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Zheng Y, Lam XY, Wu M, Lin Y. Acceleration of Orthodontic Tooth Movement: A Bibliometric and Visual Analysis. Int Dent J 2025; 75:1223-1233. [PMID: 39237400 PMCID: PMC11976635 DOI: 10.1016/j.identj.2024.08.012] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/04/2024] [Revised: 07/24/2024] [Accepted: 08/10/2024] [Indexed: 09/07/2024] Open
Abstract
BACKGROUND Prolonged orthodontic treatment duration has long been a concern for orthodontists and patients, leading to a surge in publications on accelerated orthodontic tooth movement (OTM). This study aims to investigate the knowledge landscape, hotspots, and research trends in acceleration of OTM using bibliometric and visual analyses. METHODS A comprehensive search was conducted in the Web of Science (WOS) Core Collection to identify relevant publications related to acceleration of OTM. R Biblioshiny, VOS viewer, and a bibliometric online analysis platform were used to conduct the bibliometric and visualization analysis. Curve fitting and correlation analysis were performed to examine the correlation global and country economics and publication trends, and to predict publication numbers. RESULTS A total of 647 articles on accelerated OTM were included in the analysis, with clinical and non-clinical publications accounting for 43.59% and 31.22%, respectively. The annual publication numbers exhibited an upward trend, correlating positively with both global gross domestic product (GDP) (r = 0.915, P < .001) and the GDP of individual countries/regions (r = 0.976, P < .001). China produced the most documents (94), while the USA led in citation count (2758) and international collaborations. Wilcko WM was the top-cited author, with eight of the top 10 authors from the USA and the remainder from Asia. Keywords such as 'tooth movement', 'corticotomy', 'piezocision' and 'low-level laser therapy' were the most prominent themes, while topics like 'micro-osteoperforation', 'plasma', 'gingival crevicular fluid' and 'pain' have become recent research hotspots and frontiers. CONCLUSIONS This study provides a comprehensive overview of the research on accelerated OTM, highlighting hotspots and frontiers, fostering collaboration among authors and countries/regions, and contributing to future research endeavours.
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Affiliation(s)
- Yuanyuan Zheng
- Oral Disease Prevention Center, Shenzhen Maternity and Child Healthcare Hospital, Shenzhen, China
| | - Xiang Yao Lam
- Division of Paediatric Dentistry and Orthodontics, Faculty of Dentistry, the University of Hong Kong, Hong Kong, SAR, China
| | - Min Wu
- Oral Disease Prevention Center, Shenzhen Maternity and Child Healthcare Hospital, Shenzhen, China
| | - Yifan Lin
- Division of Paediatric Dentistry and Orthodontics, Faculty of Dentistry, the University of Hong Kong, Hong Kong, SAR, China.
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Abd Elhafeez H, Fathy Aboelmahasen MM, Saleh MH, Alfeqy AAH, Abouelnour AM. Effect of a self-ligating bracket system combined with corticision on the rate of orthodontic tooth movement: A controlled clinical trial. J Orthod Sci 2025; 14:4. [PMID: 40302888 PMCID: PMC12036755 DOI: 10.4103/jos.jos_97_24] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/02/2024] [Revised: 09/08/2024] [Accepted: 11/06/2024] [Indexed: 05/02/2025] Open
Abstract
BACKGROUND The self-ligating bracket system and corticision are two methods for acceleration of orthodontic tooth movement (OTM). OBJECTIVES The current study aimed to assess the effect of a self-ligating bracket system combined with corticision on the rate of OTM. PATIENTS AND METHODS The present study was conducted on 16 female patients divided into two groups: an experimental group of eight patients treated by self-ligating bracket systems used as fixed orthodontic appliances combined with a corticision as a minimally invasive surgical technique for accelerating OTM, and a control group of eight patients treated only by self-ligating bracket systems used as fixed orthodontic appliances. The primary outcome was the percentage of change in Little's Index of Irregularity (LII). The secondary outcome was the time taken to finish the leveling and alignment stage. RESULTS In a comparison of the percentage of change in LII for the upper arch between the two groups, the experimental group recorded values that were significantly greater than those recorded in the control group at all time intervals T0-T7, except for T8-T10, which were similar. Both groups recorded (100 ± 0%), with no significant difference between groups (P = 1). CONCLUSION The combination of two methods for acceleration of OTM, a self-ligating bracket system combined with corticision, accelerates the rate of OTM more than in the case of using a self-ligating bracket system only.
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Affiliation(s)
- Hazem Abd Elhafeez
- Department of Orthodontics, Faculty of Dental Medicine, Cairo, Boys, Al-Azhar University, Egypt
| | | | - Mohamed Helmi Saleh
- Department of Orthodontics, Faculty of Dental Medicine, Cairo, Boys, Al-Azhar University, Egypt
| | - Ahmed Ahmed Hussein Alfeqy
- Department of Oral and Maxillofacial surgery, Faculty of Dental Medicine, Cairo, Boys, Al-Azhar University, Egypt
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Lipani E, Pisani E, Verrone M, Bitonto F, Verdecchia A, Spinas E. Evaluation of the Efficacy of Corticotomy and Piezocision on Canine Retraction: A Systematic Review. Dent J (Basel) 2025; 13:57. [PMID: 39996931 PMCID: PMC11854093 DOI: 10.3390/dj13020057] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/07/2025] [Revised: 01/22/2025] [Accepted: 01/24/2025] [Indexed: 02/26/2025] Open
Abstract
Background: In order to reduce the prolonged duration of orthodontic treatment, several surgical techniques have been proposed over the years. Corticotomy and piezocision are the two most widely used techniques, and, given the lack of consensus in the literature, along with the renewed interest in these approaches in recent years, the primary objective of this study is to evaluate their effectiveness in accelerating canine retraction in patients requiring extraction of the upper first premolar and, as a secondary objective, to assess if there is a worsening of periodontal health and how the surgical approach is perceived by the patient. Methods: An electronic search was performed on PubMed, Scopus, Web of Science, Embase, and the Cochrane Central Register of Controlled Trials (CENTRAL) up to 30 November 2024. The PRISMA statement was adopted for the realization of the review, and the Cochrane Collaboration's risk of bias assessment tool (RoB 2) was used to assess the studies' quality. Results: After full text assessment, fifteen randomized clinical trials (14 split mouth design, 1 single-blind, single-center design) covering 326 patients (mean age 20, 19 years) were included. The data collected reveal that corticotomy accelerates canine retraction by 1.5 to 4 times, while piezocision achieves retraction 1.5 to 2 times faster, making corticotomy the most effective technique. No statistically significant adverse effects on periodontal ligament, molar anchorage loss, or root resorption were observed following the two surgical techniques. In addition, patients reported experiencing mild to moderate pain. Conclusions: Corticotomy and piezocision are effective techniques for accelerating upper canine retraction in extraction cases, significantly reducing the overall duration of orthodontic treatment.
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Affiliation(s)
- Erica Lipani
- Department of Surgical Sciences, Orthodontics School, University of Cagliari, Via Ospedale, 09124 Cagliari, Italy; (E.P.); (M.V.); (F.B.); (A.V.)
| | | | | | | | | | - Enrico Spinas
- Department of Surgical Sciences, Orthodontics School, University of Cagliari, Via Ospedale, 09124 Cagliari, Italy; (E.P.); (M.V.); (F.B.); (A.V.)
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Jeon HH, Huang X, Rojas Cortez L, Sripinun P, Lee JM, Hong JJ, Graves DT. Inflammation and mechanical force-induced bone remodeling. Periodontol 2000 2024. [PMID: 39740162 DOI: 10.1111/prd.12619] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/25/2024] [Revised: 09/25/2024] [Accepted: 10/27/2024] [Indexed: 01/02/2025]
Abstract
Periodontitis arises from imbalanced host-microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro-inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment. There is no consensus on the factors that lead to a conversion from gingivitis to periodontitis, but one possibility is the proximity of the inflammation to the bone, which promotes bone resorption and inhibits subsequent bone formation during coupled bone formation. Conversely, orthodontic tooth movement is triggered by the mechanical force applied to the tooth, resulting in bone resorption on the compression side and new bone formation on the tension side. However, the environment around orthodontic brackets readily retains dental plaque and may contribute to inflammation and bone remodeling. The immune, epithelial, stromal, endothelial and bone cells of the host play an important role in setting the stage for bone remodeling that occurs in both periodontitis and orthodontic tooth movement. Recent advancements in single-cell RNA sequencing have provided new insights into the roles and interactions of different cell types in response to challenges. In this review, we meticulously examine the functions of key cell types such as keratinocytes, leukocytes, stromal cells, osteocytes, osteoblasts, and osteoclasts involved in inflammation- and mechanical force-driven bone remodeling. Moreover, we explore the combined effects of these two conditions: mechanical force-induced bone remodeling combined with periodontal disease (chronic inflammation) and periodontally accelerated osteogenic orthodontics (acute transient inflammation). This comprehensive review enhances our understanding of inflammation- and mechanical force-induced bone remodeling.
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Affiliation(s)
- Hyeran Helen Jeon
- Department of Orthodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
| | - Xin Huang
- Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, China
- Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, China
- Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
| | - Leticia Rojas Cortez
- Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
| | - Puttipong Sripinun
- Department of Orthodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
- Department of Orthodontics and Pediatric Dentistry, Faculty of Dentistry, Chiang Mai University, Muang, Chiang Mai, Thailand
| | - Jung-Me Lee
- Division of Nutritional Sciences, College of Human Ecology, Cornell University, Ithaca, New York, USA
| | - Julie J Hong
- Department of Orthodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
- Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
| | - Dana T Graves
- Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
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Lara-Muros M, Camps-Font O, Vilarrasa J, Vilarrasa J, Mir-Mari J, Figueiredo R, Valmaseda-Castellón E. Safety and accuracy assessment of static computer assisted localized piezoelectric alveolar decortication: an in vitro study. Clin Oral Investig 2024; 28:674. [PMID: 39617832 PMCID: PMC11609119 DOI: 10.1007/s00784-024-05920-y] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/23/2024] [Accepted: 09/08/2024] [Indexed: 12/20/2024]
Abstract
OBJECTIVES To assess the safety and accuracy of static computer assisted corticotomy surgery (sCACS) in comparison with freehand piezocision. MATERIALS AND METHODS A randomized in vitro study was conducted. A total of 260 interradicular corticotomies were performed in 20 identical printed models. sCACS was performed in half of the models, while the rest underwent freehand localized decortication. Accuracy was measured in the three spatial axes by overlapping the digital planning with a previous cone-beam computed tomography (CBCT) scan of the patient and a postoperative CBCT of the models. Safety was determined as the number of damaged root surfaces. Descriptive and bivariate analyses were performed. RESULTS Freehand corticotomies increased the likelihood of iatrogenic root damage 2.21-fold (95%CI: 1.30 to 3.77; p = 0.004). Both groups showed some degree of deviation compared to digital planning. Nevertheless, the accuracy of sCACS was significantly greater in sagittal (B = -0.21 mm, 95%CI: -0.29 to -0.12; p < 0.001), axial (B = -0.32 mm, 95%CI: -0.48 to -0.18; p < 0.001) and angular deviation (B = -2.02º; 95%CI: -2.37 to -1.66; p < 0.001) compared to freehand surgery, with the exception of depth. CONCLUSIONS The precision and safety of sCACS are greater than the freehand technique. CLINICAL RELEVANCE Corticotomies are performed in crowded areas where there is usually space limitation. Clinicians should consider the systematic use of surgical guides, since minimal deviations can cause iatrogenic root damage in areas where malocclusions are present.
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Affiliation(s)
- María Lara-Muros
- Oral Surgery and Implantology, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain
| | - Octavi Camps-Font
- Oral Surgery and Implantology, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain.
- Dental and Maxillofacial Pathology and Therapeutics Research Group, IDIBELL Research Institute, Barcelona, Spain.
- Facultat de Medicina i Ciències de la Salut, Campus de Bellvitge Universitat de Barcelona C/ Feixa Llarga s/n, Pavelló de Govern; 2a planta, Despatx 2.9, L'Hospitalet de Llobregat, 08907, Spain.
| | - Javi Vilarrasa
- Department of Periodontology, International University of Catalonia, Barcelona, Spain
| | - Jordi Vilarrasa
- Orthodontics and Dentofacial Malformations, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain
| | - Javier Mir-Mari
- Oral Surgery and Implantology, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain
| | - Rui Figueiredo
- Oral Surgery and Implantology, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain
- Dental and Maxillofacial Pathology and Therapeutics Research Group, IDIBELL Research Institute, Barcelona, Spain
| | - Eduard Valmaseda-Castellón
- Oral Surgery and Implantology, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain
- Dental and Maxillofacial Pathology and Therapeutics Research Group, IDIBELL Research Institute, Barcelona, Spain
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Vanderlei BMC, Torres MC, Paredes N, Garcez AS, Pavini PTM, Suzuki SS, Moon W. Effect of photobiomodulation and corticopuncture methods on tooth displacement and gene expression: animal study. Lasers Med Sci 2024; 39:283. [PMID: 39547960 DOI: 10.1007/s10103-024-04136-6] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/20/2023] [Accepted: 07/08/2024] [Indexed: 11/17/2024]
Abstract
AIM The aim of this study was to evaluate the expression levels of vascular endothelial growth factor (VEGF), Peroxiredoxin 1 (PRX1), glucose transporter 1 (GLUT1) and type I collagen (COL1) and the rate of tooth movement comparing 3 accelerated tooth movement (ATM) methods: Corticopuncture (CP), photobiomodulation (PBM) and the combined technique (CP + PBM) on days 1, 3, 7 and 14. METHODS Orthodontic tooth movement was induced in 24 male Wistar rats. CP procedure included three perforations: two in the palate and one mesial to the molars. GaAlAs diode laser irradiation was performed on days 0, 2, 4 and 6, totaling 4 irradiations. 14 days (810 nm, 100 mW, 15 s). Gingival tissue was collected from the cervical area of both first molars and qPCR was performed to isolate and quantify mRNA levels. RESULTS All ATM groups showed increased tooth displacement compared to control after 14 days (20% for PBM; 40% for CP and 60% for CP + PBM). PBM showed higher VEGF expression on days 1,3 and 7 followed by CP and CP + PBM. PRX1 levels increased on days 1 and 3 in PBM and CP + PBM. GLUT1 increased on day 3 in all groups. No difference was found on levels of VEGF, PRX1 and GLUT1 among the groups on day 14, except for COL1 which increased significantly in PBM group. CONCLUSION All ATM methods showed higher expression of all of VEGF, PRX1, GLUT1, COL1 than control group. PBM and CP + PBM groups had more expression related to angiogenesis, glucose uptake, oxidative stress and collagen synthesis.
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Affiliation(s)
| | | | - Ney Paredes
- School of Dentistry, University of California, Los Angeles, CA, USA
| | | | | | - Selly Sayuri Suzuki
- Department of Orthodontics and Post-graduation in Orthodontics, Faculdade São Leopoldo Mandic, Campinas, SP, 52020-060, Brazil
| | - Won Moon
- Department of Orthodontics, at Institute of Oral Health Science, Ajou University School of Medicine, Suwon, Korea
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Eid FY, El-Kalza AR. The effect of single versus multiple piezocisions on the rate of canine retraction: a randomized controlled trial. BMC Oral Health 2024; 24:1024. [PMID: 39215274 PMCID: PMC11365207 DOI: 10.1186/s12903-024-04716-6] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/15/2024] [Accepted: 08/07/2024] [Indexed: 09/04/2024] Open
Abstract
BACKGROUND Piezocision is a minimally invasive surgical method aiming to accelerate tooth movement. However, its effect was found to be transient, appertaining to the regional acceleratory phenomenon (RAP). Hence, the aim of the study was to evaluate the effect of single and multiple piezocisions on the rate of orthodontic tooth movement (OTM). Moreover, the impact of both protocols on canine tipping and orthodontically induced inflammatory root resorption (OIIRR) has been assessed. METHODS Thirty indicated patients for the therapeutic extraction of maxillary first premolars were enlisted in this split-mouth study, and they were randomly split into two equal groups, each including 15 subjects. In the Single Application Group (SAG), one side of the maxillary arch arbitrarily received a single piezocision before the onset of canine retraction, whereas in the Multiple Application Group (MAG), piezocisions were randomly performed on one side, three times on a monthly basis, over the 12-week study period. The contralateral sides of both groups served as the controls. Canine retraction was carried out bilaterally using nickel-titanium closed-coil springs, delivering 150 g of force, and the rate of tooth movement, as well as canine tipping were evaluated on a monthly basis, over a 3-month period. Cone-bean computed tomography scans were also conducted pre- and post- canine retraction, and OIIRR was assessed using Malmgren Index. RESULTS The reported outcomes revealed a significant increase in the amount of canine retraction, canine tipping, as well as root resorption scores on the experimental sides in both groups SAG and MAG post-retraction (p < 0.001). However, upon comparing the experimental sides in both groups, non-significant differences have been observed between them regarding all the assessed outcomes (p > 0.05). CONCLUSIONS Single and multiple piezocisions effectively accelerate OTM in comparison to conventional orthodontic treatment, with relative outcomes reported by both intervention frequencies. Accordingly, single piezocision is recommended as an adjunct to OTM. Furthermore, significant tooth tipping as well as a significantly higher root resorption risk accompanies both single and multiple piezocision applications in conjunction with OTM. NAME OF THE REGISTRY Clinicaltrials.gov TRIAL REGISTRATION NUMBER: NCT05782088 DATE OF REGISTRATION: 23/03/2023 "Retrospectively registered". URL: https://clinicaltrials.gov/ct2/show/NCT05782088.
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Affiliation(s)
- Farah Y Eid
- Department of Orthodontics, Faculty of Dentistry, Alexandria University, Champolion street, Azarita, Alexandria, Egypt.
| | - Ahmed R El-Kalza
- Department of Orthodontics, Faculty of Dentistry, Alexandria University, Champolion street, Azarita, Alexandria, Egypt
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Gorassini F, Fiorillo L, Marrapodi MM, D’Amico C, Basile M, Cicciù M, Cervino G. Debonding issues in orthodontics: an RCTs systematic review. EXPLORATION OF MEDICINE 2024:477-491. [DOI: 10.37349/emed.2024.00233] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/13/2024] [Accepted: 06/24/2024] [Indexed: 01/03/2025] Open
Abstract
Background: This systematic review aims to critically assess the literature on the debonding process of orthodontic brackets from enamel surfaces. The review evaluates Randomized Controlled Trials (RCTs) to determine the effectiveness and implications of various debonding techniques and materials. Methods: The study followed PRISMA guidelines, selecting RCTs published from 1999 onwards that compared the outcomes of various orthodontic bracket debonding techniques. Selection criteria included studies utilizing human teeth, with outcomes such as enamel surface roughness and Adhesive Remnant Index (ARI) analyzed. Data sources included PubMed, Scopus, Web of Science, and the Cochrane Library. Results: Out of 1,587 records identified, five studies met the inclusion criteria. These studies provided comparative data on the effectiveness of various debonding techniques, including tungsten carbide and diamond burs, in minimizing enamel damage and optimizing adhesive removal. Findings indicated that tungsten carbide burs produced the least enamel roughness. Discussion: Utilizing tungsten carbide burs for debonding orthodontic brackets significantly minimizes enamel surface roughness and potential damage, thereby enhancing the preservation of enamel integrity post-treatment. The systematic review highlights current debonding techniques are effective in adhesive removal, and the choice of instrument significantly affects enamel integrity and clinical outcomes. The findings support the need for continuous improvement and innovation in removing braces to improve orthodontic treatment results and patient satisfaction.
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Affiliation(s)
- Francesca Gorassini
- Multidisciplinary Department of Medical-Surgical and Odontostomatological Specialties, University of Campania “Luigi Vanvitelli”, 80121 Naples, Italy; FiDent - Centro Medico Odontoiatrico, 89121 Reggio Calabria, Italy
| | | | - Maria Maddalena Marrapodi
- Multidisciplinary Department of Medical-Surgical and Odontostomatological Specialties, University of Campania “Luigi Vanvitelli”, 80121 Naples, Italy; FiDent - Centro Medico Odontoiatrico, 89121 Reggio Calabria, Italy
| | - Cesare D’Amico
- Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98125 Messina, Italy; School of Dentistry, Aldent University, 1001 Tirana, Albania
| | - Michela Basile
- FiDent - Centro Medico Odontoiatrico, 89121 Reggio Calabria, Italy
| | - Marco Cicciù
- Department of General Surgery and Medical-Surgical Specialties, School of Dentistry, University of Catania, 95124 Catania, Italy
| | - Gabriele Cervino
- FiDent - Centro Medico Odontoiatrico, 89121 Reggio Calabria, Italy
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Suchak D, Kamble R, Agarwal N, Shirbhate U, Talla R. Accelerated Orthodontics: Getting Ahead of Ourselves With Corticotomy. Cureus 2023; 15:e50858. [PMID: 38249225 PMCID: PMC10798877 DOI: 10.7759/cureus.50858] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/29/2023] [Accepted: 12/20/2023] [Indexed: 01/23/2024] Open
Abstract
Corticotomy-assisted orthodontics is an emerging technique that combines orthodontic treatment with selective alveolar corticotomy to accelerate tooth movement and optimize treatment outcomes. This case report presents the successful application of corticotomy-assisted orthodontics in the management of a complex malocclusion. Following a comprehensive orthodontic assessment and treatment planning, corticotomy-assisted orthodontics was selected as the treatment approach. The surgical procedure involved selective alveolar corticotomy in the affected regions, followed by initiation of orthodontic mechanics. The case was closely monitored at regular intervals, and treatment progress was assessed using clinical examination and radiographs. The combined approach led to significantly accelerated tooth movement, a reduction in treatment time, and improved patient satisfaction. This case report underscores the potential benefits of corticotomy-assisted orthodontics in complex cases, providing clinicians with valuable insights into its successful application and the considerations involved in treatment planning and execution. Further research and long-term follow-up are warranted to elucidate the long-term stability and outcomes of this approach.
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Affiliation(s)
- Dhwani Suchak
- Orthodontics, Sharad Pawar Dental College, Datta Meghe Institute of Higher Education and Research, Wardha, IND
| | - Ranjit Kamble
- Orthodontics, Sharad Pawar Dental College, Datta Meghe Institute of Higher Education and Research, Wardha, IND
| | - Nishu Agarwal
- Orthodontics, Sharad Pawar Dental College, Datta Meghe Institute of Higher Education and Research, Wardha, IND
| | - Unnati Shirbhate
- Periodontics, Sharad Pawar Dental College, Datta Meghe Institute of Higher Education and Research, Wardha, IND
| | - Renuka Talla
- Orthodontics, Sharad Pawar Dental College, Datta Meghe Institute of Higher Education and Research, Wardha, IND
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Faik Sahin M, Baysal A. The effect of micro-osteoperforation on the rate of tooth movement during the alignment stage in patients with mandibular crowding: a randomised controlled trial. Eur J Orthod 2023; 45:505-516. [PMID: 37167078 DOI: 10.1093/ejo/cjad017] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 05/13/2023]
Abstract
BACKGROUND Orthodontic treatment is a long process that requires patient cooperation. Risks of side effects such as caries formation, periodontal problems, and root resorption increases as well as problems in patient cooperation arises with longer treatments. Several different techniques were developed that may shorten the treatment time. OBJECTIVE The aim of this study was to evaluate the effectiveness of micro-osteoperforations (MOPs) performed during the alignment stage. TRIAL DESIGN Randomized controlled trial. METHODS Twenty-eight subjects who had crowding in the mandibular arch were included in the study. The first group (4 boys and 10 girls, mean age = 17.21 ± 3.76 years) was treated with MOP (MOP) and the second group (8 boys and 6 girls, mean age = 15.29 ± 1.77 years) was treated without MOP (control). Cephalometric variables, periodontal parameters, Little irregularity index, alignment duration, patient satisfaction, and ease of operation were evaluated. The level of statistical significance was P ≤ 0.05. RESULTS Alignment duration was shorter (P = 0.000) in the MOP group (105.57 ± 18.34 days) compared to control group (135.86 ± 15.12 days). Alleviating of the crowding was more in the MOP group, compared to the control group in all time points. The pain level in the MOP group in the first appointment was higher compared to control group (P = 0.002). There was no significant difference between the groups in cephalometric parameters. Higher increases were found for gingival index (P = 0.008) and bleeding index (P = 0.039) in the control group compared to MOP group at the end of treatment. LIMITATIONS The study was a single-centre study. CONCLUSION Alignment stage was shortened with MOP application. There was no difference between groups for patient satisfaction and pain level except for the first appointment. No difference was observed between the groups regarding cephalometric values. Clinically insignificant inflammation was observed in periodontal tissues for both groups. REGISTRATION This study was registered at the Clinical Trials Registry (ClinicalTrials.gov NCT03652454).
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Affiliation(s)
| | - Asli Baysal
- Department of Orthodontics, Faculty of Dentistry, Izmir Katip Celebi University, Izmir, Turkey
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11
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Botelho BF, Torres MC, Paredes N, Garcez AS, Moon W, Suzuki SS. Biomodulation of Induced Tooth Movement by Three Methods, Corticopuncture, Photobiomodulation, and Their Combination: An Animal Study. Photobiomodul Photomed Laser Surg 2023; 41:328-342. [PMID: 37459611 DOI: 10.1089/photob.2022.0119] [Citation(s) in RCA: 2] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 07/20/2023] Open
Abstract
Objective: The aim of this study was to assess the effects of accelerated tooth movement (ATM) methods: corticopuncture (CP), photobiomodulation (PBM), and their combination (CP + PBM) by evaluating tooth displacement, alveolar bone changes, and molecular and cellular response compared with conventional induced tooth movement. Materials and methods: Tooth movement and bone changes were evaluated on days 1, 3, and 7 (9 animals per time point) using microtomography, histological, and immunohistochemical evaluation, at compression and tension sites. CP groups received two perforations in the palate and one mesial to the molars. PBM was performed using GaAlAs diode laser applied every other day for 7 days (λ = 808 nm, 100 mW) in two points for 15 sec/point and total energy of 3 J. Results: Tooth movement was significantly increased in all three ATM groups after 7 days compared with the control group (mean 0.24 mm) by 27% PBM (0.31 mm), 45% CP (0.35 mm), and 57% CP + PBM (0.38 mm) (p < 0.05). At the compression side, all ATM groups showed significant decrease in bone density on day 3 (p < 0.05) and significant less bone volume on day 7 compared with Control (p < 0.05). At the tension side, PBM group showed a significant increase in bone density and volume on day 3 (p < 0.05). Immunohistochemistry analysis showed that at the compression side, tartrate-resistant acid phosphatase-positive cells, RANKL, and tumor necrosis factor-alpha expression were highly marked of the PBM and the combined method groups (p < 0.05). PBM and CP + PBM groups showed a significant increase in expression Runt-related transcription factor 2 and osterix (p < 0.05) at the tension side. Conclusions: All ATM groups showed increase on tooth displacement with CP + PBM group showing greatest tooth displacement. CP method appears to stimulate bone catabolism, PBM has more effect on bone formation, and the combined method showing a synergistic effect on bone remodeling.
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Affiliation(s)
- Bruno Ferreira Botelho
- Department of the Postgraduation in Orthodontics, Faculdade São Leopoldo Mandic, Campinas, Brazil
| | - Martha Carolina Torres
- Section of Orthodontics, School of Dentistry, University of California Los Angeles, Los Angeles, California, USA
| | - Ney Paredes
- Section of Orthodontics, School of Dentistry, University of California Los Angeles, Los Angeles, California, USA
| | | | - Won Moon
- Department of Orthodontics, Institute of Oral Health Science Ajou University School of Medicine, Suwon, Korea
- The Forsyth Institute, Affiliate of HSDM, Cambridge, Massachusetts, USA
| | - Selly Sayuri Suzuki
- Department of the Postgraduation in Orthodontics, Faculdade São Leopoldo Mandic, Campinas, Brazil
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12
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Mousa MR, Hajeer MY, Burhan AS, Heshmeh O, Alam MK. The effectiveness of minimally-invasive corticotomy-assisted orthodontic treatment of palatally impacted canines compared to the traditional traction method in terms of treatment duration, velocity of traction movement and the associated dentoalveolar changes: A randomized controlled trial. F1000Res 2023; 12:699. [PMID: 37920456 PMCID: PMC10618642 DOI: 10.12688/f1000research.135338.1] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Accepted: 05/31/2023] [Indexed: 11/04/2023] Open
Abstract
Objective: To evaluate the effectiveness of a minimally-invasive corticotomy-assisted treatment of palatally impacted canines (PICs) compared with the traditional method by evaluating treatment time, the velocity of movement, and the associated dentoalveolar changes. Materials and methods: Forty-six patients with palatally or mid-alveolar upper impacted canines were recruited and distributed into two groups: the corticotomy-assisted traction group (CAT group, mean age: 20.39±2.27 years) and the traditional treatment group (TT group, mean age: 20.26±2.17 years). The closed surgical approach was used in both study groups. The velocity of traction movement, traction duration and overall treatment duration were evaluated clinically. In addition, the bone support ratios and the amount of root resorption were assessed on cone-beam computed tomography (CBCT) images. Results: At the end of treatment, significant differences were found between the two groups regarding the velocity of traction movement, traction time, and overall treatment time (P<0.05). The mean velocity of traction movement in the CAT group was greater than the TT group ( x velocity=1.15±0.35 mm/month; 0.70±0.33 mm/month, P=0.027, respectively). The duration of the active traction and the overall orthodontic treatment in the CAT group were significantly shorter than the TT group by 36% and 29%, respectively. The mean bone support ratios of the aligned canines did not differ significantly between the two groups (88% vs. 89% in the CAT and TT groups, respectively). No significant differences were found between the two groups regarding the mean amount of root resorption on the adjacent laterals ( x resorption = 1.30±1.18 mm; 1.22±1.02 mm, P=0.612, in CAT and TT groups, respectively). Conclusions: The traction movement velocity of the palatally impacted canines can be increased using minimally-invasive corticotomy-assisted orthodontic treatment. The side effects of the acceleration procedure were minimal and almost similar to those of the traditional technique.
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Affiliation(s)
- Mahran R. Mousa
- Department of Orthodontics, University of Damascus Faculty of Dentistry, Damascus, Damascus, Syria
| | - Mohammad Younis Hajeer
- Department of Orthodontics, University of Damascus Faculty of Dentistry, Damascus, Damascus, Syria
| | - Ahmad S. Burhan
- Department of Orthodontics, University of Damascus Faculty of Dentistry, Damascus, Damascus, Syria
| | - Omar Heshmeh
- Department of Oral and Maxillofacial Surgery, University of Damascus Faculty of Dentistry, Damascus, Damascus, Syria
| | - Mohammad Khursheed Alam
- Orthodontic Division, Department of Preventive Dentistry, College of Dentistry, Jouf University, Sakaka, 72345, Saudi Arabia
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13
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Krishna V B, Duggal I, Sharan J, Mangaraj M, Duggal R, Jena AK. Effect of leukocyte-platelet-rich fibrin (L-PRF) on the rate of orthodontic tooth movement and expression of various biomarkers in gingival crevicular fluid. Clin Oral Investig 2023; 27:2311-2319. [PMID: 37079155 PMCID: PMC10116098 DOI: 10.1007/s00784-023-05026-x] [Citation(s) in RCA: 5] [Impact Index Per Article: 2.5] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/27/2023] [Accepted: 04/16/2023] [Indexed: 04/21/2023]
Abstract
OBJECTIVES To assess the outcome of leukocyte-platelet-rich fibrin (L-PRF) on the rate of maxillary canine retraction and its correlation with the levels of Receptor activator of nuclear factor kappa-B ligand (RANKL), osteoprotegerin (OPG), and RANKL:OPG in the gingival crevicular fluid (GCF) during comprehensive orthodontic treatment. SUBJECTS AND METHODS Eighteen females who required all 1st premolars extraction for the correction of their class I bimaxillary protrusion malocclusions were included. The L-PRF plugs were placed in the experimental side 1st premolar extraction sockets. Canine retraction was performed by sliding mechanics. Canine retraction was assessed from the maxillary study models prepared just before the extraction (T0) and then at 1 week (T1), 2 weeks (T2), 4 weeks (T3), and 8 weeks (T4) after the 1st premolar extraction and placement of L-PRF plugs. The concentrations of RANKL and OPG in the GCF were evaluated at T0, T1, T2, T3, and T4. RESULTS In experimental sides, the amount of canine retraction was statistically more during the T0-T1, T1-T2, and T2-T3 periods. The mean concentration of RANKL at T1, T2, and T3 was significantly more in the experimental sides. The mean concentration of OPG was significantly less in the experimental sides at T2, T3, and T4. The RANKL:OPG was significantly more in the experimental sides at T1, T2, T3, and T4. No significant correlation was found between amount of canine retraction and concentration of RANKL and OPG and RANKL to OPG ratio in GCF. CONCLUSIONS The L-PRF accelerated the rate of maxillary canine retraction by 0.28 mm over an 8-week period. The L-PRF favored the local osteoclastogenesis by enhancing the RANKL and suppressing the OPG concentrations. There was no significant correlation between the rate of maxillary canine retraction and expression of RANKL, OPG, and RANKL:OPG in GCF. TRIAL REGISTRATION The Clinical Trials Registry of India (Reg. No. CTRI/2020/10/028390, Date-13.10.2020).
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Affiliation(s)
- Balarama Krishna V
- Department of Dentistry, All India Institute of Medical Sciences, Sijua, Bhubaneswar, Odisha, India
| | - Isha Duggal
- Department of Orthodontics and Dentofacial Orthopedics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
| | - Jitendra Sharan
- Department of Dentistry, All India Institute of Medical Sciences, Sijua, Bhubaneswar, Odisha, India
| | - Manaswini Mangaraj
- Department of Biochemistry, All India Institute of Medical Sciences, Sijua, Bhubaneswar, Odisha, India
| | - Ritu Duggal
- Department of Orthodontics and Dentofacial Orthopedics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
| | - Ashok Kumar Jena
- Department of Dentistry, All India Institute of Medical Sciences, Sijua, Bhubaneswar, Odisha, India.
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Bakr AR, Nadim MA, Sedky YW, El Kady AA. Effects of Flapless Laser Corticotomy in Upper and Lower Canine Retraction: A Split-mouth, Randomized Controlled Trial. Cureus 2023; 15:e37191. [PMID: 37159786 PMCID: PMC10163364 DOI: 10.7759/cureus.37191] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 04/05/2023] [Indexed: 05/11/2023] Open
Abstract
Aim One of the major difficulties in orthodontic treatment is the lengthy course of therapy, particularly in situations involving extractions. Hence, various methods for accelerating tooth movement rate had been devised. Flapless corticotomy is one of those methods. This study aimed to evaluate the effects of flapless laser corticotomy (FLC) compared to the conventional retraction (CR) method on the rate of canine retraction. Methods A split-mouth, randomized controlled trial included 56 canines from 14 patients (12 females and two males) with a mean age of 20.4 ± 2.5 years, who were complaining of bimaxillary protrusion requiring extraction of four premolars. All canines were randomly assigned to four groups (maxillary FLC, maxillary control CR, mandibular FLC, and mandibular control CR). Randomization was performed by creating two equal, random computer-generated lists with a 1:1 allocation ratio-one list for the right side and one for the left. The allocation concealment was achieved using opaque sealed envelopes until the time of intervention. FLC was applied on the experimental sides before canine retraction by drilling six holes penetrating 3 mm into the bone on the mesial and distal sides of the canines. Subsequently, all canines were retracted employing closed coil springs to deliver a force of 150 g using indirect anchorage from temporary anchorage devices (TADs). All canines were assessed at T0 (before retraction), T1 (one month after retraction), T2 (two months), and T3 (three months) using three-dimensional (3D) digital models. Additionally, canine rotation, molar anchorage loss assessed using 3D digital models, root resorption assessed using cone beam computed tomography (CBCT), probing depth, plaque, gingival indices, and pulp vitality were all evaluated as secondary outcomes. It was possible to blind only the outcome analysis expert (single-blinded). Results The measurements of canine retraction during the follow-up period from T0 to T3 were 2.46 ± 0.80 mm and 2.55 ± 0.79 mm in maxillary FLC and control groups, respectively, and 2.44 ± 0.96 mm and 2.31 ± 0.95 mm in mandibular FLC and control groups, respectively. The results demonstrated a statistically non-significant difference in the distance of canine retraction between the FLC and control groups at all time points. Moreover, no differences were observed between groups in canine rotation, molar anchorage loss, root resorption, probing depth, plaque, gingival indices, and pulp vitality (p > 0.05). Conclusion In the FLC procedure performed in this study, the rate of upper and lower canine retraction could not be accelerated and no significant differences were observed between FLC and control groups in canine rotation, molar anchorage loss, root resorption, periodontal condition, and pulp vitality.
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Affiliation(s)
- Abubakr R Bakr
- Department of Orthodontics, Faculty of Dentistry, Suez Canal University, Ismailia, EGY
| | - Mohamed A Nadim
- Department of Orthodontics, Faculty of Dentistry, Suez Canal University, Ismailia, EGY
| | - Youssef W Sedky
- Department of Orthodontics, Faculty of Oral and Dental Medicine, Misr International University, Cairo, EGY
| | - Abbadi A El Kady
- Department of Orthodontics, Faculty of Dentistry, Suez Canal University, Ismailia, EGY
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15
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Battista MD, Kernitsky J, Exarchos E, Ohira T, Dibart S. Quantification and comparison of the regional acceleratory phenomenon in bone following piezosurgery or bur osteotomy: A pilot study in rats. Clin Exp Dent Res 2023; 9:66-74. [PMID: 36369743 PMCID: PMC9932235 DOI: 10.1002/cre2.689] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/23/2022] [Revised: 10/25/2022] [Accepted: 10/27/2022] [Indexed: 11/13/2022] Open
Abstract
BACKGROUND/OBJECTIVE The Regional Acceleratory Phenomenon (RAP) can be induced surgically via decortication (selective cortical penetrations) of bone to accelerate orthodontic tooth movement. Few studies have compared the impact and efficiency of different decortication methods to induce the RAP. The aim of this study was to determine if there is a significant difference in the intensity of the RAP induced by a surgical defect created either using a piezoelectric knife or a rotary bur. METHODS Twenty-two Sprague-Dawley rats were divided into two treatment groups (each n = 8) and a control group (n = 6). The treatment groups were subjected to transcortical penetrations (TP) of the right tibia using either a piezoelectric knife (PTP) or a rotary bur (BTP). The right tibias of the control group animals had reflection of tissues (SHAM) and the left legs were kept for comparison (INTACT). The animals were killed at 7 and 14 days after the operation in an equally distributed manner. Microcomputed tomography images were obtained and analyzed utilizing artificial intelligence for bone cortical porosity (Ct.Po) locally and regionally. RESULTS/CONCLUSION Regionally, TP using a PTP induced significantly (p < .05, Kruskal-Wallis test) more Ct.Po than BTP or INTACT for both the 7- and 14-day time points. PTP was not found to induce significantly more Ct.Po than SHAM at any time point. However, PTP induced significantly more Ct.Po than the INTACT group for each time point, while SHAM did not. The local analysis did not reveal any relevant significant differences between groups.
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Affiliation(s)
- Massimo Di Battista
- Department of Periodontology and Oral Biology, Henry M. Goldman School of Dental MedicineBoston UniversityBostonMassachusettsUSA
| | - Jeremy Kernitsky
- Department of Periodontology and Oral Biology, Henry M. Goldman School of Dental MedicineBoston UniversityBostonMassachusettsUSA
| | - Elias Exarchos
- Department of Periodontology and Oral Biology, Henry M. Goldman School of Dental MedicineBoston UniversityBostonMassachusettsUSA
| | - Taisuke Ohira
- Department of Periodontology and Oral Biology, Henry M. Goldman School of Dental MedicineBoston UniversityBostonMassachusettsUSA
| | - Serge Dibart
- Department of Periodontology and Oral Biology, Henry M. Goldman School of Dental MedicineBoston UniversityBostonMassachusettsUSA
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16
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Desai A, Nambiar S, Unnikrishnan B, Rai S, Nayak S, Natarajan S. Effect of a Submucosal Injection of Platelet-Rich Plasma on the Rate of Orthodontic Tooth Movement - A Split-Mouth, Single-Blind Randomized Controlled Trial. Contemp Clin Dent 2023; 14:39-44. [PMID: 37250004 PMCID: PMC10209771 DOI: 10.4103/ccd.ccd_419_21] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/31/2021] [Revised: 10/22/2021] [Accepted: 01/15/2022] [Indexed: 11/12/2022] Open
Abstract
Objective To investigate the effect of submucosal injection of platelet-rich plasma (PRP) on the rate of mini-implant-supported retraction, using a split-mouth randomized clinical design. Materials and Methods Twenty subjects of either gender between 16 and 25 years of age with bimaxillary dentoalveolar protrusion and crowding of <4 mm scheduled to undergo fixed mechanotherapy with the extraction of 1st premolars; were recruited for the study. Those with a periodontally compromised dentition, blood dyscrasias, smoking/alcoholism, or with a history of fixed orthodontic treatment were not considered. The intervention side received a submucosal injection of autologous PRP which was prepared using 10 ml of the patient's blood. The rate of extraction space closure on both sides was recorded and compared monthly for 3 months using a digital caliper. Results Mean overall retraction was faster on the intervention side as compared to the control side by 1.5 times and was statistically significant with a P value of 0.001. There was no influence of gender on the rate of retraction. There was no reported swelling or discomfort associated with the PRP injection. Conclusions Submucosal injection of PRP significantly accelerates orthodontic tooth movement and can therefore be used as an effective, safe, and minimally invasive method to expedite orthodontic treatment.
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Affiliation(s)
- Asavari Desai
- Associate Professor, Department of Orthodontics, Manipal College of Dental Sciences Mangalore, Manipal Academy of Higher Education, Manipal, India
| | - Supriya Nambiar
- Professor and Head, Department of Orthodontics, Manipal College of Dental Sciences Mangalore, Manipal Academy of Higher Education, Manipal, India
| | - Bhaskaran Unnikrishnan
- Professor and Dean, Department of Community Medicine, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, India
| | - Sharada Rai
- Professor and Head, Department of Pathology, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, India
| | - Sangeeta Nayak
- Associate Professor, Department of Periodontics, Manipal College of Dental Sciences Mangalore, Manipal Academy of Higher Education, Manipal, India
| | - Srikant Natarajan
- Professor and Head, Department of Oral Pathology, Manipal College of Dental Sciences Mangalore, Manipal Academy of Higher Education, Manipal, India
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17
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Kilinc B, Baka ZM. Comparison of the effectiveness of piezocision and microosteoperforation in leveling mandibular anterior teeth. Am J Orthod Dentofacial Orthop 2022; 163:491-500. [PMID: 36517376 DOI: 10.1016/j.ajodo.2022.02.019] [Citation(s) in RCA: 4] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/01/2019] [Revised: 02/01/2022] [Accepted: 02/01/2022] [Indexed: 12/14/2022]
Abstract
INTRODUCTION The primary aim of this study was to evaluate the effectiveness of piezocision and microosteoperforation (MOP) in accelerating the leveling of mandibular anterior teeth. The secondary aim was to evaluate the changes in periodontal parameters and the differences in patient comfort. METHODS Forty-five patients in the study were randomly divided into 3 groups. After bonding mandibular teeth, the patients in the first group (9 girls, 6 boys) underwent piezocision, and the patients in the second group (10 girls, 5 boys) underwent MOP. Patients in the third group (7 girls, 8 boys) comprised the control group. The patients were asked to complete a visual analog scale for pain assessment during the first week of treatment and to complete the Oral Health Impact Profile-14 questionnaire at the end of the week. Little's irregularity index was measured from plaster models taken at the start of the mandibular bonding process, 4 weeks, 8 weeks, 12 weeks, and 16 weeks after the mandibular bonding process. Periodontal parameters were also recorded at baseline and 16 weeks. RESULTS Our study results showed statistically significantly more orthodontic tooth movement in the piezocision group (mean difference, 7.60 ± 1.55) than in the control group (mean difference, 5.95±1.28) during the total study period (P = 0.015). In the MOP group, no significant difference in the alignment rate was observed at any time compared to the piezocision and control groups (P >0.05). CONCLUSIONS The leveling of mandibular anterior teeth was accelerated by piezocision over 16 weeks, predominantly in the first 12 weeks, whereas MOP had no effect. It was concluded that piezocision is an acceptable procedure and has no destructive effect on the periodontal tissue.
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Pouliezou I, Xenou A, Vavetsi K, Mitsea A, Sifakakis I. Adverse Effects of Surgically Accelerated Orthodontic Techniques: A Systematic Review. CHILDREN (BASEL, SWITZERLAND) 2022; 9:1835. [PMID: 36553279 PMCID: PMC9777195 DOI: 10.3390/children9121835] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Subscribe] [Scholar Register] [Received: 11/08/2022] [Revised: 11/23/2022] [Accepted: 11/24/2022] [Indexed: 11/29/2022]
Abstract
Evidence on the potential adverse effects of surgically accelerated orthodontic techniques is scarce. The aim of this review was to evaluate the available scientific evidence regarding the adverse effects on periodontium, tooth vitality, and root resorption, associated with these surgical procedures in children, adolescents, and adults. The reporting of this review was based on the PRISMA2020 guidelines. Seven databases and three registers were searched for randomized clinical trials (RCTs) and controlled clinical trials (CCTs) published up to 22 June 2022. Hand searching of the reference lists of the included studies was also performed. The quality of the evidence was assessed with the Cochrane risk of bias and ROBINS-I tools. A total of 887 records were initially screened. Finally, 33 RCTs (713 patients), six CCTs (103 patients), and six ongoing protocols were eligible for this systematic review. The current review indicated that there are no significant adverse effects of surgically accelerated orthodontic techniques on periodontium, root length, or tooth vitality. High-quality clinical trials with less risk of bias should be conducted to allow reliable conclusions regarding the adverse effects of the surgical procedures associated with the acceleration of orthodontic treatment on children, adolescents, and adults.
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Affiliation(s)
- Ioanna Pouliezou
- Department of Orthodontics, School of Dentistry, National and Kapodistrian University of Athens, 11527 Athens, Greece
| | - Angeliki Xenou
- Department of Periodontics, School of Dentistry, National and Kapodistrian University of Athens, 11527 Athens, Greece
| | - Konstantina Vavetsi
- Department of Periodontics, School of Dentistry, National and Kapodistrian University of Athens, 11527 Athens, Greece
| | - Anastasia Mitsea
- Department of Oral Diagnosis & Radiology, School of Dentistry, National and Kapodistrian University of Athens, 11527 Athens, Greece
| | - Iosif Sifakakis
- Department of Orthodontics, School of Dentistry, National and Kapodistrian University of Athens, 11527 Athens, Greece
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Venkatachalapathy S, Natarajan R, Ramachandran UM, Rajakumar P, Rangarajan S, Patil D, Manickavasagam V. Effect of Frequency of Micro-osteoperforation on Miniscrew- supported Canine Retraction: A Single-centered, Split-mouth Randomized Controlled Trial. J Contemp Dent Pract 2022; 23:781-787. [PMID: 37283011 DOI: 10.5005/jp-journals-10024-3385] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 06/08/2023]
Abstract
AIM The present study aimed at evaluating the increase in the rate of tooth movement by increasing the number and frequency of micro-osteoperforations (MOPs). MATERIALS AND METHODS The study was a single-center, split-mouth, randomized controlled trial. A total of 20 patients were included in the study who had fully erupted maxillary canines with class I molar canine relationship and a bimaxillary protrusion that required the removal of both maxillary and mandibular first premolars. Out of 80 samples, the experimental and controlled groups were randomly assigned. The experimental group received five MOPs in the extracted site of the first premolar before retraction, at 28th day and 56th day. The control group received no MOPs. The rate of tooth movement was measured on 28th, 56th, and 84th day on both the experimental and control sides. RESULTS In maxillary dentition, the canine on the MOP side moved by 0.65 ± 0.21 mm, 0.74 ± 0.23 mm, and 0.87 ± 0.27 mm during 28th, 56th, and 84th day, respectively, whereas in control side the rate of tooth movement was 0.37 ± 0.09 mm, 0.43 ± 0.11 mm, and 0.47 ± 0.11 mm during 28th, 56th and 84th day, respectively, which was statistically significant (p-value = 0.000). In mandibular dentition, the canine on the MOP site has moved by 0.57 ± 0.12 mm, 0.68 ± 0.21 mm, and 0.67 ± 0.10 mm during 28th, 56th, and 84th day, respectively, whereas in control side the rate of the tooth movement was 0.34 ± 0.08 mm, 0.40 ± 0.15 mm, and 0.40 ± 0.13 mm during 28th, 56th, and 84th day, respectively, which was statistically significant. CONCLUSION Micro-osteoperforations effectively increased the rate of tooth movement. Overall, MOPs increased the rate of canine retraction by 2-fold when compared with the control group. CLINICAL SIGNIFICANCE Micro-osteoperforation is a proven methodology to increase the rate of tooth movement and decrease the treatment time. However, it is important to repeat the procedure during every activation to increase its effectiveness.
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Affiliation(s)
- Sudhakar Venkatachalapathy
- Dr MGR Educational Research and Institute University, Maduravoyal, Chennai, Tamil Nadu, India, Phone: +91 9841874253, e-mail:
| | - RajVikram Natarajan
- Department of Orthodontics and Dentofacial Orthopedics, Thai Moogambigai Dental College and Hospital, Dr MGR Educational Research and Institute University, Maduravoyal, Chennai, Tamil Nadu, India
| | - Uma Maheswari Ramachandran
- Department of Orthodontics and Dentofacial Orthopedics, Meenakshi Ammal Dental College, Maduravoyal, Chennai, Tamil Nadu, India
| | - Premkumar Rajakumar
- Department of Orthodontics and Dentofacial Orthopedics, Thai Moogambigai Dental College and Hospital, Dr MGR Educational Research and Institute University, Maduravoyal, Chennai, Tamil Nadu, India
| | - Sumanth Rangarajan
- Department of Orthodontics and Dentofacial Orthopedics, Adhiparasakthi Dental College and Hospital, Melmaruvathur, Chengalpattu, Tamil Nadu, India
| | - Digvijay Patil
- Department of Orthodontics and Dentofacial Orthopedics, Tagore Dental College and Hospital, Rathinamangalam, Tamil Nadu, India
| | - Vijayasri Manickavasagam
- Department of Orthodontics and Dentofacial Orthopedics, Adhiparasakthi Dental College and Hospital, Melmaruvathur, Chengalpattu, Tamil Nadu, India
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20
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Mousa MM, Hajeer MY, Burhan AS, Almahdi WH. Evaluation of patient-reported outcome measures (PROMs) during surgically-assisted acceleration of orthodontic treatment: a systematic review and meta-analysis. Eur J Orthod 2022; 44:622-635. [PMID: 35796046 DOI: 10.1093/ejo/cjac038] [Citation(s) in RCA: 16] [Impact Index Per Article: 5.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/13/2022]
Abstract
BACKGROUND With the widespread of surgically-assisted orthodontic acceleration, the analysis of patient-reported outcome measures (PROMs) has become very important to assure patient acceptance and satisfaction before adopting any acceleration procedure. OBJECTIVE This review aimed to critically appraise the available evidence regarding the levels of pain, discomfort, functional impairments, and other patient-reported outcome measures during surgically-assisted acceleration of orthodontic treatment compared with the traditional non-accelerated treatment. SEARCH METHODS Eight electronic bibliographic databases were searched from January 1990 till May 2022. A manual search of the selected orthodontic journals was also undertaken. SELECTION CRITERIA Randomized controlled trials (RCTs) were included in this systematic review on patients undergoing orthodontic treatment with one group subjected to an acceleration procedure. DATA COLLECTION AND ANALYSIS Cochrane's risk of bias tool (RoB2 tool) was used to assess the risk of bias of the included RCTs. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) guidelines were used to assess the overall quality of the evidence. RESULTS Thirteen RCTs were included in this review (333 patients), and only minimally invasive surgically-assisted acceleration studies were included. Two RCTs were included in the quantitative synthesis of data. After the first day of surgical intervention, the levels of pain and discomfort ranged from mild to moderate in the surgical groups (mean values ranged from 0.8 to 6.8), while it was mild in the control groups. However, on the seventh day after the surgical intervention, the levels of pain, discomfort, swelling, and functional impairments were almost similar between groups. According to the GRADE, the quality of evidence supporting these findings ranged from low to very low. CONCLUSIONS All surgical interventions were minimally invasive. There was very low to low evidence that acceleration caused mild to moderate pain and discomfort on the first day after the surgical intervention and disappeared completely at one week following surgery. Functional impairments were found within acceptable limits immediately and in the short-term follow-up. More high-quality randomized controlled clinical trials are needed to establish good evidence in this field. REGISTRATION The protocol of this systematic review was registered in PROSPERO database (CRD42021274481) during the first stages of this review.
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Affiliation(s)
- Mudar Mohammad Mousa
- Department of Orthodontics, University of Damascus Dental School, Damascus, Syria
| | - Mohammad Y Hajeer
- Department of Orthodontics, University of Damascus Dental School, Damascus, Syria
| | - Ahmad S Burhan
- Department of Orthodontics, University of Damascus Dental School, Damascus, Syria
| | - Wael H Almahdi
- Department of Periodontics, University of Damascus Dental School, Damascus, Syria
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21
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Almășan O, Duncea I, Kui A, Buduru S. Influence of Human Papillomavirus on Alveolar Bone and Orthodontic Treatment: Systematic Review and Case Report. Healthcare (Basel) 2022; 10:624. [PMID: 35455802 PMCID: PMC9028962 DOI: 10.3390/healthcare10040624] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/09/2022] [Revised: 03/16/2022] [Accepted: 03/24/2022] [Indexed: 02/01/2023] Open
Abstract
BACKGROUND As the human papillomavirus (HPV) infections are detected in healthy oral mucosa as well as in oral lesions, dental practitioners have an important role in detecting any possible lesions that might be caused by this virus. Therefore, the aim of this study was to investigate the outcomes of orthodontic treatments and HPV infections and to report a rare case of ongoing orthodontic treatment superposed on an HPV infection. METHODS An electronic English literature research of the articles published between the years 2011-2021 was conducted between December 2021-February 2022, accessing PubMed, Web of Science, Embase, Scopus, and Google Scholar. The terms "HPV", "orthodontics", "orthodontic treatment", "tooth movement", "tooth mobility", and "malocclusion" were searched. The following inclusion criteria were pursued: articles published in English language; studies reporting HPV infection in subjects with past or ongoing orthodontic treatment; and case reports of subjects with HPV and orthodontic treatment. Exclusion criteria were: articles in languages other than English, studies related to malignancies other than HPV and orthodontic treatment; and studies reporting patients with HPV and no orthodontic treatment. RESULTS Following the systematic review, which includes six papers, a case of orthodontic treatment superposed on a HPV infection is presented. CONCLUSION Incumbent, postponed HPV infection on an ongoing orthodontic treatment might affect treatment outcome and patient compliance.
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Affiliation(s)
| | - Ioana Duncea
- Prosthetic Dentistry and Dental Materials Department, Iuliu Hatieganu University of Medicine and Pharmacy, 32 Clinicilor Street, 400006 Cluj-Napoca, Romania; (O.A.); (A.K.); (S.B.)
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Micro-Osteoperforations Induce TNF-α Expression and Accelerate Orthodontic Tooth Movement via TNF-α-Responsive Stromal Cells. Int J Mol Sci 2022; 23:ijms23062968. [PMID: 35328385 PMCID: PMC8955966 DOI: 10.3390/ijms23062968] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/24/2022] [Accepted: 03/08/2022] [Indexed: 02/04/2023] Open
Abstract
Micro-osteoperforations (MOPs) have been reported to accelerate orthodontic tooth movement (OTM), and tumor necrosis factor (TNF)-α has been reported to play a crucial role in OTM. In this report, the influence of MOPs during OTM was analyzed. We evaluated the expression of TNF-α with and without MOPs by RT-PCR analysis. A Ni-Ti closed coil spring was fixed between the maxillary left first molar and the incisors as an OTM mouse model to move the first molar in the mesial direction. MOPs were prepared on the lingual side and mesial side of the upper first molars. Furthermore, to investigate the target cell of TNF-α for osteoclast formation during OTM with MOPs in vivo, we created four types of chimeric mice in which bone marrow of wild-type (WT) or TNF receptor 1- and 2-deficient mice (KO) was transplanted into lethally irradiated WT or KO mice. The results showed that MOPs increased TNF-α expression, the distance of tooth movement and osteoclast formation significantly. Furthermore, mice with TNF-α-responsive stromal cells showed a significant increase in tooth movement and number of osteoclasts by MOPs. We conclude that MOPs increase TNF-α expression, and tooth movement is dependent on TNF-α-responsive stromal cells.
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Erdenebat T, Lee DJ, Kim SJ, Choi YJ, Kim EJ, Choi EH, Liu J, Hwang CJ, Jung HS, Cha JY. Effect of the Number of Micro-Osteoperforations on the Rate of Tooth Movement and Periodontal Response in Mice. Front Physiol 2022; 13:837094. [PMID: 35309083 PMCID: PMC8928525 DOI: 10.3389/fphys.2022.837094] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/16/2021] [Accepted: 02/08/2022] [Indexed: 11/13/2022] Open
Abstract
Accelerated tooth movement can be achieved using micro-osteoperforations (MOPs) to stimulate regeneration of the alveolar bone during minimally invasive surgical trauma. However, there is currently no standardized protocol and limited reports regarding the side effects of MOPs based on biological evidence. This study sought to evaluate the biological effects of the number of MOPs on orthodontic tooth movement (OTM) and the potential risk for root resorption. Male CD1 mice were divided into 4 groups based on the number of MOPs, as follows: Sham; 0MOP+OTM; 2MOP+OTM; and 4MOP+OTM groups. Tooth movement distance and the number of osteoclasts were higher whereas bone volume and trabecular number were lower in the 4MOP+OTM group compared to those of the 0MOP+OTM group. Immunofluorescent assay analysis indicated that the 4MOP+OTM group was positively associated with rapid cementum regeneration and periodontal ligament tissue formation. Our findings revealed that the MOP procedure affected tooth movement and did not significantly contribute to root resorption, whereas it may promote constitutive activation of cementogenesis.
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Affiliation(s)
- Tselmuun Erdenebat
- Department of Orthodontics, The Institute of Craniofacial Deformity, Yonsei University College of Dentistry, Seoul, South Korea
| | - Dong-Joon Lee
- Division in Anatomy and Developmental Biology, Department of Oral Biology, Taste Research Center, BK21 FOUR Project, Yonsei University College of Dentistry, Seoul, South Korea
| | - Su-Jung Kim
- Department of Orthodontics, Kyung Hee University School of Dentistry, Seoul, South Korea
| | - Yoon Jeong Choi
- Department of Orthodontics, The Institute of Craniofacial Deformity, Yonsei University College of Dentistry, Seoul, South Korea
| | - Eun-Jung Kim
- Division in Anatomy and Developmental Biology, Department of Oral Biology, Taste Research Center, BK21 FOUR Project, Yonsei University College of Dentistry, Seoul, South Korea
| | - Eun-Hack Choi
- Department of Orthodontics, The Institute of Craniofacial Deformity, Yonsei University College of Dentistry, Seoul, South Korea
| | - Jing Liu
- Department of Orthodontics, The Institute of Craniofacial Deformity, Yonsei University College of Dentistry, Seoul, South Korea
| | - Chung-Ju Hwang
- Department of Orthodontics, The Institute of Craniofacial Deformity, Yonsei University College of Dentistry, Seoul, South Korea
| | - Han-Sung Jung
- Division in Anatomy and Developmental Biology, Department of Oral Biology, Taste Research Center, BK21 FOUR Project, Yonsei University College of Dentistry, Seoul, South Korea
- *Correspondence: Han-Sung Jung,
| | - Jung-Yul Cha
- Department of Orthodontics, The Institute of Craniofacial Deformity, Yonsei University College of Dentistry, Seoul, South Korea
- Jung-Yul Cha,
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Li J, Papadopoulou AK, Gandedkar N, Dalci K, Darendeliler MA, Dalci O. The effect of micro-osteoperforations on orthodontic space closure investigated over 12 weeks: a split-mouth, randomized controlled clinical trial. Eur J Orthod 2022; 44:427-435. [PMID: 35134142 DOI: 10.1093/ejo/cjab079] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/13/2022]
Abstract
OBJECTIVES To evaluate the effects of minimally invasive micro-osteoperforations (MOPs) on orthodontic tooth movement and pain. DESIGN Prospective, split-mouth, randomized controlled trial. SETTING Single-centre, university hospital. METHODS Twenty subjects requiring maxillary first premolar extractions were included. Right and left sides of the maxilla were randomly allocated into experimental and controls. Space closure was initiated following alignment on 0.20″ stainless steel archwires, using 150 g force, applied by coil springs on power arms. Nance-TPA was used for anchorage. On the experimental side, two 5 mm deep MOPs in vertical alignment on distal aspect of the maxillary canine mid-root region were performed prior to space closure. OUTCOMES The primary outcome was the amount of tooth movement during space closure, measured every 4 weeks for 12 weeks (T1, T2, and T3). Secondary outcome was the pain levels related to MOP, measured using Visual Analogue Scale (VAS) questionnaires. Significance was set at P < 0.01. RANDOMIZATION Randomization was generated using a randomization table, and allocation was concealed in sequentially numbered, opaque, sealed envelopes. BLINDING Blinding was not possible during the experiment but assessor was blinded during outcome assessment. RESULTS All subjects completed the study, with tooth movement measurements available for all 20 patients for T0-T2. In three patients, space was closed on one side at T2. The average tooth movement between sides at three intervals (T0-T1, T1-T2, and T2-T3) were not significantly different. Overall difference following 12 weeks (T0-T3) was 0.69 mm higher on the experimental side (P < 0.001). No harms were observed. LIMITATIONS Short-term study, cast measurements done with digital callipers. CONCLUSION This 12-week randomized split-mouth controlled clinical trial showed two MOPs that are 5 mm deep, applied once prior to space closure, did not create clinically significant increase in maxillary premolar space closure. PROTOCOL The protocol was not published before trial commencement. REGISTRATION Trial was not registered. FUNDING The Australian Society of Orthodontists Foundation for Research and Education.
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Affiliation(s)
- Jiaojiao Li
- Discipline of Orthodontics and Paediatric Dentistry Sydney Dental School, Faculty of Medicine and Health, University of Sydney, Sydney Dental Hospital, Sydney Local Health District, Surry Hills, NSW, Australia
| | - Alexandra K Papadopoulou
- Discipline of Orthodontics and Paediatric Dentistry Sydney Dental School, Faculty of Medicine and Health, University of Sydney, Sydney Dental Hospital, Sydney Local Health District, Surry Hills, NSW, Australia
| | - Narayan Gandedkar
- Discipline of Orthodontics and Paediatric Dentistry Sydney Dental School, Faculty of Medicine and Health, University of Sydney, Sydney Dental Hospital, Sydney Local Health District, Surry Hills, NSW, Australia
| | - Kerem Dalci
- Discipline of Orthodontics and Paediatric Dentistry Sydney Dental School, Faculty of Medicine and Health, University of Sydney, Sydney Dental Hospital, Sydney Local Health District, Surry Hills, NSW, Australia
| | - Mehmet Ali Darendeliler
- Discipline of Orthodontics and Paediatric Dentistry Sydney Dental School, Faculty of Medicine and Health, University of Sydney, Sydney Dental Hospital, Sydney Local Health District, Surry Hills, NSW, Australia
| | - Oyku Dalci
- Discipline of Orthodontics and Paediatric Dentistry Sydney Dental School, Faculty of Medicine and Health, University of Sydney, Sydney Dental Hospital, Sydney Local Health District, Surry Hills, NSW, Australia
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Lee KH, Cheon Lee S, Jung Kim H, Kang YG, Kim SJ. Effect of locally delivered protein complex-loaded nanoparticles on bone remodelling of atrophic alveolar ridge in beagles. Orthod Craniofac Res 2022; 25:55-63. [PMID: 33931954 DOI: 10.1111/ocr.12487] [Citation(s) in RCA: 3] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/24/2021] [Revised: 04/16/2021] [Accepted: 04/21/2021] [Indexed: 11/27/2022]
Abstract
OBJECTIVE To investigate the effect of local injection of mineralized hybrid nanoparticles loading dentin matrix protein-1 (DMP-1) and matrix metalloproteinase-13 (MMP-13) complex (P-NPs) on the bone remodelling on atrophic alveolar ridges (AAR) ahead of orthodontic tooth movement (OTM). SETTINGS AND SAMPLE POPULATION Four beagles were randomly allocated into Group C (OTM only) and Group NP (OTM with P-NPs injection). Experimental model of AAR was prepared in 8 mandibular quadrants after extraction of the third premolars (n = 4 per Group). MATERIALS AND METHODS Reciprocal traction of the second and fourth premolars was performed towards AAR for 8 weeks. P-NPs were prepared by loading recombinant DMP-1 and MMP-13 complex into calcium carbonate (CaCO3 )-mineralized hybrid nanoparticles and injected at 0, 3 and 6 weeks. The rate of OTM and the bone remodelling characteristics were compared between Groups using fluorescent microscopic analysis and microstructural histomorphometric analysis. RESULTS Group NP revealed higher bone volume fraction and higher trabecular ratio with lower bone mineral density than Group C on AAR area. Meanwhile, the root movement towards AAR was facilitated in Group NP representing more bodily movement than Group C. CONCLUSION Non-invasive intervention of P-NPs injection suggested a clinical potential to facilitate translational movement into the AAR with sustaining woven bone-like microstructural environment.
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Affiliation(s)
- Keun-Ha Lee
- Department of Dentistry, Kyung Hee University Graduate School, Seoul, Korea
| | - Sang Cheon Lee
- Department of Maxillofacial Biomedical Engineering and Institute of Oral Biology, Kyung Hee University School of Dentistry, Seoul, Korea
| | - Hye Jung Kim
- Department of Maxillofacial Biomedical Engineering and Institute of Oral Biology, Kyung Hee University School of Dentistry, Seoul, Korea
| | - Yoon-Goo Kang
- Department of Orthodontics, Kyung Hee University School of Dentistry, Seoul, Korea
| | - Su-Jung Kim
- Department of Orthodontics, Kyung Hee University School of Dentistry, Seoul, Korea
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Keser E, Naini FB. Accelerated orthodontic tooth movement: surgical techniques and the regional acceleratory phenomenon. Maxillofac Plast Reconstr Surg 2022; 44:1. [PMID: 34984554 PMCID: PMC8727645 DOI: 10.1186/s40902-021-00331-5] [Citation(s) in RCA: 30] [Impact Index Per Article: 10.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/19/2021] [Accepted: 12/15/2021] [Indexed: 11/10/2022] Open
Abstract
BACKGROUND Techniques to accelerate tooth movement have been a topic of interest in orthodontics over the past decade. As orthodontic treatment time is linked to potential detrimental effects, such as increased decalcification, dental caries, root resorption, and gingival inflammation, the possibility of reducing treatment time in orthodontics may provide multiple benefits to the patient. Another reason for the surge in interest in accelerated tooth movement has been the increased interest in adult orthodontics. REVIEW This review summarizes the different methods for surgical acceleration of orthodontic tooth movement. It also describes the advantages and limitations of these techniques, including guidance for future investigations. CONCLUSIONS Optimization of the described techniques is still required, but some of the techniques appear to offer the potential for accelerating orthodontic tooth movement and improving outcomes in well-selected cases.
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Affiliation(s)
- Elif Keser
- Department of Orthodontics, Boston University Henry M. Goldman School of Dental Medicine, Boston, USA
| | - Farhad B Naini
- Kingston and St George's Hospitals and St George's Medical School, Blackshaw Road, London, SW17 0QT, UK.
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Papadopoulos N, Beindorff N, Hoffmann S, Jost-Brinkmann PG, Präger TM. Impact of piezocision on orthodontic tooth movement. Korean J Orthod 2021; 51:366-374. [PMID: 34803025 PMCID: PMC8607123 DOI: 10.4041/kjod.2021.51.6.366] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/15/2021] [Revised: 06/14/2021] [Accepted: 07/02/2021] [Indexed: 11/10/2022] Open
Abstract
Objective This study investigated the impact of a single piezocision in the maxillary alveolar process on the speed of tooth movement. The null hypothesis was that the speed of tooth movement will be equal with and without piezocision. Methods All maxillary molars on one side were moved against the combined incisors in 10 ten-week-old male Wistar rats. Under general anesthesia, a force of 25 cN was applied on either side using a Sentalloy closed coil spring. After placing the orthodontic appliance, vertical corticision was performed using a piezotome under local anesthesia, 2 mm mesial from the mesial root of the first molar on a randomly selected side; the other side served as the control. At the beginning of the treatment, and 2 and 4 weeks later, skull micro-computed tomography was performed. After image reconstruction, the distance between the mesial root of the first molar and the incisive canal, and the length of the mesial root of the first maxillary molar were measured. Moreover, the root resorption score was determined as described by Lu et al. Results Significantly higher speed of tooth movement was observed on the corticision side; thus, the null hypothesis was rejected. The loss of root length and root resorption score were significantly more pronounced after piezocision than before. A strong correlation was observed between the speed of tooth movement and root resorption on the surgical side, but the control side only showed a weak correlation. Conclusions Piezocision accelerates orthodontic tooth movement and causes increased root resorption.
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Affiliation(s)
- Nikolaos Papadopoulos
- Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Dental and Craniofacial Sciences, Department of Orthodontics, Dentofacial Orthopedics and Pedo
| | - Nicola Beindorff
- Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin Experimental Radionuclide Imaging Center (BER
| | - Stefan Hoffmann
- Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Dental and Craniofacial Sciences, Department of Orthodontics, Dentofacial Orthopedics and Pedo
| | - Paul-Georg Jost-Brinkmann
- Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Dental and Craniofacial Sciences, Department of Orthodontics, Dentofacial Orthopedics and Pedo
| | - Thomas Michael Präger
- Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Dental and Craniofacial Sciences, Department of Orthodontics, Dentofacial Orthopedics and Pedo
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CAI YONGQING. EFFECTIVENESS OF VIBRATION (CYCLIC LOADING) IN ACCELERATING BONE REMODELING AND ORTHODONTIC TOOTH MOOVEMENT: A SHORT REVIEW. J MECH MED BIOL 2021. [DOI: 10.1142/s0219519421400315] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/18/2022]
Abstract
This paper assesses the effectiveness of vibration in accelerating bone remodeling and orthodontic tooth movement. Databases of PubMed, Web of Science, and ScienceDirect were searched from January 2017 to March 2019 for randomized or quasi-randomized controlled trials that evaluated the effectiveness of vibration in accelerating bone remodeling and orthodontic tooth movement. The inclusion criteria were as follows: (i) studies that assessed the efficacy of vibration (cyclic loading) in bone remodeling and orthodontic tooth movement and (ii) those that employed groupings (experimental vs. control/placebo groups) on the basis of the use of vibration (cyclic loading). Eight clinical trials were included in this short review. Five studies met the eligibility criteria for bone remodeling and orthodontic tooth movement. Four studies found that low-magnitude high-frequency vibration could accelerate bone remodeling. However, contradictory results were obtained with regard to the acceleration of orthodontic tooth movement by vibration in human participants. Low-magnitude high-frequency vibration can accelerate bone remodeling and orthodontic tooth movement. However, this acceleration is dependent on the magnitude and frequency. Further research is necessary to determine the most feasible protocols for investigating the effects of magnitude and frequency of vibration on the acceleration of orthodontic tooth movement in human participants.
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Affiliation(s)
- YONGQING CAI
- Department of Mechanical and Electrical Engineering, Hainan University, Haikou 570228, P. R. China
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29
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Sirri MR, Burhan AS, Hajeer MY, Nawaya FR. Evaluation of corticision-based acceleration of lower anterior teeth alignment in terms of root resorption and dehiscence formation using cone-beam computed tomography in young adult patients: A randomized controlled trial. Int Orthod 2021; 19:580-590. [PMID: 34688568 DOI: 10.1016/j.ortho.2021.10.001] [Citation(s) in RCA: 15] [Impact Index Per Article: 3.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/08/2021] [Revised: 10/01/2021] [Accepted: 10/02/2021] [Indexed: 11/27/2022]
Abstract
INTRODUCTION No randomized controlled trial (RCT) has compared flapless corticision with the conventional treatment in the non-extraction treatment of crowded lower anterior teeth (LAT) in terms of external apical root resorption (EARR) and dehiscence formation (DF). The aim of this RCT was to investigate these two complications during levelling and alignment of the LAT using cone-beam computed tomography (CBCT) imaging. METHODS Patients with mild to moderate crowding of the LAT were included. Subjects were randomly allocated to either the corticision-assisted orthodontic treatment group (CORT) or the traditional orthodontic treatment group (TRAD). In the CORT, three vertical incisions were performed after brackets' placement. CBCT images were taken before starting treatment and after treatment completion to assess the EARR and the DF. Two-sample t-test and Chi-Square tests were used to detect significant differences. RESULTS In general, 312 roots of the lower anterior teeth (156 in each group) were examined. Fifty-two patients (14 males and 38 females, mean age 21.38) were recruited. (CORT; n=26, 6 males, 20 females, mean age 21.30); (TRAD; n=26, 8 males, 18 females, mean age 21.46). No statistically significant difference was found between the two groups regarding the overall mean value of EARR following alignment (P=0.436). The greatest recorded resorption values were 0.81 and 1.02 in the CORT and TRAD groups, respectively. At the end of levelling and alignment, there was no statistically significant difference between the two groups regarding the distribution of DF (P=0.780). CONCLUSION Corticision as an acceleration technique did not produce any significant side effects on the roots of lower anterior teeth and did not cause additional alveolar bone defects (dehiscence formation) compared to the conventional non-accelerated method of alignment.
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Affiliation(s)
- Mohamad Radwan Sirri
- University of Damascus Dental School, Department of Orthodontics, Damascus, Syria
| | - Ahmad S Burhan
- University of Damascus Dental School, Department of Orthodontics, Damascus, Syria
| | - Mohammad Y Hajeer
- University of Damascus Dental School, Department of Orthodontics, Damascus, Syria.
| | - Fehmieh R Nawaya
- Faculty of Dentistry, Syrian Private University, Department of Paediatric Dentistry, Damascus, Syria
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Thomas S, Das SK, Barik AK, Raj SC, Rajasekaran A, Mishra M. Evaluation of physiodispenser assisted micro-osteoperforation on the rate of tooth movement and associated periodontal tissue status during individual canine retraction in first premolar extraction cases: A split-mouth randomized controlled clinical trial. J World Fed Orthod 2021; 10:89-97. [PMID: 34112627 DOI: 10.1016/j.ejwf.2021.05.001] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/29/2020] [Revised: 03/19/2021] [Accepted: 05/02/2021] [Indexed: 10/21/2022]
Abstract
OBJECTIVE To assess the rate of tooth movement and the periodontal tissue status over a period of 90 days with and without micro-osteoperforation (MOP). METHOD Thirty-three adults of the 19 to 25 age group undergoing labial fixed orthodontic treatment with bilateral maxillary first premolar extraction, requiring individual canine retraction as a part of the treatment plan, were recruited for this split-mouth randomized clinical trial. While performing micro-implant-assisted canine retraction in the maxillary arch, the experimental side received three MOPs each on the mesial and distal aspects of the canine root. The amount of tooth movement was measured clinically at every 15 days interval for 90 days; the periodontal status was assessed clinically (probing depth, relative attachment level) and tomographically (canine root length, alveolar bone level) at the 1st day and 90th day of retraction. The data were subjected to appropriate statistical analyses. RESULTS A statistically significant difference in tooth movement on the MOP side was observed in the first 45 days, amounting to 1.5 times more than that of the control side. However, during 45 to 90 days, the difference in the rate of tooth movement between the sides was not statistically significant. Changes in periodontal variables were also insignificant between the sides except for the distal alveolar bone level. CONCLUSION An increase in the rate of tooth movement can be achieved without any periodontal adverse effects in the first 45 days of the MOP procedure. The effectiveness of the MOP procedure on the rate of tooth movement gradually declined thereafter. TRIAL REGISTRATION CTRI/2019/07/020403.
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Affiliation(s)
- Stephy Thomas
- Former Postgraduate student, Department of Orthodontics and Dentofacial Orthopedics, SCB Dental College and Hospital, Cuttack, Odisha, India
| | - Surya Kanta Das
- Professor and Head of the Department, Department of Orthodontics and Dentofacial Orthopedics, SCB Dental College and Hospital, Cuttack, Odisha, India.
| | - Ashish Kumar Barik
- Associate Professor, Department of Orthodontics and Dentofacial Orthopedics, SCB Dental College and Hospital, Cuttack, Odisha, India
| | - Subash Chandra Raj
- Associate Professor, Department of Periodontics, SCB Dental College and Hospital, Cuttack, Odisha, India
| | - Abirami Rajasekaran
- Senior Resident, Department of Orthodontics and Dentofacial Orthopedics, SCB Dental College and Hospital, Cuttack, Odisha, India
| | - Mitali Mishra
- Assistant Professor, Department of Orthodontics and Dentofacial Orthopedics, SCB Dental College and Hospital, Cuttack, Odisha, India
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Mohaghegh S, Soleimani M, Kouhestani F, Motamedian SR. The effect of single/multiple micro-osteoperforation on the rate of orthodontic tooth movement and its possible complications: A systematic review and meta-analysis. Int Orthod 2021; 19:183-196. [PMID: 33678595 DOI: 10.1016/j.ortho.2021.02.001] [Citation(s) in RCA: 6] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/12/2020] [Revised: 02/06/2021] [Accepted: 02/11/2021] [Indexed: 11/28/2022]
Abstract
OBJECTIVE Different surgical and non-surgical approaches have been proposed to accelerate tooth movement and decrease the duration of orthodontic treatments. Recently, less invasive techniques such as micro-osteoperforation (MOP) are becoming more common. Several clinical trials have been performed to analyse the effect of MOP. This systematic review with meta-analyses was done to evaluate the effect of MOP on the rate of orthodontic tooth movement (OTM) and its complications. MATERIAL AND METHODS Electronic search was done in PubMed and Cochrane database for studies published until January 2021. Comparative randomized clinical trial studies with 10 or more participants per group were included. The risk of bias (ROB) of the studies was assessed according to the Cochrane Collaborations tool. Meta-analyses were performed to assess the mean difference in tooth movement rate and compare the level of pain between MOP and control groups. RESULTS Among a total of 15 included studies, eight studies were at low ROB, while others had unclear ROB. Ten studies evaluated the effect of MOP on OTM rate in canine retraction, and related meta-analysis showed a significant difference between the MOP and control group [SMD=0.42; 95% CI=0.20 to 0.63, P<0.01]. Besides, quantitative analysis showed MOP caused no significant higher anchorage loss [SMD=0.01; 95% CI=-0.15 to 0.13, P=0.89] and pain [SMD=0.54; 95% CI=-0.25 to 1.33, P=0.18]. CONCLUSIONS Overall, both single and multiple applications of MOP increased the rate of OTM. However, the meta-analysis results of the four studies with low risk of bias showed that there is no significant difference in the rate of tooth movement between MOP and control groups. Besides, it has been shown that MOP did not significantly increase the level of pain, anchorage loss, and periodontal complications.
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Affiliation(s)
- Sadra Mohaghegh
- Shahid Beheshti University of Medical Sciences, School of Dentistry, Dentofacial Deformities Research Center, Research Institute of Dental Sciences, Tehran, Iran
| | - Milad Soleimani
- Alborz University of Medical Sciences, School of Dentistry, Department of Orthodontics, Karaj, Iran
| | - Farnaz Kouhestani
- Shahid Beheshti University of Medical Sciences, School of Dentistry, Department of Orthodontics, Tehran, Iran
| | - Saeed Reza Motamedian
- Shahid Beheshti University of Medical Sciences, School of Dentistry, Dentofacial Deformities Research Center, Research Institute of Dental Sciences, Tehran, Iran.
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Evaluation of the efficacy of laser-assisted flapless corticotomy in accelerating canine retraction: a split-mouth randomized controlled clinical trial. Oral Maxillofac Surg 2021; 26:81-89. [PMID: 33876339 DOI: 10.1007/s10006-021-00963-x] [Citation(s) in RCA: 24] [Impact Index Per Article: 6.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/11/2021] [Accepted: 04/12/2021] [Indexed: 10/21/2022]
Abstract
OBJECTIVE To evaluate the efficacy of laser-assisted flapless corticotomy in the acceleration of canine retraction compared with the conventional technique and to evaluate patients' pain and discomfort levels after corticotomy. MATERIALS AND METHODS A single-center randomized controlled trial was conducted on 18 class II division 1 patients (7 males, 11 females; age range: 16 to 24 years) who required the first-upper-premolar extraction followed by canine retraction. A split-mouth design was used in which the Er:YAG laser-assisted flapless corticotomy was randomly allocated to one side, whereas the other side served as the control side. The primary outcome measure was the canine retraction rate which was assessed immediately after laser application, 1, 2, 4, 8, and 12 weeks after laser application. Also, the levels of pain and discomfort during the first week following laser application were assessed. Paired t-tests or Wilcoxon matched-pairs signed-rank tests were used to detect significant differences. RESULTS All of the selected eighteen patients entered the statistical analysis stage. Significant differences were observed (P < 0.001) in canine retraction rates between the experimental and control sides at the baseline to 1st-week, 1st- to 2nd-week, 2nd- to 4th-week, and 4th- to 8th-week intervals. No significant difference was found between the two sides at the 8th- to 12th-week interval. A significant reduction was seen in the mean score of pain during eating at all assessment times when compared to the baseline data (P = 0.002 at day 2, P < 0.001 at days 5 and 7). CONCLUSION Er:YAG laser-assisted flapless corticotomy appears to be an effective treatment method for accelerating canine retraction and was accompanied by a mild degree of pain and discomfort. TRIAL REGISTRATION ClinicalTrials.gov (No.: NCT04316403), retrospectively registered on the 20th of March 2020. URL: https://clinicaltrials.gov/ct2/show/NCT04316403.
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Orthodontic management of severe iatrogenic biprotrusion and resorptions with miniscrews and corticotomies. Int Orthod 2021; 19:319-328. [PMID: 33820728 DOI: 10.1016/j.ortho.2021.03.004] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/12/2021] [Revised: 03/11/2021] [Accepted: 03/12/2021] [Indexed: 11/21/2022]
Abstract
BACKGROUND This case report describes a patient with severe iatrogenic dental biprotrusion who visited for a second assessment. The patient presented first premolar maxillary extractions, resorbed maxillary incisors and dehiscences in the anterior buccal and palatal cortical bone diagnosed with cone-beam computed tomography (CBCT). MATERIAL AND METHODS At the beginning of treatment, fixed appliances were bonded on all teeth except on the upper incisors to prevent further root resorption. Mandibular first premolar extractions, miniscrews and corticotomies were scheduled for gaining distalization of the teeth in the four quadrants. When this was achieved, an occlusal splint was placed to extrude the posterior teeth with interarch elastics for increasing the vertical dimension. Next, brackets were placed on the maxillary incisors and a comprehensive orthodontic treatment was performed. RESULTS After treatment, changes in incisor positioning were evident, varying the interincisal angle by 57.6 degrees. Nevertheless, slight root resorption of the upper incisors was observed. CONCLUSIONS Correct diagnosis is necessary to design an adequate treatment plan and make orthodontists aware of possible severe unwanted tooth movements before they occur. In dental biprotrusion without overjet, the first objective should be to distalize mandibular teeth prior to maxillary teeth retraction.
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Abid MF, Alhuwaizi AF, Al-Attar AM. Do orthodontists aim to decrease the duration of fixed appliance treatment? J Orthod Sci 2021; 10:6. [PMID: 34084762 PMCID: PMC8102932 DOI: 10.4103/jos.jos_36_20] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/05/2020] [Revised: 08/17/2020] [Accepted: 01/23/2021] [Indexed: 11/09/2022] Open
Abstract
OBJECTIVES: The aim of the present study was to investigate the trends in the use of fixed appliance and accelerated orthodontics to decrease the treatment duration. Further, this study aimed to assess the effect of demographic factors on the participant's choice of treatment modality. METHODS: This was a cross-sectional study in the form of questionnaire-based online survey especially designed and distributed to 265 orthodontists via email. The questions aimed to collect basic information about the participants and respondents’ choices for decreasing the treatment duration. The data were analyzed according to gender, level of academic education and years of clinical experience using Chi-square test. RESULTS: A response rate of 85.2% was reported. Most of the orthodontists aimed to reduce the treatment duration by the biomechanical (66.8%) and surgical approaches (27.4%). The use of sliding mechanics (69.4%) and one-step retraction was more common (66.3%). MBT bracket prescription was more prevalent (51.7%), followed by Roth (41.1%). Conventional brackets were used more than self-ligating brackets, and aesthetic brackets were avoided by one third of the respondents. NiTi wires were the most commonly used wires during the alignment stage (44.2%). However, the effect of gender, years of clinical experience and specialty level of education showed some effects on the use of certain techniques and clinical practice of the respondents. CONCLUSIONS: Most of the orthodontists aimed to decrease orthodontic treatment duration by using biomechanical and surgical approaches. Gender and clinical experience to a certain extent affected the participants’ choice during orthodontic treatment.
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Affiliation(s)
- Mushriq F Abid
- Department of Orthodontic, College of Dentistry, Baghdad University, Baghdad, Iraq
| | - Akram F Alhuwaizi
- Department of Orthodontic, College of Dentistry, Baghdad University, Baghdad, Iraq
| | - Ali M Al-Attar
- Department of Orthodontic, College of Dentistry, Baghdad University, Baghdad, Iraq
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Which method is more effective for accelerating canine distalization short term, low-level laser therapy or piezocision? A split-mouth study. J Orofac Orthop 2020; 82:236-245. [PMID: 32990775 DOI: 10.1007/s00056-020-00250-6] [Citation(s) in RCA: 16] [Impact Index Per Article: 3.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/02/2020] [Accepted: 06/23/2020] [Indexed: 10/23/2022]
Abstract
OBJECTIVES This study evaluated and compared the effects of low-level laser therapy (LLLT) and piezocision on the amount of orthodontic tooth movement. MATERIALS AND METHODS Forty maxillary canines from 20 patients (mean age, 16.35 ± 1.14 years) were evaluated in a split-mouth design study. Miniscrew-supported canine distalization was performed. Piezocision was applied in the right maxillary canine region, and the left maxillary canines were irradiated with a diode laser (940 nm, 5 J/cm2). LLLT was performed on day 0 and days 3, 7, 14, 21, and 28 after the start of canine distalization in the first 4‑week period. Data were evaluated at baseline (T0) and after 4 (T1), 8 (T2), and 12 (T3) weeks. The amount of canine movement was determined from three-dimensional models, and the angulation of canines and first molars was analyzed based on lateral cephalograms. RESULTS Intragroup and intergroup comparisons of canine distalization were performed for four different time intervals (T0-T1, T1-T2, T2-T3, T0-T3). The canine tooth movement in the T0-T1 period was significantly greater in the LLLT group compared to the piezocision group. No statistically significant differences were observed between the groups for the T1-T2, T2-T3, and T0-T3 periods. The amount of canine distalization in the T0-T1 period was significantly greater than that in the T1-T2 and T2-T3 periods in both groups. Tooth movement during the T1-T2 period was higher than that in the T2-T3 period in the LLLT group. Cephalometric evaluation revealed no statistically significant difference between the groups with respect to canine and first molar angulation. CONCLUSION Although laser application seems more effective during the first 4‑week period, considering the 12-week period, the effects of LLLT and piezocision on orthodontic tooth movement during canine distalization were similar.
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Role of c-Fos in orthodontic tooth movement: an in vivo study using transgenic mice. Clin Oral Investig 2020; 25:593-601. [PMID: 32803442 PMCID: PMC7819946 DOI: 10.1007/s00784-020-03503-1] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.6] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/30/2020] [Accepted: 08/05/2020] [Indexed: 01/05/2023]
Abstract
Objectives The transcription factor c-Fos controls the differentiation of osteoclasts and is expressed in periodontal ligament cells after mechanical stimulation in vitro. However, it is unclear how c-Fos regulates orthodontic tooth movement (OTM) in vivo. The aim of this study was therefore to analyse OTM in transgenic mice with overexpression of c-Fos. Materials and methods We employed c-Fos transgenic mice (c-Fos tg) and wild-type littermates (WT) in a model of OTM induced by Nitinol tension springs that were bonded between the left first maxillary molars and the upper incisors. The unstimulated contralateral side served as an internal control. Mice were analysed by contact radiography, micro-computed tomography, decalcified histology and histochemistry. Results Our analysis of the unstimulated side revealed that alveolar bone and root morphology were similar between c-Fos tg and control mice. However, we observed more osteoclasts in the alveolar bone of c-Fos tg mice as tartrate-resistant acid phosphatase (TRAP)-positive cells were increased by 40%. After 12 days of OTM, c-Fos tg mice exhibited 62% increased tooth movement as compared with WT mice. Despite the faster tooth movement, c-Fos tg and WT mice displayed the same amount of root resorption. Importantly, we did not observe orthodontically induced tissue necrosis (i.e. hyalinization) in c-Fos tg mice, while this was a common finding in WT mice. Conclusion Overexpression of c-Fos accelerates tooth movement without causing more root resorption. Clinical relevance Accelerated tooth movement must not result in more root resorption as higher tissue turnover may decrease the amount of mechanically induced tissue necrosis. Electronic supplementary material The online version of this article (10.1007/s00784-020-03503-1) contains supplementary material, which is available to authorized users.
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Jedliński M, Romeo U, Del Vecchio A, Palaia G, Galluccio G. Comparison of the Effects of Photobiomodulation with Different Lasers on Orthodontic Movement and Reduction of the Treatment Time with Fixed Appliances in Novel Scientific Reports: A Systematic Review with Meta-Analysis. PHOTOBIOMODULATION PHOTOMEDICINE AND LASER SURGERY 2020; 38:455-465. [PMID: 32678697 DOI: 10.1089/photob.2019.4779] [Citation(s) in RCA: 7] [Impact Index Per Article: 1.4] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 11/12/2022]
Abstract
Background: The duration of orthodontic treatment is one of the most important aspects considered by patients. Photobiomodulation (PBM) depends upon the exposure of the tissue to particular, therapeutic wavelengths of light in the "therapeutic window" (from 600 to 1200 nm). PBM increases cell metabolism, which leads to higher ATP production. Increasing the amount of ATP in well-vascularized bone cells promotes cell proliferation and differentiation, creating a favorable environment for tooth movement. Objective: The aim of the study is to discuss and compare the use of PBM in accelerating the orthodontic movement and reducing the time of treatment. Materials and methods: A systematic review was conducted. Literature searches were performed using Medline (PubMed), Web of Science, and Scopus (from September 13 to September 20, 2019). The quality assessment was performed using the Jadad scale for reporting randomized controlled trials for randomized clinical trial and randomized control clinical trial studies, and the Newcastle/Ottawa Quality Assessment Form for case/control studies. Results: Thirty-three articles from PubMed, 46 from Scopus, 5 from Web of Science were selected. After removal of duplicates, 82 articles were analyzed. Subsequently, 74 articles were excluded because they did not meet the inclusion criteria. The remaining eight articles were included in the qualitative synthesis. Conclusions and summary: PBM is an efficient, effective, and noninvasive method to accelerate orthodontic tooth movement. PBM should be introduced into the daily practice of treating various malocclusions as an additional procedure. Intraoral application gives better results and its introduction to treatment seems more reasonable.
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Affiliation(s)
- Maciej Jedliński
- Student Scientific Society at the Department of Interdisciplinary Dentistry, Pomeranian Medical University in Szczecin, Szczecin, Poland.,Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy
| | - Umberto Romeo
- Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy
| | | | - Gaspare Palaia
- Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy
| | - Gabriela Galluccio
- Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy
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Examination of the effect of combined use of Er:YAG laser irradiation and mechanical force loading on bone metabolism using primary human gingival fibroblasts. Lasers Med Sci 2020; 35:2059-2064. [PMID: 32577932 DOI: 10.1007/s10103-020-03079-y] [Citation(s) in RCA: 5] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/09/2020] [Accepted: 06/16/2020] [Indexed: 10/24/2022]
Abstract
Prolonged treatment and painful tooth movement are major problems for patients undergoing orthodontic treatment. Accelerating the movement of teeth leads to shortening of the treatment period, so various studies on the movement of teeth have been conducted in the field of orthodontics. In previous studies, we performed a fiber incision-like fiberotomy using an Er:YAG laser in rats and confirmed acceleration of tooth movement. Therefore, in this study, the effect of Er:YAG laser irradiation on human gingival fibroblasts was investigated in vitro. Human gingival fibroblasts (2.0 × 105 cells) were seeded in a 6-well plate and reached 80% confluence 24 h later. A control group not undergoing any irradiation and 3 groups undergoing laser irradiation at 0.6 W, 1.0 W, and 1.2 W were investigated. Laser irradiation was performed 24 h after cell seeding. The cells were then recovered 24 h later, and the cyclooxygenase-2 (COX-2), interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), bone morphogenetic protein-2 (BMP-2), and BMP-4 genes were confirmed by PCR. In addition, a control group not undergoing any procedures, a group undergoing only Er:YAG laser irradiation, a group undergoing only centrifugal loading, and a group undergoing both Er:YAG laser irradiation and centrifugal force loading were investigated. After 24 h, cells were collected and PCR was performed. Twenty-four hours after laser irradiation, gene expressions were examined by quantitative RT-PCR, which showed that the gene expressions of COX-2, IL-1β, TNF-α, BMP-2, and BMP-4 increased depending on the amount of irradiation energy, with the largest value at 1.2 W. Gene expressions of COX-2, IL-1β, TNF-α, BMP-2, and BMP-4 were significantly higher in the laser with centrifugal load group than in the load group. These results suggest that genes related to bone metabolism are activated in human gingival fibroblasts when mechanical stimulation and laser irradiation are combined. This helps to elucidate the effects of Er:YAG laser irradiation during tooth movement.
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Zadeh HH, Borzabadi-Farahani A, Fotovat M, Kim SH. Vestibular Incision Subperiosteal Tunnel Access (VISTA) for Surgically Facilitated Orthodontic Therapy (SFOT). Contemp Clin Dent 2020; 10:548-553. [PMID: 32308335 PMCID: PMC7150560 DOI: 10.4103/ccd.ccd_720_18] [Citation(s) in RCA: 5] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/04/2022] Open
Abstract
Surgically Facilitated Orthodontic Therapy (SFOT) in combination with bone augmentation and the placement of anchorage devices installed into bone have been used to accelerate and facilitate orthodontic treatment. This is usually performed after flap surgery, which is associated with moderate morbidity, as well as possible negative sequale such as gingival recession. The present case report illustrates the clinical benefits of vestibular incision subperiosteal tunnel access (VISTA) for SFOT, and tissue augmentation to facilitate orthodontic therapy. VISTA entails making vertical incision(s) in the vestibule followed by subperiosteal elevation of tunnels to provide direct access to the facial alveolar bone. Unlike previously reported vestibular access surgical procedures, VISTA allows for wider elevation of an access tunnel for clear visual and surgical access to perform careful inter-radicular corticotomy. The present report describes VISTA for corticotomy surgery (anterior mandible and maxillary teeth) in combination with the placement of titanium fixation devices and bone augmentation to facilitate orthodontic treatment of an adult female with borderline Class II Division 1 malocclusion, with excessive overjet and deepbite. In view of the fact that VISTA does not require surface incisions in the gingival margins or papillae, it potentially minimizes gingival recession that sometimes accompanies flap surgery.
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Affiliation(s)
- Homayoun H Zadeh
- VISTA Institute for Therapeutic Innovations, Woodland Hills, CA, USA
| | - Ali Borzabadi-Farahani
- Department of Clinical Sciences and Translational Medicine, University of Rome, Rome, Italy.,Department of Orthodontics, Finchley Orthodontics, North Finchley, London, UK
| | - Mehdi Fotovat
- Private Practice Limited to Orthodontics, Valley Village, CA, USA
| | - Seong-Hun Kim
- Department of Orthodontics, Graduate School, Kyung Hee University, Seoul, Korea
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Omidkhoda M, Radvar M, Azizi M, Dehghani M. Evaluating the Efficacy of a Modified Piezo-Puncture Method on the Rate of Tooth Movement in Orthodontic Patients: A Clinical Study. Turk J Orthod 2020; 33:13-20. [PMID: 32284894 DOI: 10.5152/turkjorthod.2020.19013] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/05/2019] [Accepted: 10/01/2019] [Indexed: 12/24/2022]
Abstract
Objective Owing to the increasing demand from orthodontic patients for a more rapid treatment, many studies have focused on accelerated tooth movement. Currently, one of the prevalent methods to achieve accelerated tooth movement is piezo-puncture. The aim of the present study was to evaluate the effect of a modified piezo-puncture method on tooth movement rate and type during canine retraction. Methods A total of 17 patients who required fixed orthodontic treatment with extraction of the maxillary first premolars were included in the study. Following a split-mouth design, upper canines were retracted with Ni-Ti coil spring that applied 150 g of force on each side (piezo-puncture on one side and contralateral side served as the control). Then, the rates of tooth movement, canine angulation and rotation, and anchorage loss were evaluated at T0 (before the intervention), T1 (1 month after the intervention), and T2 (2 months after the intervention). For calculating the canine movement rate, either the distance between the canine and the lateral incisor or the space between the second premolar and the canine was measured. In addition, pain perception was documented by Visual Analog Scale. Data were analyzed using the Kolmogorov-Smirnov normality test, Spearman correlation test, paired sample t-test, and Wilcoxon signed-rank test. Results No significant acceleration was observed in canine movement, canine tipping, rotation, or anchorage loss of molar in different times. Conclusion Considering the limitations of the study, the application of piezo-puncture employing the protocol used in the present study failed to accelerate tooth movement and to decrease the unfavorable tipping, rotation, and molar anchorage loss.
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Affiliation(s)
- Maryam Omidkhoda
- Dental Materials Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.,Department of Orthodontics, Mashhad University of Medical Sciences School of Dentistry, Mashhad, Iran
| | - Mehrdad Radvar
- Dental Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.,Department of Periodontics, Mashhad University of Medical Sciences School of Dentistry, Mashhad, Iran
| | - Majid Azizi
- Department of Orthodontics, Birjand University of Medical Sciences School of Dentistry, Birjand, Iran
| | - Mahboobe Dehghani
- Dental Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.,Department of Orthodontics, Mashhad University of Medical Sciences School of Dentistry, Mashhad, Iran
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Fu T, Liu S, Zhao H, Cao M, Zhang R. Effectiveness and Safety of Minimally Invasive Orthodontic Tooth Movement Acceleration: A Systematic Review and Meta-analysis. J Dent Res 2019; 98:1469-1479. [DOI: 10.1177/0022034519878412] [Citation(s) in RCA: 32] [Impact Index Per Article: 5.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/06/2023] Open
Abstract
Doctors and patients attempt to accelerate orthodontic tooth movement with a minimally invasive surgery approach. The purpose of this systematic review was to evaluate the evidence of accelerated tooth movement in minimally invasive surgery and the adverse effects from it. A systematic search of the literature was performed in the electronic databases of PubMed, CENTRAL (Cochrane Central Register of Controlled Trials), Embase, Scopus, Web of Science, Science Direct, and Medline and was complemented by a manual search until February 2019. The inclusion criteria were prospective clinical studies of patients treated with a fixed appliance, and the intervention was accelerated orthodontic treatment with minimally invasive surgery. Nineteen articles (538 participants) were included in the review: 9 studies assessed the rate of upper canine movement; 5 considered the treatment time; 1 evaluated the en masse retraction time; and 4 studied adverse effects. We performed a meta-analysis for the rate of canine movement and treatment time and described the results for the adverse effects in a systematic review. The results of the subgroup analysis according to micro-osteoperforation and piezocision were included in the study. No accelerated tooth movement was found in the micro-osteoperforation group. After flapless corticotomy procedures, increased tooth movement rates were identified by weighted mean differences of 0.63 (95%CI = 0.22, 1.03, P = 0.003) and 0.64 (95% CI, −25 to 1.53; P = 0.16) for 1 and 2 mo, respectively. The mean treatment time was 68.42 d (95% CI, −113.19 to −23.65; P = 0.003) less that than for minimally invasive surgery. Moreover, no significant adverse effect was found. Because of the high heterogeneity of the meta-analysis, the results must be validated by additional large-sample multicenter clinical trials. There is not sufficient evidence to support that the single use of micro-osteoperforation could accelerate tooth movement, and there is only low-quality evidence to prove that flapless corticotomy could accelerate tooth movement.
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Affiliation(s)
- T. Fu
- State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Stomatology, Department of Orthodontics, School of Stomatology, The Fourth Military Medical University, Xi’an, China
| | - S. Liu
- State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Stomatology, Department of Orthodontics, School of Stomatology, The Fourth Military Medical University, Xi’an, China
| | - H. Zhao
- State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Stomatology, Department of Orthodontics, School of Stomatology, The Fourth Military Medical University, Xi’an, China
| | - M. Cao
- State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Stomatology, Department of Orthodontics, School of Stomatology, The Fourth Military Medical University, Xi’an, China
| | - R. Zhang
- State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Stomatology, Department of Orthodontics, School of Stomatology, The Fourth Military Medical University, Xi’an, China
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Ahuja S, Gupta S, Bhambri E, Jaura B, Ahuja V. Comparative Evaluation of Effects of Different Corticotomy Designs on Velocity of Upper Canine Retraction: A Finite Element Study. JOURNAL OF INDIAN ORTHODONTIC SOCIETY 2019. [DOI: 10.1177/0301574219883703] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/16/2022] Open
Abstract
Purpose: Understanding the effects of different corticotomy designs on the velocity of maxillary canine retraction. Materials and Method: The 3-dimensional model of maxillary dentition was constructed and 3 corticotomy designs were compared with the conventional approach of canine retraction. 4 models were constructed for the present study: 1 with no corticotomy cuts (model 1), 1 with vertical cuts on both buccal and palatal side (model 2), other with cuts only on buccal side (model 3), and 1 with circular holes (model 4). Stress intensity and force distribution were evaluated after applying 150 gm of orthodontic forces on maxillary canine. Results: Models with corticotomy approaches exhibited approximately twice the displacement when compared with conventional noncorticotomy procedure. The stresses were mainly concentrated on the distal side of the canine in all the models. The rate of canine retraction was the highest in model with buccal and palatal corticotomy compared to other designs. Conclusions: Corticotomies help orthodontists to alter the biomechanical responses of dentoalveolar structures during maxillary canine retraction and accelerate tooth movement. Clinically, buccal corticotomy is a better choice for the patients as it is less traumatic and more acceptable to patients.
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Affiliation(s)
- Sachin Ahuja
- Department of orthodontics, Surendera Dental College and Research Institute, Sri Ganganagar, Rajasthan, India
| | - Seema Gupta
- Department of orthodontics, Surendera Dental College and Research Institute, Sri Ganganagar, Rajasthan, India
| | - Eenal Bhambri
- Department of orthodontics, Surendera Dental College and Research Institute, Sri Ganganagar, Rajasthan, India
| | - Baljinder Jaura
- Department of orthodontics, Surendera Dental College and Research Institute, Sri Ganganagar, Rajasthan, India
| | - Varun Ahuja
- Department of orthodontics, Surendera Dental College and Research Institute, Sri Ganganagar, Rajasthan, India
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Evaluation of Vestibular Bone Thickness in Class I Malocclusion Treatment With Corticotomy-Assisted Rapid Orthodontics. J Craniofac Surg 2019; 30:e727-e733. [PMID: 31306374 DOI: 10.1097/scs.0000000000005736] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/26/2022] Open
Abstract
BACKGROUND Corticotomy-assisted rapid orthodontics is a widely used method for speeding up conventional orthodontics. This study (i) evaluates the effects of corticotomy alone, corticotomy combined with bone graft, and corticotomy with platelet-rich fibrin (PRF) on vestibular alveolar bone thickness in patients with class I malocclusion; (ii) compares the treatment time with a conventional orthodontic therapy group, and (iii) investigates the periodontal health of patients who have undergone corticotomy-assisted rapid orthodontics. METHODS The patients were divided into 3 groups: Group 1 (n = 10) underwent corticotomy alone; Group 2 (n = 10) underwent corticotomy combined with bone graft, and Group 3 (n = 10) underwent corticotomy combined with PRF. In the following stage, vestibular alveolar bone thicknesses were evaluated using 3-dimensional cone-beam computed tomography images. RESULTS The findings showed that Group 2 achieved a more significant augmentation of the vestibular alveolar bone than Groups 1 and 3 (P = 0.001, P = 0.003), while corticotomy-assisted rapid orthodontics decreased treatment times. Sufficient alveolar bone thickness and preservation of the periodontal health were achieved when the corticotomy procedure was either combined with a bone graft or with PRF in the Class-I malocclusion patients. CONCLUSION Bone grafts provided better bone thickness at the buccal surface of the anterior teeth of the mandible and maxilla, whereas the thickness of the keratinized gingiva was better with PRF.
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Abstract
Orthodontic and surgical techniques are constantly evolving and practitioners are facing an increasing demand for shorter treatments, with an expectation of results equivalent to conventional treatments. Corticotomies have made it possible to partly meet this need by facilitating dental movement in adult orthodontic care. Many surgical corticotomy techniques were proposed in the past presenting advantages but also a certain number of disadvantages. After retracing the various surgical techniques proposed and explaining the biological principles, we will introduce a new minimally invasive technique, without mucoperiosteal flap and without piezosurgery. This technique can be performed in the dental chair under local anaesthesia or sedation. It is simple and reproducible. This type of treatment combines comfort, speed and periodontal protection. Our objective is to provide more patients and practitioners with corticotomies while controlling the benefit/risk ratio.
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Feller L, Khammissa RAG, Siebold A, Hugo A, Lemmer J. Biological events related to corticotomy-facilitated orthodontics. J Int Med Res 2019; 47:2856-2864. [PMID: 31234667 PMCID: PMC6683901 DOI: 10.1177/0300060519856456] [Citation(s) in RCA: 8] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/27/2022] Open
Abstract
Corticotomy-facilitated orthodontics is a clinical treatment modality comprising the application of conventional orthodontic forces combined with selective decortication of the alveolar process of the bone, which generates a localized process of bone remodeling (turnover) that enables accelerated orthodontic tooth movement. Compared with conventional orthodontic treatment, corticotomy-facilitated orthodontics is associated with reduced treatment time and reduces the frequency of apical external root resorption; however, this modality increases morbidity and financial costs. Although the clinical outcomes of corticotomy-facilitated orthodontics appear favorable, no results of evidence-based investigations of long-term outcomes are available in the literature, and the long-term effects of corticotomy-facilitated orthodontics on the teeth and periodontium are unclear. This narrative review discusses the biological events associated with corticotomy-facilitated orthodontics. Authoritative articles found in relevant databases were critically analyzed and the findings were integrated and incorporated in the text.
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Affiliation(s)
- Liviu Feller
- 1 Department of Periodontology and Oral Medicine, Sefako Makgatho Health Sciences University, Pretoria, South Africa
| | - Razia A G Khammissa
- 1 Department of Periodontology and Oral Medicine, Sefako Makgatho Health Sciences University, Pretoria, South Africa
| | - Andreas Siebold
- 1 Department of Periodontology and Oral Medicine, Sefako Makgatho Health Sciences University, Pretoria, South Africa
| | - Andre Hugo
- 2 Private practice, Johannesburg, South Africa
| | - Johan Lemmer
- 1 Department of Periodontology and Oral Medicine, Sefako Makgatho Health Sciences University, Pretoria, South Africa
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van Gemert LN, Campbell PM, Opperman LA, Buschang PH. Localizing the osseous boundaries of micro-osteoperforations. Am J Orthod Dentofacial Orthop 2019; 155:779-790. [PMID: 31153498 DOI: 10.1016/j.ajodo.2018.07.022] [Citation(s) in RCA: 7] [Impact Index Per Article: 1.2] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/01/2017] [Revised: 07/01/2018] [Accepted: 07/01/2018] [Indexed: 12/23/2022]
Abstract
INTRODUCTION The aim of this work was to determine how far the effects of micro-osteoperforations (MOPs) extend within bone by quantifying the damage caused and the short-term bony adaptations that occur in and around the injury site. METHODS With the use of a split-mouth design, 34 MOPs (Propel) were randomly placed in the mandibular furcal bone of 13 beagle dogs either 2 or 4 weeks before killing them. The control side received no treatment. Vickers hardness microindentation, microscopic computed tomography, and histologic analyses were performed to evaluate the bone surrounding the MOPs. RESULTS Microfractures produced during insertion extended ∼0.6 mm from the MOP sites. Cortical and trabecular bone were significantly less dense on the experimental than on the control side up to 4.2 mm from the edge of the MOP, but side differences were small (<5%) beyond 1.5 mm from the MOP. Experimental cortical bone was significantly softer than the control bone up to 0.8 mm from the MOP after 2 weeks of healing, and up to 0.5 mm from the MOP after 4 weeks of healing. Hematoxylin and eosin stained sections of cortical and trabecular bone showed small areas of woven bone within the MOP sites after 2 weeks, and acellular areas of bone extending ∼0.5 mm from the MOP. After 4 weeks of healing, there were greater amounts of woven bone, as well as early signs of lamellar bone, in and around the MOP sites. Markedly increased TRAP activity extending up to 2.5 mm from the MOP was evident after 2 weeks, but not after 4 weeks. Vital fluorescence staining showed diffuse bone deposition on the experimental side up to 1.5 mm from the MOP margin. CONCLUSIONS When MOPs are performed in beagle dogs, demineralization is transient and healing of the injured area, as well as remineralization of bone affected by MOP placement, begins during the first 2 weeks. Although the transient effects extend farther, the principal effects extend only ∼1.5 mm from the MOP site.
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Affiliation(s)
| | - Phillip M Campbell
- Department of Orthodontics, Texas A&M University College of Dentistry, Dallas, Tex
| | - Lynne A Opperman
- Department of Biomedical Sciences, Texas A&M University College of Dentistry, Dallas, Tex
| | - Peter H Buschang
- Department of Orthodontics, Texas A&M University College of Dentistry, Dallas, Tex.
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Histological evaluation of combined platelet-rich fibrin membrane and piezo-incision application in orthodontic tooth movement. Int J Oral Maxillofac Surg 2019; 48:1380-1385. [PMID: 31053517 DOI: 10.1016/j.ijom.2019.04.001] [Citation(s) in RCA: 7] [Impact Index Per Article: 1.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/21/2018] [Revised: 02/11/2019] [Accepted: 04/03/2019] [Indexed: 12/25/2022]
Abstract
The aim of this study was to evaluate the effect of platelet-rich fibrin (PRF) membrane on tooth movement in comparison with shunt control and piezoelectric surgery. Sixteen White Vienna rabbits were included in the study and divided into two groups. Reciprocal forces (20 g) were applied on the maxillary incisors by an orthodontic appliance. In group 1, PRF membrane was placed sub-periosteally on the distal alveolar bone surface of the right central incisors and the left side was kept as control. In group 2, piezo-incisions 3 mm in depth were performed and combined with PRF membrane on the distal alveolar bone surface of the right central incisors, while the left side was kept as control. All rabbits were euthanized on day 21 and bilateral alveolar bone segments from the distal regions were removed for histological evaluation. Isolated PRF membrane application increased the blood vessel (8.3 ± 1.0; P = 0.026), osteoblast (6 ± 0.8; P = 0.027), and osteoclast (2.3 ± 0.8; P = 0.026) counts significantly compared to shunt control. Combined application of PRF membrane + piezo-incision increased the blood vessel (15.3 ± 0.8; P = 0.027), osteoblast (9.8 ± 1.4; P = 0.026), and osteoclast (3.3 ± 0.8; P = 0.024) counts significantly compared to shunt control. The increases in blood vessel count and osteoblast cell count were more evident in the combined application group (both P = 0.002). PRF membrane application significantly increased bone turnover, and the combined application of PRF membrane + piezo-incision was found to be the best method for increasing bone turnover.
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Gibreal O, Hajeer MY, Brad B. Evaluation of the levels of pain and discomfort of piezocision-assisted flapless corticotomy when treating severely crowded lower anterior teeth: a single-center, randomized controlled clinical trial. BMC Oral Health 2019; 19:57. [PMID: 30991984 PMCID: PMC6469154 DOI: 10.1186/s12903-019-0758-9] [Citation(s) in RCA: 22] [Impact Index Per Article: 3.7] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/06/2019] [Accepted: 04/03/2019] [Indexed: 11/21/2022] Open
Abstract
Background No randomized controlled trial (RCT) has compared flapless piezocision-assisted corticotomy in the extraction-based orthodontic decrowding of lower anterior teeth with the conventional treatment in terms of pain, discomfort and acceptability. Therefore, the aim of this trial was to compare piezocision-based orthodontic decrowding of lower anterior teeth following premolar-extraction with the conventional orthodontic treatment regarding levels of pain, discomfort, and patients’ satisfaction. Methods A parallel-group RCT was conducted on 34 patients with severely crowded lower anterior teeth. Subjects were randomly allocated to either the experimental (ExpG) or the control group. Piezoelectric corticotomies were performed on the labial surfaces of the alveolar bone in the anterior region in the ExpG. Levels of pain, discomfort, swelling, difficulties of mastication, swallowing and jaws movement limitation were recorded on a Visual Analog Scale (VAS) at 1, 7, 14 and 28 days. In the ExpG, patients were also asked to rate their level of satisfaction following acceleration. Two-sample t tests were employed to detect significant differences. Results No statistically significant differences were found between the two groups at one day following treatment commencement regarding pain, discomfort, difficulties of mastication, swallowing and limitation in jaws movement (P = 0.082, 0.367, 0.062, 0.446, 0.359; respectively). However, a statistically significant difference was found between the two groups regarding the perception of swelling at the first-day assessment (P = 0.011). No statistically significant differences were detected between the two groups at 7 days regarding the five previously mentioned variables. There was a drop down to zero level at two weeks and four weeks following treatment onset for all variables. The level of satisfaction in the ExpG had a mean value of 86.47 (±22.47) and all patients were positive towards recommending the surgical intervention to a friend. Conclusions No significant differences in the levels of pain and discomfort were found between the ExpG and the control group for all variables except for the perception of swelling at one day following intervention. Patient-centered outcomes revealed a high level of acceptance and satisfaction with this technique. Trial registration This trial was registered at Clinical Trials.gov (Identifier NCT02975765). Electronic supplementary material The online version of this article (10.1186/s12903-019-0758-9) contains supplementary material, which is available to authorized users.
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Affiliation(s)
- Omar Gibreal
- Oral and Maxillofacial Surgery Department, University of Damascus Dental School, Damascus, Syria
| | - Mohammad Y Hajeer
- Department of Orthodontics, University of Damascus Dental School, Damascus, Syria.
| | - Bassel Brad
- Department of Oral and Maxillofacial Surgery, University of Damascus Dental School, Damascus, Syria
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Charavet C, Lecloux G, Jackers N, Maes N, Lambert F. Patient-reported outcomes measures (PROMs) following a piezocision-assisted versus conventional orthodontic treatments: a randomized controlled trial in adults. Clin Oral Investig 2019; 23:4355-4363. [DOI: 10.1007/s00784-019-02887-z] [Citation(s) in RCA: 14] [Impact Index Per Article: 2.3] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/28/2018] [Accepted: 03/27/2019] [Indexed: 12/16/2022]
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Tsuka Y, Kunimatsu R, Gunji H, Nakajima K, Hiraki T, Nakatani A, Tanimoto K. Molecular biological and histological effects of Er:YAG laser irradiation on tooth movement. J Oral Sci 2019; 61:67-72. [PMID: 30713264 DOI: 10.2334/josnusd.17-0472] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/01/2022]
Abstract
The aim of this study was to evaluate the effects of a fiberotomy-like procedure using Er:YAG laser irradiation on the velocity of orthodontic tooth movement. To produce experimental tooth movement in rats, orthodontic force was applied to the upper first molars with a nickel-titanium closed coil. The right molars were irradiated with an Er:YAG laser while the non-irradiated left molars were used as controls. The rats were sacrificed at 4 weeks after the start of tooth movement and the distance between the mesial side of the second molar and the distal side of the upper first molar was measured on CT images. The amount of tooth movement was significantly greater in the irradiation group than in the control group. The TRAP-positive nuclei count at the pressure site was higher in the laser-irradiation group than in the control group. Expression of RANKL and ALP was higher at the mesial-coronal pressure site in the laser-irradiation group than in the control group. In addition, expression of OPG was higher at the pressure site in the control group than in the laser-irradiation group. These results suggest that a fiberotomy-like procedure using an Er:YAG laser stimulates osteoclasts and osteoblasts and may promote bone metabolism in the context of experimental tooth movement.
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Affiliation(s)
- Yuji Tsuka
- Department of Orthodontics, Division of Oral Health and Development, Hiroshima University Hospital
| | - Ryo Kunimatsu
- Department of Orthodontics, Division of Oral Health and Development, Hiroshima University Hospital
| | - Hidemi Gunji
- Department of Orthodontics, Division of Oral Health and Development, Hiroshima University Hospital
| | - Kengo Nakajima
- Department of Orthodontics, Division of Oral Health and Development, Hiroshima University Hospital
| | - Tomoka Hiraki
- Department of Orthodontics, Applied Life Sciences, Hiroshima University Institute of Biomedical & Health Sciences
| | - Ayaka Nakatani
- Department of Orthodontics, Applied Life Sciences, Hiroshima University Institute of Biomedical & Health Sciences
| | - Kotaro Tanimoto
- Department of Orthodontics, Division of Oral Health and Development, Hiroshima University Hospital
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