Reclassification of membranoproliferative glomerulonephritis: Identification of a new GN: C3GN

Figure 1 Proposed classification for membranoproliferative glomerulonephritis based on the presence or absence of Igs and the presence of C3 by immunofluorescence. MPGN: Membranoproliferative glomerulonephritis; Igs: Immunoglobulins; DDD: Dense deposit disease.

Figure 2 Approach to the classification of glomerulonephritis with dominant C3. DDD: Dense deposit disease; CFHR5: Complement factor H related protein.

Figure 3 Pathway of complement and complement regulator factors. C3 Con: C3 covertase; sMAC: Serum membrane attack complex; C3dg, C3c, C3d, C3g: Complement degradation products.

Figure 4 Acquired and genetic abnormalities associated with complement-mediated membranoproliferative glomerulonephritis. MCP: Membrane cofactor protein; CHFR: Complement factor H related proteins; MPGN: Membranoproliferative glomerulonephritis.

Figure 5 Proposed work-up of complement mediated membranoproliferative glomerulonephritis. APFA: Alternative pathway functional assay; CFHR: Complement factor H related proteins; CR1: Complement receptor 1; MCP: Membrane cofactor protein; sMAC: Serum membrane attack complex; MPGN: Membranoproliferative glomerulonephritis.