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Honda N, Funakoshi Y, Matuishi Y, Morifuji K, Tanabe K. Adolescent childhood cancer survivors talking about cancer: A socioecological perspective. Asia Pac J Oncol Nurs 2025; 12:100676. [PMID: 40151460 PMCID: PMC11946496 DOI: 10.1016/j.apjon.2025.100676] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/13/2024] [Accepted: 02/18/2025] [Indexed: 03/29/2025] Open
Abstract
Objective This study aimed (1) to investigate the communication patterns of adolescent childhood cancer survivors (ACCSs), including their motivations, methods, context, and outcomes and (2) to identify factors influencing their cancer-related communication (cancer communication) at each level of the socioecological model. Methods A qualitative descriptive research design was adopted to explore ACCSs' experiences of communicating about cancer and the factors influencing such experiences. Semi-structured interviews were conducted, and the collected data were analyzed using thematic analysis. This study was conducted according to the Standards for Reporting Qualitative Research. Results The ACCSs were motivated to engage in cancer-related communication by acquiring social support and an altruistic perspective. Although ACCSs rarely initiated cancer-related communication proactively, they communicated with close friends and family members about their cancer experiences. The motivation to communicate with friends shifted from sharing factual information, such as their daily lives in the hospital, to seeking emotional connections shaped by psychosocial development. Dissatisfaction with the limitations of school life and concerns about cancer were primarily discussed with parents. Furthermore, parents' perceptions of cancer and their explanations of the illness to their children appeared to influence the children's perceptions of their cancer experiences and their communication about cancer. Cancer-related communication among ACCSs was influenced by factors at multiple levels. Furthermore, institutional- and community-level factors affected individual and interpersonal factors. Conclusions A multilayered approach involving ACCSs, parents, educators, school peers, and the broader community is essential for enhancing communication about cancer within this population.
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Affiliation(s)
- Naoko Honda
- Department of Reproductive Health Institute of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
| | | | | | - Kanako Morifuji
- Department of Reproductive Health Institute of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
| | - Kazuaki Tanabe
- Department of Nursing Science, Graduate School, of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
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Silva SDO, Araújo NMD, Leal NTB, Silva ME, Santos KVGD, Silva TTMD, Fonseca JFD, Ribeiro KRB, Dantas RAN, Dantas DV. Effect of video training on anxiety and knowledge level among caregivers of children and adolescents chemotherapy: A randomized clinical trial. iScience 2025; 28:112414. [PMID: 40343285 PMCID: PMC12059707 DOI: 10.1016/j.isci.2025.112414] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/08/2024] [Revised: 02/27/2025] [Accepted: 04/08/2025] [Indexed: 05/11/2025] Open
Abstract
This study aimed to evaluate the effect of video training compared to verbal guidelines for acquiring knowledge and reducing anxiety in caregivers of children and adolescents undergoing chemotherapy. A randomized, controlled, double-blind, two-arm clinical trial with simple randomization was carried out. 26 caregivers of children and adolescents recently diagnosed with cancer participated in the study, who were randomly assigned to the experimental group, who received verbal guidance associated with an educational technology in video format about the chemotherapy process; or to the control group, which received only verbal instructions. Patients in the experimental group showed better performance in answering the questions correctly. Caregivers in the experimental group showed a reduction in State-Trait Anxiety Inventory (STAI)-State when comparing the initial period with the final period with value (95% confidence interval [CI]; p < 0.05).
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Affiliation(s)
| | | | | | | | | | | | | | | | - Rodrigo Assis Neves Dantas
- Nursing Graduate Program, Federal University of Rio Grande do Norte, Natal, Brazil
- Department of Nursing, Federal University of Rio Grande do Norte (UFRN), Natal, RN, Brazil
| | - Daniele Vieira Dantas
- Nursing Graduate Program, Federal University of Rio Grande do Norte, Natal, Brazil
- Department of Nursing, Federal University of Rio Grande do Norte (UFRN), Natal, RN, Brazil
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Akdeniz Uysal D, Yigit R. Assessment of the effectiveness of a web-based family centered empowerment program for the parents of children with oncological problems: Randomized controlled trial. J Pediatr Nurs 2025; 83:69-81. [PMID: 40300263 DOI: 10.1016/j.pedn.2025.04.018] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/05/2025] [Revised: 04/12/2025] [Accepted: 04/16/2025] [Indexed: 05/01/2025]
Abstract
PURPOSE The study aims to examine the effects of a web-based Family-Centered Empowerment Model based educational intervention given to parents of children with oncological problems on caregiving ability, self-efficacy, self-esteem, depression, anxiety, and stress. DESIGN & METHODS The present study used a parallel-group, randomized, controlled, single-blind experimental design. Participants (n = 76) were divided into two groups: intervention (I = 38) and control (C = 38). The intervention group participated in an eight-week web-based empowerment program. Data were collected before, after, and 1 month after the training using the Information Form, Scale for Assessing the Ability of Family Members Providing Care to Cancer Patients, General Self-Efficacy Scale, Rosenberg Self-Esteem Scale, Depression, Anxiety, and Stress Scale. Data were analyzed using descriptive statistics, Pearson chi-square, Fisher Exact test, independent samples t-test, two-way repeated measures ANOVA, and post hoc Bonferroni analyses. RESULTS It was determined that the care ability and self-efficacy mean scores of the parents in the intervention group increased compared to the control group, while the self-esteem and depression, anxiety, and stress mean scores decreased. CONCLUSION Web-based empowerment program is an effective method for improving parents' caregiving abilities, increasing their self-efficacy and self-esteem, and reducing depression, anxiety, and stress levels. IMPLICATIONS FOR PRACTICE In the management of this process, which is more difficult than other diseases, the web-based AMGM-based training program is an easy-to-implement and effective care approach that primarily aims to empower the caregiver. In addition, the developed website is a practical guide that parents can use at home to manage the problems they encounter.
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Affiliation(s)
| | - Rana Yigit
- Retired Faculty Member, Department of Pediatric Nursing, Faculty of Nursing, Mersin University, 33110 Mersin, Türkiye
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Hirata M, Yamaji N, Iwamoto S, Hasegawa A, Miyachi M, Yamaguchi T, Hasegawa D, Ota E, Yotani N. Pain Assessment Tools for Infants, Children, and Adolescents With Cancer: Protocol for a Scoping Review. JMIR Res Protoc 2025; 14:e66614. [PMID: 40294400 PMCID: PMC12070012 DOI: 10.2196/66614] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/01/2024] [Revised: 03/03/2025] [Accepted: 03/21/2025] [Indexed: 04/30/2025] Open
Abstract
BACKGROUND Pain management in children with cancer may be inadequate due to poor pain assessment, and evaluation using suitable tools is necessary. Despite the availability of many pain assessment scales, few studies have summarized the existing assessment tools, making it challenging to select a suitable scale. OBJECTIVE This scoping review aims to map existing pain assessment tools for children with cancer and provide a comprehensive overview of pediatric cancer-related pain screening and assessment tools. METHODS The scoping review will be conducted according to the guidelines by the Joanna Briggs Institute and reported following the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews) framework. Electronic databases, including PubMed, CINAHL, CENTRAL, ICHUSHI (Japan Medical Abstracts Society), and Embase, will be searched to identify eligible studies, without date or language restrictions. We defined the eligibility criteria based on the PCC (Population, Concept, and Context) format. Studies that focused on assessment tools for evaluating pain in children (aged 0-18 years) with cancer in a hospital or at home will be included. Although there are no restrictions on study design, protocols and conference abstracts will be excluded. Two or more reviewers will select studies by reviewing the full text of relevant articles identified by titles and abstracts, and disagreements will be resolved through discussion. Two or more reviewers will extract predefined data items, including characteristics of included studies (eg, author name, title of publication, year of publication, purpose of study, study setting, study population, outline of the assessment tool, study design, and findings) and the characteristics of assessment tools (eg, types of tools, target population, assessor, validity, instructions, precautions, and advantages and disadvantages of the tools). Pain assessment tools will be summarized in tabular format and described in a narrative synthesis. RESULTS Through electronic database searches on November 20, 2023, we identified 3748 articles. This review will provide a comprehensive overview of pain assessment tools. The final report is planned for submission to a peer-reviewed journal in 2025. CONCLUSIONS This scoping review is the first comprehensive effort to map existing tools on pediatric cancer-related pain assessment tools for infants, children, and adolescents aged <18 years, according to developmental stages. Based on the findings of this study, we will discuss future clinical and research implications for pain assessment and management in children with cancer. The findings are expected to enhance pain management practices in children with cancer and inform health care providers, policy makers, and other stakeholders. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID) DERR1-10.2196/66614.
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Affiliation(s)
- Mika Hirata
- Department of Child Health Nursing, Graduate School of Health Care and Nursing, Juntendo University, Chiba, Japan
| | - Noyuri Yamaji
- Institute of Clinical Epidemiology, Showa Medical University, Tokyo, Japan
- Global Health Nursing, Graduate School of Nursing, St. Luke's International University, Tokyo, Japan
- Department of Family Nursing, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
| | | | - Ayaka Hasegawa
- Pharmaceutical Department, National Center For Child Health and Development, Tokyo, Japan
| | - Mitsuru Miyachi
- Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
| | | | - Daisuke Hasegawa
- Department of Pediatrics, St. Luke's International Hospital, Tokyo, Japan
| | - Erika Ota
- Global Health Nursing, Graduate School of Nursing, St. Luke's International University, Tokyo, Japan
| | - Nobuyuki Yotani
- Division of Palliative Medicine, National Center for Child Health and Development, Tokyo, Japan
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Xu F, Lv D, Zhou J, Guan Z, Xiong J, Yun J, Xu X, Mao J, Shen Z, Jin L, Liu Y, Xing H, Wang J, Wang H. Parental influence on Chinese childhood cancer survivors' physical activity: a mixed methods study. Sci Rep 2025; 15:7998. [PMID: 40055371 PMCID: PMC11889262 DOI: 10.1038/s41598-025-87037-0] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/31/2024] [Accepted: 01/15/2025] [Indexed: 05/13/2025] Open
Abstract
Parents influence the physical activity (PA) of the childhood cancer survivors (CCS). This mixed-methods study, aiming to obtain an understanding of Chinese parents' perceptions of PA in CCS and how the cancer experience changes their views, which may affect these children's PA engagement. A mixed methods study was conducted at two hospitals in Hangzhou. A qualitative investigation using the thematic descriptive phenomenological approach analyzed data concerning the parents of 9-18-year-old childhood cancer survivors who had completed hospitalized treatment for at least three months. A cross-sectional investigation examined the association between parents' attitudes and children's PA levels using unconditioned binary logistic regression analysis. The qualitative investigation included 35 parents (74.3% female). More than half of the parents understood the benefits of regular PA. Most parents supported children's participation in low-intensity PA, but opposed high-intensity activities. Many parents changed their parenting style after cancer diagnosis, which might affect the development and persistence of children's PA. In the cross-sectional investigation, CCS were more likely to engage in low-level moderate-to-vigorous physical activity (MVPA) or less MVPA when receiving less paternal support (adjusted OR = 0.92, 95%CI:0.88-0.96) and maternal support (adjusted OR = 0.91, 95%CI:0.87-0.95). Insufficient paternal MVPA engagement (adjusted OR = 3.83, 95%CI: 2.57-5.70) and maternal MVPA engagement (adjusted OR = 5.65, 95%CI: 3.74-8.54) were associated with lower MVPA engagement in CCS. This study identified the understanding of parents of childhood cancer survivors concerning PA engagement and related life changes brought about by cancer experiences from the parental perspectives. These changes affect parental attitude towards children's participation in PA, and parental attitude and behavior affect children's participation in PA. Based on the above findings, some tentative practical implications for physical activity participation among childhood cancer survivors are drawn: (1) childhood cancer survivors should be encouraged to participate in more MVPA and consult a rehabilitation physician if necessary; (2) parents and children engage in exercise together is an important way to promote the levels of physical activity among childhood cancer survivors; (3) Chinese parents have insufficient awareness of the benefits of childhood cancer survivors participation in physical activity. We should strengthen health education for parents, promote parents to support childhood cancer survivors participate in physical activity.
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Affiliation(s)
- Fengjiao Xu
- Department of Nursing, School of Medicine, Shaoxing University, Shaoxing, China
- Department of Social Medicine of School of Public Health, Zhejiang University School of Medicine, Hangzhou, China
| | - Danni Lv
- Pediatric Cancer Research Center, National Clinical Research Center for Child Health, Hangzhou, China
- Department of Surgical Oncology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China
- Cancer Center, Zhejiang University, Hangzhou, China
| | - Jie Zhou
- Department of Social Medicine of School of Public Health, Zhejiang University School of Medicine, Hangzhou, China
| | - Zhonghai Guan
- Pediatric Cancer Research Center, National Clinical Research Center for Child Health, Hangzhou, China
- Department of Surgical Oncology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China
- Cancer Center, Zhejiang University, Hangzhou, China
| | - Jieni Xiong
- Pediatric Cancer Research Center, National Clinical Research Center for Child Health, Hangzhou, China
- Department of Surgical Oncology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China
- Cancer Center, Zhejiang University, Hangzhou, China
| | - Jingyi Yun
- Department of Social Medicine of School of Public Health, Zhejiang University School of Medicine, Hangzhou, China
| | - Xiaojun Xu
- Department of Hematology &Oncology, the Children's Hospital of Zhejiang University School of Medicine, Hangzhou, China
| | - Junqing Mao
- Pediatric Cancer Research Center, National Clinical Research Center for Child Health, Hangzhou, China
- Department of Surgical Oncology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China
- Cancer Center, Zhejiang University, Hangzhou, China
| | - Zhipeng Shen
- Department of Neurosurgery, the Children's Hospital of Zhejiang University School of Medicine, Hangzhou, China
| | - Libin Jin
- Department of Department of orthopedic, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China
| | - Yunxia Liu
- Department of Oncology, Hangzhou Third People's Hospital, Hangzhou, China
| | - Haiyan Xing
- Department of Nursing, School of Medicine, Shaoxing University, Shaoxing, China
| | - Jinhu Wang
- Pediatric Cancer Research Center, National Clinical Research Center for Child Health, Hangzhou, China.
- Department of Surgical Oncology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
- Cancer Center, Zhejiang University, Hangzhou, China.
| | - Hongmei Wang
- Department of Social Medicine of School of Public Health, Zhejiang University School of Medicine, Hangzhou, China.
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Ayoub M, Lövgren M, Kreicbergs U, Udo C. Voices of Children with Cancer and Their Siblings in the Family Talk Intervention. CHILDREN (BASEL, SWITZERLAND) 2025; 12:266. [PMID: 40150549 PMCID: PMC11941742 DOI: 10.3390/children12030266] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Received: 01/24/2025] [Revised: 02/15/2025] [Accepted: 02/18/2025] [Indexed: 03/29/2025]
Abstract
BACKGROUND Children in pediatric oncology report unmet needs related to communication and information about the illness, care involvement, and psychosocial support. Supporting the whole family involves challenges, with a risk that children's voices are not heard above those of the adults. Article 12 of the UNCRC has been a catalyst in supporting children's voices and their right to participate in processes that affect them. The aim of this study was to explore how children with cancer and their siblings experienced participation in a family-centered psychosocial support intervention, the Family Talk Intervention (FTI). METHODS Interviews were held with 35 children (ill and siblings) from 26 families in pediatric oncology after having completed the FTI. A combined deductive and inductive qualitative content analysis was undertaken, guided by the Lundy model of child participation. RESULTS Children's experiences of being able to express their views, being listened to, and being involved during FTI were mainly positive. This was related to their participation in individual meetings where they could raise their concerns and views, undertake small activities while talking, and have their voices and needs mediated to relevant adults, such as parents and professionals. CONCLUSIONS The findings of this study showed that the FTI for families in pediatric oncology created opportunities to promote child participation. These findings indicate that, by offering children an individual space where they can express themselves freely and supporting them in various ways to do so, the children's voices and involvement are strengthened.
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Affiliation(s)
- Maria Ayoub
- School of Health and Welfare, Dalarna University, 79188 Falun, Sweden;
| | - Malin Lövgren
- Department of Health Care Sciences, Palliative Research Centre, Marie Cederschiöld University, 11628 Stockholm, Sweden; (M.L.); (U.K.)
- Advanced Pediatric Home Care, Astrid Lindgren Children’s Hospital, Karolinska University Hospital, 17164 Stockholm, Sweden
| | - Ulrika Kreicbergs
- Department of Health Care Sciences, Palliative Research Centre, Marie Cederschiöld University, 11628 Stockholm, Sweden; (M.L.); (U.K.)
- Louis Dundas Center, Great Ormond Street Institute of Child Health, University College London, London WC1E 6BT, UK
- Department of Women’s and Children’s Health, Childhood Cancer Research Unit, Karolinska Institute, 17177 Stockholm, Sweden
| | - Camilla Udo
- School of Health and Welfare, Dalarna University, 79188 Falun, Sweden;
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Yan Q, Li X, Chen Y, Li L, Hu X. Efficacy of Supportive Care Interventions for Improving Posttraumatic Stress Symptoms and Resilience in Family Caregivers of Cancer-Affected Children: A Meta-Analysis of Randomized Controlled Trials. Worldviews Evid Based Nurs 2025; 22:e12764. [PMID: 39828279 DOI: 10.1111/wvn.12764] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/30/2024] [Revised: 12/10/2024] [Accepted: 12/15/2024] [Indexed: 01/22/2025]
Abstract
BACKGROUND The diagnosis of pediatric cancer is a major shock to family caregivers, and posttraumatic stress symptoms (PTSSs) emerge as the most prevalent adverse psychological outcomes. However, not all family caregivers have sufficient resilience to cope with these challenges; thus, supportive care interventions are necessary. These interventions, which include psychosocial support, education, and other forms of assistance, are designed to enhance the well-being of those affected by disease. In the past few years, more research has been delving into supportive care interventions for family caregivers of cancer-affected children, yet there is still a variance in the results. OBJECTIVE To investigate the impacts of supportive care interventions on PTSSs and resilience in family caregivers of cancer-affected children, also focusing on the impacts of prerecruitment time to diagnosis, duration, type of intervention, and recruitment area on the outcomes. METHODS Nine databases (Cochrane Library, Ovid MEDLINE, CINAHL Plus with Full Text, Embase, CNKI, Sinomed, WANFANG, VIP, and Web of Science) were searched from their inception to February 21, 2024. The revised Cochrane Risk of Bias tool and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) method were used to evaluate the quality of evidence. To gauge the effectiveness of the interventions, we computed the standard mean difference (SMD) and the 95% confidence interval (CI) utilizing StataCorp (version 16.0). Sensitivity analysis and Egger's test were also conducted. RESULTS Supportive care interventions significantly improved the PTSSs (SMD = -0.86, 95% CI [-1.39, -0.33], p < 0.01, I2 = 94.95%) and resilience (SMD = 0.85, 95% CI [0.26, 1.44], p < 0.01, I2 = 88.3%) among family caregivers of cancer-affected children. Subgroup analyses revealed that early interventions for family caregivers after the diagnosis of children and the short-term interventions were associated with improvements in their PTSS and resilience. Moreover, cognitive behavioral interventions were the most common type of interventions and were effective in supporting family caregivers. Additionally, supportive care interventions did not improve PTSSs among family caregivers in middle-income countries. LINKING EVIDENCE TO ACTION Supportive care interventions have demonstrated efficacy in improving PTSSs and resilience among family caregivers of cancer-affected children. This research proved the imperative of providing prompt supportive care to family caregivers early after the pediatric cancer diagnosis. Additionally, it is also necessary to further study and explore the optimal way to combine different intervention components based on caregivers' need and to develop regionally adapted and culturally sensitive supportive care interventions to better improve health outcomes for family caregivers.
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Affiliation(s)
- Qianwen Yan
- Department of Nursing, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, Sichuan, P.R. China
| | - Xia Li
- General Practice Medical Center, West China Hospital, Sichuan University, Chengdu, Sichuan, P.R. China
| | - Yang Chen
- Department of Nursing, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, Sichuan, P.R. China
| | - Linna Li
- Department of Nursing, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, Sichuan, P.R. China
| | - Xiaolin Hu
- Department of Nursing, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, Sichuan, P.R. China
- Tianfu Jincheng Laboratory, City of Future Medicine, Chengdu, Sichuan, P.R. China
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Ferraz A, Faria S, Jerónimo M, Pereira MG. Parental Psychological Adjustment in Pediatric Acute Lymphoblastic Leukemia: The Mediating Role of Family Functioning and Resilience. Cancers (Basel) 2025; 17:338. [PMID: 39941710 PMCID: PMC11816336 DOI: 10.3390/cancers17030338] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/20/2024] [Revised: 01/15/2025] [Accepted: 01/16/2025] [Indexed: 02/16/2025] Open
Abstract
Background/Objectives: Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with intense treatments affecting both children and their families. Limited information is available on parental distress and psychological well-being during the first treatment year, with most studies focusing on individuals rather than the family system. This study explores longitudinal changes in parental distress (psychological morbidity and traumatic stress symptoms), coping strategies, family resilience and functioning, and psychological well-being. The study also examines the mediating roles of family resilience, family functioning, and coping strategies in the relationships between parental distress and psychological well-being. Methods: A prospective study was conducted with 46 parents of children newly diagnosed with ALL, assessing parental distress, family functioning and resilience, coping, and psychological well-being across three treatment phases: consolidation (T0), delayed intensification (T1), and maintenance (T2). Results: Parental distress and family resilience significantly decreased from T0 to T2, while parental coping improved over time. Family functioning deteriorated from T0 to T1, stabilizing thereafter. Psychological well-being followed a non-linear trajectory, initially declining from T0 to T1 and improving from T1 to T2. Mediation analyses revealed that family resilience and family functioning partially mediated the relationships between parental distress and psychological well-being. Parental coping did not emerge as a mediator. Conclusions: Parental psychological adjustment in the context of ALL is dynamic and influenced by individual and family factors. Interventions that strengthen family functioning and resilience are crucial for supporting parental psychological well-being during treatment. A family-centered approach in healthcare delivery is essential to address individual and systemic challenges.
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Affiliation(s)
- Ana Ferraz
- Psychology Research Centre (CIPsi), School of Psychology, Applied Psychology Department, University of Minho, 4710-057 Braga, Portugal;
| | - Susana Faria
- Centre of Mathematics (CMAT), Department of Mathematics, University of Minho, 4800-058 Guimarães, Portugal;
| | - Mónica Jerónimo
- Pediatric Oncology Department, Hospital Pediátrico, Centro Hospitalar e Universitário de Coimbra, 3000-602 Coimbra, Portugal;
| | - M. Graça Pereira
- Psychology Research Centre (CIPsi), School of Psychology, Applied Psychology Department, University of Minho, 4710-057 Braga, Portugal;
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Kasinathan K, Rajkumar R, Rajendran SS, Anbalagan M, Ramasamy R, Ramu B. Biopsychosocial needs of leukemic children - A systematic review. Bioinformation 2024; 20:1678-1682. [PMID: 40230890 PMCID: PMC11993368 DOI: 10.6026/9732063002001678] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/01/2024] [Revised: 12/31/2024] [Accepted: 12/31/2024] [Indexed: 04/16/2025] Open
Abstract
Leukaemia, particularly Acute Lymphoblastic Leukaemia (ALL) and Acute Myeloblastic Leukaemia (AML), is the second leading cause of death among children aged 0-14, with survival rates of 80-90% achieved through improved treatment. Despite these advancements, challenges persist in early detection, as most cases are identified through non-standardized methods, highlighting the need for better adherence to guidelines for early recognition. A systematic review following PRISMA guidelines explored the biopsychosocial needs of children with leukaemia, focusing on mental health, emotional well-being and quality of life. The review identified significant gaps in post-treatment care, emphasized the importance of parent education and underscored the necessity for comprehensive approaches to address psychosocial and emotional challenges. Tailored interventions that address medical, emotional and social needs are crucial to improving symptom control and quality of life. In contrast, further research is needed to standardise assessment methods for pediatric leukaemia patients.
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Affiliation(s)
- Kannan Kasinathan
- Research Scholar, Meenakshi Academy of Higher Education & Research(DU), Chennai & Department of Child Health Nursing, College of Nursing, Madras Medical College, Chennai , India
| | - Rajamanickam Rajkumar
- Department of Community Medicine, Meenakshi Medical College & Research Institute & MAHER(DU), Kanchipuram, Tamil Nadu, India
| | - Shankar Shanmugam Rajendran
- Department of Paediatric Nursing, College of Nursing, Madras Medical College, The TN MGR Medical University, Chennai, India
| | - Marudan Anbalagan
- Research Scholar, Meenakshi Academy of Higher Education & Research(DU), Chennai & Department of Child Health Nursing, College of Nursing, Madras Medical College, Chennai , India
| | - Revathi Ramasamy
- Research Scholar, Meenakshi Academy of Higher Education and Research (MAHER)(DU), Chennai & Nurse Practitioner Midwifery Educator, College of Nursing, Madras Medical College, Chennai, India
| | - Bama Ramu
- Research Scholar, Meenakshi Academy of Higher Education and Research (MAHER)(DU), Chennai & Nurse Practitioner Midwifery Educator, College of Nursing, Madras Medical College, Chennai, India
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Bahrami M, Musarezaie A, Farzi S, Beigi-Harchegani H, Mosavizadeh R. Development, implementation, and evaluation of a spiritual health promotion program for mothers of children with acute leukemia based on mobile health: A mixed-methods protocol study. JOURNAL OF EDUCATION AND HEALTH PROMOTION 2024; 13:412. [PMID: 39703658 PMCID: PMC11658047 DOI: 10.4103/jehp.jehp_42_24] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 01/08/2024] [Accepted: 03/21/2024] [Indexed: 12/21/2024]
Abstract
BACKGROUND Considering the importance of the spiritual health promotion of Mothers of Children with Acute Leukemia (MoCwAL), designing a native mobile health (mHealth) application that is compatible with the beliefs, values, and cultural context of Iranian society is essential. This study aims to develop a Spiritual Health Promotion Program (SHPP) for MoCwAL based on a mHealth application, including design, implementation, and evaluation. MATERIALS AND METHODS This is a sequential exploratory mixed-methods study (qual → QUAN). This study will be conducted in four phases. The first phase includes the development of the content of the SHPP using Ewles and Simnett's (2010) designing pattern. After finalizing the SHPP, at the beginning of the second phase (mHealth application development), a panel of experts will be present. Based on the outputs obtained from this panel, the research team will proceed to design the application. The output of the second phase will be an initial version of the mHealth application. In the third phase, the usability and quality of mHealth application questionnaires will be evaluated. Results will be refined by the expert panel, and the final version of the application will be available. In the fourth phase, the SHPP for MoCwAL based on mHealth will be implemented as a quasi-experimental intervention, and mothers' spiritual health be evaluated. CONCLUSION This program can be useful in providing care, education, policy-making, and future research. Providing the SHPP in the form of an application will enable program users to benefit from the many advantages of information technology and will contribute to the expansion of the role of mHealth in the healthcare system and the strengthening of policies related to digital health in the field of chronic diseases.
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Affiliation(s)
- Masoud Bahrami
- Nursing and Midwifery Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
| | - Amir Musarezaie
- Nursing and Midwifery Care Research Center, Department of Adult Health Nursing, Faculty of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran
| | - Sedigheh Farzi
- Nursing and Midwifery Care Research Center, Department of Adult Health Nursing, Faculty of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran
| | - Hossein Beigi-Harchegani
- Health Information Technology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
| | - Rohallah Mosavizadeh
- Department of Islamic Education, Department of Palliative Medicine, MACSA Cancer Prevention and Control Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
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11
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Alanzi TM, Alharthi A, Alessa A, Alhajri AS, Abanmi S, Khalifah A, Althanayan FH, AlRubaya S, Almahaish M, Alrefai W, Madan M, Allahyani T, Alsulami R, Saadah A, Alanzi N. Quality of life and psychosocial impact on patients with blood disorders: An empirical study from patients' perspectives in Saudi Arabia. Nutr Health 2024:2601060241273570. [PMID: 39215525 DOI: 10.1177/02601060241273570] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 09/04/2024]
Abstract
STUDY PURPOSE this study aims to analyze QOL and psychosocial impact on patients with blood disorders. METHODS A cross-sectional survey design is adopted in this study. The survey questionnaire included SF-36 form for measuring quality of life (QOL), along with psychosocial impact assessment scale. Adult patients with different types of blood disorders were recruited for the survey. Out of the 417 responses received, 389 were considered for data analysis and the remaining were avoided due to incomplete data. RESULTS In terms of psychosocial impact scales, the highest mean is observed for financial stress (4.09 ± 1.22), followed by social exclusion (3.76 ± 1.19) and relationship challenges (3.31 ± 1.18). Among the QOL scales, the highest mean was observed for pain (3.81 ± 1.17), followed by physical functioning (3.68 ± 1.12). Statistically significant differences (p < 0.05) were observed among the participants groups characterized by age and type of disorder. Strong positive correlations between social exclusion and general health (r = 0.513), as well as pain and relationship challenges (r = 0.735) were observed. CONCLUSION Given the existing challenges in social exclusion, poor awareness, and support there is a need to develop comprehensive and personalized treatment plans integrating physical and mental support, awareness creation, and financial support.
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Affiliation(s)
- Turki M Alanzi
- Health Information Management and Technology Department, College of Public Health, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia
| | - Abdulaziz Alharthi
- Faculty of Medicine Jeddah, King Abdulaziz University, Jeddah, Saudi Arabia
| | - Abdullah Alessa
- College of Medicine King Saud University, Riyadh, Saudi Arabia
| | - Ahlam Saleh Alhajri
- Food Science and Nutrition Department, College of Agricultural and Food Sciences, King Faisal University, Al Ahsa, Saudi Arabia
| | - Sobhia Abanmi
- College of Medicine, Majmaah University, Majmaah, Saudi Arabia
| | | | - Fatimah H Althanayan
- Department of Hematology, Qatif Comprehensive Inspection Center, Qatif, Saudi Arabia
| | - Sarah AlRubaya
- College of Medicine - Imam abdulrahman bin faisal University, Dammam, Saudi Arabia
| | - Mariam Almahaish
- Imam Abdulrahman Bin Faisal University, College of Medicine, Dammam, Saudi Arabia
| | - Wedyan Alrefai
- Medical Laboratories, Taibah University, Madinah, Saudi Arabia
| | - Manal Madan
- Faculty of medicine, Wenzhou Medical University, Wenzhou, China
| | - Taif Allahyani
- Medical Laboratory- Applied Medical Sciences - Umm Al-Qura University, Makkah, Saudi Arabia
| | - Reyouf Alsulami
- Laboratory Department, Makkah Medical Center Hospital, Makkah, Saudi Arabia
| | - Amjad Saadah
- Health Information Management and Technology Department, College of Public Health, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia
| | - Nouf Alanzi
- Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Jouf, Saudi Arabia
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12
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Shen YZ, Chen F, Yu JW, Zhang Y, Lu LX, Huo YL, Chu ST, Cao B, Tang LW. Review of Baduanjin and resistance exercise for the mental health of patients with hematologic malignancies. World J Psychiatry 2024; 14:1165-1173. [PMID: 39165558 PMCID: PMC11331390 DOI: 10.5498/wjp.v14.i8.1165] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 06/05/2024] [Revised: 06/29/2024] [Accepted: 07/15/2024] [Indexed: 08/12/2024] Open
Abstract
Patients with hematological tumors experience physical and psychological stress, and negative psychological states. Baduanjin, an emerging psychological rehabilitation method combined with resistance exercise, has received widespread attention. This study reviews the current status of the application of Baduanjin combined with resistance exercise in improving the negative psychological state of patients with hematological tumors and discusses its problems and prospects. Through a literature review and comprehensive analysis, the application of Baduanjin and resistance exercise in the psychological rehabilitation of patients with hematological tumors was identified and evaluated. The results showed that Baduanjin with resistance exercise had a positive effect on improving negative psychological states of patients with hematological tumors, which can alleviate anxiety, depression, and other adverse emotions, and improve quality of life. However, there is a lack of unified and standardized exercise intervention programs for practical application, and patient participation and compliance must be improved. Baduanjin combined with resistance exercise can potentially improve the negative psychological status of patients with hematological tumors; however, it is still necessary to further standardize and improve the exercise program improving patient participation and compliance. Future studies should strengthen theoretical exploration and empirical research, providing more effective psychological rehabilitation strategies for patients with hematological tumors.
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Affiliation(s)
- Ya-Zhou Shen
- Department of Nursing, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310000, Zhejiang Province, China
| | - Feng Chen
- Department of Nursing, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310000, Zhejiang Province, China
| | - Jia-Wen Yu
- Department of Nursing, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310000, Zhejiang Province, China
| | - Yan Zhang
- Department of Nursing, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310000, Zhejiang Province, China
| | - Ling-Xiang Lu
- Department of Nursing, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310000, Zhejiang Province, China
| | - Yong-Li Huo
- Department of Nursing, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310000, Zhejiang Province, China
| | - Si-Ting Chu
- Department of Nursing, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310000, Zhejiang Province, China
| | - Bing Cao
- Department of Nursing, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310000, Zhejiang Province, China
| | - Lei-Wen Tang
- Department of Nursing, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310000, Zhejiang Province, China
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13
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Xu Q, Ge Q, Shi L, Zhang Y, Ma J. Assessing the mediating role of family resilience between caregiver burden and caregiver capacity: a cross-sectional study among Chinese stroke survivors and family caregivers in a real-world setting. BMJ Open 2024; 14:e083106. [PMID: 38724057 PMCID: PMC11086420 DOI: 10.1136/bmjopen-2023-083106] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 12/13/2023] [Accepted: 04/23/2024] [Indexed: 05/12/2024] Open
Abstract
OBJECTIVES To investigate the relationships among caregiver burden, family resilience, and caregiver capacity in the care of stroke survivors. We hypothesised that family resilience would mediate the relationship between caregiver burden and caregiver capacity. DESIGN A cross-sectional study design was used. SETTING The study was conducted in a tertiary care setting in Ningbo City, Zhejiang Province, China. PARTICIPANTS The study involved 413 stroke survivors and their primary caregivers. OUTCOME MEASURES The primary caregivers completed the Shortened Chinese Version of the Family Resilience Assessment Scale, Zarit Caregiver Burden Interview and Family Caregiver Task Inventor and provided their sociodemographic information. Stroke survivors were assessed for activities of daily living, and their sociodemographic information was provided. Data were analysed, controlling for sociodemographic variables and focusing on the mediating effect of family resilience. RESULTS Caregiver burden was influenced by the activities of daily living of stroke survivors, caregiver age and caregiver health status (p<0.05). Higher caregiver burden was associated with lower family resilience (p<0.01). Lower caregiver capacity corresponded to heavier caregiver burden (p<0.01). Family resilience mediated the relationship between caregiver burden and caregiver capacity (b=0.1568; 95% CI: 0.1063 to 0.2385). CONCLUSIONS Enhancing family resilience can reduce caregiver burden and improve caregiver capacity in stroke care. These findings underscore the importance of developing interventions focused on nursing skills and family resilience.
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Affiliation(s)
- Qihang Xu
- Department of Pharmacy, Ningbo Medical Centre Lihuili Hospital, Ningbo, Zhejiang, China
| | - Qingqing Ge
- Department of Nursing, Ningbo Medical Centre Lihuili Hospital, Ningbo, Zhejiang, China
| | - Lu Shi
- Ningbo Medical Centre Lihuili Hospital, Ningbo, Zhejiang, China
| | - Yiqing Zhang
- Department of Nursing, Ningbo Medical Centre Lihuili Hospital, Ningbo, Zhejiang, China
| | - Jingjing Ma
- Department of Nursing, Ningbo Medical Centre Lihuili Hospital, Ningbo, Zhejiang, China
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14
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Ayoub M, Udo C, Årestedt K, Kreicbergs U, Lövgren M. The Family Talk Intervention in Pediatric Oncology: Potential Effects Reported by Parents. CHILDREN (BASEL, SWITZERLAND) 2024; 11:95. [PMID: 38255408 PMCID: PMC10814711 DOI: 10.3390/children11010095] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Received: 12/07/2023] [Revised: 01/04/2024] [Accepted: 01/10/2024] [Indexed: 01/24/2024]
Abstract
BACKGROUND Childhood cancer impacts the family system and has psychosocial consequences for all family members. For the parents, the ill child, and the siblings to be able to adjust to this challenging situation, the whole family needs access to psychosocial support. However, only a few such family interventions in pediatric oncology have been evaluated. The aim of this study was to explore the potential effects of a family-centered intervention, the Family Talk Intervention (FTI), in pediatric oncology from the parents' perspectives. METHODS A concurrent mixed methods design was used for this study. Data were derived from a pilot study of 26 families recruited from one pediatric oncology center in Sweden. This study focused on questionnaire and interview data from 52 parents. RESULTS After participation in FTI, the parents felt more satisfied with the conversations within the family about the illness. FTI also contributed to strengthened family togetherness, including more open communication and improved family relations, as described by the parents. Parents further expressed that they felt more empowered in their parenting role following FTI. CONCLUSIONS The findings regarding FTI's ability to improve family communication and family relations, thus strengthening family togetherness in families with childhood cancer, are promising. This provides motivation for a large-scale study of FTIs in pediatric oncology.
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Affiliation(s)
- Maria Ayoub
- School of Health and Welfare, Dalarna University, 791 88 Falun, Sweden;
| | - Camilla Udo
- School of Health and Welfare, Dalarna University, 791 88 Falun, Sweden;
- Department of Health Care Sciences, Palliative Research Centre, Marie Cederschiöld University, 116 28 Stockholm, Sweden; (U.K.); (M.L.)
- Center for Clinical Research Dalarna, Uppsala University, 791 82 Falun, Sweden
| | - Kristofer Årestedt
- Department of Health and Caring Sciences, Faculty of Health and Life Science, Linnaeus University, 352 52 Växjö, Sweden;
| | - Ulrika Kreicbergs
- Department of Health Care Sciences, Palliative Research Centre, Marie Cederschiöld University, 116 28 Stockholm, Sweden; (U.K.); (M.L.)
- Department of Women’s and Children’s Health, Childhood Cancer Research Unit, Karolinska Institute, 171 77 Solna, Sweden
- Louis Dundas Center, Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK
| | - Malin Lövgren
- Department of Health Care Sciences, Palliative Research Centre, Marie Cederschiöld University, 116 28 Stockholm, Sweden; (U.K.); (M.L.)
- Advanced Pediatric Home Care, Astrid Lindgren Children’s Hospital, Karolinska University Hospital, 171 64 Solna, Sweden
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15
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Spaggiari S, Calignano G, Montanaro M, Zaffani S, Cecinati V, Maffeis C, Di Riso D. Examining Coping Strategies and Their Relation with Anxiety: Implications for Children Diagnosed with Cancer or Type 1 Diabetes and Their Caregivers. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 2024; 21:77. [PMID: 38248541 PMCID: PMC10815397 DOI: 10.3390/ijerph21010077] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 11/14/2023] [Revised: 12/18/2023] [Accepted: 01/08/2024] [Indexed: 01/23/2024]
Abstract
The onset of chronic diseases in childhood represents a stressful event for both young patients and their caregivers. In this context, coping strategies play a fundamental role in dealing with illness-related challenges. Although numerous studies have explored coping strategies employed by parents of children with chronic diseases, there remains a gap in the understanding of children's coping strategies and their correlation with their and their parents' anxiety. This study aims to investigate coping strategies and their interaction with anxiety in groups of young patients with cancer, type 1 diabetes (T1D), and their respective caregivers, in comparison to healthy children and caregivers. We recruited a total of 61 control children, 33 with cancer, and 56 with T1D, 7 to 15 years old, along with their mothers. Each participant completed a customized survey and standardized questionnaires. No significant differences emerged in coping strategies used by children among the different groups. However, when examining the association between coping strategy and anxiety, we found specific patterns of interaction between children's use of coping strategies and their and their mothers' anxiety levels. This study underscores the importance of an illness-specific approach to gain deeper insights into this topic and develop targeted interventions aimed at enhancing the psychological well-being of these vulnerable populations.
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Affiliation(s)
- Silvia Spaggiari
- Department of Developmental Psychology and Socialization (DPSS), University of Padua, 35131 Padova, Italy; (G.C.); (D.D.R.)
| | - Giulia Calignano
- Department of Developmental Psychology and Socialization (DPSS), University of Padua, 35131 Padova, Italy; (G.C.); (D.D.R.)
| | - Maria Montanaro
- Complex Structure of Pediatrics and Pediatric Oncohematology “Nadia Toffa”, Central Hospital Santissima Annunziata, 74121 Taranto, Italy; (M.M.); (V.C.)
| | - Silvana Zaffani
- Pediatric Diabetes and Metabolic Disorders, Department of Surgical Sciences, Dentistry, Paediatrics and Gynaecology, University of Verona, 37134 Verona, Italy; (S.Z.); (C.M.)
| | - Valerio Cecinati
- Complex Structure of Pediatrics and Pediatric Oncohematology “Nadia Toffa”, Central Hospital Santissima Annunziata, 74121 Taranto, Italy; (M.M.); (V.C.)
| | - Claudio Maffeis
- Pediatric Diabetes and Metabolic Disorders, Department of Surgical Sciences, Dentistry, Paediatrics and Gynaecology, University of Verona, 37134 Verona, Italy; (S.Z.); (C.M.)
| | - Daniela Di Riso
- Department of Developmental Psychology and Socialization (DPSS), University of Padua, 35131 Padova, Italy; (G.C.); (D.D.R.)
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16
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Sweileh WM. Bibliometric analysis of global research on psychological well-being, subjective burden, and psychosocial support of family caregivers of cancer patients. Health Psychol Open 2024; 11:20551029241307994. [PMID: 39668850 PMCID: PMC11635901 DOI: 10.1177/20551029241307994] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/14/2024] Open
Abstract
This study delves into the realm of informal cancer caregivers. Through a meticulous bibliometric analysis, the study sheds light on the burgeoning interest in this field, with a significant focus on the psychological well-being, subjective burden, and psychosocial support for caregivers. A significant portion of the retrieved articles (n = 1366) was published after 2017 and primarily disseminated through a select number of journals. Notably, the study reveals a substantial gap in randomized controlled trials addressing interventions tailored to family caregivers, indicating a critical need for more high-quality trials to guide effective support strategies. Despite the increasing recognition of caregivers' significance, limited research collaboration was observed, emphasizing the importance of fostering collaborative efforts to address cultural differences and expand the scope of research on cancer caregivers globally. The findings underscore the urgent call for comprehensive interventions and collaborative endeavors to optimize the well-being of family caregivers.
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17
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Tailor NK, Grewal AS, Deswal G, Dhingra AK. Germacrone: A Multi-targeting Sesquiterpene with Promising Anti-cancer and Chronic Disease Applications. Anticancer Agents Med Chem 2024; 24:1396-1406. [PMID: 39113300 DOI: 10.2174/0118715206312324240805075050] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/03/2024] [Revised: 06/25/2024] [Accepted: 07/12/2024] [Indexed: 10/26/2024]
Abstract
BACKGROUND Germacrone, a naturally occurring active compound found in essential oils extracted from medicinal plants within the Zingiberaceae family, has garnered attention for its potential therapeutic applications. Extensive research has highlighted its multi-targeting capabilities, positioning it as a promising treatment for various chronic diseases, including cancer, cardiovascular conditions, and neurodegenerative disorders like Alzheimer's disease. OBJECTIVE This review aims to provide a comprehensive overview of germacrone as a scaffold for developing multi-targeting drugs with therapeutic potential against a range of chronic disorders. The study delves into the molecular mechanisms that underlie the therapeutic effects of germacrone and explores its potential targets, including NF-κB, PI3K/AKT/mTOR, p53, JAK/STAT, caspase, apoptosis, and autophagy induction. METHODS A systematic review of literature databases was conducted to gather relevant studies on germacrone and its therapeutic applications. The molecular mechanisms and potential targets of germacrone were examined to elucidate its multi-targeting capabilities. RESULTS Germacrone exhibits significant potential in the management of chronic diseases, with demonstrated effects on various cellular pathways. The review highlights its impact on NF-κB, PI3K/AKT/mTOR, p53, JAK/STAT, caspase, apoptosis, and autophagy induction, showcasing its versatility in targeting multiple pathways associated with chronic conditions. Germacrone has emerged as a promising candidate for the treatment of diverse chronic diseases. The understanding of its multi-targeting capabilities, coupled with its natural origin, positions it as a valuable scaffold for developing therapeutics. CONCLUSION The exploration of germacrone as a structural framework for multi-targeting drugs offers a potential avenue to enhance efficacy while minimizing potential side effects. Further research and clinical trials are warranted to validate the therapeutic potential of germacrone in diverse medical contexts.
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Affiliation(s)
- Navin Kumar Tailor
- University Institute of Pharma Sciences, Chandigarh University, Gharuan, Mohali, Punjab, India
| | - Ajmer Singh Grewal
- Department of Pharmaceutical Chemistry, Guru Gobind Singh College of Pharmacy, Yamuna Nagar, Haryana, India
| | - Geeta Deswal
- Department of Pharmaceutical Chemistry, Guru Gobind Singh College of Pharmacy, Yamuna Nagar, Haryana, India
| | - Ashwani Kumar Dhingra
- Department of Pharmaceutical Sciences, Global Research Institute of Pharmacy, Radaur, Yamuna Nagar, Haryana, India
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18
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Melesse TG, Chau JPC, Li WHC, Yimer MA. Family caregivers' experiences of caring for children diagnosed with haematological malignancies receiving chemotherapy in Ethiopia: A qualitative study. Eur J Oncol Nurs 2023; 66:102376. [PMID: 37506611 DOI: 10.1016/j.ejon.2023.102376] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/26/2022] [Revised: 06/06/2023] [Accepted: 06/16/2023] [Indexed: 07/30/2023]
Abstract
PURPOSE Studies from different countries show that caregivers of children with haematological cancer receiving chemotherapy encounter substantial distress when witnessing their children's suffering from the illness and chemotherapy side effects, alongside experiencing psychosocial problems and financial difficulties. However, no studies for this are available from Ethiopia in its specific cultural background and health care system. Thus, this study aimed to explore and bring into light the experiences of Ethiopian family caregivers of children with haematological malignancies receiving chemotherapy. METHODS A qualitative descriptive study was conducted using a maximum variation purposive sampling method among 20 caregivers. Semi-structured in-depth face-to-face interviews were conducted until no new themes discovered. The data were analysed through qualitative thematic analysis. RESULTS Participants believed cancer comes from different reasons and chemotherapy is ineffective in curing cancer. They identified various chemotherapy-related side effects, and psychosocial problems. The lack of health insurance, loss of job or income, and high cost of treatments were the major financial challenges. Adhering to treatments, acceptance and reassurance, religious and spiritual therapies, traditional medicine, and a support system were the major coping strategies. They had needs for improved support in information and education, psychosocial support, and in the availability of medications. CONCLUSIONS Systematic health assessment, provision of targeted information and education, psychosocial support, nursing care respecting the caregivers' positive coping strategies, improvement in chemotherapy medication availability, and facilitating connections with supporting organisations would help improve child outcomes and address caregiver needs.
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Affiliation(s)
- Tenaw Gualu Melesse
- The Nethersole School of Nursing, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region; Department of Paediatrics and Child Health Nursing, College of Health Sciences, Debre Markos University, Ethiopia
| | - Janita Pak Chun Chau
- The Nethersole School of Nursing, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region
| | - William Ho Cheung Li
- The Nethersole School of Nursing, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region.
| | - Mulugeta Ayalew Yimer
- Unit of Paediatric Haematology-Oncology, Department of Paediatrics and Child Health, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Ethiopia
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Sheikh S, Wimberly CE, Towry L, Walsh KM. Beyond Anxiety and Grief: Mapping the Emotional Landscape of Parents Facing a Childhood Cancer Diagnosis. MEDRXIV : THE PREPRINT SERVER FOR HEALTH SCIENCES 2023:2023.05.24.23290421. [PMID: 37292771 PMCID: PMC10246129 DOI: 10.1101/2023.05.24.23290421] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 06/10/2023]
Abstract
Objective We sought to explore the variation in emotional responses and identify clusters of emotional patterns associated with sociodemographic, clinical, and familial factors. Methods A large-scale survey with questions on demographics, experiences, and emotions at the time of diagnosis was sent to childhood cancer caregivers and completed between August 2012 and April 2019. Dimensionality reduction and statistical tests for independence were used to investigate relationships between sociodemographic, clinical, and psychosocial factors and 32 representative emotions. Results Data from 3142 respondents were analyzed. Through principal components analysis and t-distributed stochastic neighbor embedding analysis, three clusters of emotional responses were identified, captured 44%, 20% and 36% of respondents, respectively. Hallmark emotions within each cluster were "anger and grief" (Cluster 1), "pessimism, relief, impatience, insecurity, discouragement, and calm" (Cluster 2), and "hope" (Cluster 3). Cluster membership was associated with differences in parental factors, such as educational attainment, family income, and biological parent status, as well as child-specific factors, including age at diagnosis and cancer type. Conclusions The study revealed substantial heterogeneity in emotional responses to a child's cancer diagnosis than previously recognized, with differences linked to both caregiver and child-related factors. These findings underscore the importance of developing responsive and effective programs to improve targeted support for caregivers from the time of diagnosis throughout a family's childhood cancer journey.
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Affiliation(s)
- Shanzeh Sheikh
- Department of Neurosurgery and Preston Robert Tisch Brain Tumor Center, Duke University School of Medicine, Durham, NC, USA
| | - Courtney E. Wimberly
- Department of Neurosurgery and Preston Robert Tisch Brain Tumor Center, Duke University School of Medicine, Durham, NC, USA
| | - Lisa Towry
- Alex’s Lemonade Stand Foundation, Bala Cynwyd, PA, USA
| | - Kyle M. Walsh
- Department of Neurosurgery and Preston Robert Tisch Brain Tumor Center, Duke University School of Medicine, Durham, NC, USA
- Duke Cancer Institute, Duke University School of Medicine, Durham, NC, USA
- Children’s Health and Discovery Institute, Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA
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20
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Neves MC, Bártolo A, Prins JB, Sales CMD, Monteiro S. Taking Care of an Adolescent and Young Adult Cancer Survivor: A Systematic Review of the Impact of Cancer on Family Caregivers. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 2023; 20:5488. [PMID: 37107768 PMCID: PMC10138338 DOI: 10.3390/ijerph20085488] [Citation(s) in RCA: 19] [Impact Index Per Article: 9.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 01/27/2023] [Revised: 03/15/2023] [Accepted: 04/07/2023] [Indexed: 05/11/2023]
Abstract
Research usually investigates adolescents and young adults (AYA) with cancer in combination with younger and older cancer patients and survivors. However, AYAs with cancer are a unique group, and their caregivers' experience may also differ from other caregivers of cancer survivors. This systematic review aims to understand the impact of a cancer diagnosis on family caregivers, comparing the experience of caregivers of AYA childhood cancer survivors (AYA CCS) and caregivers of AYA with cancer. Relevant studies were identified through PubMed, Scopus, and Web of Science databases, and their quality was assessed using the Joanna Briggs Institute's critical appraisal checklists. Sixteen studies (17 reports) met the inclusion criteria. Findings were synthesized separately for caregivers of AYA CCS and caregivers of AYA with cancer. Results showed that caregivers in both groups experienced high distress after the diagnosis. Partners of AYAs with cancer experienced diminished quality of life (QoL) and over half reported moderate to high fear of cancer recurrence (FCR). Findings indicated that cancer negatively impacts family caregivers, regardless of the patient's age at diagnosis. However, findings are heterogeneous, and most do not focus on QoL or FCR. More research is needed on the impact of cancer among these family caregivers.
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Affiliation(s)
- Maria Carolina Neves
- Center for Psychology at the University of Porto, Faculty of Psychology and Education Sciences, University of Porto, 4200-135 Porto, Portugal
| | - Ana Bártolo
- I2P—Portucalense Institute of Psychology, 4200-072 Porto, Portugal
- RECI—Research in Education and Community Intervention, Piaget Institute—ISEIT/Viseu, 3515-776 Viseu, Portugal
- CINTESIS@RISE, Department of Education and Psychology, University of Aveiro, 3810-193 Aveiro, Portugal
| | - Judith B. Prins
- Department of Medical Psychology, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands
| | - Célia M. D. Sales
- Center for Psychology at the University of Porto, Faculty of Psychology and Education Sciences, University of Porto, 4200-135 Porto, Portugal
| | - Sara Monteiro
- CINTESIS@RISE, Department of Education and Psychology, University of Aveiro, 3810-193 Aveiro, Portugal
- Departament of Social Sciences and Management, Open University, 1269-001 Lisboa, Portugal
- Center for Global Studies, Open University, 1269-001 Lisboa, Portugal
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Schwartz-Attias I, Krulik T, Amit Aharon A, Ronen T. Perceptions of children with cancer and their parents regarding illness: A qualitative study. J Pediatr Nurs 2023; 71:32-41. [PMID: 36966727 DOI: 10.1016/j.pedn.2023.03.006] [Citation(s) in RCA: 2] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/26/2022] [Revised: 03/05/2023] [Accepted: 03/10/2023] [Indexed: 06/18/2023]
Abstract
PURPOSE The current study aims to understand inter-generational differences and similarities in the perception of illness and the available resources employed by children with cancer and their parents. METHODS A qualitative descriptive research design was utilized, including face-to-face interviews with 108 parent-child dyads where the children had been diagnosed with cancer, by means of a semi-structured questionnaire. The participants were recruited from two pediatric hematology-oncology wards in two different hospitals in Israel. The data were analyzed using conventional qualitative content analysis. Debriefing and inter-rater reliability methods were utilized. FINDINGS Similarities were found between the coping of children and parents with the illness. Children with cancer and their parents can find bright sides and support for coping, such as different perspectives on life, faith, positive thoughts, and family assistance. Most of the differences between the perceptions of children and parents relate to the difficulties encountered. While parents are mainly concerned about the long-term impact, children contend with ordeals involving the here-and-now. CONCLUSIONS Parents and children demonstrate a dual process in their challenging journey. Positive and facilitating factors are intertwined with the aggravating aspects, which exist side by side. PRACTICE IMPLICATIONS Nursing staff should advise children and their parents to attain and use external and internal sources of support found in this study to help them deal with cancer.
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Affiliation(s)
- Irit Schwartz-Attias
- Meir Academic Nursing School, Meir Medical Center, Clalit Health Services, Schneider Children's Medical Center of Israel, 14 Kaplan St. Petah, Tikva, Israel.
| | - Tamar Krulik
- Sackler Faculty of Medicine, Steyer School of Health Professions, Department of Nursing, Tel Aviv University, Israel.
| | - Anat Amit Aharon
- Sackler Faculty of Medicine, Steyer School of Health Professions, Department of Nursing, Tel Aviv University, Israel.
| | - Tammie Ronen
- Faculty of Social Sciences, Tel-Aviv University, Israel.
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22
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de Oliveira Silva S, da Silva Duarte FH, de Souza Costa TM, de Araújo NM, Barros Leal NT, Medeiros KS, Neves Dantas RA, Dantas DV. Effectiveness of multimedia education for reducing anxiety among caregivers of children and adolescents undergoing chemotherapy: Randomized controlled trial protocol. PLoS One 2023; 18:e0285250. [PMID: 37159464 PMCID: PMC10168554 DOI: 10.1371/journal.pone.0285250] [Citation(s) in RCA: 2] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/28/2022] [Accepted: 04/18/2023] [Indexed: 05/11/2023] Open
Abstract
INTRODUCTION Childhood cancer affects approximately 600,000 children and adolescents worldwide, and chemotherapy is the main form of treatment. However, chemotherapy treatment causes feelings of fear and anxiety especially in the patient's caregiver. Thus, strategies that help the health education process directed towards caregivers are essential for strengthening knowledge and reducing anxiety involved with the beginning of treatment. OBJECTIVE To present a study protocol to evaluate the effect of a multimedia strategy compared to standard guidelines for acquiring knowledge and reducing anxiety among caregivers of children and adolescents with cancer undergoing chemotherapy. METHODS A randomized, controlled, single-blind, two-armed clinical trial will be carried out. Fifty-two caregivers of children and adolescents who will start chemotherapy will participate in the study, which will be randomly assigned into Experimental Group, which involves the evaluation of the effect of a multimedia strategy composed of a digital animation film about the chemotherapy process, used as tool for health education or into Control Group, which assesses the effects of standard guidelines, which are verbally provided. Two important moments will be considered to evaluate the results of the intervention (P1, and F1). The primary outcome includes reduced anxiety and the secondary outcome refers to the caregivers' acquisition of knowledge about chemotherapy treatment. EXPECTED RESULTS The results of this randomized clinical trial will have a positive impact on the participants' knowledge acquisition, and will also contribute to reduce anxiety observed at the beginning of treatment related to the caregivers' knowledge deficit. The level of knowledge between groups with anxiety before and after intervention will be compared, highlighting which intervention had the best effect. EVALUATION RECORD Registration: RBR-4wdm8q9-Brazilian Registry of Clinical Trials-REBEC (23/03/2022). This study was approved by the Research Ethics Committee of the Federal University of Rio Grande do Norte- UFRN, under CAAE-52597121.9.0000.5537.
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Affiliation(s)
| | | | | | | | | | - Kleyton Santos Medeiros
- Health Sciences Postgraduate Program, Federal University of Rio Grande do Norte (UFRN), Natal, RN, Brazil
- Instituto de Ensino, Pesquisa e Inovação, Liga Contra o Cancer, Natal, RN, Brazil
| | - Rodrigo Assis Neves Dantas
- Nursing Graduate Program, Federal University of Rio Grande do Norte, Natal, Brazil
- Department of Nursing, Federal University of Rio Grande do Norte (UFRN), Natal, RN, Brazil
| | - Daniele Vieira Dantas
- Nursing Graduate Program, Federal University of Rio Grande do Norte, Natal, Brazil
- Department of Nursing, Federal University of Rio Grande do Norte (UFRN), Natal, RN, Brazil
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23
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Meng J, Wu J, Zhang X, Guo L, Li H. A longitudinal evaluation on 3-year change of anxiety and depression, and their risk factors among parents of childhood and adolescence patients with resectable osteosarcoma: A cohort study. Medicine (Baltimore) 2022; 101:e30981. [PMID: 36281181 PMCID: PMC9592357 DOI: 10.1097/md.0000000000030981] [Citation(s) in RCA: 3] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 11/06/2022] Open
Abstract
Psychological disorders often occur among parents of children with cancer. The current study aimed to explore the longitudinal change of anxiety and depression and their related factors among parents of childhood and adolescence patients with osteosarcoma. A total of 56 childhood and adolescence patients with osteosarcoma who underwent tumor resection and corresponding 104 parents were enrolled. Hospital Anxiety and Depression Scale-Anxiety (HADS-A) and HADS-Depression (HADS-D) of parents were evaluated at baseline (the day of patients' hospital discharge), 0.5 year, 1 year, 2 years, and 3 years. From baseline to the 3rd year, HADS-A (from 8.3 ± 3.1 to 9.4 ± 3.1. P < .001), HADS-D score (from 7.7 ± 3.2 to 8.8 ± 2.9, P = .001), anxiety rate (from 45.2% to 60.6%, P = .038), depression rate (from 38.5% to 57.7%, P = .002) were elevated; meanwhile, anxiety severity (P = .001) and depression severity (P = .001) were also increased. Furthermore, multivariate logistic regression analysis presented that the role of mother, divorced/widowed marital status, declined family annual income, elevated Enneking stage, and amputation were independently correlated with elevated risk of parents' baseline anxiety or depression (all P < .05). Additionally, declined family annual income, elevated Enneking stage, and amputation were independently correlated with increased risk of parents' 3-year anxiety or depression (all P < .05). Anxiety and depression deteriorate with time in parents of childhood and adolescence patients with osteosarcoma, which are affected by parental role, marital status, family annual income, surgery type, and Enneking stage.
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Affiliation(s)
- Jie Meng
- Department of Orthopedic Surgery, Harbin Medical University Cancer Hospital, Harbin, China
| | - Jing Wu
- Department of Orthopedic Surgery, Harbin Medical University Cancer Hospital, Harbin, China
| | - Xinying Zhang
- Department of Orthopedic Surgery, Harbin Medical University Cancer Hospital, Harbin, China
| | - Libo Guo
- Department of Orthopedic Surgery, Harbin Medical University Cancer Hospital, Harbin, China
| | - Honghe Li
- Department of Orthopedic Surgery, Harbin Medical University Cancer Hospital, Harbin, China
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Silva SDO, Araújo TACD, Araújo NMD, Leal NTB, Duarte FHDS, Leite JEL, Dantas RAN, Dantas DV. Semantic validation of educational technology with caregivers of children and adolescents undergoing chemotherapy. Rev Bras Enferm 2022; 75:e20220294. [DOI: 10.1590/0034-7167-2022-0294] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/13/2022] [Accepted: 07/12/2022] [Indexed: 11/07/2022] Open
Abstract
ABSTRACT Objective: Semantically validate an educational technology with the caregiver of children and adolescents undergoing chemotherapy. Method: Methodological study, with a quantitative approach, guided by the theoretical framework of psychometry, developed between March and April 2022, with nine caregivers of children and adolescents undergoing chemotherapy. Educational technology is a digital animation film about the pediatric chemotherapy treatment process, used as a tool for health education. Results: In the reliability assessment, the Intraclass Correlation Coefficient was 0.936 [95%CI 0.868-0.984] with p < 0.05 and Cronbach’s alpha of 0.943, demonstrating satisfactory internal consistency. Regarding the semantic analysis, the domains related to objectives, organization, language, appearance, and motivation showed an agreement rate above 80%. Conclusion: Educational technology showed satisfactory rates, proving to be a valid, reliable, and important instrument to be used by caregivers of children and adolescents undergoing chemotherapy.
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