Brief Article
Copyright ©2013 Baishideng Publishing Group Co.
World J Nephrol. Nov 6, 2013; 2(4): 129-135
Published online Nov 6, 2013. doi: 10.5527/wjn.v2.i4.129
Table 1 Comparing demographic and clinical profile of patients treated with combined dose Aliskerin and Angiotensin receptor blockers, Aliskerin alone and high dose Angiotensin receptor blockers
Combined Aliskerin and ARBAliskerinHigh dose ARB1P value
n= 49n= 46n= 48
Sex (F : M)16:3322:2423:25NS
Age at biopsy (yr)58 ± 1257 ± 1260 ± 11NS
Duration of Trial (mo)37 ± 136 ± 136 ± 1NS
Hypertension (Yes : No)16:1515:3117:31NS
Serum Creatinine (µmol/L)
Baseline142 ± 39142 ± 40139 ± 32NS
Year 3159 ± 53 (P = 0.001)161 ± 54 (P < 0.001)150 ± 47 (P = 0.015)NS
eGFR (mL/min)
Baseline49 ± 1948 ± 1448 ± 14NS
Year 344 ± 18 (P < 0.001)42 ± 15 (P < 0.001)45 ± 15 (P = 0.002)NS
Decrease in eGFR (mL/min per year)1.8 ± 2.52.0 ± 3.01.0 ± 2.1P = 0.119
Urinary Protein (gm/d)
Baseline0.7 ± 0.60.8 ± 0.90.6 ± 0.7NS
Year 30.5 ± 0.8 (P = 0.002)0.6 ± 0.7 (P = 0.043)0.3 ± 0.3 (P < 0.001)P = 0.007
Blood Pressure (mmHg)
Systolic before132 ± 12135 ± 10132 ± 12NS
Systolic after127 ± 10 (P < 0.001)130 ± 9 (P < 0.001)128 ± 11 (P < 0.001)NS
Diastolic before84 ± 785 ± 684 ± 7NS
Diastolic after82 ± 5 P = 0.04083 ± 6 P = 0.08483 ± 6 P = 0.361NS
Distribution of CKD at baseline
CKD 11000.465
CKD 2854
CKD 3404144
Distribution of CKD at year 30.606
CKD 1100
CKD 2875
CKD 3282634
CKD 412139
Non-ESRF494648NS
ESRF000
Improvement in eGFR
Yes1215150.645
No373133
Table 2 Test of within-subject contrast (change from baseline and change from previous year) for estimated glomerular filtration rate and total urinary protein
VariableMeasureYearFP value
Change from baselineYear1 treatmenteGFRyear 1 vs baseline10.630.530
year 2 vs baseline0.460.632
year 3 vs baseline2.160.119
TUPyear 1 vs baseline6.000.003
year 2 vs baseline4.160.018
year 3 vs baseline0.900.409
Change from previous yearYear1 treatmenteGFRyear 1 vs baseline10.630.536
year 2 vs year 10.030.967
year 3 vs year 22.930.057
TUPyear 1 vs baseline6.010.003
year 2 vs year 10.160.851
year 3 vs year 23.110.048