Past, present and future of cyanide antagonism research: From the early remedies to the current therapies

doi:10.5662/wjm.v5.i2.88

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 5, Issue 2

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (10652)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Tables (1-2) series.

Item

Count

PDF

735

WORD

393

HTML

5435

Tables (1-2)

110

Sum=6673

Featured Article

The chart showing Browse series, Download series.

Item

Count

Browse

514

Download

1592

Sum=2106

Publishing Process of This Article

Item

Count

Browse

835

Download

1038

Sum=1873

Jun 26, 2015 (publication date) through Apr 25, 2024

Times Cited of This Article

Times Cited (47)

Journal Information of This Article

Publication Name

World Journal of Methodology

ISSN

2222-0682

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Review

World J Methodol. Jun 26, 2015; 5(2): 88-100
Published online Jun 26, 2015. doi: 10.5662/wjm.v5.i2.88

Table 1 Present cyanide therapies worldwide

Antidotal therapy	Country availability
Sodium nitrite, amyl nitrite and sodium thiosulfate	Europe, Asia (Lilly kit; Talor kit; Pasadena kit) United States (Nithiodote™)
Hydroxocobalamin	European Union/United States (Cyanokit^®)
4-Dimethylaminophenol	Germany/Austria/Netherlands
Dicobalt edetate	Netherlands/France/United Kingdom/Australia/Israel (Kelocyanor)

Table 2 Novel cyanide therapies in development for rapid IM delivery in mass casualty situations

Novel therapy	Mechanism of action	Older analog
Cobinamide	Direct CN Scavenger	Hydroxocobalamin
Sulfanegen	CN Transformer (Leverages the mercaptopyruvate sulfur transferase enzyme)	Mercaptopyruvate
Next generation sulfane sulfur donors	CN Transformer (Leverages the rhodanese enzyme)	Thiosulfate

CN: Cyanide.

Citation: Petrikovics I, Budai M, Kovacs K, Thompson DE. Past, present and future of cyanide antagonism research: From the early remedies to the current therapies. World J Methodol 2015; 5(2): 88-100
URL: https://www.wjgnet.com/2222-0682/full/v5/i2/88.htm
DOI: https://dx.doi.org/10.5662/wjm.v5.i2.88