Advanced wasting in peritoneal dialysis patients

Table 1 Abbreviations used in this report

Abbreviation	Interpretation
V	Body water, L; VWatson = body water estimated by the Watson formula
W	Body weight, kg
IW	Ideal body weight, kg
BF	Body fat, kg
FFM	Fat-free mass, kg
BMI	Body mass index, kg/m2
PNA	Protein nitrogen appearance, g; nPNA/W = PNA normalized to W, g/kg; nPNA/IW = PNA/IW = PNA normalized to IW, g/kg
Cr Ex	Creatinine excretion rate, mg/24-h; (MCr Ex)/W = measured Cr Ex normalized to W, (mg/kg)/24-h; (MCr Ex)/IW = Measured Cr Ex normalized to IW, (mg/kg)/24-h
M/P Cr Ex	Measured/Predicted creatinine excretion rate
LBM	Lean body mass estimated from Cr Ex, kg; LBM/W = LBM normalized to W; LBM/IW = LBM normalized to IW

Table 2 Clinical characteristics of peritoneal dialysis patients with advanced wasting

Clinical characteristic	Patient 1	Patient 2
Sex	Male	Male
Cause of ESRD	Glomerulonephritis	Glomerulonephritis
Age, yr	21	23
Height, cm	149	155
Weight, kg	36.7	40.0
Kt/V urea1, weekly	1.34	2.92
Creatinine clearance1, L/1.73 m2 weekly	49	218
Peritoneal transport (4-h D/P creatinine)2	High (0.84)	Low-average (0.54)

¹Total (renal plus peritoneal) clearance;

²Characterized by the value of the 4-h dialysate/plasma (D/P) creatinine concentration ratio in a peritoneal equilibration test (PET)[27]. ESRD: End-stage renal disease.

Table 3 Nutrition indices in two males with advanced wasting (Patient 1, Patient 2) and a control group

Nutrition index	Patient 1	Patent 2	Control group1
VWatson/0.73	1.036	1.030	0.744 (0.521-0.932)
BMI, kg/m2	16.5	16.6	25.5 (18.9-32.8)
W/IW	0.778	0.816	1.151 (0.935-1.367)
Serum albumin, g/dL	2.60	2.80	3.60 (3.15-4.05)
Serum urea nitrogen, mg/dL	41.0	58.0	56.8 (43.2-70.4)
Serum creatinine, mg/dL	2.02	13.55	7.38 (5.25-9.51)
nPNA/W, g/kg per 24 h	0.94	1.21	0.86 (0.70-1.02)
nPNA/IW, g/kg per 24-h	0.81	1.07	0.99 (0.75-1.13)
(MCr Ex)/W, mg/kg per 24-h	13.0	35.9	18.7 (13.9-23.5)
(MCr Ex)/IW, mg/kg per 24-h	11.4	27.9	21.5 (17.5-25.5)
M/P Cr Ex	0.51	1.680	0.97 (0.55-1.39)
LBM/W	0.64	1.420	0.66 (0.55-0.77)
LBM/IW	0.52	1.100	0.76 (0.66-0.86)

¹The control group consisted of 260 men on PD analyzed in their first clearance study. The values in the control group column indicate mean (95%CI). BMI: Body mass index; PNA: Protein nitrogen appearance; LBM: Lean body mass; IW: Ideal body weight; PD: Peritoneal dialysis.