Copyright ©The Author(s) 2023.
World J Transplant. Dec 18, 2023; 13(6): 299-308
Published online Dec 18, 2023. doi: 10.5500/wjt.v13.i6.299
Figure 1
Figure 1 Mechanisms of action of anti-thymocyte globulin. A: T-cell depletion in blood through complement-mediated lysis and in secondary lymphoid tissue by T cell apoptosis; B: B-cell apoptosis by anti-thymocyte globulin (ATG); C: ATG-VLA-4 complex leading to decreased adhesion proteins in endothelial cells required by leukocyte/endothelium interaction; D: Dendritic cell maturation by HLA1/ATG interaction; E: Increased natural killer T cells.