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©The Author(s) 2025.
World J Transplant. Sep 18, 2025; 15(3): 104308
Published online Sep 18, 2025. doi: 10.5500/wjt.v15.i3.104308
Published online Sep 18, 2025. doi: 10.5500/wjt.v15.i3.104308
Table 1 Demographic and clinical parameters of the study population
Parameter | n = 78 |
Age of recipients (years) | 29.57 ± 10.11 |
Recipient gender | |
Males | 49 (62.8) |
Females | 29 (37.2) |
Age of donors (years) | 34.53 ± 9.09 |
Donor gender | |
Males | 46 (59.0) |
Females | 32 (51.0) |
Donor relation | |
Siblings | 46 (58.9) |
Parents | 14 (17.9) |
Spouses | 17 (21.8) |
Offspring | 1 (1.3) |
HLA mismatches | |
1-2 | 21 (27.0) |
3-4 | 37 (47.4) |
5-6 | 20 (25.6) |
Duration of hemodialysis (months) | 14.01 ± 15.48 |
End-stage kidney disease cause | |
Unknown | 48 (61.5) |
Chronic glomerulonephritis | 20 (25.6) |
Stone disease | 5 (6.4) |
Bladder outlet obstruction and neurogenic bladder | 3 (3.8) |
Table 2 Donor-specific antibodies against human leukocyte antigen class positivity and rejection episodes
Parameter | Mean DSA MFI |
DSA Class I, n = 36 (46.2%) | 3286.58 ± 4530.50; Range: 933-9994 |
DSA Class II, n = 35 (44.8%) | 3207.47 ± 4219.00; Range: 1041-9383 |
DSA Class I and II, n = 7 (8.9%) | Class I = 3245.00 ± 2117.00; Range: 5515-6518 |
Class II = 2101.00 ± 959.00; Range: 2336- 3610 | |
In rejection (n = 8) | |
Class I, n = 2 (25.0%) | Median = 4994 (IQR = 3922-4994) |
Class II, n = 6 (75.0%) | Median = 2718 (IQR = 1221-5173) |
In no rejection (n = 63) | |
Class I, n = 34 (48.5%) | Median = 2481 (IQR = 1732-4136) |
Class II, n = 29 (41.4%) | Median = 3088 (IQR = 1479- 5249) |
- Citation: Abbas K, Mubarak M, Musharraf W, Hafeez AR, Aziz T, Zafar MN. Impact of low-level pretransplant donor-specific antibodies detected by the Luminex platform on acute rejection and long-term graft survival. World J Transplant 2025; 15(3): 104308
- URL: https://www.wjgnet.com/2220-3230/full/v15/i3/104308.htm
- DOI: https://dx.doi.org/10.5500/wjt.v15.i3.104308