I am Maurizio Salvadori, Professor of Nephrology at the Careggi University Hospital of Florence, Italy (Figure 1) and the Editor-in-Chief of the World Journal of Transplantation (World J Transplant, WJT, online ISSN 2220-3230, DOI: 10.5500). It is a great privilege to introduce the WJT as a new forum for exchanging thoughts and experiences about the rapidly evolving field of transplantation both of solid organs and tissues. Congratulations to the publisher, members of editorial board of the journal, all the authors and readers.
Figure 1 Editor-in-Chief of the World Journal of Transplantation.
Maurizio Salvadori, MD, Professor of Nephrology, Department of Renal Transplantation, Careggi University Hospital, viale Pieraccini 18, 50139 Florence, Italy.
I am very pleased to announce that the first issue of the WJT, whose preparatory work was initiated on Jaunary 16, 2011, will be officially published on December 24, 2011. The WJT Editorial board has now been established and consists of 100 distinguished experts from 29 countries. What is the purpose of launching the WJT? What is the scope and how are the columns designed?
Solid organ transplantation has made incredible breakthroughs in the last decades. After initial success in kidneys, liver, heart, lung and small intestine, more recently new complex grafts of hands and faces have been made successfully. Now outstanding papers and works are distributed over a wide range of topics that allow translating findings from the bench to affect patient care. From this point of view, an open access journal has the privilege to rapidly allow new findings to spread among investigators, improving knowledge sharing in a rapidly evolving field.
The main topics emerging in the more recent international meetings are (1) the relevance of donor-specific antibodies as cause of late allograft failure; growing evidence of (2) novel mediators for late allograft failures as monocytes and natural killer cells[2,3]; (3) Novel pathways of allograft injury have been identified as LFA1/ICAM, an adhesion pathway in T cell activation[4,5]. As available organs are not enough with respect to the need, expanding the donor pool became essential; In this context (4) tissue engineering seems to be essential for the evolution of transplantation[6,7]; These strategies include (5) the recellurization of a decellularized organ to realize bio-artificial organs; (6) Organ preservation is also improving and there is a general move towards new technologies in donation after cardiac death. A recent study suggests that the normothermic ex vivo lung perfusion can salvage lungs which would otherwise not be transplanted; and (7) Discovery of new immunosuppressive agents is more and more difficult and expensive, also because many of these drugs fail before entering the market (Figure 2). At present, Belatacept, a CTLA4-Ig protein engineered with high affinity for CD86 and CD80 on antigen presenting cells, is one of the more promising molecules with CP-690,550, an oral Janus associated kinase 3 inhibitor suppressing signaling from a number of cytokines.
Figure 2 Graveyard of recent immunosuppressive agents.
The aim of the WJT is to rapidly report new theories, methods and techniques for prevention, diagnosis, treatment, rehabilitation and nursing in the field of transplantation. The WJT covers topics concerning organ and tissue donation and preservation; tissue injury, repair, inflammation and aging; immune recognition, regulation, effector mechanisms, and opportunities for induction of tolerance, thoracic transplantation (heart, lung), abdominal transplantation (kidney, liver, pancreas, islets), transplantation of tissues, cell therapy and islet transplantation, clinical transplantation, experimental transplantation, immunobiology and genomics, xenotransplantation, and transplantation-related traditional medicine, and integrated Chinese and Western medicine. The journal also publishes original articles and reviews that report the results of transplantation-related applied and basic research in fields such as immunology, physiopathology, cell biology, pharmacology, medical genetics, and pharmacology of Chinese herbs.
The columns in the issues of WJT will include: (1) Editorial: to introduce and comment on the substantial advance and its importance in the fast-developing areas; (2) Frontier: to review the most representative achievements and comment on the current research status in the important fields and propose directions for the future research; (3) Topic Highlight: this column consists of three formats, including (A) 10 invited review articles on a hot topic, (B) a commentary on common issues of this hot topic, and (C) a commentary on the 10 individual articles; (4) Observation: to update the development of old and new questions, highlight unsolved problems, and provide strategies on how to solve the questions; (5) Guidelines for Clinical Practice: to provide guidelines for clinical diagnosis and treatment; (6) Review: to systematically review the most representative progress and unsolved problems in the major scientific disciplines, comment on the current research status and make suggestions on future work; (7) Original Articles: to originally report the innovative and valuable findings in transplantation; (8) Brief Articles: to briefly report novel and innovative findings in transplantation; (9) Case Report: to report a rare or typical case; (10) Letters to the Editor: to discuss and reply to the contributions published in the WJT, or to introduce and comment on a controversial issue of general interest; (11) Book Reviews: to introduce and comment on quality monographs of transplantation; and (12) Guidelines: to introduce consensuses and guidelines reached by international and national academic authorities worldwide on the research in transplantation.
In conclusion, if you want to share your studies and findings rapidly with the aid of the format of an open access journal, you now have the possibility of using the WJT.