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HasanPour V, Farsi A, Aghdaei M, Hutchinson JC. Investigating the Effect of Motivational Music and Video and the Role of Cognitive Style on the Gait Kinematics of Elderly Individuals. Percept Mot Skills 2025:315125251332016. [PMID: 40221911 DOI: 10.1177/00315125251332016] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 04/15/2025]
Abstract
In the present study, we investigated the impact of motivational music and video on gait parameters in older adults with different cognitive styles. Participants (N = 24; M age = 68.83 years, SD = 2.61) were divided into two cognitive style groups: field-dependent and field-independent, based on a hidden figures test. Participants completed a treadmill walking task under three different conditions (motivational music, motivational video, and no intervention). We measured their step width and step length and their hip, knee, and ankle joint angles at heel strike and toe-off. Results showed a significant positive effect of the music condition on step width and stride length and hip joint angle at heel strike, and ankle joint angle at toe-off. There was a significant effect of group (cognitive style) on step width, the angle of the hip joint and the angle of the knee joint at toe-off; however, there was no significant group by condition interaction for any of the assessed variables. Thus, walking with motivational music improved gait parameters in older adults.
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Affiliation(s)
- Vahid HasanPour
- Department of Behavioral and Cognitive Sciences in Sports, Faculty of Sports and Health Sciences, Shahid Beheshti University, Tehran, Iran
| | - Alireza Farsi
- Department of Behavioral and Cognitive Sciences in Sports, Faculty of Sports and Health Sciences, Shahid Beheshti University, Tehran, Iran
| | - Mahin Aghdaei
- Department of Behavioral and Cognitive Sciences in Sports, Faculty of Sports and Health Sciences, Shahid Beheshti University, Tehran, Iran
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Harrison EC, Grossen S, Tueth LE, Haussler AM, Rawson KS, Campbell MC, Earhart GM. Neural mechanisms underlying synchronization of movement to musical cues in Parkinson disease and aging. Front Neurosci 2025; 19:1550802. [PMID: 40134419 PMCID: PMC11933100 DOI: 10.3389/fnins.2025.1550802] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/24/2024] [Accepted: 02/21/2025] [Indexed: 03/27/2025] Open
Abstract
Introduction External and internal musical cues provide therapeutic techniques for gait rehabilitation in aging and neurological disorders. For people with Parkinson disease (PwPD), mental singing is a type of internal cue that can regularize gait timing. No studies to date have directly measured brain activity during external and internal musical cues as used in gait rehabilitation. Evidence suggests the neural mechanisms of external vs. internal cued movement differ. External cues are thought to drive movement via recruitment of cerebello-thalamo-cortical (CTC) pathways, while internal cues are thought to rely more on striato-pallido-thalamocortical (SPT) pathways. Methods We investigated the neural mechanisms that underlie acute responses to external cues (listening to music) and internal cues (mental singing). Using fMRI, we imaged PwPD and age-matched healthy controls (HC) while performing finger tapping during musical cueing tasks. Results No differences were seen between PwPD and HC in any of the comparisons. Functional imaging results showed activation of sensorimotor cortex, temporal gyri, supplementary motor areas, and putamen for both cueing tasks. External cues additionally activated auditory cortex while internal cues additionally activated the cerebellum. When directly comparing cue types, external cues displayed greater activity in the primary auditory cortex and temporal gyri. Discussion These results suggest similar brain regions are activated during musically-cued movements for both PwPD and HC and both cue types utilize parallel pathways for processing. Both cue types may facilitate use of remaining function of areas that degenerate in PD (e.g., putamen) and potentially also activate routes through less impaired areas (e.g., cerebellum). This supports the idea that the CTC and SPT pathways work in tandem and facilitate sensorimotor activity via a complex interplay between neural circuits. These findings have implications for how external and internal cues may be administered in future therapies.
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Affiliation(s)
- Elinor C. Harrison
- Program in Physical Therapy, Washington University in St. Louis School of Medicine, St. Louis, MO, United States
- Performing Arts Department, Washington University in St. Louis, St. Louis, MO, United States
| | - Sarah Grossen
- Department of Neurology, Washington University in St. Louis School of Medicine, St. Louis, MO, United States
| | - Lauren E. Tueth
- Program in Physical Therapy, Washington University in St. Louis School of Medicine, St. Louis, MO, United States
| | - Allison M. Haussler
- Program in Physical Therapy, Washington University in St. Louis School of Medicine, St. Louis, MO, United States
| | - Kerri S. Rawson
- Program in Physical Therapy, Washington University in St. Louis School of Medicine, St. Louis, MO, United States
- Department of Neurology, Washington University in St. Louis School of Medicine, St. Louis, MO, United States
| | - Meghan C. Campbell
- Department of Neurology, Washington University in St. Louis School of Medicine, St. Louis, MO, United States
- Department of Radiology, Washington University in St. Louis School of Medicine, St. Louis, MO, United States
| | - Gammon M. Earhart
- Program in Physical Therapy, Washington University in St. Louis School of Medicine, St. Louis, MO, United States
- Department of Neurology, Washington University in St. Louis School of Medicine, St. Louis, MO, United States
- Department of Radiology, Washington University in St. Louis School of Medicine, St. Louis, MO, United States
- Department of Neuroscience, Washington University in St. Louis School of Medicine, St. Louis, MO, United States
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Strübbe S, Roy S, Sidorenko I, Lampe R. Motor-Sensory Learning in Children with Disabilities: Does Piano Practice Help? CHILDREN (BASEL, SWITZERLAND) 2025; 12:335. [PMID: 40150617 PMCID: PMC11941049 DOI: 10.3390/children12030335] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Received: 01/22/2025] [Revised: 03/04/2025] [Accepted: 03/06/2025] [Indexed: 03/29/2025]
Abstract
Background/Objectives: Patients with physical disabilities, like cerebral palsy, the most common movement disorder in childhood, can benefit from instrumental therapy using piano. Playing the piano promotes the interaction between different brain regions and integrates motor skills, sensory skills, musical hearing, and emotions. A pilot music study examined the effects of six months of piano lessons on hand motor skills and musical hearing in groups of children with motor disabilities. Methods: The allocation to the group was not randomized. Various tests, including the standardized Box and Block Test (BBT) and piano tests, assessed hand motor skills. Musical hearing was evaluated, and a questionnaire was used to determine the participants' enjoyment and experience with the piano lessons. The regularity, tempo of keystrokes, and synchronization between the two hands were assessed and compared to evaluate the effects of six months of piano training. Results: After six months of piano training, statistically significant improvements were observed in the BBT, as well as in the regularity and tempo of the non-dominant hand. The children showed significant improvement in hand-motor control, moving 27.3% more cubes in the BBT. Regularity and tempo in piano playing, especially in the non-dominant hand, also improved. Moreover, 55% of the children better recognized the correct pitches of notes. Conclusions: Thus, this study supports the concept that piano lessons are an effective form of physical therapy for the development of hand motor skills and musical hearing.
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Affiliation(s)
- Simon Strübbe
- Research Unit of the Buhl-Strohmaier Foundation for Cerebral Palsy and Pediatric Neuroorthopaedics, Department of Orthopaedics and Sports Orthopaedics, School of Medicine and Health, TUM University Hospital Rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany; (S.S.); (S.R.); (I.S.)
| | - Susmita Roy
- Research Unit of the Buhl-Strohmaier Foundation for Cerebral Palsy and Pediatric Neuroorthopaedics, Department of Orthopaedics and Sports Orthopaedics, School of Medicine and Health, TUM University Hospital Rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany; (S.S.); (S.R.); (I.S.)
| | - Irina Sidorenko
- Research Unit of the Buhl-Strohmaier Foundation for Cerebral Palsy and Pediatric Neuroorthopaedics, Department of Orthopaedics and Sports Orthopaedics, School of Medicine and Health, TUM University Hospital Rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany; (S.S.); (S.R.); (I.S.)
| | - Renée Lampe
- Research Unit of the Buhl-Strohmaier Foundation for Cerebral Palsy and Pediatric Neuroorthopaedics, Department of Orthopaedics and Sports Orthopaedics, School of Medicine and Health, TUM University Hospital Rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany; (S.S.); (S.R.); (I.S.)
- Markus Würth Professorship, Technical University of Munich, Ismaninger Strasse 22, 81675 Munich, Germany
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Zaferiou A, Hirsch Z, Bacani T, Dahl L. A review of concurrent sonified biofeedback in balance and gait training. J Neuroeng Rehabil 2025; 22:38. [PMID: 40011952 PMCID: PMC11866693 DOI: 10.1186/s12984-025-01565-4] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/26/2024] [Accepted: 01/28/2025] [Indexed: 02/28/2025] Open
Abstract
BACKGROUND Sonified biofeedback is a subtype of auditory biofeedback that conveys biological data through specific non-verbal sounds. It can be designed to provide augmented biomechanical feedback in near-real-time when provided as "concurrent" biofeedback. As a practice that developed spanning across engineering and the arts, sonified biofeedback can extend beyond simple tones and beeps, towards more fully incorporating music in movement training. Sonified biofeedback may leverage the motivational aspects of music in movement training, the neuroplasticity benefits demonstrated from participation in music-based interventions, and neurological auditory-motor coupling, all while providing task-relevant cues to facilitate motor (re)learning. Sonified biofeedback may also provide similar benefits as rhythmic cueing (e.g., rhythmic auditory stimulation), or added benefits because sonified biofeedback does not impose a strict isochronous rhythm when it follows rhythms that are driven by outputs of the motor control system. In this review paper, the unique opportunity presented by concurrent sonified biofeedback as a movement training tool for balance and gait is introduced and discussed. RESULTS AND DISCUSSION This review paper brings together prior research from clinical, engineering, and artistic design sources using sonified biofeedback in balance and gait training across diverse end-users to highlight trends, reveal gaps in knowledge, and provide perspective for future work in the area. The goal was to review progress and critically assess research using sonified biofeedback during movement training for postural control or gait. 49 papers were selected based on their experimental investigation and statistical analyses of the effects of using sonified biofeedback to assist in movement training for feet-in-place balance tasks (20 papers) or gait tasks such as walking and running (29 papers). The sound design choices, experimental design features, and movement training results are summarized and reviewed. All but two studies reported at least one statistically significant positive effect of training with sonified biofeedback in biomechanical, clinical, or psychosocial measures. Conversely, only seven studies shared any negative effect on one biomechanical, clinical, or psychosocial measure (with five of these studies also reporting at least one other positive effect). After describing these encouraging findings, this review closes by sharing perspectives about future directions for designing and using sonified biofeedback in balance and gait training, and opportunities for more cohesive growth in this practice. One such suggestion is to pursue sonified designs and experimental designs that can translate to the neurorehabilitation field. This includes strategically selecting control groups and evaluation tasks to understand if improvements from training with one task transfer to additional relevant movement tasks. Additionally, it is important that future publications share details about the design processes and sound designs so researchers can more readily learn from one another. CONCLUSIONS Overall, this review shares the positive impact of using sonified biofeedback in balance and gait training. This review highlights the evidence of existing successes and potential for even more impactful future positive effects from using sonified biofeedback to help diverse populations with a spectrum of balance and mobility challenges and goals.
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Affiliation(s)
- Antonia Zaferiou
- Musculoskeletal Control and Dynamics Lab, Department of Biomedical Engineering, Stevens Institute of Technology, Hoboken, NJ, USA.
| | - Zahava Hirsch
- Musculoskeletal Control and Dynamics Lab, Department of Biomedical Engineering, Stevens Institute of Technology, Hoboken, NJ, USA
| | - Tristan Bacani
- Musculoskeletal Control and Dynamics Lab, Department of Biomedical Engineering, Stevens Institute of Technology, Hoboken, NJ, USA
| | - Luke Dahl
- McIntire Department of Music, University of Virginia, Charlottesville, VA, USA
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Numata A, Terao Y, Sugawara K, Ugawa Y, Furubayashi T. Differences in the movement phase condition and sensory inputs on temporal synchronization and continuation during bilateral foot-tapping tasks. Front Hum Neurosci 2025; 19:1518230. [PMID: 39949986 PMCID: PMC11821618 DOI: 10.3389/fnhum.2025.1518230] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/28/2024] [Accepted: 01/15/2025] [Indexed: 02/16/2025] Open
Abstract
In the sensorimotor synchronization (synchronized and continuous tapping) task, subjects move their limbs in synchrony with an isochronous tone presented at various tempos and continue tapping at the same pace after the tones have ceased. We investigated the ability of bilateral lower limb motor control for performing this task as a crucial metric for examining motor coordination relevant to human locomotion, such as walking. Here, sensory information such as auditory and tactile inputs is considered to improve the accuracy of sensorimotor synchronization. In this study, we explored the change in tapping variability of rhythmic motor control of the bilateral lower limb with different movement phase conditions in the presence or absence of sensory information. Thirty-three healthy volunteers performed three types of foot-tapping tasks: synchronization-continuation (SC-tap), air-tapping (A-tap), and a combination of both (SCA-tap). Participants were instructed to tap the foot-switch (or perform a similar movement in the A-tap) in synchrony with the tones presented at fixed interstimulus intervals (ISIs) between 500 and 4,800 ms. Taps were performed with either unilateral foot or, in the case of bilateral movements, with both feet, either simultaneously (in-phase) or alternately for bilateral movements (antiphase). The synchronizing tapping error and the inter-tap interval (ITI) were evaluated. The coefficient of variation (CV) of ITI was significantly smaller for the antiphase condition than for the unilateral or in-phase conditions in the SC-tap and SCA-tap tasks. In addition, considering the timing of taps on both sides, the CV was significantly lower for antiphase only in the SC-tap task. The findings indicated that the antiphase condition exhibited superior temporal stability in repetitive lower limb movements. The findings also underscored the significance of tactile feedback from the soles of the feet when stability of rhythmic limb movements unpaced by the tones in antiphase movements was taken into consideration.
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Affiliation(s)
- Atsuki Numata
- Physical Therapy Course, Department of Rehabilitation, Faculty of Medical Science and Welfare, Tohoku Bunka Gakuen University, Sendai, Japan
| | - Yasuo Terao
- Department of Medical Physiology, Faculty of Medicine, Kyorin University, Mitaka, Japan
| | - Kenichi Sugawara
- Graduate Course of Health and Social Services, Kanagawa University of Human Services Graduate School, Yokosuka, Japan
| | - Yoshikazu Ugawa
- Department of Human Neurophysiology, Institute of Brain Medical Sciences, Fukushima Medical University, Fukushima, Japan
| | - Toshiaki Furubayashi
- Graduate School of Health and Environmental Science, Tohoku Bunka Gakuen University, Sendai, Japan
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Huang CW, Tsai HY, Lin YH, Lin WW, Lin CH, Tseng MT. Striatal-cortical dysconnectivity underlies somatosensory deficits in Parkinson's disease: Insights from rhythmic auditory-motor training. Neurobiol Dis 2025; 204:106778. [PMID: 39719198 DOI: 10.1016/j.nbd.2024.106778] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/10/2024] [Revised: 12/06/2024] [Accepted: 12/19/2024] [Indexed: 12/26/2024] Open
Abstract
Evidence indicates that neurodegenerative diseases spread through distinct brain networks. For Parkinson's disease (PD), somatosensory abnormalities may accompany motor dysfunction in early disease stages when dopaminergic degeneration is limited to the basal ganglia. It remains unclear whether, based on the network-spread account, these abnormalities emanated from aberrant functional connectivity with the basal ganglia, and whether interventions normalizing this connectivity could reverse these abnormalities. Here, we employed functional MRI to record brain responses to tactile stimuli in patients with idiopathic PD and healthy controls before and after three-week rhythmic auditory stimulation-assisted gait (RASg) training. Consistent with the presence of striatal degeneration, patients showed right posterior putamen (pPut) hypoactivation when detecting tactile stimuli of their left leg. They also exhibited reduced functional connectivity from the right pPut to the right parietal somatosensory region (inferior parietal lobule, IPL), whose hypoactivation reflected patients' impaired tactile detectability. Importantly, this dysconnectivity predicted right IPL hypoactivation, indicating that pPut-IPL dysconnectivity underlay patients' impaired tactile detectability. Intriguingly, RASg training normalized patients' tactile detectability, which was mirrored by normalization of right IPL activation and pPut-IPL connectivity. Training-induced changes in pPut-IPL connectivity predicted changes in IPL activation during tactile detection, reinforcing the role of pPut-IPL connectivity in patients' tactile detectability. These findings suggest that somatosensory abnormalities in PD may arise from the spread of striatal pathology to relevant cortical regions. Rhythmic auditory-motor training acts to recover striatal connectivity, improving PD patients' somatosensory deficits.
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Affiliation(s)
- Cheng-Wei Huang
- Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei 10048, Taiwan
| | - Hsin-Yun Tsai
- Taiwan International Graduate Program in Interdisciplinary Neuroscience, National Taiwan University and Academia Sinica, Taipei 11574, Taiwan
| | - Yi-Hsuan Lin
- Taiwan International Graduate Program in Interdisciplinary Neuroscience, National Taiwan University and Academia Sinica, Taipei 11574, Taiwan
| | - Wen-Wei Lin
- Graduate Institute of Brain and Mind Sciences, National Taiwan University College of Medicine, Taipei 10051, Taiwan
| | - Chin-Hsien Lin
- Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan; Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
| | - Ming-Tsung Tseng
- Graduate Institute of Brain and Mind Sciences, National Taiwan University College of Medicine, Taipei 10051, Taiwan.
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Impellizzeri F, Maggio MG, De Pasquale P, Bonanno M, Bonanno L, De Luca R, Paladina G, Alibrandi A, Milardi D, Thaut M, Hurt C, Quartarone A, Calabrò RS. Coupling neurologic music therapy with immersive virtual reality to improve executive functions in individuals with Parkinson's disease: A Quasi-Randomized Clinical Trial. Clin Park Relat Disord 2024; 11:100277. [PMID: 39507632 PMCID: PMC11539655 DOI: 10.1016/j.prdoa.2024.100277] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/09/2024] [Revised: 10/09/2024] [Accepted: 10/19/2024] [Indexed: 11/08/2024] Open
Abstract
Introduction Parkinson's disease (PD) is one the most common neurodegenerative movement disorder, leading to motor and non-motor symptoms, including deficits in executive functions (EF), memory, visuospatial abilities, and psychomotor speed. Current treatments are primarily symptomatic, involving pharmacological, surgical strategies. Neurologic Music Therapy (NMT) has gained recognition for its effectiveness in neurorehabilitation of PD patients and improving motor and cognitive domains, such as EF. This study combines NMT with the virtual reality (VR) platform Computer-Assisted Rehabilitation Environment (CAREN), offering customizable environments for rhythmic cue practice to provide an innovative approach to Parkinson's rehabilitation. Methods In our single-blind quasi-randomized controlled trial, forty patients were assigned to either an experimental group (EG = 20) or a control group (CG = 20). Both groups underwent two months of training with CAREN scenarios (three times a week for 24 sessions). The experimental group additionally received NMT applied to the selected scenarios. Participants were evaluated by a neuropsychologist at baseline and immediately after training. Results Intra-group analysis showed significant improvements in the EG for MOCA (p = 0.007), FAB (p = 0.008), Stroop Error (p = 0.003), Stroop Time (p < 0.001), and Visual Search (p < 0.001). The CG showed a significant difference only in Stroop Error (p = 0.02). Conclusions This pilot study is the first to combine NMT with CAREN in PD patients. Our findings suggest that NMT, within an immersive VR environment, effectively improves cognitive and EF in PD. Music structured within NMT techniques, coupled with advanced audio-visual feedback from VR, offers an innovative and potentially more effective approach for managing cognitive and executive deficits associated with PD.
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Affiliation(s)
| | | | | | - Mirjam Bonanno
- IRCCS Centro Neurolesi Bonino Pulejo, 98124 Messina, Italy
| | - Lilla Bonanno
- IRCCS Centro Neurolesi Bonino Pulejo, 98124 Messina, Italy
| | | | | | - Angela Alibrandi
- Department of Economics, Unit of Statistical and Mathematical Sciences, University of Messina, Messina, Italy
| | - Demetrio Milardi
- Department of Biomedical, Dental and Morphological and Functional Imaging Sciences, University of Messina, Messina, Italy
| | - Michael Thaut
- Music and Health Science Research Collaboratory, Faculty of Music, Faculty of Medicine, Institute of Medical Sciences and Rehabilitation Science Institute, University of Toronto, Toronto, ON, Canada
| | - Corene Hurt
- Music and Health Science Research Collaboratory, Faculty of Music, Faculty of Medicine, Institute of Medical Sciences and Rehabilitation Science Institute, University of Toronto, Toronto, ON, Canada
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Igusa T, Uchida H, Tsuchiya K, Sema S, Kaneko S, Yoshita T, Nagai S, Kobayashi T, Akiba T, Tanaka Y, Kikuchi S, Hirao K. Effects of rhythmic auditory stimulation on gait speed in older adult inpatients in a convalescent rehabilitation ward: a pilot randomized controlled trial. Eur Geriatr Med 2024; 15:1425-1435. [PMID: 38890234 DOI: 10.1007/s41999-024-01010-0] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/13/2024] [Accepted: 06/12/2024] [Indexed: 06/20/2024]
Abstract
PURPOSE To assess the impact of gait training with rhythmic auditory stimulation (RAS) on enhancing gait speed in older people admitted to a convalescent rehabilitation ward (CRW), compared to conventional gait training methods. METHODS The study was designed as a single-center, open-label, pilot, randomized, parallel-group study. Thirty older people admitted to CRW were divided into two groups: the experimental group, which received gait training with RAS (n = 15, females = 53.3%, mean age = 83.9, SD = 6.5), and the control group, which underwent usual gait training (n = 15, females = 60.0%, mean age = 81.3, SD = 8.4). Regardless of their assigned group, all participants underwent 30 min training sessions, five times a week, for 3 weeks. The primary outcome was the 10 m walk test (10mWT), and the secondary outcomes included the Medical Outcome Study 8-Item Short-Form Health Survey and the Japanese version of the modified Gait Efficacy Scale. All measurements were taken at baseline and again at week 3. RESULTS Results indicated that older people in CRWs in the experimental group showed significant improvements in their 10mWT (effect size - 1.02) compared to the control group. None of the secondary outcomes were significant. CONCLUSIONS This study suggests the preliminary effectiveness and feasibility of a gait practice intervention using RAS in a CRW. TRIAL REGISTRATION The University Hospital Medical Information Network (UMIN) Registered 1 October 2022 (UMIN000049089).
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Affiliation(s)
- Takumi Igusa
- Graduate School of Health Sciences, Gunma University, 3-39-22 Showa, Maebashi, Gunma, 371-8514, Japan
- Department of Rehabilitation, Medical Corporation Taiseikai, Uchida Hospital, Numata, Japan
| | - Hiroyuki Uchida
- Graduate School of Health Sciences, Gunma University, 3-39-22 Showa, Maebashi, Gunma, 371-8514, Japan
- Department of Rehabilitation, Kurashiki Heisei Hospital, Kurashiki, Japan
| | - Kenji Tsuchiya
- Department of Rehabilitation, Faculty of Health Sciences, Nagano University of Health and Medicine, Nagano, Japan
| | - Shota Sema
- Department of Rehabilitation, Medical Corporation Taiseikai, Uchida Hospital, Numata, Japan
| | - Shunsuke Kaneko
- Department of Rehabilitation, Medical Corporation Taiseikai, Uchida Hospital, Numata, Japan
| | - Taiki Yoshita
- Department of Rehabilitation, Medical Corporation Taiseikai, Uchida Hospital, Numata, Japan
| | - Sakyo Nagai
- Department of Rehabilitation, Medical Corporation Taiseikai, Uchida Hospital, Numata, Japan
| | - Takuya Kobayashi
- Graduate School of Health Sciences, Gunma University, 3-39-22 Showa, Maebashi, Gunma, 371-8514, Japan
- Department of Rehabilitation, Japan Community Healthcare Organization, Gunma Chuo Hospital, Maebashi, Japan
| | - Takanari Akiba
- Department of Rehabilitation, Japan Community Healthcare Organization, Gunma Chuo Hospital, Maebashi, Japan
| | - Yukiko Tanaka
- Department of Rehabilitation, Medical Corporation Taiseikai, Uchida Hospital, Numata, Japan
| | - Senichiro Kikuchi
- Graduate School of Health Sciences, Gunma University, 3-39-22 Showa, Maebashi, Gunma, 371-8514, Japan
| | - Kazuki Hirao
- Graduate School of Health Sciences, Gunma University, 3-39-22 Showa, Maebashi, Gunma, 371-8514, Japan.
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Hutin E, Poirier T, Meimoun M, Mardale V, Ghédira M. Model-based cueing-as-needed for walking in Parkinson's disease: A randomized cross-over study. Rev Neurol (Paris) 2024; 180:798-806. [PMID: 38834484 DOI: 10.1016/j.neurol.2024.05.003] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/20/2023] [Revised: 03/29/2024] [Accepted: 05/03/2024] [Indexed: 06/06/2024]
Abstract
BACKGROUND Correcting of the lack of regularity in steps is a key component of gait rehabilitation in Parkinson's disease. We proposed to introduce adaptive spatial auditory cueing (ASAC) based on verbal instruction "lengthen the step" automatically delivered when the stride length decreased below a predetermined threshold. OBJECTIVES The present study compared the effect of usual rhythmic auditory cueing versus ASAC used during a walking training in Parkinson's disease. METHODS Fifteen patients with Parkinson's disease performed both interventions in randomized order, one week apart: a 20-minute walking training with rhythmic auditory cueing, in form of a metronome adjusted on 110% of the patient's own cadence, or ASAC delivered when the stride length is less than 110% of the patient's own stride length. Assessment criteria were walking distance covered during the intervention, speed, step length, cadence, coefficients of variation of step length and step duration, and indexes of spatial and temporal asymmetry during a walking test before and just after the intervention. RESULTS The walking distance is higher with ASAC compared with rhythmic auditory cueing (rhythmic auditory cueing, 905 (203) m, mean (standard deviation); ASAC, 1043 (212) m; P=0.002). Between-intervention comparison showed some similar effects on walking after the intervention including free speed and step length increases (P<0.05). CONCLUSION The distance covered during 20-minute walking with ASAC increases by 15% compared to the use of classical rhythmic auditory cueing, while the immediate therapeutic effects show similar spatial-temporal benefits on short-distance walking. Auditory biofeedback cueing promoting the increase in step length might improve gait relearning in Parkinson's disease.
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Affiliation(s)
- E Hutin
- Laboratoire Analyse et Restauration du Mouvement (ARM), Service de Rééducation Neurolocomotrice, Hôpitaux Universitaires Henri-Mondor, AP-HP, 1, rue Gustave-Eiffel, 94010 Créteil cedex, France.
| | - T Poirier
- Institut de Formation en Masso-Kinésithérapie Saint-Michel, 68, rue du Commerce, 75015 Paris, France
| | - M Meimoun
- Laboratoire Analyse et Restauration du Mouvement (ARM), Service de Rééducation Neurolocomotrice, Hôpitaux Universitaires Henri-Mondor, AP-HP, 1, rue Gustave-Eiffel, 94010 Créteil cedex, France
| | - V Mardale
- Laboratoire Analyse et Restauration du Mouvement (ARM), Service de Rééducation Neurolocomotrice, Hôpitaux Universitaires Henri-Mondor, AP-HP, 1, rue Gustave-Eiffel, 94010 Créteil cedex, France; Service de Médecine Physique et de Réadaptation, Hôpital Dupuytren, AP-HP, 1, avenue Eugène-Delacroix, 91210 Draveil, France
| | - M Ghédira
- Laboratoire Analyse et Restauration du Mouvement (ARM), Service de Rééducation Neurolocomotrice, Hôpitaux Universitaires Henri-Mondor, AP-HP, 1, rue Gustave-Eiffel, 94010 Créteil cedex, France
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Heng JG, Zhang J, Bonetti L, Lim WPH, Vuust P, Agres K, Chen SHA. Understanding music and aging through the lens of Bayesian inference. Neurosci Biobehav Rev 2024; 163:105768. [PMID: 38908730 DOI: 10.1016/j.neubiorev.2024.105768] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/09/2024] [Revised: 06/05/2024] [Accepted: 06/10/2024] [Indexed: 06/24/2024]
Abstract
Bayesian inference has recently gained momentum in explaining music perception and aging. A fundamental mechanism underlying Bayesian inference is the notion of prediction. This framework could explain how predictions pertaining to musical (melodic, rhythmic, harmonic) structures engender action, emotion, and learning, expanding related concepts of music research, such as musical expectancies, groove, pleasure, and tension. Moreover, a Bayesian perspective of music perception may shed new insights on the beneficial effects of music in aging. Aging could be framed as an optimization process of Bayesian inference. As predictive inferences refine over time, the reliance on consolidated priors increases, while the updating of prior models through Bayesian inference attenuates. This may affect the ability of older adults to estimate uncertainties in their environment, limiting their cognitive and behavioral repertoire. With Bayesian inference as an overarching framework, this review synthesizes the literature on predictive inferences in music and aging, and details how music could be a promising tool in preventive and rehabilitative interventions for older adults through the lens of Bayesian inference.
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Affiliation(s)
- Jiamin Gladys Heng
- School of Computer Science and Engineering, Nanyang Technological University, Singapore.
| | - Jiayi Zhang
- Interdisciplinary Graduate Program, Nanyang Technological University, Singapore; School of Social Sciences, Nanyang Technological University, Singapore; Centre for Research and Development in Learning, Nanyang Technological University, Singapore
| | - Leonardo Bonetti
- Center for Music in the Brain, Department of Clinical Medicine, Aarhus University & The Royal Academy of Music, Aarhus, Aalborg, Denmark; Centre for Eudaimonia and Human Flourishing, Linacre College, University of Oxford, United Kingdom; Department of Psychiatry, University of Oxford, United Kingdom; Department of Psychology, University of Bologna, Italy
| | | | - Peter Vuust
- Center for Music in the Brain, Department of Clinical Medicine, Aarhus University & The Royal Academy of Music, Aarhus, Aalborg, Denmark
| | - Kat Agres
- Centre for Music and Health, National University of Singapore, Singapore; Yong Siew Toh Conservatory of Music, National University of Singapore, Singapore
| | - Shen-Hsing Annabel Chen
- School of Social Sciences, Nanyang Technological University, Singapore; Centre for Research and Development in Learning, Nanyang Technological University, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; National Institute of Education, Nanyang Technological University, Singapore.
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11
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Colverson A, Barsoum S, Cohen R, Williamson J. Rhythmic musical activities may strengthen connectivity between brain networks associated with aging-related deficits in timing and executive functions. Exp Gerontol 2024; 186:112354. [PMID: 38176601 DOI: 10.1016/j.exger.2023.112354] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/06/2023] [Revised: 12/14/2023] [Accepted: 12/27/2023] [Indexed: 01/06/2024]
Abstract
Brain aging and common conditions of aging (e.g., hypertension) affect networks important in organizing information, processing speed and action programming (i.e., executive functions). Declines in these networks may affect timing and could have an impact on the ability to perceive and perform musical rhythms. There is evidence that participation in rhythmic musical activities may help to maintain and even improve executive functioning (near transfer), perhaps due to similarities in brain regions underlying timing, musical rhythm perception and production, and executive functioning. Rhythmic musical activities may present as a novel and fun activity for older adults to stimulate interacting brain regions that deteriorate with aging. However, relatively little is known about neurobehavioral interactions between aging, timing, rhythm perception and production, and executive functioning. In this review, we account for these brain-behavior interactions to suggest that deeper knowledge of overlapping brain regions associated with timing, rhythm, and cognition may assist in designing more targeted preventive and rehabilitative interventions to reduce age-related cognitive decline and improve quality of life in populations with neurodegenerative disease. Further research is needed to elucidate the functional relationships between brain regions associated with aging, timing, rhythm perception and production, and executive functioning to direct design of targeted interventions.
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Affiliation(s)
- Aaron Colverson
- Memory and Aging Center, Weill Institute for Neurosciences, University of California, 1651 4th street, San Francisco, CA, United States of America.
| | - Stephanie Barsoum
- Center for Cognitive Aging and Memory, College of Medicine, University of Florida, PO Box 100277, Gainesville, FL 32610-0277, United States of America
| | - Ronald Cohen
- Center for Cognitive Aging and Memory, College of Medicine, University of Florida, PO Box 100277, Gainesville, FL 32610-0277, United States of America
| | - John Williamson
- Center for Cognitive Aging and Memory, College of Medicine, University of Florida, PO Box 100277, Gainesville, FL 32610-0277, United States of America
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12
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Kibushi B, Maekaku K, Kimura T. Reduced center of mass acceleration during regular walking with electromyography biofeedback. Gait Posture 2024; 108:335-340. [PMID: 38219328 DOI: 10.1016/j.gaitpost.2024.01.008] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/30/2022] [Revised: 10/10/2023] [Accepted: 01/06/2024] [Indexed: 01/16/2024]
Abstract
BACKGROUND Regular walking in healthy adults is known to be kinematically stable, but it is unclear how to further kinematically stabilize regular walking. Electromyography biofeedback (EMG-BF) during walking improves walking ability in patients. However, the effect of EMG-BF on walking stability in healthy adults is unknown. Therefore, this study aimed to investigate whether EMG-BF enhances the stability of regular walking in healthy adults. RESEARCH QUESTION Does the EMG-BF enhance the stability of regular walking in healthy adults? METHODS Auditory biofeedback of single muscle activity was given to twelve participants during regular walking. The target muscles were the ankle plantar flexor, ankle dorsiflexor, and knee flexor. We compared the root mean square of the center of mass acceleration (RMS-CoMacc), which represents walking smoothness, between biofeedback conditions. RESULTS We found that EMG-BF during regular walking partially reduced the RMS-CoMacc (p = 0.01). In particular, biofeedback of the ankle plantar flexor muscle reduced the RMS-CoMacc in both the anteroposterior and vertical directions. In the mediolateral RMS-CoMacc, no significant difference was found (p = 0.24). SIGNIFICANCE Our study is novel because it is the first study to reveal the impact of EMG-BF on the stability of walking among healthy adults. It identifies the key muscles for EMG-BF, potentially leading to the development of a more effective EMG-BF system in the rehabilitation. Especially, biofeedback of the ankle plantar flexor muscle could improve walking stability in both the anteroposterior and vertical directions. The effect of EMG-BF for reducing the RMS-CoMacc during regular walking might depend on the target muscles of biofeedback.
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Affiliation(s)
- Benio Kibushi
- Graduate School of Human Development and Environment, Kobe University, 3-11 Tsurukabuto, Nada, Kobe, Japan.
| | - Kei Maekaku
- Graduate School of Human Development and Environment, Kobe University, 3-11 Tsurukabuto, Nada, Kobe, Japan
| | - Tetsuya Kimura
- Graduate School of Human Development and Environment, Kobe University, 3-11 Tsurukabuto, Nada, Kobe, Japan
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13
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Tueth LE, Haussler AM, Lohse KR, Rawson KS, Earhart GM, Harrison EC. Effect of musical cues on gait in individuals with Parkinson disease with comorbid dementia. Gait Posture 2024; 107:275-280. [PMID: 37891141 PMCID: PMC10909245 DOI: 10.1016/j.gaitpost.2023.10.015] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 08/10/2023] [Revised: 10/16/2023] [Accepted: 10/19/2023] [Indexed: 10/29/2023]
Abstract
BACKGROUND Individuals with Parkinson disease and comorbid dementia (PDD) demonstrate gait impairments, but little is known about how these individuals respond to interventions for gait dysfunction. Rhythmic auditory stimulation (RAS), which utilizes music or other auditory cues to alter gait, has been shown to be effective for improving gait in individuals with PD without dementia, but has not been explored in individuals with PDD. RESEARCH QUESTION Can individuals with PDD modulate their gait in response to music and mental singing cues? METHODS This single center, cross-sectional, interventional study included 17 individuals with PDD. Participants received Music and Mental singing cues at tempos of 90 %, 100 %, 110 %, and 120 % of their uncued walking cadence. Participants were instructed to walk to the beat of the song. Gait variables were collected using APDM Opal sensors. Data were analyzed using mixed effect models to explore the impact of tempo and cue type (Music vs Mental) on selected gait parameters of velocity, cadence, and stride length. RESULTS Mixed effects models showed a significant effect of tempo but not for cue type for velocity (F=11.51, p < .001), cadence (F=11.13, p < .001), and stride length (F=5.68, p = .002). When looking at the marginal means, velocity at a cue rate of 90 % was significantly different from 100 %, indicating participants walked slower with a cue rate of 90 %. Participants did not significantly increase their velocity, cadence, or stride length with faster cue rates of 110 % and 120 % SIGNIFICANCE: Individuals with PDD appear to be able to slow their velocity in response to slower cues, but do not appear to be able to increase their velocity, cadence, or stride length in response to faster cue tempos. This is different from what has been reported in individuals with PD without dementia. Further research is necessary to understand the underlying mechanism for these differences.
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Affiliation(s)
- Lauren E Tueth
- Washington University in St. Louis School of Medicine, Program in Physical Therapy, United States
| | - Allison M Haussler
- Washington University in St. Louis School of Medicine, Program in Physical Therapy, United States
| | - Keith R Lohse
- Washington University in St. Louis School of Medicine, Program in Physical Therapy, United States; Washington University in St. Louis School of Medicine, Department of Neurology, United States
| | - Kerri S Rawson
- Washington University in St. Louis School of Medicine, Program in Physical Therapy, United States; Washington University in St. Louis School of Medicine, Department of Neurology, United States
| | - Gammon M Earhart
- Washington University in St. Louis School of Medicine, Program in Physical Therapy, United States; Washington University in St. Louis School of Medicine, Department of Neurology, United States; Washington University in St. Louis School of Medicine, Department of Neuroscience, United States.
| | - Elinor C Harrison
- Washington University in St. Louis School of Medicine, Program in Physical Therapy, United States; Washington University in St. Louis, Performing Arts Department, United States
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14
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Tran S, Heida TC, Heijs JJA, Al-Ozzi T, Sumarac S, Alanazi FI, Kalia SK, Hodaie M, Lozano AM, Milosevic L, Chen R, Hutchison WD. Subthalamic and pallidal neurons are modulated during externally cued movements in Parkinson's disease. Neurobiol Dis 2024; 190:106384. [PMID: 38135193 DOI: 10.1016/j.nbd.2023.106384] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/03/2023] [Revised: 12/13/2023] [Accepted: 12/13/2023] [Indexed: 12/24/2023] Open
Abstract
External sensory cues can reduce freezing of gait in people with Parkinson's disease (PD), yet the role of the basal ganglia in these movements is unclear. We used microelectrode recordings to examine modulations in single unit (SU) and oscillatory local field potentials (LFP) during auditory-cued rhythmic pedaling movements of the feet. We tested five blocks of increasing cue frequencies (1 Hz, 1.5 Hz, 2 Hz, 2.5 Hz, and 3 Hz) in 24 people with PD undergoing deep brain stimulation surgery of the subthalamic nucleus (STN) or globus pallidus internus (GPi). Single unit firing and beta band LFPs (13-30 Hz) in response to movement onsets or cue onsets were examined. We found that the timing accuracy of foot pedaling decreased with faster cue frequencies. Increasing cue frequencies also attenuated firing rates in both STN and GPi neurons. Peak beta power in the GPi and STN showed different responses to the task. GPi beta power showed persistent suppression with fast cues and phasic modulation with slow cues. STN beta power showed enhanced beta synchronization following movement. STN beta power also correlated with rate of pedaling. Overall, we showed task-related responses in the GPi and STN during auditory-cued movements with differential roles in sensory and motor control. The results suggest a role for both input and output basal ganglia nuclei in auditory rhythmic pacing of gait-like movements in PD.
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Affiliation(s)
- Stephanie Tran
- Institute of Medical Science, University of Toronto, Ontario, Canada
| | - Tjitske C Heida
- Department of Biomedical Signals and Systems, University of Twente, Enschede, the Netherlands
| | - Janne J A Heijs
- Department of Biomedical Signals and Systems, University of Twente, Enschede, the Netherlands
| | - Tameem Al-Ozzi
- Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Ontario, Canada
| | - Srdjan Sumarac
- Krembil Brain Institute, Leonard Ave, Toronto, Ontario, Canada; Department of Biomedical Engineering, University of Toronto, Canada
| | - Frhan I Alanazi
- Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Ontario, Canada
| | - Suneil K Kalia
- Division of Neurosurgery, Toronto Western Hospital, 399 Bathurst St, Toronto, Canada; Department of Surgery, Temerty Faculty of Medicine, University of Toronto, Canada; Krembil Brain Institute, Leonard Ave, Toronto, Ontario, Canada
| | - Mojgan Hodaie
- Division of Neurosurgery, Toronto Western Hospital, 399 Bathurst St, Toronto, Canada; Department of Surgery, Temerty Faculty of Medicine, University of Toronto, Canada; Krembil Brain Institute, Leonard Ave, Toronto, Ontario, Canada
| | - Andres M Lozano
- Division of Neurosurgery, Toronto Western Hospital, 399 Bathurst St, Toronto, Canada; Department of Surgery, Temerty Faculty of Medicine, University of Toronto, Canada; Krembil Brain Institute, Leonard Ave, Toronto, Ontario, Canada
| | - Luka Milosevic
- Krembil Brain Institute, Leonard Ave, Toronto, Ontario, Canada; Department of Biomedical Engineering, University of Toronto, Canada
| | - Robert Chen
- Krembil Brain Institute, Leonard Ave, Toronto, Ontario, Canada; Dept of Neurology, Temerty Faculty of Medicine, University of Toronto, Canada
| | - William D Hutchison
- Departments of Surgery and Physiology, Temerty Faculty of Medicine, University of Toronto, Canada, and Krembil Brain Institute, Leonard Ave, Toronto, Ontario, Canada.
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15
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Emmery L, Hackney ME, Kesar T, McKay JL, Rosenberg MC. An integrated review of music cognition and rhythmic stimuli in sensorimotor neurocognition and neurorehabilitation. Ann N Y Acad Sci 2023; 1530:74-86. [PMID: 37917153 PMCID: PMC10841443 DOI: 10.1111/nyas.15079] [Citation(s) in RCA: 5] [Impact Index Per Article: 2.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/03/2023]
Abstract
This work reviews the growing body of interdisciplinary research on music cognition, using biomechanical, kinesiological, clinical, psychosocial, and sociological methods. The review primarily examines the relationship between temporal elements in music and motor responses under varying contexts, with considerable relevance for clinical rehabilitation. After providing an overview of the terminology and approaches pertinent to theories of rhythm and meter from the musical-theoretical and cognitive fields, this review focuses on studies on the effects of rhythmic sensory stimulation on gait, rhythmic cues' effect on the motor system, reactions to rhythmic stimuli attempting to synchronize mobility (i.e., musical embodiment), and the application of rhythm for motor rehabilitation for individuals with Parkinson's disease, stroke, mild cognitive impairment, Alzheimer's disease, and other neurodegenerative or neurotraumatic diseases. This work ultimately bridges the gap between the musical-theoretical and cognitive science fields to facilitate innovative research in which each discipline informs the other.
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Affiliation(s)
- Laura Emmery
- Department of Music, Emory College of Arts and Sciences, Emory University, Atlanta, Georgia, USA
| | - Madeleine E. Hackney
- Center for Visual and Neurocognitive Rehabilitation, Atlanta VA HealthCare System, Decatur, Georgia, USA
- Department of Medicine, Division of Geriatrics and Gerontology, Emory University School of Medicine, Atlanta, Georgia, USA
- Department of Veterans Affairs Birmingham/Atlanta Geriatric Research Education and Clinical Center
- Department of Rehabilitation Medicine, Division of Physical Therapy, Emory University School of Medicine, Atlanta, Georgia, USA
- Emory University School of Nursing, Atlanta, Georgia, USA
| | - Trisha Kesar
- Department of Rehabilitation Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
| | - J. Lucas McKay
- Department of Neurology, Emory University School of Medicine, Atlanta, Georgia, USA
- Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, Georgia, USA
- Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA
| | - Michael C. Rosenberg
- Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, Georgia, USA
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16
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Iseki C, Suzuki S, Fukami T, Yamada S, Hayasaka T, Kondo T, Hoshi M, Ueda S, Kobayashi Y, Ishikawa M, Kanno S, Suzuki K, Aoyagi Y, Ohta Y. Fluctuations in Upper and Lower Body Movement during Walking in Normal Pressure Hydrocephalus and Parkinson's Disease Assessed by Motion Capture with a Smartphone Application, TDPT-GT. SENSORS (BASEL, SWITZERLAND) 2023; 23:9263. [PMID: 38005649 PMCID: PMC10674367 DOI: 10.3390/s23229263] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Received: 10/26/2023] [Revised: 11/17/2023] [Accepted: 11/17/2023] [Indexed: 11/26/2023]
Abstract
We aimed to capture the fluctuations in the dynamics of body positions and find the characteristics of them in patients with idiopathic normal pressure hydrocephalus (iNPH) and Parkinson's disease (PD). With the motion-capture application (TDPT-GT) generating 30 Hz coordinates at 27 points on the body, walking in a circle 1 m in diameter was recorded for 23 of iNPH, 23 of PD, and 92 controls. For 128 frames of calculated distances from the navel to the other points, after the Fourier transforms, the slopes (the representatives of fractality) were obtained from the graph plotting the power spectral density against the frequency in log-log coordinates. Differences in the average slopes were tested by one-way ANOVA and multiple comparisons between every two groups. A decrease in the absolute slope value indicates a departure from the 1/f noise characteristic observed in healthy variations. Significant differences in the patient groups and controls were found in all body positions, where patients always showed smaller absolute values. Our system could measure the whole body's movement and temporal variations during walking. The impaired fluctuations of body movement in the upper and lower body may contribute to gait and balance disorders in patients.
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Affiliation(s)
- Chifumi Iseki
- Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan; (S.K.); (K.S.)
- Division of Neurology and Clinical Neuroscience, Department of Internal Medicine III, Yamagata University School of Medicine, Yamagata 990-2331, Japan; (T.K.); (Y.O.)
| | - Shou Suzuki
- Department of Informatics, Faculty of Engineering, Yamagata University, Yonezawa 992-8510, Japan; (S.S.); (T.F.)
| | - Tadanori Fukami
- Department of Informatics, Faculty of Engineering, Yamagata University, Yonezawa 992-8510, Japan; (S.S.); (T.F.)
| | - Shigeki Yamada
- Department of Neurosurgery, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan;
- Interfaculty Initiative in Information Studies, Institute of Industrial Science, The University of Tokyo, Tokyo 113-8654, Japan
- Normal Pressure Hydrocephalus Center, Rakuwakai Otowa Hospital, Kyoto 607-8062, Japan;
| | - Tatsuya Hayasaka
- Department of Anesthesiology, Yamagata University School of Medicine, Yamagata 990-2331, Japan;
| | - Toshiyuki Kondo
- Division of Neurology and Clinical Neuroscience, Department of Internal Medicine III, Yamagata University School of Medicine, Yamagata 990-2331, Japan; (T.K.); (Y.O.)
| | - Masayuki Hoshi
- Department of Physical Therapy, Fukushima Medical University School of Health Sciences, 10-6 Sakaemachi, Fukushima 960-8516, Japan;
| | - Shigeo Ueda
- Shin-Aikai Spine Center, Katano Hospital, Katano 576-0043, Japan;
| | - Yoshiyuki Kobayashi
- Human Augmentation Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Kashiwa II Campus, University of Tokyo, Kashiwa 277-0882, Japan;
| | - Masatsune Ishikawa
- Normal Pressure Hydrocephalus Center, Rakuwakai Otowa Hospital, Kyoto 607-8062, Japan;
- Rakuwa Villa Ilios, Rakuwakai Healthcare System, Kyoto 607-8062, Japan
| | - Shigenori Kanno
- Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan; (S.K.); (K.S.)
| | - Kyoko Suzuki
- Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan; (S.K.); (K.S.)
| | | | - Yasuyuki Ohta
- Division of Neurology and Clinical Neuroscience, Department of Internal Medicine III, Yamagata University School of Medicine, Yamagata 990-2331, Japan; (T.K.); (Y.O.)
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Melo-Thomas L, Schwarting RKW. Paradoxical kinesia may no longer be a paradox waiting for 100 years to be unraveled. Rev Neurosci 2023; 34:775-799. [PMID: 36933238 DOI: 10.1515/revneuro-2023-0010] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/23/2023] [Accepted: 02/10/2023] [Indexed: 03/19/2023]
Abstract
Parkinson's disease (PD) is a progressive neurodegenerative disorder mainly characterized by bradykinesia and akinesia. Interestingly, these motor disabilities can depend on the patient emotional state. Disabled PD patients remain able to produce normal motor responses in the context of urgent or externally driven situations or even when exposed to appetitive cues such as music. To describe this phenomenon Souques coined the term "paradoxical kinesia" a century ago. Since then, the mechanisms underlying paradoxical kinesia are still unknown due to a paucity of valid animal models that replicate this phenomenon. To overcome this limitation, we established two animal models of paradoxical kinesia. Using these models, we investigated the neural mechanisms of paradoxical kinesia, with the results pointing to the inferior colliculus (IC) as a key structure. Intracollicular electrical deep brain stimulation, glutamatergic and GABAergic mechanisms may be involved in the elaboration of paradoxical kinesia. Since paradoxical kinesia might work by activation of some alternative pathway bypassing basal ganglia, we suggest the IC as a candidate to be part of this pathway.
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Affiliation(s)
- Liana Melo-Thomas
- Experimental and Biological Psychology, Behavioral Neuroscience, Faculty of Psychology, Philipps-University of Marburg, Gutenbergstraße 18, 35032 Marburg, Germany
- Marburg Center for Mind, Brain, and Behavior (MCMBB), Hans-Meerwein-Straße 6, 35032 Marburg, Germany
- Behavioral Neurosciences Institute (INeC), Av. do Café, 2450, Monte Alegre, Ribeirão Preto, 14050-220, São Paulo, Brazil
| | - Rainer K W Schwarting
- Experimental and Biological Psychology, Behavioral Neuroscience, Faculty of Psychology, Philipps-University of Marburg, Gutenbergstraße 18, 35032 Marburg, Germany
- Marburg Center for Mind, Brain, and Behavior (MCMBB), Hans-Meerwein-Straße 6, 35032 Marburg, Germany
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18
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Park KS, Buseth L, Hong J, Etnier JL. Music-based multicomponent exercise training for community-dwelling older adults with mild-to-moderate cognitive decline: a feasibility study. Front Med (Lausanne) 2023; 10:1224728. [PMID: 37671396 PMCID: PMC10475546 DOI: 10.3389/fmed.2023.1224728] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/18/2023] [Accepted: 07/24/2023] [Indexed: 09/07/2023] Open
Abstract
Introduction This study explored the feasibility and preliminary efficacy of a music-based, multicomponent exercise intervention among community-dwelling older adults with mild-to-moderate cognitive impairment. Methods 16 older adults aged 85±9 years with mild-to-moderate cognitive impairment received music-based multicomponent exercise training for 20 weeks at an independent living facility. Participants received aerobic, resistance, and balance training paired with beat-accentuated music stimulation. Participants' adherence to the training was tracked down and their cognitive and physical functioning and health-related quality of life were assessed at pre- and post-test. Results 3 participants withdrew due to unexpected issues unrelated to the intervention and thus 13 participants (7 females) attended an average of 4.6 days/week over 20 weeks and reported high satisfaction with the intervention (90.6%). Participants showed significant improvement in global cognition, cognitive processing speed, and walking endurance/aerobic fitness at post-test. Discussion These findings support the feasibility of music-based, multicomponent exercise training for older adults in an independent living facility and set the stage for future studies to test the efficacy of music on physical activity and ensuing health outcomes. We conclude that music-based, multicomponent exercise training can be beneficial for community-dwelling older adults with mild-to-moderate cognitive decline. As a form of rhythmic auditory stimulation, beat-accentuated music can be combined with exercise training to manipulate exercise tempo and may provide a source of motivation to help older adults adhere to exercise.
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Affiliation(s)
- Kyoung Shin Park
- Department of Kinesiology, University of North Carolina at Greensboro, Greensboro, NC, United States
| | - Lake Buseth
- Department of Kinesiology, University of North Carolina at Greensboro, Greensboro, NC, United States
| | - Jiyeong Hong
- Freelance Musician, Greensboro, NC, United States
| | - Jennifer L. Etnier
- Department of Kinesiology, University of North Carolina at Greensboro, Greensboro, NC, United States
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19
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Scataglini S, Van Dyck Z, Declercq V, Van Cleemput G, Struyf N, Truijen S. Effect of Music Based Therapy Rhythmic Auditory Stimulation (RAS) Using Wearable Device in Rehabilitation of Neurological Patients: A Systematic Review. SENSORS (BASEL, SWITZERLAND) 2023; 23:5933. [PMID: 37447782 DOI: 10.3390/s23135933] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Subscribe] [Scholar Register] [Received: 04/21/2023] [Revised: 06/09/2023] [Accepted: 06/17/2023] [Indexed: 07/15/2023]
Abstract
(1) Background: Even though music therapy is acknowledged to have positive benefits in neurology, there is still a lack of knowledge in the literature about the applicability of music treatments in clinical practice with a neurological population using wearable devices. (2) Methods: a systematic review was conducted following PRISMA 2020 guidelines on the 29 October 2022, searching in five databases: PubMed, PEDro, Medline, Web of Science, and Science Direct. (3) Results: A total of 2964 articles were found, including 413 from PubMed, 248 from Web of Science, 2110 from Science Direct, 163 from Medline, and none from PEDro. Duplicate entries, of which there were 1262, were eliminated. In the first screening phase, 1702 papers were screened for title and abstract. Subsequently, 1667 papers were removed, based on population, duplicate, outcome, and poor study design. Only 15 studies were considered after 35 papers had their full texts verified. Results showed significant values of spatiotemporal gait parameters in music-based therapy rhythmic auditory stimulation (RAS), including speed, stride length, cadence, and ROM. (4) Conclusions: The current findings confirm the value of music-based therapy RAS as a favorable and effective tool to implement in the health care system for the rehabilitation of patients with movement disorders.
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Affiliation(s)
- Sofia Scataglini
- 4D4ALL Lab, Department of Rehabilitation Sciences and Physiotherapy, Center for Health and Technology (CHaT), Faculty of Medicine and Health Sciences, University of Antwerp, 2000 Antwerpen, Belgium
| | - Zala Van Dyck
- 4D4ALL Lab, Department of Rehabilitation Sciences and Physiotherapy, Center for Health and Technology (CHaT), Faculty of Medicine and Health Sciences, University of Antwerp, 2000 Antwerpen, Belgium
| | - Véronique Declercq
- 4D4ALL Lab, Department of Rehabilitation Sciences and Physiotherapy, Center for Health and Technology (CHaT), Faculty of Medicine and Health Sciences, University of Antwerp, 2000 Antwerpen, Belgium
| | - Gitte Van Cleemput
- 4D4ALL Lab, Department of Rehabilitation Sciences and Physiotherapy, Center for Health and Technology (CHaT), Faculty of Medicine and Health Sciences, University of Antwerp, 2000 Antwerpen, Belgium
| | - Nele Struyf
- 4D4ALL Lab, Department of Rehabilitation Sciences and Physiotherapy, Center for Health and Technology (CHaT), Faculty of Medicine and Health Sciences, University of Antwerp, 2000 Antwerpen, Belgium
| | - Steven Truijen
- 4D4ALL Lab, Department of Rehabilitation Sciences and Physiotherapy, Center for Health and Technology (CHaT), Faculty of Medicine and Health Sciences, University of Antwerp, 2000 Antwerpen, Belgium
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Koshimori Y, Thaut MH. Rhythmic auditory stimulation as a potential neuromodulator for Parkinson's disease. Parkinsonism Relat Disord 2023:105459. [PMID: 37277293 DOI: 10.1016/j.parkreldis.2023.105459] [Citation(s) in RCA: 2] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 03/24/2023] [Revised: 05/23/2023] [Accepted: 05/24/2023] [Indexed: 06/07/2023]
Abstract
Auditory rhythm-based therapeutic interventions such as rhythmic auditory stimulation (RAS) are effective in improving gait and balance and preventing falls in idiopathic Parkinson's disease (PD). Research showing associated neuromodulatory effects of RAS on brain oscillations is also emerging. The neuromodulation may be induced by neural entrainment and cross-frequency oscillatory coupling. Auditory rhythm and RAS based interventions are potentially effective in improving other PD symptoms and can be extended to atypical parkinsonism.
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Affiliation(s)
- Yuko Koshimori
- Music and Health Science Research Collaboratory, Faculty of Music, University of Toronto, 90 Wellesley Street West, Toronto, ON, M5S 1C5, Canada.
| | - Michael H Thaut
- Music and Health Science Research Collaboratory, Faculty of Music, University of Toronto, 90 Wellesley Street West, Toronto, ON, M5S 1C5, Canada.
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21
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Mainka S, Lauermann M, Ebersbach G. Arm swing deviations in patients with Parkinson's disease at different gait velocities. J Neural Transm (Vienna) 2023; 130:655-661. [PMID: 36917345 PMCID: PMC10121495 DOI: 10.1007/s00702-023-02619-4] [Citation(s) in RCA: 2] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/30/2022] [Accepted: 03/06/2023] [Indexed: 03/16/2023]
Abstract
Asymmetry of arm swing (AS) has been described as a characteristic of normal physiological gait. In patients with Parkinson's disease (PWPD), a one-sided reduction of AS can occur already as a prodromal symptom. There is limited evidence regarding AS in PWPD, but a growing interest in AS as a focus of exercise therapy. The differences of AS between 32 healthy subjects (HS) and 36 mildly-to-moderately impaired PWPD were assessed in overground walking at various gait speeds. Assessments were carried out with a sensor-based gait measurement system over a 40 m walk in very slow, slow, preferred, fast, and very fast gait speed. Longitudinal and AS kinematics were compared with ANOVA function and regression analysis. PWPD exhibited a one-sided reduction of AS compared to HS at normal, fast, and very fast walking. AS coordination, representing the timing of reciprocity of right and left AS, was reduced in PWPD in very slow and normal walking. With respect to leg movements, PWPD exhibited an increase in stride time variability in very slow gait. There were no group differences for cadence, stride length, and gait velocity. This study informs about the kinematics of AS at various gait velocities ranging from very slow to very fast in mildly-to-moderately impaired PWPD. Reduced one-sided AS can be considered as a very early sign of parkinsonian gait disturbance that precedes alterations of locomotive leg movements and improves at faster gait speeds.
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Affiliation(s)
- Stefan Mainka
- Movement Disorder Clinic, Parkinsonklinik, Str. n. Fichtenwalde 16, 14547, Beelitz-Heilstätten, Germany.
| | | | - Georg Ebersbach
- Movement Disorder Clinic, Parkinsonklinik, Str. n. Fichtenwalde 16, 14547, Beelitz-Heilstätten, Germany
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22
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Pranjić M, Hashemi N, Arnett AB, Thaut MH. Auditory-Perceptual and Auditory-Motor Timing Abilities in Children with Developmental Coordination Disorder: A Scoping Review. Brain Sci 2023; 13:729. [PMID: 37239201 PMCID: PMC10216155 DOI: 10.3390/brainsci13050729] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/27/2023] [Revised: 04/18/2023] [Accepted: 04/25/2023] [Indexed: 05/28/2023] Open
Abstract
Developmental coordination disorder (DCD) remains largely underdiagnosed and masked by other co-occurring conditions. The aim of this study was to (1) provide the first review of research regarding auditory-motor timing and synchronization abilities in children with DCD and (2) examine whether reduced motor performance may be associated with difficulties in auditory perceptual timing. The scoping review was carried out across five major databases (MEDLINE, Embase, PsycINFO, CINAHL, and Scopus) in accordance with the PRISMA-ScR guidelines. Studies were screened by two independent reviewers against the inclusion criteria, without publication date restrictions. From an initial return of 1673 records, 16 articles were included in the final review and synthesized based on the timing modality studied (i.e., auditory-perceptual, motor, or auditory-motor). Results suggest that children with DCD have difficulties with rhythmic movements both with and without external auditory cues and further indicate that variability in and slowness of motor response are key characteristics of DCD, regardless of the experimental task. Importantly, our review highlights a significant gap in the literature regarding auditory perceptual abilities in DCD. In addition to testing auditory perception, future studies should compare the performance of children with DCD on paced and unpaced tasks to determine whether auditory stimuli contribute to a more or less stable performance. This knowledge may inform future therapeutic interventions.
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Affiliation(s)
- Marija Pranjić
- Music and Health Science Research Collaboratory, University of Toronto, Toronto, ON M5S 1C5, Canada
- Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, ON M4G 1R8, Canada
| | - Niloufaralsadat Hashemi
- Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, ON M4G 1R8, Canada
- Institute of Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada
| | - Anne B. Arnett
- Division of Developmental Medicine, Boston Children’s Hospital, Boston, MA 02115, USA
- Pediatrics, Harvard Medical School, Boston, MA 02115, USA
| | - Michael H. Thaut
- Music and Health Science Research Collaboratory, University of Toronto, Toronto, ON M5S 1C5, Canada
- Faculty of Medicine, Institute of Medical Science and Rehabilitation Research Institute, University of Toronto, Toronto, ON M5S 1A8, Canada
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23
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Igusa T, Kobayashi T, Uchida H, Tsuchiya K, Akiba T, Sema S, Kaneko S, Yoshita T, Nagai S, Tanaka Y, Kikuchi S, Hirao K. Effect of gait training using rhythmic auditory stimulation on gait speed in older adults admitted to convalescent rehabilitation wards: A study protocol for a pilot randomized controlled clinical trial. Contemp Clin Trials Commun 2023; 33:101125. [PMID: 37091510 PMCID: PMC10119504 DOI: 10.1016/j.conctc.2023.101125] [Citation(s) in RCA: 3] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/16/2022] [Revised: 03/23/2023] [Accepted: 03/29/2023] [Indexed: 04/03/2023] Open
Abstract
Background Decreased walking speed in older patients admitted to convalescent rehabilitation wards (CRWs) is one of the factors that inhibit home discharge. Therefore, interventions to improve gait speed in older patients admitted to CRWs are important, and rhythmic auditory stimulation (RAS) may be an effective intervention strategy. However, the effect of RAS on gait speed in older patients admitted to CRWs is not well known. Therefore, this study protocol aims to determine the feasibility of the RAS-based gait practice for older patients admitted to the CRW. Methods The study is designed as a single-center, open-label, pilot, randomized, parallel-group study. Participants will be 30 patients aged ≥65 years admitted to the CRW and randomly assigned to the experimental group (RAS-based gait practice; n = 15) or the control group (normal gait practice; n = 15). In both groups, interventions will be conducted for 30 min per session, 5 times per week for 3 weeks. The primary outcome is the change in the 10-m walk test 3 weeks after the baseline assessment. Secondary outcome is the change in the score of the Medical Outcome Study 8-Item Short-Form Health Survey and the Japanese version of the modified Gait Efficacy Scale from baseline assessment to 3 weeks later. Discussion This exploratory RCT was developed using strict scientific standards and is based on defined protocols. Thus, this study will be used to assess the viability of a larger investigation into RAS-based gait practice. If our theory is accurate, this study could serve as a foundation for establishing RAS-based gait practice in CRWs as a common rehabilitation strategy. Trial registration This study was registered in the University Hospital Medical Information Network (UMIN) clinical trials registry in Japan (UMIN000049089).
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Affiliation(s)
- Takumi Igusa
- Graduate School of Health Sciences, Gunma University, Maebashi, Japan
- Department of Rehabilitation, Medical Corporation Taiseikai, Uchida Hospital, Numata, Japan
| | - Takuya Kobayashi
- Graduate School of Health Sciences, Gunma University, Maebashi, Japan
- Department of Rehabilitation, Japan Community Healthcare Organization, Gunma Chuo Hospital, Maebashi, Japan
| | - Hiroyuki Uchida
- Department of Rehabilitation, Kurashiki Heisei Hospital, Kurashiki, Japan
| | - Kenji Tsuchiya
- Department of Rehabilitation, Faculty of Health Sciences, Nagano University of Health and Medicine, Nagano, Japan
| | - Takanari Akiba
- Department of Rehabilitation, Japan Community Healthcare Organization, Gunma Chuo Hospital, Maebashi, Japan
| | - Shota Sema
- Department of Rehabilitation, Medical Corporation Taiseikai, Uchida Hospital, Numata, Japan
| | - Shunsuke Kaneko
- Department of Rehabilitation, Medical Corporation Taiseikai, Uchida Hospital, Numata, Japan
| | - Taiki Yoshita
- Department of Rehabilitation, Medical Corporation Taiseikai, Uchida Hospital, Numata, Japan
| | - Sakyo Nagai
- Department of Rehabilitation, Medical Corporation Taiseikai, Uchida Hospital, Numata, Japan
| | - Yukiko Tanaka
- Department of Rehabilitation, Medical Corporation Taiseikai, Uchida Hospital, Numata, Japan
| | - Senichiro Kikuchi
- Graduate School of Health Sciences, Gunma University, Maebashi, Japan
| | - Kazuki Hirao
- Graduate School of Health Sciences, Gunma University, Maebashi, Japan
- Corresponding author. Graduate School of Health Sciences, Gunma University, 3-39-22 Showa, Maebashi, Gunma, 371-8514, Japan.
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24
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Park KS, Williams DM, Etnier JL. Exploring the use of music to promote physical activity: From the viewpoint of psychological hedonism. Front Psychol 2023; 14:1021825. [PMID: 36760458 PMCID: PMC9905642 DOI: 10.3389/fpsyg.2023.1021825] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/17/2022] [Accepted: 01/09/2023] [Indexed: 01/26/2023] Open
Abstract
Despite the global efforts to encourage people to regularly participate in physical activity (PA) at moderate-to-vigorous intensity, an inadequate number of adults and adolescents worldwide meet the recommended dose of PA. A major challenge to promoting PA is that sedentary or low-active people experience negative shifts in affective valence (feeling bad versus good) in response to moderate-to-vigorous intensity PA. Interestingly, empirical data indicate that listening to music during acute bouts of PA positively alters affective valence (feeling good versus bad), reduces perceived exertion, and improves physical performance and oxygen utilization efficiency. From the viewpoint of the ancient principle of psychological hedonism - humans have ultimate desires to obtain pleasure and avoid displeasure - we elaborate on three putative mechanisms underlying the affective and ergogenic effects of music on acute bouts of PA: (1) musical pleasure and reward, (2) rhythmic entrainment, and (3) sensory distraction from physical exertion. Given that a positive shift in affective valence during an acute bout of PA is associated with more PA in the future, an important question arises as to whether the affective effect of music on acute PA can be carried over to promote long-term PA. Although this research question seems intuitive, to our knowledge, it has been scarcely investigated. We propose a theoretical model of Music as an Affective Stimulant to Physical Activity (MASPA) to further explain the putative mechanisms underlying the use of music to promote long-term PA. We believe there have been important gaps in music-based interventions in terms of the rationale supporting various components of the intervention and the efficacy of these interventions to promote long-term PA. Our specification of relevant mechanisms and proposal of a new theoretical model may advance our understanding of the optimal use of music as an affective, ergogenic, and sensory stimulant for PA promotion. Future directions are suggested to address the gaps in the literature.
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Affiliation(s)
- Kyoung Shin Park
- Department of Kinesiology, University of North Carolina at Greensboro, Greensboro, NC, United States,*Correspondence: Kyoung Shin Park, ✉
| | - David M. Williams
- Center for Health Promotion and Health Equity, Brown University, Providence, RI, United States
| | - Jennifer L. Etnier
- Department of Kinesiology, University of North Carolina at Greensboro, Greensboro, NC, United States
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25
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Harrison EC, Earhart GM. The effect of auditory cues on gait variability in people with Parkinson's disease and older adults: a systematic review. Neurodegener Dis Manag 2023; 13:113-128. [PMID: 36695189 DOI: 10.2217/nmt-2021-0050] [Citation(s) in RCA: 7] [Impact Index Per Article: 3.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/26/2023] Open
Abstract
Aim: The goal of this study was to analyze the effects of external rhythmic auditory stimulation (RAS) on gait variability in older adults and people with Parkinson's disease (PD). Methods: Academic databases searched included PubMed, Web of Science, PEDro and Cochrane, from inception to September 2021. Eligible articles scored a minimum of 4 on the PEDro scale. Results: Twenty-three papers were included. People with PD show varied responses in gait variability to RAS during cued walking trials. Healthy older adults tended to increase variability during cued trials. Cue rates below preferred walking cadence tend to increase gait variability. Conclusion: Gait variability is closely associated with fall risk and an important consideration in development of gait rehabilitation techniques.
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Affiliation(s)
- Elinor C Harrison
- Washington University in St. Louis School of Medicine, Program in Physical Therapy, St. Louis, MO 63110, USA.,Washington University in St. Louis, Performing Arts Department, St. Louis, MO 63105, USA
| | - Gammon M Earhart
- Washington University in St. Louis School of Medicine, Program in Physical Therapy, St. Louis, MO 63110, USA.,Washington University in St. Louis School of Medicine, Department of Neurology, St. Louis, MO 63110, USA.,Washington University in St. Louis School of Medicine, Department of Neuroscience, St. Louis, MO 63110, USA
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26
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Lee H, Ko B. Effects of Music-Based Interventions on Motor and Non-Motor Symptoms in Patients with Parkinson's Disease: A Systematic Review and Meta-Analysis. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 2023; 20:1046. [PMID: 36673802 PMCID: PMC9859027 DOI: 10.3390/ijerph20021046] [Citation(s) in RCA: 5] [Impact Index Per Article: 2.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Figures] [Subscribe] [Scholar Register] [Received: 11/30/2022] [Revised: 01/03/2023] [Accepted: 01/04/2023] [Indexed: 06/17/2023]
Abstract
This systematic review and meta-analysis examined previous studies on music-based interventions for individuals with Parkinson’s disease (PD). The effectiveness of the interventions on various motor and non-motor outcomes was evaluated. This review was conducted by searching PubMed, CINAHL, PsycINFO, and Cochrane Library CENTRAL prior to June 2022 for randomized controlled trial (RCT) and controlled clinical trial (CCT) studies published in English. Data were expressed as weighted/standardized mean difference (MD/SMD) with 95% confidence intervals (CI). I2 index was used for heterogeneity. The initial search identified 745 studies, and 13 studies involving 417 participants with PD which met the inclusion criteria included in this review. The results of the meta-analysis revealed that music-based interventions can significantly improve walking velocity (MD = 0.12, 95% CI = 0.07~0.16, p < 0.00001), stride length (MD = 0.04, 95% CI = 0.02~0.07, p = 0.002), and mobility (MD = −1.05, 95% CI = −1.53~−0.57, p < 0.0001). However, the results did not support significant effects for music-based interventions on cadence (MD = 3.21, 95% CI = −4.15~10.57, p = 0.39), cognitive flexibility (MD = 20.91, 95% CI = −10.62~52.44, p = 0.19), inhibition (SMD = 0.07, 95% CI = −0.40~0.55, p = 0.76), and quality of life (SMD = −0.68, 95% CI= −1.68~0.32, p = 0.18). The findings suggest that music-based interventions are effective for the improvement of some motor symptoms, but evidence for non-motor symptoms is limited. Further high-quality studies with a larger sample size are required to obtain the robust effects of music-based interventions on various outcomes among patients with PD.
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Affiliation(s)
- Hyunjung Lee
- Department of Music Therapy, Graduate School, Ewha Womans University, Seoul 03760, Republic of Korea
| | - Bumsuk Ko
- Department of Music, Graduate School, Hansei University, Gunpo 15852, Republic of Korea
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27
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Zhang M, Li F, Wang D, Ba X, Liu Z. Mapping Research Trends from 20 Years of Publications in Rhythmic Auditory Stimulation. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 2022; 20:215. [PMID: 36612537 PMCID: PMC9819413 DOI: 10.3390/ijerph20010215] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Figures] [Subscribe] [Scholar Register] [Received: 10/19/2022] [Revised: 12/05/2022] [Accepted: 12/07/2022] [Indexed: 06/17/2023]
Abstract
This study aims to create an all-around insight into the evolutions, status, and global trends of rhythmic auditory stimulation (RAS) research via enhanced bibliometric methods for the 2001-2020 time period. Articles concerning RAS were extracted from the Web of Science database. CiteSpace, Bibliometrix, VOSviewer, and Graphpad Prism were employed to analyze publication patterns and research trends. A total of 586 publications related to RAS between 2001 and 2020 were retrieved from the Web of Science database. The researcher Goswami U. made the greatest contribution to this field. The University of Toronto was the institution that published the most articles. Motor dysfunction, sensory perception, and cognition are the three major domains of RAS research. Neural tracking, working memory, and neural basis may be the latest research frontiers. This study reveals the publication patterns and topic trends of RAS based on the records published between 2001 and 2020. The insights obtained provided useful references for the future research and applications of RAS.
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Affiliation(s)
- Meiqi Zhang
- Department of Physical Education and Health Education, Springfield College, Springfield, MA 01109, USA
- Yale/VA Learning-Based Recovery Center, Yale University, New Haven, CT 06510, USA
| | - Fang Li
- Department of Neurology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121001, China
| | - Dongyu Wang
- Department of Neurology, The Center Hospital of Jinzhou, Jinzhou 121001, China
| | - Xiaohong Ba
- Department of Neurology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121001, China
| | - Zhan Liu
- Department of Physical Education and Health Education, Springfield College, Springfield, MA 01109, USA
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28
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Li F, Wang D, Ba X, Liu Z, Zhang M. The comparative effects of exercise type on motor function of patients with Parkinson's disease: A three-arm randomized trial. Front Hum Neurosci 2022; 16:1033289. [PMID: 36530197 PMCID: PMC9751317 DOI: 10.3389/fnhum.2022.1033289] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/31/2022] [Accepted: 10/20/2022] [Indexed: 10/05/2023] Open
Abstract
BACKGROUND Yang-ge dancing is a culturally specific exercise in which people are required to perform motor skills in coordination with rhythmic music. As an integrated exercise with both physical (decelerating the progression of aged-related motor function degeneration) and mental benefits, it has gained great popularity in China, especially among middle-aged and older adults. It remains largely unknown whether Yang-ge dancing (YG) can effectively improve main symptoms of Parkinson's disease (PD), while conventional exercise rehabilitation program has been recommended in the hospital setting. To this end, this study aimed to investigate the comparative effects of exercise therapy on motor function of PD patients. MATERIALS AND METHODS A sample of 51 PD patients were randomly assigned to Yang-ge dancing, conventional exercise, or conventional exercise with music. Participants in each group performed 60 min per session, five sessions per week of interventions for 4 weeks. All the participants were assessed using the Unified Parkinson's Disease Rating Scale-motor examination, Berg balance test, timed up and go test, and Purdue pegboard test. Motor performances were examined before and after intervention. RESULTS All the three groups were benefited from exercise. Compared to conventional exercise, the Yang-ge dancing and conventional exercise with music had additional positive effects in mobility with reference to baseline.In addition, compared to the two conventional exercise groups (either with/without music), the Yang-ge dancing further enhanced manual dexterity. CONCLUSION Exercise with rhythmic auditory stimulation optimized mobility in PD, while YG dance specifically contributed to improvement in manual dexterity. CLINICAL TRIAL REGISTERATION [https://clinicaltrials.gov/], identifier [ChiCTR2200061252].
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Affiliation(s)
- Fang Li
- Department of Neurology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China
| | - Dongyu Wang
- Department of Neurology, The Center Hospital of Jinzhou, Jinzhou, China
| | - Xiaohong Ba
- Department of Neurology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China
| | - Zhan Liu
- Department of Physical Education and Health Education, Springfield College, Springfield, MA, United States
| | - Meiqi Zhang
- Department of Physical Education and Health Education, Springfield College, Springfield, MA, United States
- Learning-Based Recovery Center, Yale University, New Haven, CT, United States
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29
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Pantelyat A, Dayanim G, Kang K, Turk B, Pagkatipunan R, Huenergard SK, Mears A, Bang J. Rhythmic auditory cueing in atypical parkinsonism: A pilot study. Front Neurol 2022; 13:1018206. [PMID: 36388209 PMCID: PMC9650086 DOI: 10.3389/fneur.2022.1018206] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/12/2022] [Accepted: 10/03/2022] [Indexed: 11/30/2022] Open
Abstract
Rhythmic auditory cueing (RAC) can improve gait parameters in neurological disorders such as Parkinson's disease and stroke. However, there is a lack of research on the effects of RAC in patients with atypical parkinsonian disorders (APD). Using a smartphone metronome application, we aimed to investigate the immediate effects of RAC in patients with clinically diagnosed APD, namely Progressive Supranuclear Palsy (PSP-Richardson Syndrome and other variants, PSP-nonRS), Corticobasal Syndrome (CBS), Multiple System Atrophy (MSA), and Dementia with Lewy Bodies (DLB). A total of 46 APD participants (25 PSP, 9 CBS, 8 MSA and 4 DLB; age: mean = 70.17, standard deviation = 7.15) walked at their preferred pace for 2 min without any rhythmic auditory cueing (RAC). Participants then walked the same path for another 2 min with RAC set at a tempo 10% faster than the baseline cadence of each participant. After a 10–15-min break, participants walked the same path for another 2 min without RAC to observe for carryover effects. Gait parameters [cadence (steps/minute), gait velocity (meters/minute), and stride length (centimeters)] were collected at baseline, during RAC, and post-RAC. There was a significant improvement in cadence in all participants from baseline to during RAC and post-RAC (corrected p-values = 0.009 for both). Gait velocity also improved from baseline to during RAC and post-RAC in all participants, although this improvement was not significant after correcting for multiple comparisons. The changes in cadence and gait velocity were most pronounced in PSP. In addition, our exploratory analysis showed that the cadence in the suspected TAU group (PSP+CBS) showed a significant improvement from baseline to during RAC and post-RAC (corr. p-value = 0.004 for both). This pilot study using short-term RAC in APD patients demonstrated improvements in cadence and velocity. There is an urgent need for effective gait rehabilitation modalities for patients with APD, and rhythmic cueing can be a practical and useful intervention to improve their gait pattern.
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Affiliation(s)
- Alexander Pantelyat
- Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States
- Center for Music and Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States
- *Correspondence: Alexander Pantelyat
| | - Gabriel Dayanim
- College of Computer, Mathematical, and Natural Sciences, University of Maryland, College Park, MD, United States
| | - Kyurim Kang
- Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States
- Center for Music and Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States
| | - Bela Turk
- Departments of Neurology and Pediatrics, Moser Center for Leukodystrophies, Kennedy Krieger Institute, Johns Hopkins Medical Institutions, Baltimore, MD, United States
| | - Ruben Pagkatipunan
- Department of Rehabilitation, Johns Hopkins Bayview Medical Center, Baltimore, MD, United States
| | - Sera-Kim Huenergard
- Department of Rehabilitation, Johns Hopkins Bayview Medical Center, Baltimore, MD, United States
| | - Albert Mears
- Department of Rehabilitation, Johns Hopkins Bayview Medical Center, Baltimore, MD, United States
| | - Jee Bang
- Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States
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30
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Detecting Parkinson's Disease through Gait Measures Using Machine Learning. Diagnostics (Basel) 2022; 12:diagnostics12102404. [PMID: 36292093 PMCID: PMC9600300 DOI: 10.3390/diagnostics12102404] [Citation(s) in RCA: 3] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/19/2022] [Revised: 09/29/2022] [Accepted: 10/01/2022] [Indexed: 11/25/2022] Open
Abstract
Parkinson’s disease (PD) is one of the most common long-term degenerative movement disorders that affects the motor system. This progressive nervous system disorder affects nearly one million Americans, and more than 20,000 new cases are diagnosed each year. PD is a chronic and progressive painful neurological disorder and usually people with PD live 10 to 20 years after being diagnosed. PD is diagnosed based on the identification of motor signs of bradykinesia, rigidity, tremor, and postural instability. Though several attempts have been made to develop explicit diagnostic criteria, this is still largely unrevealed. In this manuscript, we aim to build a classifier with gait data from Parkinson patients and healthy controls using machine learning methods. The classifier could help facilitate a more accurate and cost-effective diagnostic method. The input to our algorithm is the Gait in Parkinson’s Disease dataset published on PhysioNet containing force sensor data as the measurement of gait from 92 healthy subjects and 214 patients with idiopathic Parkinson’s Disease. Different machine learning methods, including logistic regression, SVM, decision tree, KNN were tested to output a predicted classification of Parkinson patients and healthy controls. Baseline models including frequency domain method can reach similar performance and may be another good approach for the PD diagnostics.
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31
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Yang S, Suh JH, Kwon S, Chang MC. The effect of neurologic music therapy in patients with cerebral palsy: A systematic narrative review. Front Neurol 2022; 13:852277. [PMID: 36176557 PMCID: PMC9514322 DOI: 10.3389/fneur.2022.852277] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/11/2022] [Accepted: 08/15/2022] [Indexed: 12/02/2022] Open
Abstract
BACKGROUND Cerebral palsy (CP) is one of the most common causes of disability in children. It is characterized by impairment in motor function and coordination and difficulties in performing daily life activities. Previous research supports that neurologic music therapy (NMT) was effective in improving motor function, cognition, and emotional wellbeing in patients with various neurologic disorders. However, the benefit of NMT in patients with CP have not yet been thoroughly investigated. The aim of this review was to investigate the potential effect of NMT motor rehabilitation techniques for patients. MATERIALS AND METHODS We searched articles published up to May 24, 2022 in PubMed, Embase, Scopus, Cochrane library, Web of science, and Ovid MEDLINEdatabases. We included studies that investigated the effect of NMT in patients with CP. RESULTS After search, 4,117 articles were identified using the search terms. After reading the titles and abstracts, 4,089 articles that did not meet our inclusion criteria were excluded. The remaining 28 articles which were assessed for eligibility. Finally, 15 studies were included in this systematic review. Among 15 studies that investigated the effect of NMT on patients with CP, 7 studies were on rhythmic auditory stimulation (RAS), 6 studies were on therapeutic instrumental music performance (TIMP), and 2 studies were on patterned sensory enhancement (PSE). CONCLUSIONS Various techniques of NMT brings beneficial effects for gross and fine motor improvements in patients with CP. NMT techniques, such as RAS, TIMP, and PSE, may be a potential alternative rehabilitation strategy to enhance gross and fine motor skills for patients with CP.
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Affiliation(s)
- Seoyon Yang
- Department of Rehabilitation Medicine, College of Medicine, Ewha Woman's University, Seoul, South Korea
| | - Jee Hyun Suh
- Department of Rehabilitation Medicine, College of Medicine, Ewha Woman's University, Seoul, South Korea
| | - SuYeon Kwon
- Department of Rehabilitation Medicine, College of Medicine, Ewha Woman's University, Seoul, South Korea
| | - Min Cheol Chang
- Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Daegu, South Korea
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Park KS. Decomposing the Effects of Familiarity with Music Cues on Stride Length and Variability in Persons with Parkinson's Disease: On the Role of Covariates. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 2022; 19:10793. [PMID: 36078509 PMCID: PMC9518111 DOI: 10.3390/ijerph191710793] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Figures] [Subscribe] [Scholar Register] [Received: 07/26/2022] [Revised: 08/24/2022] [Accepted: 08/28/2022] [Indexed: 06/15/2023]
Abstract
This study aimed to determine the role of cognitive and affective responses to music cues in modulating the effects of familiarity with music on stride length and stride-to-stride variability in people with Parkinson's disease (PD). Using multilevel modeling, people with PD's spatiotemporal gait parameters and self-reported ratings of familiarity, enjoyment, cognitive and physical demand, beats salience of music cues after each walking trial, as well as music reward, were analyzed. Our findings indicate that (1) condition-varying perceived enjoyment and beat salience are positively associated with increased stride length; (2) participants with a greater music reward for mood regulation and emotion evocation show greater stride length changes compared with those with less music reward; (3) condition-varying perceived enjoyment is positively associated with decreases in stride-to-stride variability; and (4) participants with lower cognitive demand of walking with music cues and higher beat salience show lower stride-to-stride variability compared with those with higher cognitive demand and lower beat salience. These results provide behavioral evidence of independent and interactive influences of cognitive and affective responses to music cues on spatiotemporal gait parameters in people with PD.
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Affiliation(s)
- Kyoung Shin Park
- Department of Kinesiology, University of North Carolina at Greensboro, Greensboro, NC 27412, USA
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Karpodini CC, Dinas PC, Angelopoulou E, Wyon MA, Haas AN, Bougiesi M, Papageorgiou SG, Koutedakis Y. Rhythmic cueing, dance, resistance training, and Parkinson's disease: A systematic review and meta-analysis. Front Neurol 2022; 13:875178. [PMID: 36034281 PMCID: PMC9413961 DOI: 10.3389/fneur.2022.875178] [Citation(s) in RCA: 8] [Impact Index Per Article: 2.7] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/23/2022] [Accepted: 07/14/2022] [Indexed: 11/30/2022] Open
Abstract
Objectives The aim of the present systematic review and meta-analysis was to synthesize evidence associated with the functional and clinical effectiveness of rhythmic cueing, dance, or resistance training (RT) on motor and non-motor parameters in Parkinson's Disease patients, and to provide a comparative perspective not offered by existing systematic reviews. Methodology Eligibility criteria for selecting studies retained no restrictions in methodological design and included interventions of rhythmic cueing, dance, RT, and measurements of motor and non-motor parameters. Animal studies, reviews, editorials, conferences, magazines, and gray literature articles were excluded. Two independent investigators searched Cochrane Library, Medline, PubMed, and SPORTDiscus from the date of their inception until 1 June 2021. The ROBINS-I tool was employed for the non-randomized controlled trials, and the updated for Risk of Bias 2 tool of Cochrane Library used for randomized controlled trials. For meta-analyses, the RevMan 5.4.13 software was used. For incompatible meta-analysis studies, a narrative data synthesis was conducted. Results A total of 49 studies included in the systematic review involving 3767 PD participants. Meta-analyses revealed that rhythmic cueing training assists gait velocity (p = 0.01), stride length (p = 0.01), and motor symptoms (p = 0.03). Similarly, dance training benefits stride length (p = 0.05), lower extremity function-TUG (p = 0.01), and motor symptoms (p = 0.01), whilst RT improves lower extremity function-TUG (p = 0.01), quality of life (p = 0.01), knee flexion (p = 0.02), and leg press (p = 0.01). Subgroup analyses have shown non-significant differences in gait velocity (p = 0.26), stride length (p = 0.80), functional mobility-TUG (p = 0.74), motor symptoms-UPDRS-III (p = 0.46), and quality of life-PDQ39 (p = 0.44). Conclusion Rhythmic cueing, dance, or RT positively affect the examined outcomes, with rhythmic cueing to be associated with three outcomes (Gait, Stride, and UPDRS-III), dance with three outcomes (TUG, Stride, and UPDRS-III), and RT with two outcomes (TUG and PDQ-39). Subgroup analyses confirmed the beneficial effects of these forms of exercise. Clinicians should entertain the idea of more holistic exercise protocols aiming at improving PD manifestations.International Prospective Register of systematic reviews (PROSPERO) (registration number: CRD42020212380).
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Affiliation(s)
- Claire Chrysanthi Karpodini
- Sport and Physical Activity Research Centre, Faculty of Education, Health and Wellbeing, University of Wolverhampton, Wolverhampton, United Kingdom
| | - Petros C. Dinas
- Functional Architecture of Mammals in their Environment Laboratory, Department of Physical Education and Sport Science, University of Thessaly, Volos, Greece
| | - Efthalia Angelopoulou
- First Department of Neurology, Medical School, National and Kapodistrian University of Athens, Eginition University Hospital, Athens, Greece
| | - Matthew A. Wyon
- Sport and Physical Activity Research Centre, Faculty of Education, Health and Wellbeing, University of Wolverhampton, Wolverhampton, United Kingdom
| | - Aline Nogueira Haas
- School of Physical Education Physiotherapy and Dance, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil
| | - Maria Bougiesi
- Functional Architecture of Mammals in their Environment Laboratory, Department of Physical Education and Sport Science, University of Thessaly, Volos, Greece
| | - Sokratis G. Papageorgiou
- First Department of Neurology, Medical School, National and Kapodistrian University of Athens, Eginition University Hospital, Athens, Greece
| | - Yiannis Koutedakis
- Sport and Physical Activity Research Centre, Faculty of Education, Health and Wellbeing, University of Wolverhampton, Wolverhampton, United Kingdom
- Functional Architecture of Mammals in their Environment Laboratory, Department of Physical Education and Sport Science, University of Thessaly, Volos, Greece
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Wu Z, Kong L, Zhang Q. Research Progress of Music Therapy on Gait Intervention in Patients with Parkinson’s Disease. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 2022; 19:ijerph19159568. [PMID: 35954925 PMCID: PMC9368619 DOI: 10.3390/ijerph19159568] [Citation(s) in RCA: 7] [Impact Index Per Article: 2.3] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Download PDF] [Subscribe] [Scholar Register] [Received: 07/13/2022] [Revised: 07/28/2022] [Accepted: 08/02/2022] [Indexed: 11/16/2022]
Abstract
Music therapy is an effective way to treat the gait disorders caused by Parkinson’s disease. Rhythm music stimulation, therapeutic singing, and therapeutic instrument performance are often used in clinical practice. The mechanisms of music therapy on the gait of patients with Parkinson’s disease include the compensation mechanism of cerebellum recruitment, rhythm entrainment, acceleration of motor learning, stimulation of neural coherence, and increase of cortical activity. All mechanisms work together to complete the intervention of music therapy on patients’ gait and help patients to recover better. In this paper, the effect of music therapy on gait disorders in Parkinson’s disease patients was reviewed, and some suggestions were put forward.
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Motor Influence in Developing Auditory Spatial Cognition in Hemiplegic Children with and without Visual Field Disorder. CHILDREN 2022; 9:children9071055. [PMID: 35884039 PMCID: PMC9320626 DOI: 10.3390/children9071055] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 06/19/2022] [Revised: 07/06/2022] [Accepted: 07/12/2022] [Indexed: 12/05/2022]
Abstract
Spatial representation is a crucial skill for everyday interaction with the environment. Different factors seem to influence spatial perception, such as body movements and vision. However, it is still unknown if motor impairment affects the building of simple spatial perception. To investigate this point, we tested hemiplegic children with (HV) and without visual field (H) disorders in an auditory and visual-spatial localization and pitch discrimination task. Fifteen hemiplegic children (nine H and six HV) and twenty with typical development took part in the experiment. The tasks consisted in listening to a sound coming from a series of speakers positioned at the front or back of the subject. In one condition, subjects were asked to discriminate the pitch, while in the other, subjects had to localize the position of the sound. We also replicated the spatial task in a visual modality. Both groups of hemiplegic children performed worse in the auditory spatial localization task compared with the control, while no difference was found in the pitch discrimination task. For the visual-spatial localization task, only HV children differed from the two other groups. These results suggest that movement is important for the development of auditory spatial representation.
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Effects of rhythmic auditory stimulation on upper-limb movements in patients with Parkinson's disease. Parkinsonism Relat Disord 2022; 101:27-30. [PMID: 35763906 DOI: 10.1016/j.parkreldis.2022.06.020] [Citation(s) in RCA: 6] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 04/19/2022] [Revised: 06/20/2022] [Accepted: 06/20/2022] [Indexed: 11/21/2022]
Abstract
INTRODUCTION Rhythmic auditory stimulation (RAS) is an effective technique extensively used to alleviate lower-limb bradykinesia in patients with Parkinson's disease (PD). However, RAS effects on upper-limb bradykinesia have not been well studied. This study investigated immediate effects of RAS on upper-limb movements in PD patients and healthy people. METHODS PD patients (n = 23) and age- and gender-matched healthy controls (n = 23) executed left-hand, right-hand, and both-hand movement tasks of the Purdue Pegboard Test when listening to the beats of RAS, including 100%, 110%, and 120% of the baseline tempo, which was fastest movement performance of each participant without the aid of RAS. Sequence of RAS and tasks was randomized for each participant. RESULTS PD patients had slower upper-limb movements than did health controls. An interaction was found between RAS and tasks. In both patients and controls and for all task conditions, 120%RAS induced higher scores than did 110% RAS, and the latter induced higher scores than did 100%RAS. In both patients and controls and for all RAS conditions, the right-hand condition induced higher scores than did the left-hand condition, and the latter induced higher scores than did the both-hand condition. CONCLUSIONS RAS was effective in regulating upper-limb movements in PD patients, which may be explained by rich neural connections between auditory and motor cortical areas in humans. Clinical practitioners should consider using RAS in clinical therapy. Future neuroimaging studies are needed to explore neural mechanisms of RAS in PD patients.
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Tekriwal A, Felsen G, Ojemann SG, Abosch A, Thompson JA. Motor context modulates substantia nigra pars reticulata spike activity in patients with Parkinson's disease. J Neurol Neurosurg Psychiatry 2022; 93:386-394. [PMID: 35193951 PMCID: PMC10593310 DOI: 10.1136/jnnp-2021-326962] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 04/25/2021] [Accepted: 02/01/2022] [Indexed: 12/14/2022]
Abstract
OBJECTIVE The severity of motor symptoms in Parkinson's disease (PD) depends on environmental conditions. For example, the presence of external patterns such as a rhythmic tone can attenuate bradykinetic impairments. However, the neural mechanisms for this context-dependent attenuation (e.g., paradoxical kinesis) remain unknown. Here, we investigate whether context-dependent symptom attenuation is reflected in single-unit activity recorded in the operating room from the substantia nigra pars reticulata (SNr) of patients with PD undergoing deep brain stimulation surgery. The SNr is known to influence motor planning and execution in animal models, but its role in humans remains understudied. METHODS We recorded SNr activity while subjects performed cued directional movements in response to auditory stimuli under interleaved 'patterned' and 'unpatterned' contexts. SNr localisation was independently confirmed with expert intraoperative assessment as well as post hoc imaging-based reconstructions. RESULTS As predicted, we found that motor performance was improved in the patterned context, reflected in increased reaction speed and accuracy compared with the unpatterned context. These behavioural differences were associated with enhanced responsiveness of SNr neurons-that is, larger changes in activity from baseline-in the patterned context. Unsupervised clustering analysis revealed two distinct subtypes of SNr neurons: one exhibited context-dependent enhanced responsiveness exclusively during movement preparation, whereas the other showed enhanced responsiveness during portions of the task associated with both motor and non-motor processes. CONCLUSIONS Our findings indicate the SNr participates in motor planning and execution, as well as warrants greater attention in the study of human sensorimotor integration and as a target for neuromodulatory therapies.
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Affiliation(s)
- Anand Tekriwal
- Departments of Neurosurgery and Physiology and Biophysics, Neuroscience Graduate Program, Medical Scientist Training Program, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA
| | - Gidon Felsen
- Department of Physiology and Biophysics, Neuroscience Graduate Program, Medical Scientist Training Program, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA
| | - Steven G Ojemann
- Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA
| | - Aviva Abosch
- Department of Neurosurgery, University of Nebraska Medical Center, Omaha, Nebraska, USA
| | - John A Thompson
- Departments of Neurosurgery and Neurology, Neuroscience Graduate Program, Medical Scientist Training Program, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA
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Ossmy O, Mansano L, Frenkel-Toledo S, Kagan E, Koren S, Gilron R, Reznik D, Soroker N, Mukamel R. Motor learning in hemi-Parkinson using VR-manipulated sensory feedback. Disabil Rehabil Assist Technol 2022; 17:349-361. [PMID: 32657187 DOI: 10.1080/17483107.2020.1785561] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/17/2020] [Revised: 05/07/2020] [Accepted: 06/17/2020] [Indexed: 01/10/2023]
Abstract
AIMS Modalities for rehabilitation of the neurologically affected upper-limb (UL) are generally of limited benefit. The majority of patients seriously affected by UL paresis remain with severe motor disability, despite all rehabilitation efforts. Consequently, extensive clinical research is dedicated to develop novel strategies aimed to improve the functional outcome of the affected UL. We have developed a novel virtual-reality training tool that exploits the voluntary control of one hand and provides real-time movement-based manipulated sensory feedback as if the other hand is the one that moves. The aim of this study was to expand our previous results, obtained in healthy subjects, to examine the utility of this training setup in the context of neuro-rehabilitation. METHODS We tested the training setup in patient LA, a young man with significant unilateral UL dysfunction stemming from hemi-parkinsonism. LA underwent daily intervention in which he intensively trained the non-affected upper limb, while receiving online sensory feedback that created an illusory perception of control over the affected limb. Neural changes were assessed using functional magnetic resonance imaging (fMRI) scans before and after training. RESULTS Training-induced behavioral gains were accompanied by enhanced activation in the pre-frontal cortex and a widespread increase in resting-state functional connectivity. DISCUSSION Our combination of cutting edge technologies, insights gained from basic motor neuroscience in healthy subjects and well-known clinical treatments, hold promise for the pursuit of finding novel and more efficient rehabilitation schemes for patients suffering from hemiplegia.Implications for rehabilitationAssistive devices used in hospitals to support patients with hemiparesis require expensive equipment and trained personnel - constraining the amount of training that a given patient can receive. The setup we describe is simple and can be easily used at home with the assistance of an untrained caregiver/family member. Once installed at the patient's home, the setup is lightweight, mobile, and can be used with minimal maintenance . Building on advances in machine learning, our software can be adapted to personal use at homes. Our findings can be translated into practice with relatively few adjustments, and our experimental design may be used as an important adjuvant to standard clinical care for upper limb hemiparesis.
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Affiliation(s)
- Ori Ossmy
- Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv, Israel
- School of Psychological Sciences, Tel-Aviv University, Tel-Aviv, Israel
| | - Lihi Mansano
- Department of Neurological Rehabilitation, Loewenstein Hospital, Ra'anana, Israel
| | - Silvi Frenkel-Toledo
- Department of Physiotherapy, Faculty of Health Sciences, Ariel University, Ariel, Israel
| | - Evgeny Kagan
- Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv, Israel
| | - Shiri Koren
- School of Psychological Sciences, Tel-Aviv University, Tel-Aviv, Israel
| | - Roee Gilron
- Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv, Israel
- School of Psychological Sciences, Tel-Aviv University, Tel-Aviv, Israel
| | - Daniel Reznik
- Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv, Israel
- School of Psychological Sciences, Tel-Aviv University, Tel-Aviv, Israel
| | - Nachum Soroker
- Department of Neurological Rehabilitation, Loewenstein Hospital, Ra'anana, Israel
- Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel
| | - Roy Mukamel
- Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv, Israel
- School of Psychological Sciences, Tel-Aviv University, Tel-Aviv, Israel
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Hebb C, Raynor G, Perez DL, Nappi-Kaehler J, Polich G. The use of rhythmic auditory stimulation for functional gait disorder: A case report. NeuroRehabilitation 2022; 50:219-229. [DOI: 10.3233/nre-228005] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/15/2022]
Abstract
BACKGROUND: Functional gait disorders (FGD) are a common and disabling condition. Consensus-based rehabilitation techniques for treating FGD and other functional neurological disorder presentations at large utilize a variety of therapeutic strategies, including distraction, novel approaches to movement, entrainment, stress/hypervigilance modulation, and psychotherapy. CASE REPORT: Here we present a case of a 24-year-old woman with a complex history of anxiety, depression, left frontal astrocytoma, postural orthostatic tachycardia syndrome (POTS) and FGD. During a multidisciplinary inpatient rehabilitation stay for FGD, the patient underwent rhythmic auditory stimulation (RAS) delivered by a neurologic music therapist in conjunction with physical therapy, occupational therapy, and psychotherapy. RESULTS: The RAS intervention appeared to play a significant role in symptom resolution for this patient. Improvement in the patient’s truncal displacement, foot dragging, and well as overall gait speed occurred following serial RAS trials performed over a single treatment session. Benefits persisted immediately following the intervention and upon subsequent reassessment. Although at four-year follow-up the patient’s FGD symptoms remained resolved, fatigue continued to limit her ambulatory capacity and overall endurance. CONCLUSION: RAS represents a unique therapeutic approach for treating FGD, complementary to existing consensus-based rehabilitation recommendations, and may warrant further consideration by the field.
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Affiliation(s)
- Caitlin Hebb
- MedRhythms, Inc., Boston, MA, USA
- Spaulding Rehabilitation Hospital, Boston, MA, USA
| | - Geoffrey Raynor
- Department of Psychiatry, Brigham’s and Women’s Hospital, Boston, MA, USA
| | - David L. Perez
- Department of Neurology and Psychiatry, Massachusetts General Hospital, Boston, MA, USA
| | | | - Ginger Polich
- Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Brigham’s and Women’s Hospital, Boston, MA, USA
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Naro A, Pignolo L, Bruschetta D, Calabrò RS. What about the role of the cerebellum in music-associated functional recovery? A secondary EEG analysis of a randomized clinical trial in patients with Parkinson disease. Parkinsonism Relat Disord 2022; 96:57-64. [PMID: 35220062 DOI: 10.1016/j.parkreldis.2022.02.012] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/05/2021] [Revised: 02/06/2022] [Accepted: 02/17/2022] [Indexed: 10/19/2022]
Abstract
Rhythmic Auditory Stimulation (RAS) has been shown to be of help in an effective gait training of people with idiopathic Parkinson's disease (PD). The cerebellum may play an important role in RAS aftereffects by compensating the detrimental internal clock for automatic and rhythmic motricity. However, the neurophysiological mechanisms underlying RAS aftereffects are still poorly understood. In the present study, we tested the contribution of the cerebellum to RAS-based gait training aftereffects in people with PD by examining cerebellum-cerebral connectivity indices using standard EEG recording. We enrolled 50 patients with PD who were randomly assigned to two different modalities of treadmill gait training using GaitTrainer3 with and without RAS (non_RAS) during an 8-week training program. We measured clinical and kinematic gait indices and electrophysiological data (standard EEG recording during walking on GaitTrainer3) of both the gait trainings. We found that the greater improvement in gait performance following RAS than non_RAS training, as per clinical and kinematic assessment, was paralleled by a more evident reshape of cerebellum-brain functional connectivity with regard to specific brain areas (pre-motor, sensorimotor and temporal cortices) and gait-cycle phases (mainly 25-75% of the gait cycle duration). These findings suggest that the cerebellum mediates the reshape of sensorimotor rhythms and fronto-centroparietal connectivity in relation to specific gait-cycle phases. This may be consistent with a recovery of the internal timing mechanisms generating and controlling motor rhythmicity, eventually improving gait performance. The precise definition of the cerebellar role to gait functional recovery in people with PD may be crucial to create patient-tailored rehabilitative approaches.
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Affiliation(s)
- Antonino Naro
- IRCCS Centro Neurolesi Bonino Pulejo, Messina, Italy
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Adhikary S, Ghosh A. Dynamic time warping approach for optimized locomotor impairment detection using biomedical signal processing. Biomed Signal Process Control 2022. [DOI: 10.1016/j.bspc.2021.103321] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/18/2022]
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Braun Janzen T, Koshimori Y, Richard NM, Thaut MH. Rhythm and Music-Based Interventions in Motor Rehabilitation: Current Evidence and Future Perspectives. Front Hum Neurosci 2022; 15:789467. [PMID: 35111007 PMCID: PMC8801707 DOI: 10.3389/fnhum.2021.789467] [Citation(s) in RCA: 43] [Impact Index Per Article: 14.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/05/2021] [Accepted: 12/27/2021] [Indexed: 12/17/2022] Open
Abstract
Research in basic and clinical neuroscience of music conducted over the past decades has begun to uncover music’s high potential as a tool for rehabilitation. Advances in our understanding of how music engages parallel brain networks underpinning sensory and motor processes, arousal, reward, and affective regulation, have laid a sound neuroscientific foundation for the development of theory-driven music interventions that have been systematically tested in clinical settings. Of particular significance in the context of motor rehabilitation is the notion that musical rhythms can entrain movement patterns in patients with movement-related disorders, serving as a continuous time reference that can help regulate movement timing and pace. To date, a significant number of clinical and experimental studies have tested the application of rhythm- and music-based interventions to improve motor functions following central nervous injury and/or degeneration. The goal of this review is to appraise the current state of knowledge on the effectiveness of music and rhythm to modulate movement spatiotemporal patterns and restore motor function. By organizing and providing a critical appraisal of a large body of research, we hope to provide a revised framework for future research on the effectiveness of rhythm- and music-based interventions to restore and (re)train motor function.
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Affiliation(s)
- Thenille Braun Janzen
- Center of Mathematics, Computing and Cognition, Universidade Federal do ABC, São Bernardo do Campo, Brazil
| | - Yuko Koshimori
- Music and Health Science Research Collaboratory, Faculty of Music, University of Toronto, Toronto, ON, Canada
- Brain Health Imaging Centre, CAMH, Toronto, ON, Canada
| | - Nicole M. Richard
- Music and Health Science Research Collaboratory, Faculty of Music, University of Toronto, Toronto, ON, Canada
- Faculty of Music, Belmont University, Nashville, TN, United States
| | - Michael H. Thaut
- Music and Health Science Research Collaboratory, Faculty of Music, University of Toronto, Toronto, ON, Canada
- Rehabilitation Sciences Institute, University of Toronto, Toronto, ON, Canada
- *Correspondence: Michael H. Thaut,
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Sheppard K, Gardin J, Sabnis GS, Peer A, Darrell M, Deats S, Geuther B, Lutz CM, Kumar V. Stride-level analysis of mouse open field behavior using deep-learning-based pose estimation. Cell Rep 2022; 38:110231. [PMID: 35021077 PMCID: PMC8796662 DOI: 10.1016/j.celrep.2021.110231] [Citation(s) in RCA: 25] [Impact Index Per Article: 8.3] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/27/2020] [Revised: 04/29/2021] [Accepted: 12/16/2021] [Indexed: 12/20/2022] Open
Abstract
Gait and posture are often perturbed in many neurological, neuromuscular, and neuropsychiatric conditions. Rodents provide a tractable model for elucidating disease mechanisms and interventions. Here, we develop a neural-network-based assay that adopts the commonly used open field apparatus for mouse gait and posture analysis. We quantitate both with high precision across 62 strains of mice. We characterize four mutants with known gait deficits and demonstrate that multiple autism spectrum disorder (ASD) models show gait and posture deficits, implying this is a general feature of ASD. Mouse gait and posture measures are highly heritable and fall into three distinct classes. We conduct a genome-wide association study to define the genetic architecture of stride-level mouse movement in the open field. We provide a method for gait and posture extraction from the open field and one of the largest laboratory mouse gait and posture data resources for the research community.
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Affiliation(s)
- Keith Sheppard
- The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
| | - Justin Gardin
- The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
| | - Gautam S Sabnis
- The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
| | - Asaf Peer
- The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
| | - Megan Darrell
- The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
| | - Sean Deats
- The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
| | - Brian Geuther
- The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
| | - Cathleen M Lutz
- The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
| | - Vivek Kumar
- The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
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Haire CM, Tremblay L, Vuong V, Patterson KK, Chen JL, Burdette JH, Schaffert N, Thaut MH. Therapeutic Instrumental Music Training and Motor Imagery in Post-Stroke Upper-Extremity Rehabilitation: A Randomized-Controlled Pilot Study. Arch Rehabil Res Clin Transl 2022; 3:100162. [PMID: 34977544 PMCID: PMC8683865 DOI: 10.1016/j.arrct.2021.100162] [Citation(s) in RCA: 7] [Impact Index Per Article: 2.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/25/2022] Open
Abstract
Objective To investigate the potential benefits of 3 therapeutic instrumental music performance (TIMP)-based interventions in rehabilitation of the affected upper-extremity (UE) for adults with chronic poststroke hemiparesis. Design Randomized-controlled pilot study. Setting University research facility. Participants Community-dwelling volunteers (N=30; 16 men, 14 women; age range, 33-76 years; mean age, 55.9 years) began and completed the protocol. All participants had sustained a unilateral stroke more than 6 months before enrollment (mean time poststroke, 66.9 months). Intervention Two baseline assessments, a minimum of 1 week apart; 9 intervention sessions (3 times/week for 3 weeks), in which rhythmically cued, functional arm movements were mapped onto musical instruments; and 1 post-test following the final intervention. Participants were block-randomized to 1 of 3 conditions: group 1 (45 minutes TIMP), group 2 (30 minutes TIMP, 15 minutes metronome-cued motor imagery [TIMP+cMI]), and group 3 (30 minutes TIMP, 15 minutes motor imagery without cues [TIMP+MI]). Assessors and investigators were blinded to group assignment. Main Outcome Measures Fugl-Meyer Upper-Extremity (FM-UE) and Wolf Motor Function Test- Functional Ability Scale (WMFT-FAS). Secondary measures were motor activity log (MAL)–amount of use scale and trunk impairment scale. Results All groups made statistically significant gains on the FM-UE (TIMP, P=.005, r=.63; TIMP+cMI, P=.007, r=.63; TIMP+MI, P=.007, r=.61) and the WMFT-FAS (TIMP, P=.024, r=.53; TIMP+cMI, P=.008, r=.60; TIMP+MI, P=.008, r=.63). Comparing between-group percent change differences, on the FM-UE, TIMP scored significantly higher than TIMP+cMI (P=.032, r=.57), but not TIMP+MI. There were no differences in improvement on WMFT-FAS across conditions. On the MAL, gains were significant for TIMP (P=.030, r=.54) and TIMP+MI (P=.007, r=.63). Conclusion TIMP-based techniques, with and without MI, led to significant improvements in paretic arm control on primary outcomes. Replacing a physical training segment with imagery-based training resulted in similar improvements; however, synchronizing internal and external cues during auditory-cMI may pose additional sensorimotor integration challenges.
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Affiliation(s)
- Catherine M Haire
- Faculty of Music, University of Toronto, Toronto, Ontario, Canada.,Music and Health Science Research Collaboratory, University of Toronto, Toronto, Ontario, Canada
| | - Luc Tremblay
- Faculty of Kinesiology, University of Toronto, Toronto, Ontario, Canada.,Toronto Rehabilitation Institute, Toronto, Ontario, Canada
| | - Veronica Vuong
- Faculty of Music, University of Toronto, Toronto, Ontario, Canada.,Music and Health Science Research Collaboratory, University of Toronto, Toronto, Ontario, Canada.,Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
| | - Kara K Patterson
- Toronto Rehabilitation Institute, Toronto, Ontario, Canada.,Department of Physical Therapy, University of Toronto, Toronto, Ontario, Canada
| | - Joyce L Chen
- Faculty of Kinesiology, University of Toronto, Toronto, Ontario, Canada.,Toronto Rehabilitation Institute, Toronto, Ontario, Canada
| | | | - Nina Schaffert
- Department of Movement Science, University of Hamburg, Hamburg, Germany.,BeSB GmbH Sound Engineering Berlin, Berlin, Germany
| | - Michael H Thaut
- Faculty of Music, University of Toronto, Toronto, Ontario, Canada.,Music and Health Science Research Collaboratory, University of Toronto, Toronto, Ontario, Canada.,Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
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Using a Portable Gait Rhythmogram to Examine the Effect of Music Therapy on Parkinson's Disease-Related Gait Disturbance. SENSORS 2021; 21:s21248321. [PMID: 34960415 PMCID: PMC8704390 DOI: 10.3390/s21248321] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 11/07/2021] [Revised: 11/29/2021] [Accepted: 12/10/2021] [Indexed: 11/17/2022]
Abstract
External cues improve walking by evoking internal rhythm formation related to gait in the brain in patients with Parkinson’s disease (PD). This study examined the usefulness of using a portable gait rhythmogram (PGR) in music therapy on PD-related gait disturbance. A total of 19 subjects with PD who exhibited gait disturbance were evaluated for gait speed and step length during a 10 m straight walking task. Moreover, acceleration, cadence, and trajectory of the center of the body were estimated using a PGR. Walking tasks were created while incorporating music intervention that gradually increased in tempo from 90 to 120 beats per minute (BPM). We then evaluated whether immediate improvement in gait could be recognized even without music after walking tasks by comparing pre- (pre-MT) and post-music therapy (post-MT) values. Post-MT gait showed significant improvement in acceleration, gait speed, cadence, and step length. During transitions throughout the walking tasks, acceleration, gait speed, cadence, and step length gradually increased in tasks with music. With regard to the trajectory of the center of the body, we recognized a reduction in post-MT medio-lateral amplitude. Music therapy immediately improved gait disturbance in patients with PD, and the effectiveness was objectively shown using PGR.
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Aichert I, Lehner K, Falk S, Späth M, Franke M, Ziegler W. In Time with the Beat: Entrainment in Patients with Phonological Impairment, Apraxia of Speech, and Parkinson's Disease. Brain Sci 2021; 11:brainsci11111524. [PMID: 34827523 PMCID: PMC8615970 DOI: 10.3390/brainsci11111524] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/02/2021] [Revised: 11/08/2021] [Accepted: 11/12/2021] [Indexed: 11/25/2022] Open
Abstract
In the present study, we investigated if individuals with neurogenic speech sound impairments of three types, Parkinson’s dysarthria, apraxia of speech, and aphasic phonological impairment, accommodate their speech to the natural speech rhythm of an auditory model, and if so, whether the effect is more significant after hearing metrically regular sentences as compared to those with an irregular pattern. This question builds on theories of rhythmic entrainment, assuming that sensorimotor predictions of upcoming events allow humans to synchronize their actions with an external rhythm. To investigate entrainment effects, we conducted a sentence completion task relating participants’ response latencies to the spoken rhythm of the prime heard immediately before. A further research question was if the perceived rhythm interacts with the rhythm of the participants’ own productions, i.e., the trochaic or iambic stress pattern of disyllabic target words. For a control group of healthy speakers, our study revealed evidence for entrainment when trochaic target words were preceded by regularly stressed prime sentences. Persons with Parkinson’s dysarthria showed a pattern similar to that of the healthy individuals. For the patient groups with apraxia of speech and with phonological impairment, considerably longer response latencies with differing patterns were observed. Trochaic target words were initiated with significantly shorter latencies, whereas the metrical regularity of prime sentences had no consistent impact on response latencies and did not interact with the stress pattern of the target words to be produced. The absence of an entrainment in these patients may be explained by the more severe difficulties in initiating speech at all. We discuss the results in terms of clinical implications for diagnostics and therapy in neurogenic speech disorders.
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Affiliation(s)
- Ingrid Aichert
- Clinical Neuropsychology Research Group, Institute of Phonetics and Speech Processing, Ludwig-Maximilians-Universität München, 80799 Munich, Germany; (K.L.); (M.F.); (W.Z.)
- Correspondence:
| | - Katharina Lehner
- Clinical Neuropsychology Research Group, Institute of Phonetics and Speech Processing, Ludwig-Maximilians-Universität München, 80799 Munich, Germany; (K.L.); (M.F.); (W.Z.)
| | - Simone Falk
- International Laboratory for Brain, Music and Sound Research (BRAMS), Département de Linguistique et de Traduction, Université de Montréal, Montréal, QC H3C 3J7, Canada;
| | - Mona Späth
- Neolexon, Limedix GmbH, 80538 Munich, Germany;
| | - Mona Franke
- Clinical Neuropsychology Research Group, Institute of Phonetics and Speech Processing, Ludwig-Maximilians-Universität München, 80799 Munich, Germany; (K.L.); (M.F.); (W.Z.)
| | - Wolfram Ziegler
- Clinical Neuropsychology Research Group, Institute of Phonetics and Speech Processing, Ludwig-Maximilians-Universität München, 80799 Munich, Germany; (K.L.); (M.F.); (W.Z.)
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Tekriwal A, Lintz MJ, Thompson JA, Felsen G. Disrupted basal ganglia output during movement preparation in hemiparkinsonian mice is consistent with behavioral deficits. J Neurophysiol 2021; 126:1248-1264. [PMID: 34406873 DOI: 10.1152/jn.00001.2021] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/22/2022] Open
Abstract
Parkinsonian motor deficits are associated with elevated inhibitory output from the basal ganglia (BG). However, several features of Parkinson's disease (PD) have not been accounted for by this simple "classical rate model" framework, including the observation in patients with PD that movements guided by external stimuli are less impaired than otherwise identical movements generated based on internal goals. Is this difference due to divergent processing within the BG itself or due to the recruitment of extra-BG pathways by sensory processing? In addition, surprisingly little is known about precisely when, in the sequence from selecting to executing movements, BG output is altered by PD. Here, we address these questions by recording activity in the substantia nigra pars reticulata (SNr), a key BG output nucleus, in hemiparkinsonian mice performing a well-controlled behavioral task requiring stimulus-guided and internally specified directional movements. We found that hemiparkinsonian mice exhibited a bias ipsilateral to the side of dopaminergic cell loss that was stronger when movements were internally specified rather than stimulus guided, consistent with clinical observations in patients with Parkinson's disease. We further found that changes in parkinsonian SNr activity during movement preparation were consistent with the ipsilateral behavioral bias, as well as its greater magnitude for internally specified movements. Although these findings are inconsistent with some aspects of the classical rate model, they are accounted for by a related "directional rate model" positing that SNr output phasically overinhibits motor output in a direction-specific manner. These results suggest that parkinsonian changes in BG output underlying movement preparation contribute to the greater deficit in internally specified than stimulus-guided movements.NEW & NOTEWORTHY Movements of patients with Parkinson's disease are often less impaired when guided by external stimuli than when generated based on internal goals. Whether this effect is due to distinct processing in the basal ganglia (BG) or due to compensation from other motor pathways is an open question with therapeutic implications. We recorded BG output in behaving parkinsonian mice and found that BG activity during movement preparation was consistent with the differences between these forms of movement.
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Affiliation(s)
- Anand Tekriwal
- Department of Physiology and Biophysics, University of Colorado School of Medicine, Aurora, Colorado.,Department of Neurosurgery, University of Colorado School of Medicine, Aurora, Colorado.,Neuroscience Program, University of Colorado School of Medicine, Aurora, Colorado.,Medical Scientist Training Program, University of Colorado School of Medicine, Aurora, Colorado
| | - Mario J Lintz
- Department of Physiology and Biophysics, University of Colorado School of Medicine, Aurora, Colorado.,Department of Psychiatry, University of Colorado School of Medicine, Aurora, Colorado.,Neuroscience Program, University of Colorado School of Medicine, Aurora, Colorado.,Medical Scientist Training Program, University of Colorado School of Medicine, Aurora, Colorado
| | - John A Thompson
- Department of Neurosurgery, University of Colorado School of Medicine, Aurora, Colorado.,Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado.,Neuroscience Program, University of Colorado School of Medicine, Aurora, Colorado.,Medical Scientist Training Program, University of Colorado School of Medicine, Aurora, Colorado
| | - Gidon Felsen
- Department of Physiology and Biophysics, University of Colorado School of Medicine, Aurora, Colorado.,Neuroscience Program, University of Colorado School of Medicine, Aurora, Colorado.,Medical Scientist Training Program, University of Colorado School of Medicine, Aurora, Colorado
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48
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Musical enjoyment does not enhance walking speed in healthy adults during music-based auditory cueing. Gait Posture 2021; 89:132-138. [PMID: 34284333 DOI: 10.1016/j.gaitpost.2021.04.008] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/29/2020] [Revised: 03/11/2021] [Accepted: 04/06/2021] [Indexed: 02/02/2023]
Abstract
BACKGROUND Rhythmic Auditory Stimulation (RAS) involves synchronizing footsteps to music or a metronome to improve gait speed and stability in patients with neurological disorders, such as Parkinson's disease. However, responses to RAS vary across individuals, perhaps because of differences in enjoyment of the music or in musical abilities. RESEARCH QUESTION Intuitively, musical enjoyment may influence gait responses to RAS, but enjoyment has not been systematically manipulated nor the effects empirically assessed. In addition, differences in beat perception ability are likely to influence gait responses to music, particularly when synchronizing to the beat. Therefore, we asked: how does music enjoyment alter gait, and do gait parameters differ between individuals with good versus poor beat perception ability, specifically when instructed to 'walk freely' versus 'synchronize to the beat'? METHOD Young adults and older adults walked on a pressure sensor walkway in silence and to music that they had rated as either high or low in enjoyment, as well as a metronome. All stimuli were presented at 15 % faster than baseline cadence. Participants either walked freely to the music or synchronized to the beat. RESULTS Music enjoyment had no significant effects on gait in either younger or older adults. Compared to baseline, younger adults walked faster (by taking longer strides) to music than the metronome, whereas older adults walked faster (by taking more steps per minute) to the metronome than music. When instructed to synchronize vs. walk freely, young adults walked faster, but older adults walked slower. Finally, regardless of instruction type, young adults with poor beat perception took shorter and slower strides to the music, whereas older adults with poor beat perception took slower strides to the music. SIGNIFICANCE Beat perception ability, instruction type, and age affect gait more than music enjoyment does, and thus should be considered when optimizing RAS outcomes.
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Buard I, Lattanzio L, Stewart R, Thompson S, Sjoberg K, Hookstadt K, Morrow M, Holden SK, Sillau S, Thaut M, Kluger B. Randomized controlled trial of neurologic music therapy in Parkinson's disease: research rehabilitation protocols for mechanistic and clinical investigations. Trials 2021; 22:577. [PMID: 34454592 PMCID: PMC8403394 DOI: 10.1186/s13063-021-05560-7] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/06/2021] [Accepted: 08/20/2021] [Indexed: 11/12/2022] Open
Abstract
Background Presently available medications and surgical treatments for Parkinson’s disease have limited effects on fine motor problems and often leave patients with significant fine motor disability. Standard of care occupational therapy (OT) yields low efficacy, potentially due to a lack of standard protocols. Neurologic music therapy (NMT) techniques, especially rhythmic auditory stimulation which relies on interaction between rhythm and movement, have shown to be effective in PD gait rehabilitation possibly through their reliance on neural pathways that are not affected by PD. Therapeutic instrumental music performance (TIMP) is one other NMT technique that holds promise but which mode of action and efficacy has not been investigated in PD yet. Methods One hundred PD participants will be randomly assigned to receive 15 sessions of either TIMP with rhythm or TIMP without rhythm, standard of care OT, or to be waitlisted (control) over 5 consecutive weeks. Brain oscillatory responses will be collected using magnetoencephalography during an auditory-motor task to understand the underlying mechanisms. The Grooved Pegboard, the UPDRS III finger tap, and the finger-thumb opposition will be assessed to investigate clinical changes related to fine motor function. This project will also serve to confirm or refute our pilot data findings suggesting NMT relies on compensatory brain networks utilized by the PD brain to bypass the dysfunctional basal ganglia. Discussion This study aims to use standardized TIMP and OT research protocols for investigating the neuronal pathways utilized by each intervention and possibly study their efficacy with respect to fine motor rehabilitation via a randomized control trial in the PD population. Trial registration ClinicalTrials.gov NCT03049033. Registered on September 29, 2020 Supplementary Information The online version contains supplementary material available at 10.1186/s13063-021-05560-7.
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Affiliation(s)
- Isabelle Buard
- Department of Neurology, University of Colorado Denver, Fitzsimons Building, Mailstop F548, 13001 E. 17th Place, R24-002, Aurora, CO, 80045, USA.
| | - Lucas Lattanzio
- Department of Neurology, University of Colorado Denver, Fitzsimons Building, Mailstop F548, 13001 E. 17th Place, R24-002, Aurora, CO, 80045, USA
| | | | | | | | | | | | - Samantha K Holden
- Department of Neurology, University of Colorado Denver, Fitzsimons Building, Mailstop F548, 13001 E. 17th Place, R24-002, Aurora, CO, 80045, USA
| | - Stefan Sillau
- Department of Neurology, University of Colorado Denver, Fitzsimons Building, Mailstop F548, 13001 E. 17th Place, R24-002, Aurora, CO, 80045, USA
| | - Michael Thaut
- Faculty of Music, University of Toronto, Toronto, Canada
| | - Benzi Kluger
- Department of Neurology, University of Rochester Medical Center, Rochester, NY, USA
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50
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Crosby LD, Chen JL, Grahn JA, Patterson KK. The Effect of Rhythm Abilities on Metronome-Cued Walking with an Induced Temporal Gait Asymmetry in Neurotypical Adults. J Mot Behav 2021; 54:267-280. [PMID: 34334109 DOI: 10.1080/00222895.2021.1953959] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/20/2022]
Abstract
ABSRACT. Human gait is inherently rhythmical, thus walking to rhythmic auditory stimulation is a promising intervention to improve temporal gait asymmetry (TGA) following neurologic injury such as stroke. However, the degree of benefit may relate to an individual's underlying rhythmic ability. We conducted an initial investigation into the relationship between rhythm abilities and responsiveness of TGA when walking to a metronome. TGA was induced in neurotypical young adults with ankle and thigh cuff weights. Participants were grouped by strong or weak rhythm ability based on beat perception and production tests. TGA was induced using a unilateral load affixed to the non-dominant leg. Participants walked under three conditions: uncued baseline, metronome set to 100% of baseline cadence, and metronome set to 90% of baseline cadence. Repeated measures analysis using generalized estimating equations was conducted to determine how rhythm ability affected TGA response in each walking condition. Most participants improved TGA when walking to a metronome at either tempo compared to baseline; however, this improvement did not differ between strong and weak rhythm ability groups. Those who scored worse on the rhythm perception test also were poorer at synchronizing their steps to the beat. The induced TGA is smaller than what is commonly experienced after stroke. A larger induced TGA may be necessary to reveal subtle differences in responsiveness to rhythmical auditory stimulation between those with strong and weak rhythm abilities.
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Affiliation(s)
- Lucas D Crosby
- Rehabilitation Sciences Institute, University of Toronto, Toronto, Canada
| | - Joyce L Chen
- Rehabilitation Sciences Institute, University of Toronto, Toronto, Canada.,Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, Canada
| | - Jessica A Grahn
- Brain and Mind Institute, Department of Psychology, University of Western Ontario, London, Canada
| | - Kara K Patterson
- Rehabilitation Sciences Institute, University of Toronto, Toronto, Canada.,Department of Physical Therapy, University of Toronto, Toronto, Canada.,KITE Toronto Rehabilitation Institute, University Health Network, Toronto, Canada
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