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Iyer V, de Kroon MLA, Klaver CCW, Reijneveld SA. Preterm-born children, screen time, and spectacle wear in the Longitudinal Preterm Outcome Project: a cohort study. Front Pediatr 2025; 13:1514413. [PMID: 40017711 PMCID: PMC11865031 DOI: 10.3389/fped.2025.1514413] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/20/2024] [Accepted: 01/27/2025] [Indexed: 03/01/2025] Open
Abstract
Introduction Preterm born children are at a higher risk for refractive errors. A long duration of screen time and activities with short working distance (≤30 cm) may further add to the increased risk. The aim of this study was to assess the separate and combined effects of preterm birth and screen time on spectacle wear among 5-year-olds and adolescents. Methods We analyzed data from the community-based preterm cohort study, part of the Longitudinal Preterm Outcome Project (LOLLIPOP). Early preterm-born (EP < 32 weeks), moderately-late preterm-born (MLP 32-36 weeks) and full-term born (FT 38-42 weeks) children were followed. Spectacle wear and screen time were assessed by questionnaire at the age of 5 (n = 1,515) and at adolescence, ages 13-16, for a subsample (n = 227). Results At age 5, the prevalences of spectacle wear were 7.8%, 7.6% and 3.2%, for EP, MLP, and FT children, respectively (p = 0.007); the risk of spectacle wear decreased by 7% for each additional week of gestational age. In adolescence, prevalences were 36.6%, 20.8% and 22.4%, for EP, MLP, and FT children, respectively (p = 0.12). We found no relationship between screen-time and spectacle wear or a combined effect with preterm birth at age 5 or adolescence. Conclusions EP and MLP children have a significantly increased risk of spectacle wear at age 5, but not significantly at adolescence. At that age, the prevalences of spectacle wear were generally higher. We found no evidence for an association of screen time preterm birth with spectacle wear, and neither an impact of screentime on such an association.
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Affiliation(s)
- V. Iyer
- Department of Health Sciences, University Medical Center Groningen, Groningen, Netherlands
- Department of Child Health, TNO, Leiden, Netherlands
| | - M. L. A. de Kroon
- Department of Health Sciences, University Medical Center Groningen, Groningen, Netherlands
- Department of Public Health and Primary Care, Centre Environment & Health, KU Leuven, Leuven, Belgium
| | - C. C. W. Klaver
- Department of Ophthalmology, Erasmus Medical Center, Rotterdam, Netherlands
- Department of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands
- Department of Ophthalmology, Radboud University Medical Center, Nijmegen, Netherlands
- Institute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland
| | - S. A. Reijneveld
- Department of Health Sciences, University Medical Center Groningen, Groningen, Netherlands
- Department of Child Health, TNO, Leiden, Netherlands
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Morkuniene R, Levuliene R, Gegzna V, Jakimaviciene EM, Tutkuviene J. Surviving prematurity: retrospective longitudinal study of multisystem consequences in preterm-born individuals from infancy to adolescence. BMC Pediatr 2025; 25:46. [PMID: 39827142 PMCID: PMC11742796 DOI: 10.1186/s12887-025-05393-2] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/13/2024] [Accepted: 01/03/2025] [Indexed: 01/22/2025] Open
Abstract
BACKGROUND Prematurity is linked to diverse and significant health outcomes, but a comprehensive understanding of its long-term multisystem impacts remains limited. METHODS Retrospective longitudinal cohort study on 417 preterm children born between 2000 and 2015 explores the incidence, dynamics, and interrelationships of health conditions from infancy to adolescence. Data on 1818 diagnoses, categorised by birth weight (BW) and gestational age (GA) and documented according to ICD-10, were analysed using non-parametric tests and negative binomial regression models. RESULTS Most diagnoses occurred by age 7, with eye diseases, congenital malformations, and infections most prevalent, but the greatest disparities with the general population were in blood, nervous system, mental, and neoplastic diseases. Lower BW significantly correlated with higher mean disease counts and greater diversity of health conditions across various ICD-10 chapters, while GA showed less pronounced associations. Children in "Extremely and very low," "Low," and "Sub-optimal" BW categories exhibited 1.77, 1.50, and 1.34 times more diseases, respectively, than those in the "Normal" BW category. Unique and highly individual patterns of disease co-occurrence were observed, increasing in complexity as BW decreased. CONCLUSIONS The highest disease burden for preterm-born individuals occurred by age 7, with lower BW linked to greater health complexity and unique comorbidities.
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Affiliation(s)
- Ruta Morkuniene
- Department of Anatomy, Histology and Anthropology, Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University, Ciurlionio Str. 21, Vilnius, 03101, Lithuania
| | - Ruta Levuliene
- Institute of Applied Mathematics, Vilnius University, Vilnius, Lithuania
| | - Vilmantas Gegzna
- Institute of Biosciences, Life Sciences Center, Vilnius University, Vilnius, Lithuania
| | - Egle Marija Jakimaviciene
- Department of Anatomy, Histology and Anthropology, Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University, Ciurlionio Str. 21, Vilnius, 03101, Lithuania
| | - Janina Tutkuviene
- Department of Anatomy, Histology and Anthropology, Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University, Ciurlionio Str. 21, Vilnius, 03101, Lithuania.
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Marinov VG, Sivkova NP, Krasteva MB, Simitchiev KK. Visual and refractive outcome after 12 years of treatment of type 1 prethreshold retinopathy of prematurity. Folia Med (Plovdiv) 2024; 66:645-652. [PMID: 39512032 DOI: 10.3897/folmed.66.e133949] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/05/2024] [Accepted: 10/14/2024] [Indexed: 11/15/2024] Open
Abstract
AIM In this study, the best corrected visual acuity (BCVA) and refraction in preterm-born infants in South-Eastern Bulgaria after 12 years of treatment for type 1 prethreshold retinopathy of prematurity were presented, and the outcomes of laser treatment and cryotherapy were compared.
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Musa M, Enaholo E, Bale BI, Salati C, Spadea L, Zeppieri M. Retinoscopes: Past and present. World J Methodol 2024; 14:91497. [PMID: 39310243 PMCID: PMC11230066 DOI: 10.5662/wjm.v14.i3.91497] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 12/29/2023] [Revised: 05/14/2024] [Accepted: 05/29/2024] [Indexed: 06/25/2024] Open
Abstract
BACKGROUND Retinoscopy is arguably the most important method in the eye clinic for diagnosing and managing refractive errors. Advantages of retinoscopy include its non-invasive nature, ability to assess patients of all ages, and usefulness in patients with limited cooperation or communication skills. AIM To discuss the history of retinoscopes and examine current literature on the subject. METHODS A search was conducted on the PubMed and with the reference citation analysis (https://www.referencecitationanalysis.com) database using the term "Retinoscopy," with a range restricted to the last 10 years (2013-2023). The search string algorithm was: "Retinoscopy" (MeSH Terms) OR "Retinoscopy" (All Fields) OR "Retinoscopes" (All Fields) AND [(All Fields) AND 2013: 2023 (pdat)]. RESULTS This systematic review included a total of 286 records. Publications reviewed iterations of the retinoscope into autorefractors, infrared photo retinoscope, television retinoscopy, and the Wifi enabled digital retinoscope. CONCLUSION The retinoscope has evolved significantly since its discovery, with a significant improvement in its diagnostic capabilities. While it has advantages such as non-invasiveness and broad applicability, limitations exist, and the need for skilled interpretation remains. With ongoing research, including the integration of artificial intelligence, retinoscopy is expected to continue advancing and playing a vital role in eye care.
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Affiliation(s)
- Mutali Musa
- Department of Optometry, University of Benin, Benin 300283, Nigeria
- Department of Ophthalmology, Africa Eye Laser Centre, Benin 300105, Nigeria
| | - Ehimare Enaholo
- Department of Ophthalmology, Africa Eye Laser Centre, Benin 300105, Nigeria
- Department of Ophthalmology, Centre for Sight Africa, Nkpor 434101, Nigeria
| | | | - Carlo Salati
- Department of Ophthalmology, University Hospital of Udine, Udine 33100, Italy
| | - Leopoldo Spadea
- Eye Clinic, Policlinico Umberto I, "Sapienza" University of Rome, Rome 00142, Italy
| | - Marco Zeppieri
- Department of Ophthalmology, University Hospital of Udine, Udine 33100, Italy
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Charpak N, Montealegre-Pomar A. Follow-up of Kangaroo Mother Care programmes in the last 28 years: results from a cohort of 57 154 low-birth-weight infants in Colombia. BMJ Glob Health 2023; 8:e011192. [PMID: 37208122 PMCID: PMC10201238 DOI: 10.1136/bmjgh-2022-011192] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/07/2022] [Accepted: 03/14/2023] [Indexed: 05/21/2023] Open
Abstract
BACKGROUND Kangaroo Mother Care (KMC) is an evidence-based intervention focused on premature and low-birth-weight (LBW) infants. In different healthcare systems, outpatient KMC programmes (KMCPs) have been pioneers in the follow-up of these high-risk newborns.Here, we describe an overview analysis performed in an unprecedented data set comprising Colombian infants and spanning 28 years. METHODS Cohort study of 57 154 infants discharged home in kangaroo position (KP) for follow-up in four KMCPs between 1993 and 2021. RESULTS At birth and at hospital discharge to a KMCP, median gestational age and weight were 34.5 and 36 weeks, 2000 g and 2200 g, respectively. Chronological age at admission was 8 days. Over time, anthropometric measures at birth and somatic growth during follow-up improved; on the other hand, percentages of mechanical ventilation, intraventricular haemorrhage and need for intensive care decreased as neuropsychomotor, sensory disorders and bronchopulmonary dysplasia incidence at 40 weeks. Risk of cerebral palsy and teenage mothers' frequency was higher in the poorest population. Early home discharge in KP in less than 72 hours was possible in 19% of the cohort. During the COVID-19 pandemic, we observed a more than twofold increase in exclusive breast feeding at 6 months and a reduction in readmission rates. CONCLUSION This study provides a general overview of KMCPs follow-up during the last 28 years within the Colombian healthcare system. These descriptive analyses have allowed us to structure KMC as an evidence-based method. KMCPs allow close monitoring with regular feedback about preterm or LBW infants' perinatal care, quality of care over time and health status during their first year of life. Monitoring these outcomes is challenging but guarantees access to high-risk infants' care with equity.
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Affiliation(s)
| | - Adriana Montealegre-Pomar
- Research Group, Kangaroo Foundation, Bogota DC, Colombia
- Facultad de Medicina, Departamento de Pediatría, Pontificia Universidad Javeriana, Bogota, Colombia
- Neonatal Unit, Hospital Universitario San Ignacio, Bogota, Colombia
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Cheng H, Cao D, Qian J, Gu W, Zheng Z, Ma M. Refractive status and retinal morphology in children with a history of intravitreal ranibizumab for retinopathy of prematurity. Eur J Pediatr 2023:10.1007/s00431-023-04965-7. [PMID: 37097446 DOI: 10.1007/s00431-023-04965-7] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/10/2022] [Revised: 03/20/2023] [Accepted: 03/30/2023] [Indexed: 04/26/2023]
Abstract
This study investigated the characteristics of refractive status, visual acuity, and retinal morphology in children with a history of receiving intravitreal ranibizumab for retinopathy of prematurity (ROP). Children 4-6 years of age were enrolled and divided into the following four groups: group 1, children with a history of ROP who had been treated with intravitreal ranibizumab; group 2, children with a history of ROP who had not received any treatment; group 3, premature children without ROP; and group 4, full-term children. Refractive status, peripapillary retinal nerve fiber layer (RNFL), and macular thickness were measured. A total of 204 children were enrolled. In group 1, myopic shift was not noted, but poorer best corrected visual acuity (BCVA) and shorter axial length were observed. Significantly lower peripapillary RNFL thickness in the average total and superior quadrant, higher central subfield thickness, lower parafoveal retinal thickness in average total, superior, and nasal and temporal quadrants were observed in group 1 than in the other groups. The poor BCVA in patients with ROP was correlated with the lower RNFL thickness in the superior quadrant. Conclusion: Children with a history of type 1 ROP treated with ranibizumab did not show a myopic shift but did show abnormal retinal morphology and the poorest BCVA among all groups. We suggest that pediatric ophthalmologists should always pay attention to visual development in patients with ROP with a history of intravitreal ranibizumab. What is Known: • Anti-VEGF is efficiently and widely used in the treatment of type 1 retinopathy of prematurity (ROP), and different anti-VEGF agents are associated with different prevalence of myopia. • Patients with ROP who receive treatment such as laser therapy or cryotherapy have abnormal macular development and retinal nerve fiber layer (RNFL) thickness. What is New: • Children with a history of ROP treated with intravitreal ranibizumab did not show a myopic shift but did show poor BCVA at 4-6 years of age. • Abnormal macular morphology and lower peripapillary RNFL thickness were found in these children.
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Affiliation(s)
- Haixia Cheng
- Department of Ophthalmology, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
- Department of Ophthalmology, Shanghai General Hospital of Nanjing Medical University, Shanghai, China
| | - Di Cao
- Department of Ophthalmology, Shanghai General Hospital of Nanjing Medical University, Shanghai, China
- Department of Ophthalmology, Wuxi Maternity and Child Health Care Hospital, Women's Hospital of Jiangnan University, Jiangnan University, Wuxi, Jiangsu, China
| | - Jing Qian
- Department of Ophthalmology, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
| | - Wei Gu
- Department of Quality Management, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
| | - Zhi Zheng
- Department of Ophthalmology, Shanghai General Hospital of Nanjing Medical University, Shanghai, China.
- Department of Ophthalmology, Shanghai General Hospital; National Clinical Research Center for Eye Diseases; Shanghai Key Laboratory of Ocular Fundus Diseases; Shanghai Engineering Center for Visual Science and Photomedicine; Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, No. 85, Wujin Road, Hongkou District, Shanghai, China.
| | - Mingming Ma
- Department of Ophthalmology, Shanghai General Hospital; National Clinical Research Center for Eye Diseases; Shanghai Key Laboratory of Ocular Fundus Diseases; Shanghai Engineering Center for Visual Science and Photomedicine; Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, No. 85, Wujin Road, Hongkou District, Shanghai, China.
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Chou YB, Wang AG, Yang HY, Chen KJ, Yang CS. Refractive status, biometric components, and functional outcomes of patients with threshold retinopathy of prematurity: systemic review and a 17-year longitudinal study. Graefes Arch Clin Exp Ophthalmol 2022; 260:3809-3816. [PMID: 35729410 DOI: 10.1007/s00417-022-05730-6] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/04/2022] [Revised: 05/01/2022] [Accepted: 06/07/2022] [Indexed: 11/26/2022] Open
Abstract
OBJECTIVE To assess the long-term refractive status, visual outcome, astigmatism, and the change in biometric optic components in older adolescents up to age 17 years with threshold retinopathy of prematurity (ROP) treated with diode laser. METHODS A retrospective, longitudinal study in which cycloplegic refraction, keratometry, and the biometric measurement of optic components were performed on 28 consecutive preterm eyes with laser-treated threshold ROP at age 17 years. The study results were statistically analysed and compared with age-matched full-term control. RESULTS All patients with ROP had myopia (average spherical equivalent of - 6.35 D, ranges from - 1.25 to - 12.38 D), and 12 eyes (43%) were highly myopic (spherical equivalent < - 6.0 D). Threshold ROP eyes exhibited a significantly poorer visual acuity (P < 0.001), greater cylinder refractive error (P < 0.001), higher corneal astigmatism (P < 0.001), and flatter horizontal corneal curvature (P = 0.01) compared with age-matched controls. Biometric optic components analysis revealed a significant shallower anterior chamber depth (P < 0.001), thicker lens (P < 0.001), and shorter axial length (P = 0.021) in laser-treated ROP eyes compared with age-matched controls. CONCLUSIONS In this 17-year longitudinal study, a higher prevalence of myopia and astigmatism was observed in laser-treated threshold ROP eyes compared with age-matched control eyes. Myopia and astigmatism in laser-treated ROP eyes typically progress through adolescence after school age. Therefore, we recommend that preterm patients with laser-treated threshold ROP should attend regular follow-up not only for refractive status but also for structural change of anterior segment until their adolescence.
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Affiliation(s)
- Yu-Bai Chou
- Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan
- School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
| | - An-Guor Wang
- Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan
- School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
| | - Hsin-Yu Yang
- Department of Ophthalmology, Taipei Veterans General Hospital Yuanshan and Suao Branch, Yilan, Taiwan
| | - Kuan-Jung Chen
- Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan
| | - Chang-Sue Yang
- Department of Ophthalmology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
- Department of Ophthalmology, School of Medicine, Taipei Medical University, Taipei, Taiwan.
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Preterm refraction and ocular biometry in children with and without retinopathy of prematurity in the first year of life. J AAPOS 2021; 25:271.e1-271.e6. [PMID: 34582950 DOI: 10.1016/j.jaapos.2021.05.012] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/29/2021] [Revised: 04/30/2021] [Accepted: 05/02/2021] [Indexed: 11/21/2022]
Abstract
PURPOSE To determine ocular biometric and refractive profiles of premature children at risk of retinopathy of prematurity (ROP), comparing those who did and did not require laser treatment. METHODS In this prospective study, premature infants underwent biometry and refraction with their first ROP examination. Study parameters were assessed again at 3 months, 6 months, and 1 year. The main outcome measures were spherical equivalent, axial length, and keratometry. RESULTS A total of 122 infants (243 eyes) were included. At baseline, infants without ROP, those with ROP who never needed treatment, and those who later needed treatment had overall comparable axial length (P = 0.53) and myopia (P = 0.05); the highest severity group had higher corneal steepness and more myopia at baseline. At 1 year, children with laser-treated ROP had the shortest axial lengths, with the least decrease in keratometry, and the greatest increase in myopia (-2.0 D; P = 0.001). Anisometropia, if present initially, persisted through the 1-year examination. Mean refractive error was more myopic in zone 1 disease (P = 0.3) and in aggressive posterior ROP (P = 0.15). CONCLUSIONS Severe ROP is associated with disruption of emmetropization, and steeper corneas and more myopia at the first ROP examination, before any intervention. In our study cohort, these differences became more marked over the course of 1 year after laser therapy. The myopia in these cases was not axial. Laser therapy did not induce new anisometropia.
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Wang H, Zhang Y, Liu X, Wang Y, Shi J, Yin T, Zhao F, Yang T. The effect of continuous clustered care on the physical growth of preterm infants and the satisfaction with the nursing care. Am J Transl Res 2021; 13:7376-7381. [PMID: 34306508 PMCID: PMC8290826] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/05/2021] [Accepted: 02/09/2021] [Indexed: 06/13/2023]
Abstract
PURPOSE This study aimed to evaluate the effect of continuous clustered care on the physical growth of preterm infants and on the satisfaction with the nursing care. METHODS 120 preterm infants who were admitted to our hospital from Jan 2018 to Dec 2018 were recruited as the study cohort. These infants were randomly divided into a control group (n=60, routine care) and an experimental group (n=60, continuous clustered nursing care). The study compared the parenting skills in the two groups, the infant development at 6 and 12 months, the prevalence of diseases within one year after discharge, and the parents' satisfaction with the nursing care. RESULTS There was no significant difference in the parenting skill levels between the two groups. The body masses, heights, and head circumferences of the infants at 6-months and 12-months in the experimental group were better than they were in the control group. The experimental group's physical and intellectual development were significantly better than the physical and intellectual development in the control group (P<0.05). In the experimental group, the number of cases with infantile respiratory, umbilical, and intestinal infections was lower than it was in the control group. The parental satisfaction level with the nursing care in the experimental group was significantly higher than it was in the control group (96.67% vs 78.33%) (P<0.05). CONCLUSION Continuous clustered nursing care can improve the physical growth of preterm infants, reduce the adverse events and improve the nursing satisfaction level.
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Affiliation(s)
- Hongyan Wang
- Department of NICU, Gansu Provincial Maternal and Child HospitalLanzhou, China
| | - Yu Zhang
- Department of NICU, Gansu Provincial Maternal and Child HospitalLanzhou, China
| | - Xiaoling Liu
- Department of Obstetrics, Gansu Provincial Maternal and Child HospitalLanzhou, China
| | - Youliang Wang
- Department of Pediatric Surgery, Gansu Provincial Maternal and Child HospitalLanzhou, China
| | - Jingyun Shi
- Department of NICU, Gansu Provincial Maternal and Child HospitalLanzhou, China
| | - Tingting Yin
- Department of NSCU, Gansu Provincial Maternal and Child HospitalLanzhou, China
| | - Fangping Zhao
- Department of NICU, Gansu Provincial Maternal and Child HospitalLanzhou, China
| | - Ting Yang
- Department of NSCU, Gansu Provincial Maternal and Child HospitalLanzhou, China
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