Retrospective Cohort Study
Copyright ©The Author(s) 2025.
World J Transplant. Sep 18, 2025; 15(3): 101865
Published online Sep 18, 2025. doi: 10.5500/wjt.v15.i3.101865
Table 1 King’s College criteria for selection of acute hepatic failure patients suitable for liver transplantation[6]
Classifications
Characteristics
Paracetamol-induced acute hepatic failureArterial blood pH < 7.30 (irrespective of grade of encephalopathy)
Or all of the followingProthrombin time > 100 seconds (INR > 6.5)
Serum creatinine > 300 μmol/L
Grade III or IV hepatic encephalopathy
Non-paracetamol induced acute hepatic failureProthrombin time > 100 seconds (INR > 6.5) (irrespective of grade of encephalopathy)
Or any 3 of the following (irrespective of grade of encephalopathy)Age < 10 years or > 40 years
Aetiology: Non-A/non-B hepatitis, drug-induced
Duration of jaundice to encephalopathy > 7 days
Prothrombin time > 50 (INR > 3.5)
Serum bilirubin > 300 μmol/L
Table 2 Clichy criteria for selection of acute hepatic failure patients for liver transplantation[7]
Number
Criteria
1Presence of hepatic encephalopathy
2Factor V level of < 20% (if patient’s age < 30 years) or < 30% (if patient’s age ≥ 30 years)
Table 3 Absolute and relative psychiatric contraindications to urgent liver transplant in the Scottish Liver Transplant Unit, Royal Infirmary of Edinburgh[14]
Absolute contraindications
Relative contraindications
5 or more episodes of deliberate self-harm, unless previous events occurred many years ago2-4 Lifetime episodes of self-harm
Current substance dependence of active misuse in a severe, chaotic fashionCurrent/recent substance misuse
Chronic, severe, poor-prognosis mental disorders, especially if refractory to treatment or where leading to patient incapacity to express wishes or understand circumstancesOther significant or serious pervasive mental disorder
Repeated non-compliance with medical or psychiatric care-
Patient refusal of transplant with capacity