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Song N, Xu X, Liu P, Jiang Y, Tang X, Zuo D, Lai Z, Cheng J. Integrative analysis of microbiota and metabolomics in individuals exhibiting different TCM constitutions utilizing 16S rDNA sequencing and LC/MS metabolomics. Microb Pathog 2025; 205:107621. [PMID: 40258500 DOI: 10.1016/j.micpath.2025.107621] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/07/2024] [Revised: 11/27/2024] [Accepted: 04/18/2025] [Indexed: 04/23/2025]
Abstract
BACKGROUND Traditional Chinese Medicine (TCM) theory posits a close relationship between an individual's constitutional types and the overall health. Variations in metabolic processes and microbial composition have been observed across different constitution types. This study aims to explore the relationship between TCM constitutions, intestinal flora, and metabolites to devise personalized TCM treatment strategies, enhancing evidence-based guidance for clinical practice. METHODS The research investigated differences in microbial diversity and composition among three TCM constitution types: yin-deficiency constitution (PA), balanced constitution (PH), and yang-deficiency constitution (PI). A significant elevation of the Chao1 metric was noted in the PH group compared to the PI group. RESULTS PCoA and CPCoA analyses demonstrated distinct group separation based on floral samples. Dominant phyla included Firmicutes, Bacteroidetes, Proteobacteria, Actinobacteria, and Fusobacteria, with varying abundance at the genus level. Metabolic pathway analysis unveiled disparities in metabolites associated with different pathways among constitution groups. KEGG pathway enrichment analysis emphasized pathways such as steroid hormone biosynthesis, ovarian steroidogenesis, and tryptophan metabolism. Furthermore, correlation analysis revealed associations between specific bacterial taxa and metabolites. CONCLUSION This study delineated the variations in intestinal flora and metabolic profiles among individuals with PA, PH, and PI constitution types, providing valuable insights for the development of personalized TCM treatment approaches.
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Affiliation(s)
- Na Song
- Department of Oncology, Chongqing Traditional Chinese Medicine Hospital, 400021, Chongqing, China
| | - Xinyi Xu
- Department of Oncology, Chongqing Traditional Chinese Medicine Hospital, 400021, Chongqing, China; Hunan University of Chinese Medicine, 410208, Hunan, China
| | - Pingyu Liu
- Department of Oncology, Chongqing Traditional Chinese Medicine Hospital, 400021, Chongqing, China; Hunan University of Chinese Medicine, 410208, Hunan, China
| | - Yutong Jiang
- Physical Examination Center, Chongqing Traditional Chinese Medicine Hospital, 400021, Chongqing, China
| | - Xiaohui Tang
- Department of Oncology, Chongqing Traditional Chinese Medicine Hospital, 400021, Chongqing, China
| | - Deyu Zuo
- Department of Rehabilitation Medicine, Chongqing Traditional Chinese Medicine Hospital, 400021, Chongqing, China; Chongqing Precision Medical Industry Technology Research Institute, Chongqing, 400000, China.
| | - Zonglang Lai
- Department of Oncology, Chongqing Traditional Chinese Medicine Hospital, 400021, Chongqing, China.
| | - Jun Cheng
- Department of Oncology, Chongqing Traditional Chinese Medicine Hospital, 400021, Chongqing, China; Shapingba District Hospital of TCM, Chongqing, 400030, China.
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Yang JJ, Wang Q, Jiang W. Harmonizing the mind and body: The interrelationship between traditional Chinese medicine body constitution, mental health and sleep quality. World J Psychiatry 2025; 15:103033. [PMID: 40110014 PMCID: PMC11886318 DOI: 10.5498/wjp.v15.i3.103033] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/06/2024] [Revised: 12/31/2024] [Accepted: 01/20/2025] [Indexed: 02/26/2025] Open
Abstract
BACKGROUND Traditional Chinese medicine (TCM) body constitution is a key factor in determining and influencing the occurrence, development, and variation of diseases. As the mind interact with the body, TCM body constitution is useful in preventing and treating psychiatric disorders and insomnia. AIM To investigate the interrelationship between TCM body constitution, psychiatric disorders and sleep quality. METHODS A total of 2441 participants were enrolled in our study. TCM body constitution was measured using the Constitution in Chinese Medicine Questionnaire, sleep quality was assessed using the Chinese version of the Pittsburgh Sleep Quality Index, and psychopathological symptoms were evaluated using Symptom Checklist-90. Logistic regression was used to estimate the interrelationship between TCM body constitution, psychiatric disorders and sleep quality. RESULTS The Pittsburgh Sleep Quality Index score and the proportions of participants with Qi-deficiency constitution, Qi-stagnation constitution, and blood-stasis constitution were significantly higher in the psychiatric symptoms group. Additionally, psychiatric symptoms were considerably associated with sleep quality, Qi-deficiency constitution, and Qi-stagnation constitution, but were inversely associated with male sex. Obsessive-compulsive symptoms were considerably associated with sleep quality, Qi-deficiency constitution and Qi-stagnation constitution. Depression was considerably associated with sleep quality, hyperuricemia, and Qi-stagnation constitution. Anxiety was considerably associated with sleep quality, diabetes, and Qi-stagnation constitution. Finally, poor sleep quality was considerably associated with Qi-deficiency constitution, Qi-stagnation constitution, dampness-heat constitution, phlegm-dampness constitution, and blood-stasis constitution but was inversely associated with male sex and body mass index > 23.9. CONCLUSION TCM body constitutions are strongly associated with psychiatric symptoms and sleep quality. Further research is needed to verify whether TCM body constitution can be used to treat and prevent psychiatric conditions as well as enhance sleep quality.
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Affiliation(s)
- Juan-Juan Yang
- Department of Health Management, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China
| | - Qian Wang
- Department of Health Management, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China
| | - Wei Jiang
- The Comprehensive Breast Care Center, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China
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Chien TJ. The Holistic Philosophy of Traditional Chinese Medicine and Conflicts With Modern Medicine. Holist Nurs Pract 2023; 37:153-160. [PMID: 35435882 DOI: 10.1097/hnp.0000000000000508] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/26/2022]
Abstract
Traditional Chinese medicine (TCM) has sparked the public's attention for its potential in new drug development and its holistic view toward health, which is totally different from the reductionistic science of modern medicine. Although many scholars try to connect TCM with precision medicine or apply new methods and technology to integrate TCM with modern medicine, the misunderstandings and gap between TCM and modern medicine limit the development of evidence-based TCM. Traditional Chinese medicine is actually a medical science encompassing not only medicine but also philosophy and art in direct contrast to molecular-based modern medicine. As more and more multidisciplinary studies are being published, finding ways to integrate TCM with modern or precision medicine through artificial intelligence, new study design and technology may become a critical issue. This article aims to briefly review the unique philosophy of TCM and its conflicts with modern medicine, with a focus on the potential integration of TCM and modern medicine. We also provide insight for the key attributes of TCM and the associated investigation with Western research approaches.
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Affiliation(s)
- Tsai-Ju Chien
- Division of Hemato-Oncology, Department of Internal Medicine, Branch of Zhong-Zhou, Taipei City Hospital, Taipei, Taiwan; Division of Hemato-Oncology, Department of Internal Medicine, Branch of Jen-Ai, Taipei City Hospital, Taipei, Taiwan; and Institute of Traditional Medicine, National Yang-Ming Chiao Tung University, Taipei, Taiwan
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Hsu MF, Tang PL, Pan TC, Hsueh KC. Different traditional Chinese medicine constitution is associated with dietary and lifestyle behaviors among adults in Taiwan. Medicine (Baltimore) 2022; 101:e30692. [PMID: 36181077 PMCID: PMC9524912 DOI: 10.1097/md.0000000000030692] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 01/05/2023] Open
Abstract
The World Health Organization states prevention of chronic diseases should be based on good lifestyle behaviors and healthy diets as they can reduce the risk of chronic diseases by 80%. The theory of traditional Chinese medicine constitution (TCMC) emphasizes the congenital differences of TCMC stem from the genes of parents, while acquired differences in TCMC are caused by factors as living environments, lifestyle behaviors, and dietary habits. From the perspective of preventive medicine, this study explores the correlation between dietary habits and lifestyle behaviors as potential risk factors for different types of TCMC-balanced constitution, Yang deficiency, Yin deficiency, and Phlegm stasis. Research data were collected from 2760 subjects aged 30 to 70 years participating in a survey conducted by Taiwan Biobank in 2012 to 2017. The survey included basic demographic characteristics, lifestyle behaviors, and dietary habits along with a Body Constitution Questionnaire. Compared to men, women were 3 to 4 times more likely to develop Yang-deficiency, Yin-deficiency, and Phlegm stasis. Variables that affected TCMC were smoking, midnight snack consumption, consumption of gravy-soaked or lard-soaked rice/noodles, deep-fried soybean products, bread spread, pickled vegetables as side dishes for the main course of a meal, and the dietary habit of vegetables or fruits instead of high-fat desserts. Poor dietary habits and lifestyle behaviors are the cause of unbalanced TCMCs. Understanding the specific TCMC of individual can provide useful information and predictions to maintain physical health and achieve early disease prevention to meet the goal of preventive medicine.
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Affiliation(s)
- Min-Fen Hsu
- Department of Nursing, Pingtung Veterans General Hospital, Pingtung, Taiwan (ROC)
- Department of Nursing, Meiho University, Pingtung, Taiwan (ROC)
| | - Pei-Ling Tang
- Research Center of Medical Informatics, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan (ROC)
- School of Nursing, Fooyin University, Kaohsiung, Taiwan (ROC)
- School of Nursing, Kaohsiung Medical University, Kaohsiung, Taiwan (ROC)
| | - Tzu-Cheng Pan
- Research Center of Medical Informatics, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan (ROC)
| | - Kuang-Chieh Hsueh
- Department of Family Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan (ROC)
- Department of Nursing, Shu-Zen Junior College of Medicine and Management, Kaohsiung, Taiwan (ROC)
- *Correspondence: Kuang-Chieh Hsueh, Department of Family Medicine, Kaohsiung Veterans General Hospital, 386, Dazhong 1st Road, Kaohsiung City 81362, Taiwan (ROC) (e-mail: )
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Liu LY, Zhou L, Liu XZ, Zou DJ. Effect of Hedan Tablets on Body Weight and Insulin Resistance in Patients with Metabolic Syndrome. Obes Facts 2022; 15:180-185. [PMID: 34969035 PMCID: PMC9021653 DOI: 10.1159/000520711] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 08/31/2021] [Accepted: 11/01/2021] [Indexed: 11/19/2022] Open
Abstract
INTRODUCTION Apart from their recognized lipid-lowering effect, Hedan tablets, a mixture of Chinese herbal medicines, have demonstrated a certain weight-loss effect in clinical practice. The aim of this randomized, double-blind, placebo-controlled study was to verify the effect of Hedan tablets on body weight (BW) and insulin resistance (IR) in patients with metabolic syndrome (MetS). METHODS A total of 62 eligible patients with MetS were divided into two groups: the treatment group (Hedan tablets at 4.38 g/day tid) and the control group (placebo treatment). Both groups attended follow-ups at 8, 16, and 24 weeks during the process. The parameters of the assessment include lipid level, BW, triglyceride (TG) to high-density lipoprotein cholesterol (HDLc) ratio (TG/HDLc), homeostasis model assessment for IR (HOMA-IR) index, and adiponectin. RESULTS Patients in the treatment group showed a significant decrease in BW compared to those in the control group (-4.47 vs. 0.06 kg) after 8 weeks of treatment. A significant decrease in body mass index (BMI) was also observed in the treatment group after 16 weeks of treatment (-1.79 vs. -0.03 kg/m2). In the treatment group, 20 out of 31 (64.5%) patients lost 5-10% BW and 4 out of 31 (12.9%) patients lost over 10% BW after 24 weeks of treatment. Although there were no significant changes in the patients' HOMA-IR, the treatment group showed a significant reduction in TG/HDLc (-0.98 vs. -0.19) after 8 weeks of treatment and a significant increase in adiponectin (6.87 vs. -0.43) after 16 weeks of treatment. DISCUSSION/CONCLUSION The Hedan tablets significantly improve BW, BMI, TG/HDLc, and adiponectin in patients with MetS. Thus, Hedan tablets may be used as an adjunct to existing MetS management methods.
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Affiliation(s)
- Lian-Yong Liu
- Department of Endocrinology, Punan Hospital of Pudong New District, Shanghai, China
| | - Lin Zhou
- Department of Endocrinology, Punan Hospital of Pudong New District, Shanghai, China
| | - Xing-Zhen Liu
- Hangzhou Aeronautical Sanatorium of China Air Force, Hangzhou, China
- *Xing-Zhen Liu,
| | - Da-Jin Zou
- Thyroid Disease Research Center, Tenth People's Hospital of Tongji University, Shanghai, China
- *Xing-Zhen Liu,
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Yeh TP, Huang LC, Chen YF, Cheng JF. The Relationship between the Second-Generation Antipsychotics Efficacy and the Traditional Chinese Medicine Body Constitutions in Patients with Schizophrenia. Healthcare (Basel) 2021; 9:healthcare9111480. [PMID: 34828526 PMCID: PMC8622047 DOI: 10.3390/healthcare9111480] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/06/2021] [Revised: 10/23/2021] [Accepted: 10/28/2021] [Indexed: 11/17/2022] Open
Abstract
Background: Schizophrenia requires lifelong treatment; Second-generation Antipsychotics (SGAs) have become the most prescribed medication for schizophrenia patients. The efficacy of various SGAs treatment may differ in schizophrenia patients with various traditional Chinese medicine (TCM) body constitution (BC) types. Method: This study applied a longitudinal quantitative research design, where a total of 66 participants were recruited. The Positive and Negative Symptom Scale (PANSS) and the Clinical Global Impression (CGI) score were used to evaluate patients’ psychopathology status in hospitalization, and body constitution questionnaires were conducted by face-to-face interviews in the 1st, 3rd, and 6th week of hospitalization. Results: More than 60% of schizophrenia patients who were treated with SGAs were classified to have unbalanced BC types including Yin-Xu, Yang-Xu and Stasis. Generalized estimating equation analysis revealed significant time effects in CGI and PANSS score improvements in both unbalanced and gentleness (balance) BC types, but no significant changes in the group and group-time interaction in the CGI and PANSS scores in different BC type groups. Conclusions: Schizophrenia patients under SGAs treatment had a higher proportion of unbalanced BC types which may lead to poorer physical or mental statuses, such as overweight problems. Health care providers could apply interventions according to patients’ BC types for disease prevention.
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Affiliation(s)
- Tzu-Pei Yeh
- School of Nursing, China Medical University, Taichung 406040, Taiwan; (T.-P.Y.); (L.-C.H.)
- Department of Nursing, China Medical University Hospital, Taichung 404332, Taiwan
| | - Li-Chi Huang
- School of Nursing, China Medical University, Taichung 406040, Taiwan; (T.-P.Y.); (L.-C.H.)
- Department of Nursing, China Medical University Hospital, Taichung 404332, Taiwan
| | - Yu-Fen Chen
- Department of Nursing, Taichung Veterans General Hospital, Taichung 40705, Taiwan;
| | - Jui-Fen Cheng
- School of Nursing, China Medical University, Taichung 406040, Taiwan; (T.-P.Y.); (L.-C.H.)
- Department of Nursing, China Medical University Hospital, Taichung 404332, Taiwan
- Correspondence: ; Tel.: +886-4-22053366 (ext. 7118.)
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Zhang X, Wang J, Liu B, Yao H, Chen Y, Yin Y, Yang X, Li L. Potential mechanism of Huatan Qushi decoction on improving phlegm-dampness constitution using microRNA array and RT-qPCR targeting on hsa-miR-1237–3p. JOURNAL OF TRADITIONAL CHINESE MEDICAL SCIENCES 2021. [DOI: 10.1016/j.jtcms.2021.01.007] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/22/2022] Open
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Luo H, Li L, Li T, Liao X, Wang Q. Association between metabolic syndrome and body constitution of traditional Chinese medicine: A systematic review and meta-analysis. JOURNAL OF TRADITIONAL CHINESE MEDICAL SCIENCES 2020. [DOI: 10.1016/j.jtcms.2020.10.004] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/23/2022] Open
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Rostami H, Tavakoli HR, Rahimi MH, Mohammadi M. Metabolic Syndrome Prevalence among Armed Forces Personnel (Military Personnel and Police Officers): A Systematic Review and Meta-Analysis. Mil Med 2020; 184:e417-e425. [PMID: 31247092 DOI: 10.1093/milmed/usz144] [Citation(s) in RCA: 12] [Impact Index Per Article: 2.4] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/26/2019] [Revised: 03/27/2019] [Accepted: 05/30/2019] [Indexed: 12/27/2022] Open
Abstract
INTRODUCTION Metabolic syndrome (MetS) is closely linked to type 2 diabetes and cardiovascular disease. Various studies have reported the prevalence of MetS in different armed forces personnel in different countries. However, performing a systematic review and meta-analysis on this subject seems necessary. The aim of this study was to estimate the pooled prevalence of MetS among armed forces personnel including members of the military and police forces. MATERIALS AND METHODS A systematic review was carried out on all associated papers published in PubMed, Scopus, Web of Science and Cochrane Library, encompassing the timeframe: November, 2018 to January 2000. The overall prevalence of MetS, and its prevalence based on different diagnostic criteria [National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III), American Heart Association (AHA) and International Diabetes Federation (IDF)] were pooled using a random-effects model. RESULTS Twenty five eligible studies were selected for the meta-analysis. Among all police officers contained in this study group, the overall prevalence of MetS was 26.2% (95% CI: 19.7-34%; Q = 229.45, p = 0.00). Among different military personnel contained in this study group, the overall estimation of MetS prevalence was 8.3% (95% CI: 6.3-11%; Q = 540.88, p = 0.00) the prevalence of MetS was 8.0% (95% CI: 5.7-11%; Q = 409.76, p = 0.00) according to the NCEP-ATP III criterion. CONCLUSION The findings from the present meta-analyses displayed a low prevalence of metabolic syndrome in armed forces in general. These findings will allow healthcare providers and policy-makers to find solutions in order to take action to reduce MetS risks on a wider scale, especially among police officers.
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Affiliation(s)
- Hosein Rostami
- Health Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
| | - Hamid Reza Tavakoli
- Health Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
| | - Mohammad Hossein Rahimi
- Health Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
- Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran
| | - Mohammad Mohammadi
- Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
- Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
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Baygi F, Herttua K, Jensen OC, Djalalinia S, Mahdavi Ghorabi A, Asayesh H, Qorbani M. Global prevalence of cardiometabolic risk factors in the military population: a systematic review and meta-analysis. BMC Endocr Disord 2020; 20:8. [PMID: 31931788 PMCID: PMC6958577 DOI: 10.1186/s12902-020-0489-6] [Citation(s) in RCA: 21] [Impact Index Per Article: 4.2] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 04/26/2019] [Accepted: 12/31/2019] [Indexed: 12/28/2022] Open
Abstract
BACKGROUND Although there are numerous studies on the global prevalence of cardiometabolic risk factors (CMRFs) in military personnel, the pooled prevalence of CMRFs in this population remains unclear. We aimed to systematically review the literature on the estimation of the global prevalence of CMRFs in the military population. METHODS We simultaneously searched PubMed and NLM Gateway (for MEDLINE), Institute of Scientific Information (ISI), and SCOPUS with using standard keywords. All papers published up to March 2018 were reviewed. Two independent reviewers assessed papers and extracted the data. Chi-square-based Q test was used to assess the heterogeneity of reported prevalence among studies. The overall prevalence of all CMRFs, including overweight, obesity, high low-density lipoprotein (LDL), high total cholesterol (TC), high triglyceride (TG), low high-density lipoprotein (HDL), hypertension (HTN) and high fasting blood sugar (FBS) was estimated by using the random effects meta-analysis. A total of 37 studies met the eligibility criteria and were included in the meta-analysis. RESULTS According the random effect meta-analysis, the global pooled prevalence (95% confidence interval) of MetS, high LDL, high TC, high TG, low HDL and high FBS were 21% (17-25), 32% (27-36), 34% (10-57), 24% (16-31), 28% (17-38) and 9% (5-12), respectively. Moreover, global pooled prevalence of overweight, generalized obesity, abdominal obesity and HTN were estimated to be 35% (31-39), 14% (13-16), 29% (20-39) and 26 (19-34), respectively. CONCLUSIONS The overall prevalence of some cardio-metabolic risk factors was estimated to be higher in military personnel. Therefore, the necessary actions should be taken to reduce risk of developing cardiovascular diseases. SYSTEMATIC REVIEW REGISTRATION NUMBER IN PROSPERO CRD42018103345.
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Affiliation(s)
- Fereshteh Baygi
- Center of Maritime Health and Society, Department of Public Health, University of Southern Denmark, Esbjerg, Denmark
| | - Kimmo Herttua
- Center of Maritime Health and Society, Department of Public Health, University of Southern Denmark, Esbjerg, Denmark
| | - Olaf Chresten Jensen
- Center of Maritime Health and Society, Department of Public Health, University of Southern Denmark, Esbjerg, Denmark
| | - Shirin Djalalinia
- Non-communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
- Deputy of Research and Technology, Ministry of Health and Medical Education, Tehran, Iran
| | - Armita Mahdavi Ghorabi
- Non-communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
| | - Hamid Asayesh
- Department of Medical emergency, Qom University of Medical Sciences, Qom, Iran
| | - Mostafa Qorbani
- Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran.
- Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
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Badely M, Sepandi M, Samadi M, Parastouei K, Taghdir M. The effect of whey protein on the components of metabolic syndrome in overweight and obese individuals; a systematic review and meta-analysis. Diabetes Metab Syndr 2019; 13:3121-3131. [PMID: 31790966 DOI: 10.1016/j.dsx.2019.11.001] [Citation(s) in RCA: 27] [Impact Index Per Article: 4.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 07/29/2019] [Accepted: 11/11/2019] [Indexed: 12/14/2022]
Abstract
BACKGROUND The risk of developing chronic diseases such as diabetes, cardiovascular disease, dyslipidemia, and stroke is increased following an outbreak of metabolic syndrome. Whey protein can play a major role in preventing metabolic syndrome. OBJECTIVE This study was conducted to systematically evaluate the effect of whey protein on the components of metabolic syndrome in overweight and obesity patients. METHODS This systematic review and meta-analysis was conducted on RCTs (PROSPERO registration number: CDR42019114794). Published articles of controlled trials between 1 January 2000 to 30 May 2019 indexed in PubMed, Scopus, Web of Science and Cochrane Library were reviewed. Keywords were Whey Protein, Metabolic Syndrome, HDL Lipoprotein, Blood Pressure, Triglyceride, Fasting Blood Glucose, Waist Circumference, Overweight and Obesity or a combination of them in the title/abstracts. The mean difference was extracted for each study. All analyses performed using STATA version 11. RESULTS There were 2344 individuals reviewed in this systematic review of 37 published articles. CONCLUSION According to the results, whey supplementation significantly reduced the SBP, DBP, HDL, waist circumference, TG and FBS in intervention groups in comparing to control groups.
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Affiliation(s)
- Mustafa Badely
- Health Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
| | - Mojtaba Sepandi
- Health Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
| | - Mohammad Samadi
- Exercise Physiology Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
| | - Karim Parastouei
- Health Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
| | - Maryam Taghdir
- Health Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
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A Study of Traditional Chinese Medicine Body Constitution Associated with Overweight, Obesity, and Underweight. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2017; 2017:7361896. [PMID: 29234426 PMCID: PMC5671717 DOI: 10.1155/2017/7361896] [Citation(s) in RCA: 20] [Impact Index Per Article: 2.5] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 06/08/2017] [Revised: 08/21/2017] [Accepted: 09/11/2017] [Indexed: 01/06/2023]
Abstract
Objective The aim of the study was to investigate the associations among the nine types of body constitution in traditional Chinese medicine (TCM) with the outcomes of overweight, obesity, and underweight. Method Participants aged 30 to 90 years were recruited from communities in Shanghai and assessed using a self-administered questionnaire pertaining to their demographics, lifestyles, and self-reported medical history. The data of 3748 participants with complete information was available for the analysis. Multinomial logistic regression (MLR) analysis was performed to determine the associations among the TCM constitution variables and the health outcomes. Results The standards of classification and determination of the constitution in TCM were used to gauge the patients' constitution type. MLR revealed independent and significant associations among the Qi_Deficient and Yang_Deficient groups with the outcomes of overweight, obesity, and underweight (P < 0.10 for all). MLR revealed independent and significant associations among the Qi_Deficient and Yang_Deficient groups with the outcomes of overweight, obesity, and underweight (P < 0.05 for all). Conclusion Our study revealed significant negative correlations between the Qi_Deficient and Yang_Deficient groups with the outcomes of overweight, obesity, and underweight. On the other hand, positive correlations were found between Phlegm_Dampness and the outcomes of overweight and obesity.
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Association of TCM body constitution with insulin resistance and risk of diabetes in impaired glucose regulation patients. Altern Ther Health Med 2017; 17:459. [PMID: 28893239 PMCID: PMC5594579 DOI: 10.1186/s12906-017-1964-0] [Citation(s) in RCA: 24] [Impact Index Per Article: 3.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/20/2016] [Accepted: 09/01/2017] [Indexed: 12/16/2022]
Abstract
Background Impaired glucose regulation (IGR) patients have increased risk of type 2 diabetes mellitus (T2DM). Identifying relevant risk factors in IGR subjects could facilitate early detection and prevention of IGR progression to diabetes. This study investigated the association between Traditional Chinese Medicine (TCM) body constitution and serum cytokines, and whether body constitution could independently predict diabetes in IGR subjects. Method Patients with IGR (n = 306) received a blood test and their body constitution type was assessed using a body constitution questionnaire (BCQ). Serum levels of cytokines were measured by ELISA. Patients were followed up for at least three years, and their status of diabetes were recorded. Multivariate logistic regression was used to estimate odds ratios (ORs) of diabetes for body constitution. Results Phlegm-damp, Damp-heat and Qi-deficiency were three most common unbanlenced constitutions among IGR subjects. Phlegm-damp and Damp-heat constitution subjects showed higher serum levels of interleukin 6 (IL-6), tumour necrosis factor-α (TNF-α), leptin and lower serum levels of adiponectin (P<0.05). Qi-deficiency constitution subjects showed higher serum levels of leptin and lower serum levels of adiponectin, glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP) (P<0.05). Subjects with Phlegm-damp or Damp-heat constitution demonstrated a significantly higher risk of diabetes (P<0.05). Conclusion Phlegm-damp and Damp-heat TCM body constitution are strongly associated with abnormal serum cytokines, and could potentially serve as a predictor of diabetes in IGR subjects. Body constitution can help to identify IGR subjects who are at a high risk of progression to diabetes.
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Xu F, Zhang Y, Cui W, Yi T, Tang Z, Dong J. The association between metabolic syndrome and body constitution in traditional Chinese medicine. Eur J Integr Med 2017. [DOI: 10.1016/j.eujim.2017.08.008] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/03/2023]
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15
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Zhu Y, Shi H, Wang Q, Wang Y, Yu X, Di J, Zhang X, Li Y, Li T, Yan H. Association between Nine Types of TCM Constitution and Five Chronic Diseases: A Correspondence Analysis Based on a Sample of 2,660 Participants. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE : ECAM 2017; 2017:9439682. [PMID: 28656056 PMCID: PMC5471571 DOI: 10.1155/2017/9439682] [Citation(s) in RCA: 21] [Impact Index Per Article: 2.6] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 01/17/2017] [Revised: 03/11/2017] [Accepted: 05/08/2017] [Indexed: 12/28/2022]
Abstract
OBJECTIVE The purpose of this study was to explore the association of nine types of Traditional Chinese Medicine (TCM) constitution with the five chronic diseases: hypertension, hyperlipidemia, diabetes mellitus, heart disease, and obesity. METHODS Chi-squared test was performed to investigate the distribution characteristics of TCM constitutions in the participants with the five chronic diseases in questionnaire. Correspondence analysis was used to explore the correlation between them. RESULTS A total of 2,660 participants (1,400 males; 1,260 females) were included in this study. The mean age was 52.54 ± 13.92. Of them, 600 were of gentleness type accounting for 22.56%. Proportions of gentleness type in the chronic diseases (16.00%~23.70%) were less than that in general population (32.14%). The gentleness type and yin-deficiency type were significantly correlated with hypertension and diabetes mellitus, qi-deficiency type was correlated with heart disease, phlegm-dampness type was associated with obesity, and dampness-heat type was correlated with hyperlipidemia. CONCLUSIONS The correlations between TCM constitution types and the five chronic diseases were different. This may have a significant implication for TCM practice, and even the people with gentleness type should not be ignored in health management.
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Affiliation(s)
- Yanbo Zhu
- School of Management, Beijing University of Chinese Medicine, Beijing 100029, China
| | - Huimei Shi
- School of Preclinical Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
| | - Qi Wang
- School of Preclinical Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
| | - Yangyang Wang
- School of Management, Beijing University of Chinese Medicine, Beijing 100029, China
| | - Xiaohan Yu
- School of Preclinical Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
| | - Jie Di
- School of Management, Beijing University of Chinese Medicine, Beijing 100029, China
| | - Xiaomei Zhang
- School of Management, Beijing University of Chinese Medicine, Beijing 100029, China
| | - Yanni Li
- School of Management, Beijing University of Chinese Medicine, Beijing 100029, China
| | - Tong Li
- School of Management, Beijing University of Chinese Medicine, Beijing 100029, China
| | - Hui Yan
- School of Management, Beijing University of Chinese Medicine, Beijing 100029, China
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Payab M, Hasani-Ranjbar S, Merati Y, Esteghamati A, Qorbani M, Hematabadi M, Rashidian H, Shirzad N. The Prevalence of Metabolic Syndrome and Different Obesity Phenotype in Iranian Male Military Personnel. Am J Mens Health 2016; 11:404-413. [PMID: 28201955 PMCID: PMC5675284 DOI: 10.1177/1557988316683120] [Citation(s) in RCA: 14] [Impact Index Per Article: 1.6] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/22/2022] Open
Abstract
Obesity, especially when concentrated in the abdominal area, is often associated with the presence of metabolic syndrome. Stress, particularly occupational stress, is one of the most important factors contributing to the increased prevalence of metabolic syndrome components among different populations. This study aimed to investigate the prevalence of overweight and obesity as well as the criteria for metabolic syndrome and its risk factors and different obesity phenotype in a population of military personnel aged 20 to 65 years. This study is a retrospective cross-sectional study in which data are extracted from the database of a military hospital (2,200 participants). The records of participants contained information such as age, marital status, educational level, weight, height, body mass index, blood pressure, waist circumference, history of drug use and smoking, as well as the results of tests including lipid profile and fasting blood glucose. The Adult Treatment Panel III criteria as well as two national criteria were used to identify metabolic syndrome among participants. Data analysis was p1erformed using SPSS version 16. The average age of participants was 33.37 (7.75) years. The prevalence of metabolic syndrome according to Iranian cutoff was 26.6% for the waist circumference >90 cm (585 persons) and 19.6% for the waist circumference >95 cm (432 persons). The rate of metabolic syndrome was identified as 11.1% (432 cases) according to Adult Treatment Panel III criteria. Results of the current study identified that the prevalence of metabolic syndrome among military individuals is less than other populations, but the prevalence of the syndrome is higher than other military personnel in other countries.
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Affiliation(s)
- Moloud Payab
- 1 Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular -Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
| | - Shirin Hasani-Ranjbar
- 1 Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular -Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.,2 Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
| | - Yaser Merati
- 3 Internal Medicine Resident,Tehran University of Medical Sciences, Tehran, Iran
| | - Alireza Esteghamati
- 4 Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
| | - Mostafa Qorbani
- 5 Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran
| | - Mahboobeh Hematabadi
- 6 Department of Endocrinology, Vali-Asr Hospital, Imam Khomeini Complex Hospital, Tehran University of Medical Sciences, Tehran, Iran
| | - Hoda Rashidian
- 2 Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
| | - Nooshin Shirzad
- 2 Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.,6 Department of Endocrinology, Vali-Asr Hospital, Imam Khomeini Complex Hospital, Tehran University of Medical Sciences, Tehran, Iran
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Han SH, Zheng JM, Li KZ, Liu YR, Ye MY. Influence of traditional Chinese medicine constitution type on the susceptibility of hypertensive cases to intracerebral haemorrhage. Chin J Integr Med 2014; 20:923-7. [PMID: 25022550 DOI: 10.1007/s11655-014-1711-z] [Citation(s) in RCA: 5] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/02/2013] [Indexed: 10/25/2022]
Abstract
OBJECTIVE To explore the influence of Chinese medicine constitution type on the susceptibility of hypertensive patients to intracerebral haemorrhage. METHODS Primary hypertensive patients were studied and divided into the hypertension and the hypertensive intracerebral haemorrhage groups, depending on whether or not the patients had intracerebral haemorrhage. The demographic characteristics, physiological characteristics, living habits, biochemical tests, other chronic diseases, Chinese medicine constitution type, etc. were collected and compared between the two groups. The neurological deficit in the hypertensive intracerebral haemorrhage group was also compared among the different constitution types. RESULTS A total of 304 patients participated in this investigation, including 213 cases in the hypertension group and 91 cases in the hypertensive intracerebral haemorrhage group. The percentages of dampness-heat and qi-depression types in the intracerebral haemorrhage group were greater than those with the same types in the hypertension group (20.9% vs 6.1%, 22.0% vs 8.0%; P<0.05). The percentages of each constitution type were different between genders in both groups. In addition, there were more male cases (14/20) with qi-depression type and more female cases (7/8) with phlegm-dampness type in the hypertensive intracerebral haemorrhage group than those with the same types (3/17 and 9/34, respectively) in the hypertension group (P<0.05). The cases with phlegm-dampness and qi-depression types had greater levels of blood lipids in the intracerebral haemorrhage group than those with the same types in the hypertension group (P<0.05). Furthermore, the cases with the qi-deficiency type presented with a more severe neurological deficit than those with the other types (P<0.05). CONCLUSIONS Chinese medicine constitution type might have an impact on the susceptibility of hypertensive patients to have an intracerebral haemorrhage. The heat-dampness and qi-depression types might lead to greater susceptibility than the other types. In addition, the patient's gender and blood lipids might also influence the susceptibility along with the constitution type.
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Affiliation(s)
- Shu-hui Han
- Neurology Department, The Affiliated Mindong Hospital of Fujian Medical University, Fuan, Fujian Province, 355000, China
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