Copyright ©2012 Baishideng.
World J Nephrol. Dec 6, 2012; 1(6): 151-154
Published online Dec 6, 2012. doi: 10.5527/wjn.v1.i6.151
Table 1 Symptoms and laboratory findings in patients with proton pump inhibitor-associated hypomagnesemia1
Proton pump inhibitorSymptomsLaboratory findingsRef.
OmeprazoleDiarrhea, vomiting, hallucinations, muscular excitabilityHypomagnesemia, hypocalcemia, hypophosphatemia and low urinary magnesium and calcium levels[31]
OmeprazoleMuscle cramps, paresthesia, Trousseau’s sign, atrial flutter, pauses (4 s) in ECGHypomagnesemia, hypocalcemia and hypokalemia, PTH within the reference range[31]
OmeprazoleCarpopedal and truncal spasmHypomagnesemia and hypocalcemia without an appropriate increase of PTH[18]
Omeprazole, Esomeprazole, Pantoprazole, Rabeprazole (4 cases)ECG abnormalities (QT interval prolongation, ST depression, Q waves)Hypomagnesemia and hypocalcemia without an appropriate increase of PTH, hypokalemia, very low magnesium and calcium and increased potassium urinary levels[19]
OmeprazoleGrand mal seizuresHypomagnesemia, hypocalcemia, low urine magnesium levels[17]
EsomeprazoleLethargy, muscle cramps in extremities and abdomenHypomagnesemia, hypocalcemia, hypokalemia and low serum PTH levels, low urine magnesium levels[20]
OmeprazoleParesthesia, numbness, limb weaknessHypomagnesemia, hypocalcemia, low vitamin D levels[21]