Clinicopathological features and medium-term outcomes of histologic variants of primary focal segmental glomerulosclerosis in adults: A retrospective study

Figure 1 Histological features of common variants of focal segmental glomerulosclerosis. A: Medium-power view showing three glomeruli with segmental scars in indeterminate locations in a case of focal segmental glomerulosclerosis (FSGS), not otherwise specified. Mild patchy tubular atrophy and interstitial scarring is seen in the background [Periodic Acid-Schiff (PAS), × 200]; B: High-power view showing one glomerulus with segmental scar and adhesion formation involving the tip domain diagonally opposite the vascular pole, an example of the TIP variant (PAS, × 400); C: High-power view showing one glomerulus with segmental collapse of capillary tufts accompanied by podocyte hypertrophy and hyperplasia in a case of collapsing FSGS. Many proteinaceous droplets are also seen in the cytoplasm of podocytes (Jone’s methenamine silver, × 400).

Figure 2 Flow diagram showing total number of patients and response rates of patients with the three histological variants of focal segmental glomerulosclerosis who were treated with steroids and cyclosporine. NOS: Not otherwise specified; CR: Complete remission; PR: Partial remission.

Figure 3 Treatment responses and final clinical outcomes of patients with the three most common histological variants of focal segmental glomerulosclerosis who were treated with immunosuppressive drugs (n = 302). NOS: Not otherwise specified; TIP: Tip; KF: Kidney failure.

Figure 4 The means ± SDs of the initial and final estimated glomerular filtration rates of patients with the three most common histological variants of focal segmental glomerulosclerosis. FSGS: Focal segmental glomerulosclerosis; GFR: Glomerular filtration rate; NOS: Not otherwise specified.

Figure 5 Treatment responses and cumulative kidney survival rates of patients with the three most common variants of focal segmental glomerulosclerosis. A: Kaplan-Meier plot of complete remission; B: Kaplan-Meier plot of partial remission; C: Kaplan-Meier plot of kidney survival (all patients); D: Kaplan-Meier plot of kidney survival by focal segmental glomerulosclerosis morphologic variants. NOS: Not otherwise specified; TIP: Tip.