal skin problems, and 19% (n = 89) indicated that having an ostomy negatively affected their ability to work. When experiencing ostomy-related problems, 60% (n = 280) sought assistance from a nurse specialized in wound, ostomy, and continence (NSWOC) and spent significantly less on ostomy supplies (χ = 231.267, P < .001). CONCLUSION This study demonstrated that living with an ostomy may result in financial burden and that Canadian regional variations in funding and access to an NSWOC should be explored.
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Xiao C, Zhou M, Yang X, Xiao F, Liu X, Guo Y, Li X, Cao H, Luo J. Novel nomogram with microvascular density in the surgical margins can accurately predict the risk for anastomotic leakage after anterior resection for rectal cancer. J Surg Oncol 2019; 120:1412-1419. [PMID: 31621086 DOI: 10.1002/jso.25730] [Citation(s) in RCA: 6] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/12/2019] [Accepted: 09/30/2019] [Indexed: 12/11/2022]
Abstract
BACKGROUND Anastomotic leakage (AL) is a serious complication after anterior resection. The purpose of this study was to determine the role of microvascular density (MVD) in AL and to develop a nomogram to accurately predict AL. METHODS This study retrospectively enrolled 477 consecutive patients who underwent anterior resection for rectal cancer from January 2011 to January 2019. Tissue samples of the resection margins were assessed for MVD. Univariate and multivariate regression analyses were used to identify the risk factors for AL. RESULTS The incidence of clinical AL was 6.7%. MVD in the distal margin was associated with AL (P < .001). Univariate and multivariate regression analysis identified the following variables as independent risk factors for AL: preoperative albumin ≤35 g/L (odds ratio [OR] = 2.511), neoadjuvant treatment (OR = 3.560), location of tumor ≤7 cm (OR = 3.381), blood loss ≥100 mL (OR = 2.717), and MVD in the distal margin ≤20 (OR = 4.265). Then, a nomogram including these predictors was developed. The nomogram showed good discrimination (AUC = 0.816) and calibration (concordance index = 0.816). The decision curve analysis demonstrated that the nomogram was clinically useful. CONCLUSIONS MVD in the distal margin is closely associated with AL. The nomogram can be used for individualized prediction of AL after anterior resection for patients with rectal cancer.
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Affiliation(s)
- Chanchan Xiao
- Department of Surgical Oncology, Chenzhou No. 1 People's Hospital, Chenzhou, Hunan, China
| | - Meihua Zhou
- Department of Nursing, Chenzhou No. 1 People's Hospital, Chenzhou, Hunan, China
| | - Xihua Yang
- Department of Surgical Oncology, Chenzhou No. 1 People's Hospital, Chenzhou, Hunan, China
| | - Fangtao Xiao
- Department of Surgical Oncology, Chenzhou No. 1 People's Hospital, Chenzhou, Hunan, China
| | - Xiaofei Liu
- Department of Surgical Oncology, Chenzhou No. 1 People's Hospital, Chenzhou, Hunan, China
| | - Yi Guo
- Department of Surgical Oncology, Chenzhou No. 1 People's Hospital, Chenzhou, Hunan, China
| | - Xiaojie Li
- Department of Pathology, Chenzhou No. 1 People's Hospital, Chenzhou, Hunan, China
| | - Huiqiu Cao
- Department of Pathology, Chenzhou No. 1 People's Hospital, Chenzhou, Hunan, China
| | - Jihui Luo
- Department of Surgical Oncology, Chenzhou No. 1 People's Hospital, Chenzhou, Hunan, China
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