Assessment of diagnostic capacity and decision-making based on the 2015 American Thyroid Association ultrasound classification system

Figure 1 The threshold approach to clinical decision-making.

Figure 2 Flowchart of study selection process.

Figure 3 Test-treatment threshold formula. Ttrx: Test-treatment threshold; Pneg/nd: Probability of a negative result in patients without disease; Rrx: Risk of treatment in patients without disease; Rt: Risk of diagnostic test; Pneg/d: Probability of a negative result in patients with disease; Brx: Benefit of treatment in patients with disease.

Figure 4 Decision curve analysis methodology.

Figure 5 Pooled diagnostic value of very low risk pattern.

Figure 6 Pooled diagnostic value of low risk pattern.

Figure 7 Pooled diagnostic value of intermediate risk pattern.

Figure 8 Pooled diagnostic value of high risk pattern.

Figure 9 Results by Bayesian analysis and the threshold approach to clinical decision-making.

Figure 10  Net benefit, number of interventions avoided, in study patterns.

Figure 11  Pooled subgroups analysis.

Figure 12  Bayesian subgroups analysis and the threshold approach to clinical decision-making.