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Yu J, He Y, Yu X, Gu L, Wang Q, Wang S, Tao F, Sheng J. Associations Between Mild Cognitive Impairment and Whole Blood Zinc and Selenium in the Elderly Cohort. Biol Trace Elem Res 2023; 201:51-64. [PMID: 35113349 DOI: 10.1007/s12011-022-03136-3] [Citation(s) in RCA: 10] [Impact Index Per Article: 5.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/10/2021] [Accepted: 01/24/2022] [Indexed: 01/11/2023]
Abstract
Some studies have shown that an imbalance in trace element homeostasis can lead to cognitive dysfunction, but data are lacking. The purpose of this study was to investigate the association between whole blood zinc (Zn), selenium (Se), copper-zinc ratio (Cu/Zn), copper-selenium ratio (Cu/Se), and zinc-selenium ratio (Zn/Se) and mild cognitive impairment (MCI) in elderly Chinese individuals. The study was based on the Elderly Health and Controlled Environmental Factors Cohort in Lu'an, Anhui Province, China, from June to September 2016. The cognitive function of the elderly was determined by the Mini-Mental State Examination (MMSE) and activities of daily living (ADL) scales. The concentrations of Zn, Cu, and Se in the whole blood were measured by inductively coupled plasma-mass spectrometry (ICP-MS). Binary logistic regression was used to analyze the associations between trace elements and MCI. A total of 1006 participants with an average age of 71.70 years old were included in this study. Compared with healthy people, MCI patients had higher whole blood Zn levels and lower Se levels, and Cu/Zn, Cu/Se, and Zn/Se were also significantly different. Binary logistic regression analysis showed that Zn, Cu/Se, and Zn/Se exposure in the third tertile was associated with an increased risk of MCI, while Se exposure in the third tertile was associated with a reduced risk of MCI. After adjustment for sex, age, marital status, BMI, and living status, whole blood Zn, Se, Cu/Zn, Cu/Se, and Zn/Se were significantly associated with MCI risk, especially in elderly women.
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Affiliation(s)
- Jinhui Yu
- Department of Occupational Health and Environmental Health, School of Public Health, Anhui Medical University, Hefei, 230032, Anhui, China
| | - Yu He
- Department of Occupational Health and Environmental Health, School of Public Health, Anhui Medical University, Hefei, 230032, Anhui, China
| | - Xuemin Yu
- School of Public Health, Anhui Medical University, Hefei, 230032, Anhui, China
| | - Ling Gu
- Department of Occupational Health and Environmental Health, School of Public Health, Anhui Medical University, Hefei, 230032, Anhui, China
- Changzhou Center for Disease Control and Prevention, Changzhou, 213000, Jiangsu, China
| | - Qunan Wang
- School of Public Health, Anhui Medical University, Hefei, 230032, Anhui, China
| | - Sufang Wang
- School of Public Health, Anhui Medical University, Hefei, 230032, Anhui, China
| | - Fangbiao Tao
- School of Public Health, Anhui Medical University, Hefei, 230032, Anhui, China
- MOE Key Laboratory of Population Health Across Life Cycle/Anhui Provincial Key Laboratory of Population Health and Aristogenics, Hefei, 230032, Anhui, China
| | - Jie Sheng
- School of Public Health, Anhui Medical University, Hefei, 230032, Anhui, China.
- MOE Key Laboratory of Population Health Across Life Cycle/Anhui Provincial Key Laboratory of Population Health and Aristogenics, Hefei, 230032, Anhui, China.
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Hawley AL, Liang X, Børsheim E, Wolfe RR, Salisbury L, Hendy E, Wu H, Walker S, Tacinelli AM, Baum JI. The potential role of beef and nutrients found in beef on outcomes of wellbeing in healthy adults 50 years of age and older: A systematic review of randomized controlled trials. Meat Sci 2022; 189:108830. [PMID: 35483315 DOI: 10.1016/j.meatsci.2022.108830] [Citation(s) in RCA: 7] [Impact Index Per Article: 2.3] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/06/2021] [Revised: 02/25/2022] [Accepted: 04/18/2022] [Indexed: 12/19/2022]
Abstract
Shifts in wellbeing and health occur as we age. As life expectancy increases, maintenance of wellbeing and health becomes increasingly important. Nutrients found in beef are associated with outcomes of wellbeing such as physical and cognitive function, lean body mass, and mood in older adults and individuals with chronic disease. However, it is unclear how beef and nutrients found in beef impact wellbeing in healthy adults ≥50 years of age. This study systematically reviewed evidence linking the intake of beef and nutrients found in beef to markers of wellbeing in healthy adults. PubMed, CINAHL, and Web of Science were searched up to August 31, 2021 for eligible randomized controlled trials (RCTs). Nutrients included in the analysis were beef, red meat, dietary protein, essential amino acids, branched chain amino acids, tryptophan, arginine, cysteine, glycine, glutamate, vitamin B6, vitamin B12, choline, zinc, and iron. We identified nine RCTs with results from 55 measurements of markers of wellbeing. An overall positive effect was found of beef and beef's nutrients on wellbeing. There was an overall positive effect of amino acids and protein on wellbeing, with no effect of arginine, vitamin B-12, leucine, and zinc. Physical function was also influenced by beef and nutrients found in beef. Eight of the studies found focused on specific nutrients found in beef, and not beef itself in older adults with one or more chronic diseases. This study identified a need for further research regarding the effect of beef and nutrients found in beef on defined functional outcomes of wellbeing in healthy adults ≥50 years of age.
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Affiliation(s)
- Aubree L Hawley
- Center for Human Nutrition, University of Arkansas System Division of Agriculture, Fayetteville, AR 72704, United States of America; Department of Food Science, Bumpers College for Agricultural and Life Sciences, University of Arkansas, Fayetteville, AR 72704, United States of America
| | - Xinya Liang
- Department of Rehabilitation, Human Resources, and Communication Disorders, College of Education and Health Professions, University of Arkansas, Fayetteville, AR 72701, United States of America
| | - Elisabet Børsheim
- Department of Pediatrics, Arkansas Children's Nutrition Center, Arkansas Children's Research Institute, University of Arkansas for Medical Sciences, Little Rock, AR, United States of America; Department of Geriatrics, Donald W. Reynold's Institute on Aging, University of Arkansas for Medical Sciences, Little Rock, AR 72205, United States of America
| | - Robert R Wolfe
- Department of Geriatrics, Donald W. Reynold's Institute on Aging, University of Arkansas for Medical Sciences, Little Rock, AR 72205, United States of America
| | - Lutishoor Salisbury
- University of Arkansas Libraries, Fayetteville, AR 72701, United States of America
| | - Emma Hendy
- Center for Human Nutrition, University of Arkansas System Division of Agriculture, Fayetteville, AR 72704, United States of America; Department of Food Science, Bumpers College for Agricultural and Life Sciences, University of Arkansas, Fayetteville, AR 72704, United States of America
| | - Hexirui Wu
- Center for Human Nutrition, University of Arkansas System Division of Agriculture, Fayetteville, AR 72704, United States of America; Department of Food Science, Bumpers College for Agricultural and Life Sciences, University of Arkansas, Fayetteville, AR 72704, United States of America
| | - Sam Walker
- Center for Human Nutrition, University of Arkansas System Division of Agriculture, Fayetteville, AR 72704, United States of America; Department of Food Science, Bumpers College for Agricultural and Life Sciences, University of Arkansas, Fayetteville, AR 72704, United States of America
| | - Angela M Tacinelli
- Center for Human Nutrition, University of Arkansas System Division of Agriculture, Fayetteville, AR 72704, United States of America; Department of Food Science, Bumpers College for Agricultural and Life Sciences, University of Arkansas, Fayetteville, AR 72704, United States of America
| | - Jamie I Baum
- Center for Human Nutrition, University of Arkansas System Division of Agriculture, Fayetteville, AR 72704, United States of America; Department of Food Science, Bumpers College for Agricultural and Life Sciences, University of Arkansas, Fayetteville, AR 72704, United States of America.
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Marchetti MF, Silva GMD, Freiria CN, Borim FSA, Brito TRPD, Milanski M, Corona LP. Association between zinc deficiency and cognitive decline in community-dwelling older adults. CIENCIA & SAUDE COLETIVA 2022; 27:2805-2816. [PMID: 35730848 DOI: 10.1590/1413-81232022277.19932021] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/08/2021] [Accepted: 02/16/2022] [Indexed: 11/22/2022] Open
Abstract
This is a cross-sectional study evaluating the association between zinc deficiency and cognitive decline in 591 community-dwelling older adults living in the cities of Campinas, Limeira, and Piracicaba-SP. Cognitive status was evaluated using the Cognitive Abilities Screening Instrument-CASI-S, considering a decline for scores <23 for those aged 60-69 and <20 for those aged ≥70 years. Among the evaluated cognitive domains, older adults with zinc deficiency had significantly lower mean scores on the memory test (p=0.018). For zinc deficiency, values below 70 µg/dL were considered for women and 74 µg/dL for men. The prevalence of zinc deficiency was 3.9%, and cognitive deficit was 9.4%, being significantly higher in those with zinc deficiency compared with those with normal serum zinc concentrations. In adjusted multiple logistic regression analysis, the factors that remained associated with cognitive decline were zinc deficiency (OR=3.80; 95%CI=1.30-11.12), low schooling level (OR=3.12; 95%CI=1.49-6.50), lack of a partner (OR=1.88; 95%CI=1.04-3.42), risk of malnutrition (OR=3.98; 95%CI=2.36-6.71), and a history of encephalic vascular accident (OR=2.70; 95%CI=1.04-6.98). Zinc deficiency was associated with the presence of cognitive decline in older adults. Actions in primary health care are necessary to prevent the deficiency of this nutrient.
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Affiliation(s)
- Maísa Furlanetto Marchetti
- Laboratório de Epidemiologia Nutricional, Faculdade de Ciências Aplicadas, Universidade Estadual de Campinas (Unicamp). R. Pedro Zaccaria 1300, Jd. Santa Luiza. 13484-350 Limeira SP Brasil.
| | - Graziele Maria da Silva
- Laboratório de Epidemiologia Nutricional, Faculdade de Ciências Aplicadas, Universidade Estadual de Campinas (Unicamp). R. Pedro Zaccaria 1300, Jd. Santa Luiza. 13484-350 Limeira SP Brasil.
| | - Carolina Neves Freiria
- Laboratório de Epidemiologia Nutricional, Faculdade de Ciências Aplicadas, Universidade Estadual de Campinas (Unicamp). R. Pedro Zaccaria 1300, Jd. Santa Luiza. 13484-350 Limeira SP Brasil.
| | | | | | - Marciane Milanski
- Laboratório de Distúrbios do Metabolismo, Faculdade de Ciências Aplicadas, Unicamp. Limeira SP Brasil
| | - Ligiana Pires Corona
- Laboratório de Epidemiologia Nutricional, Faculdade de Ciências Aplicadas, Universidade Estadual de Campinas (Unicamp). R. Pedro Zaccaria 1300, Jd. Santa Luiza. 13484-350 Limeira SP Brasil.
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Gong Z, Song W, Gu M. Serum Copper and Zinc Concentrations and Cognitive Impairment in Older Adults Aged 60 Years and Older. Biol Trace Elem Res 2022; 200:1495-1501. [PMID: 34057653 DOI: 10.1007/s12011-021-02765-4] [Citation(s) in RCA: 8] [Impact Index Per Article: 2.7] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 04/26/2021] [Accepted: 05/24/2021] [Indexed: 12/20/2022]
Abstract
Epidemiological evidence on serum zinc and copper and cognitive impairment in older adults are not consistent. Results on serum zinc and copper and cognitive impairment in older adults from the National Health and Nutrition Examination Survey (NHANES) have not been reported. Data on serum zinc and copper and cognitive impairment from individuals ≥ 60 years of age were obtained from the 2011-2014 NHANES. Serum zinc and copper concentrations were determined with inductively coupled plasma dynamic reaction cell mass spectrometry. Cognitive impairment was assessed with four cognitive tests: the Digit Symbol Substitution Test (DSST), the Animal Fluency (AF), the Consortium to Establish a Registry for Alzheimer's Disease Delayed Recall (CERAD-DR), and the Word Learning (CERAD-WL) tests. Compared with the lowest tertile of serum copper, the multivariate-adjusted odds ratios of scoring low on the AF were 0.86 (0.44-1.68) in tertile 2 and 0.46 (0.25-0.82) in tertile 3, and the inverse association was also found in women. No association was found between serum copper and the DSST, CERAD-DR, and CRAD-WL, respectively. Compared with the lowest tertile of serum zinc, the multivariate-adjusted odds ratios of scoring low on the DSST were 0.83 (0.37-1.90) in tertile 2 and 0.42 (0.22-0.80) in tertile 3, and the inverse association was also found in men. No association was found between serum zinc and the AF, CERAD-DR, and CRAD-WL, respectively. In conclusion, serum copper and zinc were associated with certain cognitive performance tests among older adults, and the causality deserves to be confirmed further.
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Affiliation(s)
- Zonglin Gong
- Department of Integrated Services, Kunshan Centers for Disease Control and Prevention, Kunshan, 215300, Jiangsu, China
| | - Wenlei Song
- Department of Disease Control, Kunshan Centers for Disease Control and Prevention, Kunshan, 215300, Jiangsu, China.
- Department of Tuberculosis Control, Kunshan Centers for Disease Control and Prevention, No.458, West Tongfeng Road, Kunshan, 215300, Jiangsu, China.
| | - Minjun Gu
- Department of Disease Control, Kunshan Centers for Disease Control and Prevention, Kunshan, 215300, Jiangsu, China
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Wang X, Wang H, Zhang F, Cui Y, Zhang D, Shen X. Threshold effects and interactive effects of total zinc and selenium intake on cognitive function in older adults. Clin Nutr ESPEN 2022; 47:383-390. [PMID: 35063231 DOI: 10.1016/j.clnesp.2021.11.001] [Citation(s) in RCA: 11] [Impact Index Per Article: 3.7] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/19/2021] [Accepted: 11/01/2021] [Indexed: 10/19/2022]
Abstract
BACKGROUND & AIMS The aim of this study was to assess threshold effects and interactive effects of total zinc and selenium intake on cognitive function in older adults. METHODS We used data from the National Health and Nutrition Examination Survey (NHANES) 2011-2014. Zinc and selenium intake were obtained through two 24-h dietary recalls. Cognitive performance was evaluated by the Digit Symbol Substitution Test (DSST). Smooth curve fitting, two-piecewise multivariable linear regression models, binary logistic regression model, multiplicative interactions model, and additive interactions model were used to evaluate the association between zinc, selenium intake and their interactive effect on cognitive function. RESULTS A total of 2450 participants aged 60 years or older were included. Zinc and selenium intake was non-linearly associated with cognitive function. The inflection point for zinc intake was 8.94 mg/d in males and 7.58 mg/d in females. When zinc intake was below inflection point, zinc intake was positively associated with the DSST test in males (β = 1.02, 95% CI, 0.44 to 1.60) and females (β = 0.94, 95% CI, 0.26 to 1.62). When zinc intake above inflection point, there is no association between zinc intake and the DSST test in both sexs. The inflection point for selenium intake was 186.33 μg/d in males and 68.40 μg/d in females. Among males, the β (95% CIs) was 0.03 (0.01,0.06) to the left side of the inflection point and -0.06 (-0.10, -0.02) to the right of the inflection point. Among females, the β (95% CIs) was 0.13 (0.04,0.22) to the left side of the inflection point and 0.01 (-0.01,0.04) to the right of the inflection point. Besides, zinc and selenium have significant interaction on DSST test only in females (P = 0.028, RERI = 0.418). CONCLUSIONS The present study demonstrated that zinc and selenium intake was non-linearly associated with cognitive function in different sex. There was an interactive effect between zinc and selenium intake on improving cognitive function, especially in females.
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Affiliation(s)
- Xiaoxu Wang
- Department of Epidemiology and Health Statistics, School of Public Health, Qingdao University, Qing Dao, Shandong Province, China
| | - Hao Wang
- Department of Epidemiology and Health Statistics, School of Public Health, Qingdao University, Qing Dao, Shandong Province, China
| | - Fan Zhang
- Department of Epidemiology and Health Statistics, School of Public Health, Qingdao University, Qing Dao, Shandong Province, China
| | - Yixin Cui
- Department of Epidemiology and Health Statistics, School of Public Health, Qingdao University, Qing Dao, Shandong Province, China
| | - Dongfeng Zhang
- Department of Epidemiology and Health Statistics, School of Public Health, Qingdao University, Qing Dao, Shandong Province, China
| | - Xiaoli Shen
- Department of Epidemiology and Health Statistics, School of Public Health, Qingdao University, Qing Dao, Shandong Province, China.
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Marchetti MF, Silva GMD, Freiria CN, Borim FSA, Brito TRPD, Milanski M, Corona LP. Association between zinc deficiency and cognitive decline in community-dwelling older adults. CIENCIA & SAUDE COLETIVA 2022. [DOI: 10.1590/1413-81232022277.19932021en] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/22/2022] Open
Abstract
Abstract This is a cross-sectional study evaluating the association between zinc deficiency and cognitive decline in 591 community-dwelling older adults living in the cities of Campinas, Limeira, and Piracicaba-SP. Cognitive status was evaluated using the Cognitive Abilities Screening Instrument-CASI-S, considering a decline for scores <23 for those aged 60-69 and <20 for those aged ≥70 years. Among the evaluated cognitive domains, older adults with zinc deficiency had significantly lower mean scores on the memory test (p=0.018). For zinc deficiency, values below 70 µg/dL were considered for women and 74 µg/dL for men. The prevalence of zinc deficiency was 3.9%, and cognitive deficit was 9.4%, being significantly higher in those with zinc deficiency compared with those with normal serum zinc concentrations. In adjusted multiple logistic regression analysis, the factors that remained associated with cognitive decline were zinc deficiency (OR=3.80; 95%CI=1.30-11.12), low schooling level (OR=3.12; 95%CI=1.49-6.50), lack of a partner (OR=1.88; 95%CI=1.04-3.42), risk of malnutrition (OR=3.98; 95%CI=2.36-6.71), and a history of encephalic vascular accident (OR=2.70; 95%CI=1.04-6.98). Zinc deficiency was associated with the presence of cognitive decline in older adults. Actions in primary health care are necessary to prevent the deficiency of this nutrient.
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Gau JT, Chavan B, Li Y, Clark BC, Haile ZT. Association between serum zinc levels and basic physical functioning: secondary data analysis of NHANES 2011-14. BMC Nutr 2021; 7:57. [PMID: 34629117 PMCID: PMC8504005 DOI: 10.1186/s40795-021-00461-z] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/19/2021] [Accepted: 08/20/2021] [Indexed: 12/02/2022] Open
Abstract
Background Serum zinc (Zn) levels have been shown to be associated with functional status; however, it is not clear whether this association differs by other sociodemographic characteristics. We examined the association between serum Zn levels and physical functioning difficulty in a representative sample of older adults in the US. Design and methods A cross-sectional study was conducted on participants 50 years and older from the 2011–12 and 2013–14 National Health and Nutrition Examination Surveys (n = 1136). Serum Zn levels were analyzed as tertiles. The main outcome of interest was physical functioning difficulty, defined as self-reported difficulty of basic physical functioning that included walking, transferring, dressing, and feeding. Results Mean Zn levels (SE) were 0.67(0.1), 0.81(0.1), and 0.98(0.1) μg/mL in the low, middle, and high Zn groups, respectively. Approximately 24.9% participants reported physical functioning difficulty. In the multivariable model, we found a significant multiplicative interaction between sex and serum Zn (P for interaction =0.028) and between education and serum Zn (P for interaction = 0.001) on basic physical functioning difficulty. The stratified analysis revealed that among men, compared to those with low serum Zn, the odds of having physical functioning difficulty were lower in men who had high serum Zn [aOR 0.43 (95% CI: 0.25–0.76)]. For women, compared to those with low serum Zn the odds of having physical functioning difficulty were higher in women who had middle serum Zn [aOR 2.67 (1.58–4.50)]. Among individuals with less than high school education, the odds of having physical functioning difficulty were lower in those who had middle serum Zn compared to those who had low serum Zn [aOR 0.48 (0.26–0.89)]. However, the odds of having physical functioning difficulty were higher in those who had middle serum Zn compared to those who had low serum Zn for individuals with high school [aOR 5.72 (1.92–17.00)] and beyond high school education [aOR 1.77 (1.05–2.97)], respectively. Conclusion Sex and educational attainment interact with serum Zn levels to influence basic physical functioning difficulty in older adults. Supplementary Information The online version contains supplementary material available at 10.1186/s40795-021-00461-z.
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Affiliation(s)
- Jen-Tzer Gau
- Department of Primary Care, Heritage College of Osteopathic Medicine (HCOM), Ohio University, Athens, OH, 45701, USA.
| | - Bhakti Chavan
- Office of Research and Grants, HCOM, Athens, OH, 45701, USA
| | - Yang Li
- Department of Biomedical Sciences, HCOM, Athens, OH, 45701, USA
| | - Brian C Clark
- Department of Biomedical Sciences and Ohio Musculoskeletal and Neurological Institute, HCOM, Athens, OH, 45701, USA
| | - Zelalem T Haile
- Department of Social Medicine, HCOM, Dublin campus, Ohio University, Dublin, OH, 43016, USA.
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Alqabbani HM, AlBadr NA. Zinc status (intake and level) of healthy elderly individuals in Riyadh and its relationship to physical health and cognitive impairment. CLINICAL NUTRITION EXPERIMENTAL 2020. [DOI: 10.1016/j.yclnex.2019.12.001] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 10/25/2022]
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