• DNA methylation
• Early stressful life events
• Epigenetics
• Methylation profile scores
• Relapse
• Schizophrenia

• Humans
• Schizophrenia/genetics
• Schizophrenia/etiology
• Schizophrenia/metabolism
• Schizophrenia/epidemiology
• Female
• DNA Methylation
• Male
• Adult
• Recurrence
• Pregnancy
• Environmental Exposure/adverse effects
• Young Adult
• Risk Factors
• Cohort Studies
• Adverse Childhood Experiences
• Adolescent
• Stress, Psychological

• Compulsory treatment
• First episode psychosis
• Follow-up
• Hospitalization
• Intervention
• Outcome

• Humans
• Male
• Italy/epidemiology
• Female
• Psychotic Disorders/therapy
• Psychotic Disorders/epidemiology
• Adult
• Young Adult
• Follow-Up Studies
• Incidence
• Early Medical Intervention/statistics & numerical data
• Schizophrenia/therapy
• Schizophrenia/epidemiology
• Adolescent
• Longitudinal Studies
• Psychiatric Status Rating Scales

• Health behavior
• Medication adherence
• Mental illness
• Pandemic (COVID-19)
• Physical health
• Psychotic disorders
• Schizophrenia
• Suicidal behavior

• Humans
• Male
• COVID-19/epidemiology
• Female
• Psychotic Disorders/epidemiology
• Psychotic Disorders/drug therapy
• Adult
• Follow-Up Studies
• Middle Aged
• Medication Adherence/statistics & numerical data
• Health Behavior
• Weight Gain
• Suicidal Ideation

• Adherence
• non-adherence
• schizophrenia

• Humans
• Morocco
• Cross-Sectional Studies
• Male
• Schizophrenia/drug therapy
• Female
• Medication Adherence/statistics & numerical data
• Adult
• Antipsychotic Agents/administration & dosage
• Middle Aged
• Young Adult
• Surveys and Questionnaires
• Psychiatric Status Rating Scales
• Adolescent
• Severity of Illness Index
• Schizophrenic Psychology

• bipolar disorder
• health inequities
• psychotic disorders
• schizophrenia
• treatment adherence

• involuntary psychiatric hospitalizations
• nonadherence to treatment
• pandemic
• revolving door

• funding

• Cognition
• Polygenic risk score
• Relapse
• Schizophrenia

• Intracortical myelin
• Long-acting injectable antipsychotic
• Magnetic resonance imaging
• Paliperidone palmitate
• Schizophrenia
• Schizophreniform disorder

• community treatment order
• first-episode psychosis
• involuntary treatment

• Clinical decision support systems (CDSS)
• Digital psychiatry
• Embedded mixed-methods study design
• Interaction design
• Proactive care

• Free
• Long-acting injectable
• Psychosis

• Anticholinergic burden
• Antipsychotics
• Cognition
• Dopamine burden
• First episode psychosis
• Relapse

The theory of planned behavior (TPB) states that behavioral intention is the best predictor of actual behavior change. However, intention explains only a portion of the variance in behavior. Of specific interest is the question of which moderating or mediating variables can be leveraged to aid health promotion interventions utilizing the tenets of behavioral economics (delay discounting and commitment contracts) in the intention–behavior pathway. Impulsivity has been postulated to fill this role and may be applied to multiple behaviors. We aim to determine if impulsivity moderates the association between intention and actual behavior in the TPB, to discover what other variables may moderate or mediate this association, and to apply the findings to future studies in the field of behavioral economics. To this end, a systematic review was conducted using the PubMed, PsychINFO, and Embase online databases. Eligible studies in peer-reviewed journals published prior to November 2021 were selected. Thirty-three studies were included in the final review, examining physical activity, diet, preventive health, mental health, addiction, and medication adherence behaviors. Three main concepts emerged: (1) impulsivity moderates the association between intention and behavior change; (2) self-efficacy moderates the association between intention and behavior change; and (3) planning and self-efficacy contribute to moderated mediation. This review demonstrates a gap in the literature regarding the application of the TPB to the intention–behavior pathway for health behaviors. Future studies in behavioral economics may leverage the variables of impulsivity, self-efficacy, and planning to predict follow-through in this area and to develop targeted change initiatives.

• early psychosis
• first-episode psychosis
• hospitalization
• long-acting injectable antipsychotics
• naturalistic
• recent-onset psychosis
• relapse

• antipsychotic
• long-acting injectable
• meta-analysis
• oral antipsychotic
• psychosis
• schizophrenia

• Disease modification
• Long-acting injectable antipsychotics
• Oral antipsychotics
• Paliperidone palmitate
• Recent-onset schizophrenia
• Relapse
• Schizophrenia
• Schizophreniform disorder
• Treatment failure

• Antipsychotic Agents/adverse effects
• Cohort Studies
• Delayed-Action Preparations
• Humans
• Paliperidone Palmitate
• Psychotic Disorders/drug therapy
• Risperidone

• Antipsychotics
• GRADE
• discontinuation
• first episode
• non-affective psychosis

• antipsychotic treatment
• borderline personality disorder
• cariprazine
• delusional disorder
• first-episode psychosis
• psychosis
• schizophrenia spectrum disorders
• tolerability

While specialized early intervention programs represent the gold standard in terms of optimal management of first-episode psychosis (FEP), poor medication adherence remains a predominant unmet need in the treatment of psychosis. In this regard, an interaction between insight and adherence in FEP patients has been hypothesized but has been challenged by multiple pitfalls.

Latent profile analysis and trajectory modeling techniques were used to evaluate insight and adherence of 331 FEP patients engaged at the beginning, middle, and end of a 3-year specialized early psychosis program. A Bayesian model comparison approach was used to compare scores of clinical, functional, and socioeconomic outcomes at the end point of the study.

Nearly one-third of the patients maintain a high level of insight and adherence during the entire program. At the end of the 3-year follow-up, more than three-quarters of patients are considered adherent to their medication. Patients with low levels of insight and adherence at the beginning of the program improve first in terms of adherence and then of insight. Furthermore, patients with high levels of insight and adherence are most likely to reach functional recovery and to experience an increase in environmental quality of life.

Latent FEP subpopulations can be identified based on insight and adherence. Medication adherence was the first variable to improve, but a gain in insight possibly plays a role in the reinforcement of adherence.

• antipsychotics
• cognitive impairment
• negative symptoms
• psychosocial interventions
• side effects
• treatment adherence

• antipsychotic treatment
• first-episode psychosis
• long-acting injectables
• relapse
• side-effects

• app
• mhealth
• psychosis
• relapse
• smartphone

• Functional outcome
• Medication adherence
• Psychosocial rehabilitation
• Quality of life
• Self-stigma

Knowledge about the needs of psychiatric patients is essential for mental health care planning. However, research on met and unmet needs is still scarce, particularly in low- and middle-income countries. This study aimed to describe the patients' needs (met and unmet) at least four years after their first psychiatric hospitalization and to verify the role of demographic and clinical features as possible predictors of these needs. Patients who had their first psychiatric admission between January 1, 2006 and December 31, 2007 at an inpatient unit in the city of Ribeirão Preto, Brazil, were eligible to participate in the study. Patients were contacted and face-to-face interviews were conducted by psychologists using the Camberwell Assessment of Need. Data were analyzed using zero-inflated negative binomial regression model. Of 933 eligible patients, 333 were interviewed. The highest level of needs was related to welfare benefits (32.4%, unmet=25.5%), followed by household skills (30.3%, unmet=3.0%), psychotic symptoms (29.4%, unmet=9.0%), psychological distress (27.6%, unmet=8.4%), physical health (24.3%, unmet=5.4%), daytime activities (19.5%, unmet=16.5%), and money (16.8%, unmet=9.0%). Fewer years of schooling, living with relatives, and unemployment at the moment of the first admission were significantly associated with a higher number of both met and unmet needs in the follow-up. Unmet needs were also more often reported by patients living alone. In conclusion, socioeconomic indicators were the best predictors of needs. The unmet needs related to welfare benefits point to the need for specific social and health policies.

• Follow-up study
• Hospitalization
• Nonadherence
• Schizoaffective disorder
• Schizophrenia

• dai-10
• long-acting injectable antipsychotics
• patient-reported outcome measures
• schizophrenia
• treatment discontinuation

• Antipsychotic Agents/administration & dosage
• Antipsychotic Agents/therapeutic use
• Attitude to Health
• Delayed-Action Preparations
• Humans
• Injections
• Outpatients/psychology
• Retrospective Studies
• Schizophrenia/drug therapy
• Surveys and Questionnaires
• Withholding Treatment/statistics & numerical data

• caregivers
• first-episode schizophrenia
• qualitative research
• relapse
• substance abuse

• Antipsychotic Agents
• Chronic Disease
• Humans
• Protective Factors
• Qualitative Research
• Recurrence
• Schizophrenia
• Substance-Related Disorders
• Thailand

• Hospitalization
• Model development
• Psychosis
• Relapse
• Risk prediction

• Claims data
• Complex comorbidity
• Diabetes screening
• Healthcare effectiveness data and information set (HEDIS)
• Healthcare quality
• Medicaid
• Medication adherence
• Mental health
• Mixed effects logistic regression
• Serious mental illness
• Social determinants of health

• Adult
• Antipsychotic Agents/therapeutic use
• Diabetes Mellitus
• Florida
• Humans
• Medicaid
• Medication Adherence
• Retrospective Studies
• United States/epidemiology

• Adherence
• Attitudes toward neuroleptic treatment scale
• Clozapine
• Compliance
• Psychotic disorder

• adherence
• first‐episode psychosis
• follow‐up
• predictors

• antipsychotic drugs
• long-acting injectable
• schizophrenia

• Adult
• Antipsychotic Agents/administration & dosage
• Antipsychotic Agents/therapeutic use
• Asia, Southeastern
• Asia, Western
• Delayed-Action Preparations
• Drug Prescriptions/statistics & numerical data
• Female
• Hospitalization/statistics & numerical data
• Humans
• Injections
• Male
• Middle Aged
• Schizophrenia/drug therapy
• Schizophrenia/physiopathology
• Sex Factors

• China
• MARS
• Medication adherence
• Schizophrenia

• Early psychosis
• long-term follow-up
• predictors
• relapse
• schizophrenia

• Adult
• Female
• Follow-Up Studies
• Hong Kong
• Humans
• Logistic Models
• Male
• Memory/physiology
• Psychiatric Status Rating Scales
• Psychotic Disorders/psychology
• Randomized Controlled Trials as Topic
• Recurrence
• Risk Factors
• Schizophrenic Psychology
• Young Adult

• adherence
• duration of untreated psychosis
• first-episode psychosis
• hospitalization
• positive symptoms
• substance misuse