Copyright ©2011 Baishideng Publishing Group Co.
World J Transplant. Dec 24, 2011; 1(1): 13-18
Published online Dec 24, 2011. doi: 10.5500/wjt.v1.i1.13
Table 1 Criteria for clinical islet transplantation in Japan
Inclusion criteria
< 75 yr of age
Undetectable C-peptide levels (< 0.1 ng/mL)
Duration of type 1 diabetes mellitus for > 5 yr accompanied by recurrent neuroglycopenia
Reduced awareness of hypoglycemic episodes and/or severe glycemic lability despite intensive insulin therapy and glycemic monitoring
Exclusion criteria
Presence of uncorrectable coronary disease
A body mass index of > 25 kg/m2
Inadequate renal reserve defined as serum creatinine level of > 1.5 mg/dL, creatinine clearance of < 80 mL/min per 1.73 m2 of body surface area, or a urinary albumin level of > 300 mg/24 h
Negative serological findings for Epstein-Barr virus at the time of assessment