Copyright ©The Author(s) 2017.
World J Virol. Feb 12, 2017; 6(1): 1-8
Published online Feb 12, 2017. doi: 10.5501/wjv.v6.i1.1
Table 1 Roles of viral protein and RNA during viral infection in permissive cells
Name of the vital materialLocation in cellFunction
Viral genome + ssRNA (approximately 11000 nt)CytoplasmTemplate for protein translation and for viral genome replication
Envelope, E (53 KDa)[52]Cell membraneViral assembly, budding, attachment to target cells, and viral membrane fusion
Membrane precursor, PrM (20 KDa)[53]Cell membraneFacilitating E protein folding and trafficking, and virion maturation
Capsid, C (12 KDa)[54]CytoplasmVirion maturation
NS1 (glycoprotein)[55] (46-55 kDa)Endoplasmic reticulumSubverting immune response
vesicular compartments,virus-induced intracellular RNA
cell surfacereplication, neurovirulence
NS2a (25 kDa)[56]TransmembraneVirus assembly, inhibit IFN-response
NS2b (14 kDa)[1,57]Cytoplasm, nucleusViral protein cleavage
NS3 (69 kDa)[1]Cytoplasm, nucleusViral protein cleavage, RNA
triphosphatase, mRNA capping,
RNA helicase
NS4a (16 kDa)[58]TransmembraneViral RNA replication
NS4b (21.5 kDa)[59]Integral membraneSuppression of (IFN-α/β),
suppression of the host RNAi,
negatively regulate the helicase
function, viral replication
NS5 (103 kDa)[60,61]Cytoplasm, nucleusThe RNA triphosphatase,
RNA-dependent RNA polymerase