Genetic barriers in transplantation medicine

Table 1 List of killer cell immunoglobulin-like receptors and their human leukocyte antigen ligands

KIR	Alleles	Protein variants	HLA ligands
2DL1	43	24	C2
2DL2	28	11	C1, C2
2DL3	34	17	C1, C2
2DL4	46	22	G
2DL5	41	17	Unknown
2DS1	15	7	C2
2DS2	22	8	Unknown
2DS3	14	5	Unknown
2DS4	30	13	A*11, some C
2DS5	16	11	Unknown
3DL1	73	58	Bw4
3DS1	16	12	Unknown
3DL2	84	61	A*03,-11
3DL3	107	55	Unknown
3DP1	22	0	0
2DP1	23	0	0

The C1 are HLA-C allotypes with serine and asparagines at position 77 and 80 of α1 domain, respectively. The C2 are HLA-C allotypes with asparagines and lysine at position 77 and 80 of α1 domain, respectively. The Bw4 are HLA-B allotypes with isoleucine or threonine at position 80 of α1 domain. This table is adapted from Robinson et al[99] and Parham et al[104]. KIRs: Killer cell immunoglobulin-like receptors; HLA: Human leukocyte antigen.

Table 2 Here are the examples of both, gene content and allelic variations of the genes code for killer cell immunoglobulin-like receptors

KIR gene	KIR haplotype
	A	A	A	B	B	B
1KIR3DL1	*015	*086	*005	*007	*086	X
1KIR2DL1	*003	*003	*003	*010	*004	X
1KIR2DL3	*001	*001	*001	X	X	X
1KIR2DS4	*001	*001	*010	*003	*001	X
2KIR2DL2	X	X	X	*003	*001	*001
2KIR2DL5	X	X	X	*B002	*B002	A*001
2KIR3DS1	X	X	X	X	X	*013
2KIR2DS1	X	X	X	X	X	*002
2KIR2DS2	X	X	X	*001	*001	X
2KIR2DS3	X	X	X	*001	*003	X
2KIR2DS5	X	X	X	X	X	*001
3KIR2DL4	*001	*028	*011	*006	*028	*005
3KIR3DL2	*002	*002	*010	*002	*002	*007
3KIR3DL3	*013	*002	*009	*014	*013	*003
1KIR2DP1	*009	*001	*001	*004	*007	*007
3KIR3DP1	*001	*001	*003	*001	*003	*003

^1,2,3The haplotype A and B and framework KIR genes, respectively. The X indicates the absent of KIR genes/alleles.