Hepatocyte transplantation: Consider infusion before incision

Table 1 Summary of hepatocyte transplantation reports in human patients

Ref.	Indication	No. of patients	Infusion site	Outcome
Ambrosino et al[21]	Criggler-Najjar TypeI	A 9-year-old boy	Portal vein	Decreased bilirubin approximately 4 mo, underwent OLT
Lysy et al[22]	Criggler-Najjar TypeI	A 9-year-old girl	Jejunal vein	Decreased bilirubin approximately 6 mo, underwent OLT
Lysy et al[22]	Criggler-Najjar TypeI	A 1-year-old girl	Splenic vein	Decreased bilirubin approximately 4 mo, underwent OLT
Zhou et al[53]	Criggler-Najjar TypeI	2 (4-mo-old boy and newborn boy)	Portal vein	Decreased bilirubin approximately 3-4 mo with subsequent OLT
Meyburg et al[24]	Urea cycle disorders	4 (1-d to 3-year-old)	Portal vein	Stable 4-13 mo before OLT, 1 death at 4-mo
Grossman et al[29]	Familial hyper-cholesterolemia	5 (7-year-old to 41-year-old)	Portal vein	Three patients with approximately 40% reduction in LDL lasting 4 mo
Lee et al[31]	Glycogen storage disorders	A 8-year-old kid	Portal vein	Followed for 7 mo, on tacrolimus and able to fast for 7 h without hypoglycemia
Muraca et al[1]	Glycogen storage disorders	47-year-old, female	Portal vein	Followed for 9 mo, on tacrolimus and able to fast for 7 h without hypoglycemia
Sokal et al[33]	Refsum disease	4-year-old girl	Portal vein	16 mo improvement
Dhawan et al[36]	Hemophilia A	2 (3-mo-old and 35-mo-old)	Portal vein	6 mo with 70% reduction in Factor VII requirements
Hansel et al[42]	A1AT deficiency	A 52-year-old	Portal vein	A1AT levels did increase before OLT available 2 d later
Soltys et al[52]	Phenyl-ketonuria	A 27-year-old female	Portal vein	7 mo of unrestricted diet

A1AT: Alpha 1 antitrypsin; OLT: Orthotopic liver transplantation.