This study aimed to investigate the impact of nutritional status and frailty phenotype and the predictors of temporal changes on health-related quality of life (HRQoL) of patients with bladder or kidney cancer.

Frailty phenotype, Patient-Generated Subjective Global Assessment, and Quality-of-life questionnaire Core-30 were applied twice to patients diagnosed with bladder or kidney cancer. Patients also completed a sociodemographic questionnaire, and clinical data were collected from records.

Sixty-two individuals completed the study, mostly male, with a mean age of 62.5 (± 11.4) years. The median time of follow-up was 14.5 months. Role functioning, emotional functioning, and fatigue improved over time (p < 0.05). The factors that negatively affected the long-term quality of life summary score were being female, malnourished, pre-frail and frail, cancer treatment, performance status, and lower income. Using the multivariate model, being malnourished (β =  - 7.25; 95% CI, - 10.78 to - 3.71; p < 0.001), frail (β =  - 7.25; 95% CI, - 13.39 to - 1.11; p = 0.021), and each one-point increase in performance status (β =  - 6.9; 95% CI, - 9.54 to - 4.26; p < 0.001), were the ones that most negatively impacted the HRQoL between the two assessments.

This study confirmed that frailty, nutritional status, and performance status are the main predictors of HRQoL of patients with bladder or kidney cancer over time.

These findings may be the first step towards highlighting the importance of preventing malnutrition and frailty, in favor of a better long-term QoL for cancer patients.

New investigators (NI), encompassing graduate students, recent doctoral graduates, and early-career faculty, are instrumental in advancing quality of life (QoL) research through innovative methodologies and diverse perspectives. Within the International Society for Quality of Life Research (ISOQOL), the New Investigators Special Interest Group (NI-SIG) fosters collaboration and supports this community. This study utilizes bibliometric analysis to examine the contributions of NI-SIG members, focusing on publication trends, collaboration patterns, and thematic developments in QoL research.

Data on publications authored by 56 NI-SIG members between 2019 and 2023 were extracted from Web of Science and Scopus. A two-step screening process, guided by the Wilson and Cleary model of QoL, identified 561 unique documents for analysis. Descriptive metrics included publication trends, citations, journal impact factors, and geographic distribution, while network analysis explored co-authorship patterns. Thematic mapping was conducted using clustering algorithms to identify established and emerging research areas.

Publication output rose steadily from 2019 to 2022, peaking at 163 publications before declining to 135 in 2023, accompanied by a reduction in average citations per document from 4.8 to 1.3. The majority of publications appeared in leading journals such as Quality of Life Research (n = 128), Journal of Patient-Reported Outcomes (n = 17), and BMJ Open (n = 15). Geographic analysis revealed that most contributors were from high-income countries, with the United States, Canada, and Australia accounting for over 50% of publications. Co-authorship network analysis highlighted a robust, interconnected cluster of authors, though opportunities remain to enhance global partnerships, particularly with low- and middle-income countries. Thematic analysis identified well-established areas, including psychometric validation and cancer, alongside emerging topics such as mixed methods in QoL research.

This study highlights robust collaborations among NI-SIG members while identifying opportunities to enhance international collaboration and methodological innovation. Expanding partnerships with underrepresented regions and embracing advanced technologies such as natural language processing could foster inclusivity and drive transformative advancements in QoL measurement and application.

Knee osteoarthritis (OA) is a common chronic condition among the elderly, leading to a decline in OA patients' quality of life. This study aimed to investigate the relationship between radiographic severity and health-related quality of life (HRQoL) in elderly women with knee OA.

A total of 80 elderly women with knee OA were enrolled in this study. Radiographic severity was assessed with the Kellgren-Lawrence (K/L) scale, we divided the subjects into early (1-2) and late (3-4) according to the K/L stage. HRQoL assessment was conducted using the MOS item Short-Form 36 (SF-36). The association of HRQoL with knee OA severity was estimated using logistic regression. Applied a random forest model to assess the importance and accuracy of relevant variables in the occurrence of OA. The LASSO (Least Absolute Shrinkage and Selection Operator) regression was then used to identify key factors associated with OA, which were incorporated into the development of a risk prediction nomogram model. Furthermore, a receiver operating characteristic (ROC) curve was constructed to evaluate the model's discriminative ability for OA.

The mean age of the patients was 64.7 ± 6.74 years, and the mean course of disease was 5.01 ± 2.12 years. HRQoL score (SF-36 PCS and MCS) was significantly worse in the late-stage group compared to the early group (p < 0.05). The late group K/L scale has a negative correlation with SF-36 PCS (r = -0.598) and MCS (r = -0.625) and a strong positive correlation. In logistic regression analysis, the K/L scale were significantly associated with SF-36MCS (OR = 0.86, p = 0.041), SF-36 PCS (OR = 0.85, p = 0.025) and TUG (OR = 1.80, p = 0.001). The nomogram model based on key OA risk factors identified by LASSO regression demonstrated substantial predictive value for OA, with an area under the curve (AUC) of 72.2%.

The radiographic severity of knee OA was correlated with health-related quality of life. The HRQoL is an important predictive indicator of the severity of knee OA severity, which might provide beneficial management and treatment for patients with knee OA.

This study examined associations between three levels of social exclusion and quality of life in the Australian oldest old. We performed cross-sectional analyses of the Household, Income and Labour Dynamics in Australia data using 203 participants aged ≥85. Principal component analysis was used to construct social exclusion variables at an individual level (lack of supportive relationships), neighborhood level (disadvantaged neighborhood social climates), and community level (community disengagement). Quality of life was assessed using physical and mental component summary scores of SF-36. Multiple linear regression analysis was performed separately for men and women. Lack of supportive relationships was negatively associated with physical and mental quality of life in all participants. Among men, community disengagement was associated with low physical quality of life. Policies to reduce social exclusion in this age group should focus on improving supportive relationships to enhance quality of life, rather than neighborhood or community levels.

Many adolescents will not survive their cancer diagnosis and will live with advanced cancer (cancer i.e. difficult to cure). Due to the advancement of cancer therapies, many adolescents will live with advanced cancer for long periods of time. Enhancing QoL is a well-established goal of their clinical oncology and palliative care however, there has been little research to conceptualize QoL in ways meaningful to them. There has also been a lack of QoL research focused on the inclusion of their voices and experiences into QoL construct development.

The aim of this study was to develop proposed conceptual domains of QoL relevant to adolescents with advanced cancer.

This study was a qualitative study grounded in Interpretive Description. We used social media content created by adolescents living with advanced cancer to inform the development of QoL domains. Adolescents are increasingly using social media to share their experiences and we believed social media would facilitate access to rich data.

235 social media posts recorded by 14 adolescents were included in the analysis. This analysis generated domains relevant to the QoL of adolescents with advanced cancer: (1) Perceived Health, (2) The Lived Body, (3) Emotional Wellbeing, (4) Normalcy, (5) Purpose and Direction and (6) Re-Orientation.

The QoL of adolescents with advanced cancer is poorly understood. This research has generated unique conceptual domains of QoL relevant to this population of adolescents. These concepts will inform the future development of a patient-reported outcome measure (PROM) that can measure their QoL.

Multimorbidity is a major public health concern. According to previous studies, multimorbidity has been shown to be associated with health-related quality of life (HRQoL). However, existing data concerning high income countries are mainly based on cross-sectional studies. Consequently, longitudinal investigations have been called for. There exist several definitions of multimorbidity in previous population studies, and usually definition is based on self-reported symptoms or diseases or included only few diagnoses. This study aimed to examine how the number of doctor-diagnosed chronic diseases influences HRQoL over time in a population-based setting.

At 31 and 46 years, participants (n = 3573) of the Northern Finland Birth Cohort 1966 answered 15-Dimensional HRQoL questionnaire (15D). Mean 15D-Scores (varies between 0 and 1) were counted according to the number of 43 chosen chronic diseases. These diseases were found and the definition of multimorbidity was measured by a method using both self-reported doctor-diagnosed and register-based chronic diseases.

In both genders, the mean difference of 15D-Scores increased monotonously in line with the increasing number of new emerging diseases diagnosed for 15 years of follow-up from the age of 31-46 years (p < .05). Furthermore, the more diseases the patient had at the age of 31, the more mean 15D-Scores decreased when having more new emerging diseases at the age of 46.

In general, HRQoL decreased during 15-year follow-up for everyone. Furthermore, decrease in the quality of life is significantly associated with multimorbidity in this longitudinal setting.

Psoriasis significantly impacts patients' mental health and social relationships, often leading to feelings of stigmatization and shame due to the visibility of skin lesions. This study aimed to identify factors influencing the quality of life in patients with psoriasis.

A cross-sectional study was conducted from November 2018 to December 2020, involving 100 patients treated for psoriasis. The research utilized the WHO Quality of Life Questionnaire (WHOQoL-Bref), the Psoriasis Area and Severity Index (PASI), the Acceptance of Illness Scale (AIS), the Hospital Anxiety and Depression Scale (HADS), and the Mini Nutritional Assessment (MNA). The analysis included demographic, clinical, and psychological variables to evaluate their impact on quality of life.

The multivariate linear regression model revealed that significant independent predictors of quality of life included age (p=0.001), duration of disease (p=0.004), and nutritional status (p=0.002). In the physical domain, factors such as phototherapy (r=2.46) and anxiety levels assessed by the HADS anxiety subscale (r=-0.23) were particularly relevant. In the psychological domain, the presence of psoriatic arthritis (r=1.978), hand and foot psoriasis (r=2.34), and scores on the HADS anxiety (r=-0.212) and depression subscales (r=-0.226) were significant. Male gender (r=1.632) and depressive symptoms (r=-0.352) impacted the social domain. In the environmental domain, predictors included erythrodermic psoriasis (r=1.98), hand and foot psoriasis (r=2.312), phototherapy (r=1.877), PASI score (r=-0.04), and depression as measured by HADS (r=-0.228).

The primary predictors of quality of life in patients with psoriasis are the type of psoriasis, the presence of anxiety and depressive disorders, and treatment with phototherapy. However, the study's single-center design and relatively small sample size may limit the generalizability of the findings. Further multi-center studies are needed to confirm these results and broaden their applicability.

Muscle energy techniques (MET) for shoulder muscles improve both shoulder muscle tension and the range of motion of the glenohumeral joint. This systematic literature review will investigate the effects of MET on shoulder pain as a result of muscle tension in the glenohumeral joints of patients with shoulder disorders and collect clinical evidence regarding the effectiveness of muscle energy techniques on glenohumeral joint pain. Based on previous studies, we anticipate that MET may significantly affect shoulder joint pain. We expect to provide moderate to high levels of evidence regarding the effectiveness of MET in the treatment of shoulder pain.

Nine electronic databases will be searched for articles published up to November 2024, including PubMed, EMBASE, CENTRAL, KCI, KISS, KMbase, RISS, DBpia, and OASIS. Search terms will consist of terms related to the outcome (e.g., "shoulder") and intervention (e.g., "muscle energy technique," "post-isometric relaxation," "isometric stretching"). Studies selected for the systematic review and meta-analysis will include randomized controlled clinical trials and studies using MET applied to the human shoulder muscles. Qualitative and case studies will be excluded. Two authors will independently assess each study for eligibility and risk of bias and extract the data. This study will analyze the effects of MET on shoulder pain. Additionally, we intend to demonstrate the effect size of muscle energy techniques on factors such as range of motion. Our study will provide clinical evidence for the effects of muscle energy techniques on shoulder joint pain. Our study aims to provide clinical evidence supporting the moderate-to-high effectiveness of MET in treating shoulder joint pain.

ClinicalTrials.gov CRD42024532367.

Premonitory urges (PU) in tic disorder (TD) are recognized as a crucial factor influencing tic symptoms and overall well-being. This study employs network analysis to explore the intricate relationships among PU, tic symptoms, obsessive-compulsive symptoms (OCS), and quality of life (QoL) in drug-naïve children and adolescents with TD. Participants were drug-naïve TD patients aged 6 to 16 years. All participants consented to undergo multiple accessments, including the Yale Global Tic Severity Scale (YGTSS), Premonitory Urge to Tic Scale (PUTS), Gilles de la Tourette-Quality of Life Scale (GTS-QOL), Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS), and Obsessive-Compulsive Inventory-Revised (OCI-R). Network analysis was conducted using the R-package qgraph. Based on a sample of 344 TD patients, robust associations were identified between PU and tic symptoms, OCS, and QoL deficits. Centrality analysis identified ordering symptoms and obsessive thoughts as key nodes. Notable cross-scale associations were observed, such as the connections between PU and checking symptoms, as well as PU and obsessive thoughts. Bridge centrality analysis revealed that obsessive thoughts were identified as the strongest bridge symptom. PU was indirectly related to QoL in individuals with TD, while OCS exerted a direct association. Our study underscores the role of OCS in tic-related symptoms among individuals with TD. Highlighting the significant associations between PU and OCS, it emphasizes the necessity for targeted interventions to improve overall well-being.

SCN8A-related epilepsy is associated with a spectrum of seizure and neurodevelopmental phenotypes; however, there is limited information regarding nonseizure outcomes. We performed a cross-sectional study investigating quality of life (QoL) and adaptive functioning in this population utilizing the Quality of Life Inventory-Disability (QI-Disability) survey and Vineland Adaptive Behavior Scales (VABS). Nineteen patients with SCN8A pathogenic variants were included. There was a significant difference in QI-Disability and VABS scores between clinical epilepsy phenotypes. Greater seizure frequency and number of antiseizure medications were both associated with lower VABS and QI-Disability total scores, but number of antiseizure medications was associated with more QoL domains than seizure frequency. QI-Disability scores were positively associated with adaptive functioning except for the QoL domain of Negative Emotions. This study is the first to characterize the spectrum of QoL and adaptive functioning in the SCN8A-related disorder population and investigate their relationships to each other and to seizure outcomes. Both the QI-Disability and VABS show promise as potential clinical outcome assessments in future SCN8A-related disorder cohorts.

Liver transplantation significantly improves the health-related quality of life of patients with cirrhosis and high MELD scores. This study highlights rapid health-related quality of life gains after transplantation that were sustained during the one-year follow-up period, emphasizing the role of multidisciplinary care in achieving these outcomes.

To assess the effects of liver transplantation on the health-related quality of life of patients with cirrhosis on the waiting list for transplantation.

This retrospective study analyzed HRQOL using the EQ-5D questionnaire before (T0), and 3 (T3), 6 (T6), and 12 (T12) months after, transplantation. The questionnaire comprised five health status scores, which were also combined into a single utility score. Changes in each dimension and in the utility score were examined.

A total of 212 patients were included in the study, with a mean age of 54 (SD, 12) years, and a median Model for End-Stage Liver Disease score of 17 (Q1= 11; Q3= 24). The most frequent etiology was chronic alcoholism (26.9%). Improvements in EQ-5D utility scores were registered at all post-transplantation time points compared to the score at T0: an increase of 0.22 points (p<0.001) at T3, 0.27 (p<0.001) at T6, and 0.268 (p<0.001) at T12. Scores increased over time in all domains of the EQ-5D.

In a large sample of high-risk transplant recipients, a significant improvement in HRQOL occurred three months after transplantation, and was sustained over the one-year follow-up period.

■ Liver transplantation improves health-related quality of life in patients with cirrhosis and high MELD scores.

■ Significant health-related quality of life improvements occur within three months of transplantation.

■ Multidisciplinary care programs enhance post-iver transplantation physical and mental recovery.

■ Sustained health-related quality of life gains highlight the long-term benefits of liver transplantation.

Atrial fibrillation (AF) stands as the most common cardiac arrhythmia on a global scale with a substantial symptom burden impacting the quality of life (QoL) of patients with AF. Consequently, assessing and monitoring symptoms in patients with AF has gained increased interest, leading to a rise in patient-reported outcome measures (PROMs). PROMs provide valuable insights into the patient's perspective, allowing for a more patient-centric approach to care. One of these PROMs is the Atrial Fibrillation Severity Scale (AFSS), a convenient and straightforward instrument for assessing symptom severity in patients with AF, potentially enabling healthcare professionals to tailor interventions accordingly. However, no Danish version of AFSS exists. This study aims to translate and linguistically validate the AFSS in accordance with MAPI Research Trust Guidelines.

The translation of AFSS from English to Danish was conducted using forward and backward translation, yielding versions 1 and 2, respectively. Afterwards, the translated AFSS was linguistically validated in patients with AF by cognitive interviews producing a third version. The third version was then proofread, finalizing the Danish version of AFSS.

Derived from the cognitive interviews, the Danish version of AFSS demonstrated comprehensibility and readability among all included patients with AF. No revisions were deemed necessary based on the patient testing, culminating in the submission of the final version of AFSS for approval.

A certified and linguistically validated Danish version of the AFSS has been established and is accessible through MAPI Trust Research.

To compare the short-term outcomes and postoperative quality of life of patients with nonmyasthenic early-stage thymoma who underwent subxiphoid approach to video-assisted thoracic surgery (S-VATS) or lateral intercostal approach VATS (L-VATS).

A prospective, nonrandomized study was conducted. From July 2020 to June 2022, 60 patients with nonmyasthenic early-stage thymoma were enrolled and divided into two groups: 30 received S-VATS and 30 received L-VATS. The Quality-of-Life Questionnaire-Core 30 scale was used to measure the quality of life of the patients before surgery and at 1, 2, 4, and 8 wk after surgery. Linear mixed-effects models with an interaction term (surgery type × time) were used to test for differences in mean domain scores and differing effects of approach over time, adjusting for baseline scores.

The S-VATS group had less postoperative drainage (P = 0.021), shorter drainage duration (P = 0.12), and shorter postoperative hospital stay (P = 0.006) than the L-VATS. The quality-of-life dimensions of the two groups were similar before surgery, but they changed after surgery: the functional domains and general health status decreased, while the symptomatic domains increased. The S-VATS group had higher scores in global health status (difference 4.9; 95% confidence interval [CI] 2.0, 7.8; P < 0.01), physical functioning (difference 4.5; 95% CI 1.8, 7.2; P < 0.01), emotional functioning (difference 3.5; 95% CI 1.7, 5.3; P < 0.01), social functioning (difference 6.9; 95% CI 3.4, 10.5; P < 0.01), and lower scores in fatigue (difference -3.6; 95% CI -5.2, -2.0; P < 0.01), pain (difference -6.7; 95% CI -8.9, -4.4; P < 0.01).

S-VATS is an effective treatment for patients with nonmyasthenic early-stage thymoma, and it can significantly improve perioperative outcomes and the postoperative quality of life.

To investigate the current status of stigma in patients with rheumatoid arthritis (RA), and its correlation with treatment adherence and quality of life.

The convenience sample of 266 patients diagnosed with RA was surveyed at the rheumatology and immunology outpatient department of a tertiary hospital in Jiangsu Province from May 2022 to September 2022. In addition to this, 20 RA patients were purposively sampled for semi-structured in-depth interviews, and the data were analysed using content analysis methods.

The total stigma's score of the 266 participants was (47.8 ± 10.8), which indicates a moderate level of stigma. The mean scores for alienation, stereotype endorsement, perceived discrimination, and social withdrawal were (2.2 ± 0.7), (2.4 ± 0.7), (2.9 ± 0.6), and (2.2 ± 0.6) respectively. A comparison of the average family monthly income, family roles, duration, disease activity, duration of morning stiffness, visual analogue scale score, C-reactive protein, erythrocyte sedimentation rate, and total stigma score revealed significant differences (p < 0.05). The total treatment adherence score was negatively correlated with the total stigma's score and scores in each dimension (p < 0.05). Similarly, the total psychological health score and total physical health score were negatively correlated with the total stigma score and scores in each dimension (p < 0.05). The qualitative study identified six themes: self-denial, discrimination, lack of disease-related knowledge, high medical costs, increased life burden and resistance to stigma.

Stigma affects RA patients' treatment adherence and quality of life negatively. Healthcare workers are advised to develop comprehensive intervention programs that address the current status of stigma, with the aim of controlling disease progression, reducing disability rates, and improving the quality of life for RA patients.

Quality of life (QOL) broadly encompasses constructs including health, well-being, life satisfaction, and psychosocial functioning. Depression, a major cause of global disability, is linked to lower QOL. Despite the rise of measurement-based care and patient-reported outcomes, there is no consensus on QOL definitions or models, resulting in varied assessments. This study aims to describe the item content overlap among commonly used QOL measures in depression research. We analyzed 10 QOL measures from a meta-analysis, calculating Jaccard indices to quantify overlap, and used two coding approaches: one for similarly worded items and another for exact word matches. We also categorized items into broader themes. At the most, average Jaccard similarity was M = 0.14 (SD = 0.12), indicating significant heterogeneity among QOL measures in depression. This suggests that QOL outcomes may not be reproducible across different scales. Future research should examine the relationships between the content assessed by various QOL measures.

Latinos/as are the largest ethnic group in the U.S. and are a continuous source of population growth. Therefore, their health and quality of life are important public health concerns. Acculturation is an important determinant of health for Latinos/as. However, few studies examine models identifying determinants of acculturation along with its relationship to other social and health behaviors. The current study uses social network data from a sample of crowdsourced recruited Latinos/as (N = 300) to examine a structural model between network acculturation, psychological acculturation, social capital, help-seeking, and quality of life (QoL). The model posits several paths through which social networks (i.e., network acculturation) relate to acculturation and other model variables. Directly, network acculturation was found to be significantly related to Latino/a enculturation (-0.83, p = 0.002) and White American Acculturation (0.47, p = 0.003). Latino/a enculturation was related to help-seeking (0.21, p = 0.029) and social capital (0.36, p < 0.001), while White American acculturation was only related to social capital (0.35, p = 0.003). Social capital demonstrated a robust relationship with help-seeking (0.48, p = 0.004) and QoL (0.96, p = 0.003). The findings suggest that determinants of acculturation (i.e., network acculturation) are meaningful contributors to psychological acculturation and other variables relating to Latino/as' QoL.

Palliative care (PC) consultation in high-risk patients with liver disease who are undergoing liver transplant (LT) evaluation is underused due to common beliefs that PC would negatively impact a patient's desire for transplant. This population is at risk due to high morbidity, mortality, and negative impact to overall quality of life. A 4-week pilot study was conducted in a transplant surgical intensive care unit at a single academic center to increase PC consultation during inpatient LT evaluation and improve transitions in care. Two Plan, Do, Study, Act quality improvement cycles were subsequently led by the PC nurse practitioner and social worker to increase the effectiveness of this intervention. The first cycle (November 29, 2018, to September 30, 2019) identified the need to increase PC education of intensive care unit nurses and promote interdisciplinary collaboration. The second cycle (October 1, 2019, to June 13, 2022) modified the study protocol to prioritize high-risk patients undergoing inpatient LT evaluation. Palliative care consultation increased by 262.5% from 2018 to 2019, with consults completed on 19% of all patients admitted for inpatient LT evaluations throughout the duration of the quality improvement study. Palliative care consultation on high-risk patients undergoing inpatient LT evaluation is a promising targeted strategy to increase utilization of PC in this population.

Tongue cancer treatment often involves glossectomy and flap reconstruction. Since the tongue plays a vital role in swallowing, chewing, speaking, airway protection, and taste, it also plays a major role in the patient's quality of life (QOL) after reconstruction. Therefore, the flap that best preserves QOL should be determined. A literature review was conducted using PubMed, Scopus, and Ovid MEDLINE, with a total of 446 articles retrieved. Four studies were included in this integrative review, which all utilized the University of Washington Quality of Life questionnaire to assess QOL in tongue cancer patients post-glossectomy and flap reconstruction. The articles specifically compared radial forearm free flap to pectoralis major myocutaneous flap, submental island pedicled flap, anterolateral thigh flap, and lateral upper forearm flap. Based on the included articles, no flap significantly preserved QOL. However, a certain flap may be more suitable for a patient based on the patient's preferences, lifestyle, health status, and goals. Therefore, it is important for providers to complete a thorough history and assessment prior to surgery so that the flap chosen upholds the patient's goals and preserves overall QOL.

Understanding university students' health-related quality of life (HRQoL) can help propose strategies that support targeted care for this population and identify issues affecting these individuals. Therefore, it is necessary to identify the commonly used instruments and possible study designs for the university population, enabling the standardization of interventions and instruments to evaluate the HRQoL of university students. We aim to conduct a scoping review to identify the main measurement instruments and key characteristics in studies using HRQoL measures among university students. It is also aimed at identifying the foundations for guiding future research priorities.

This review will consider original peer-reviewed articles that used any generic HRQoL measurement instruments exclusively used with university students aged 18-59. Validation, qualitative, language translation, or adaptation studies will be excluded. This review will follow the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR). The research will be conducted in five electronic databases (PubMed, Embase, Web of Science, Scopus, and SPORTDiscus). Two reviewers will independently screen records using predefined eligibility criteria and extract data using tables. The extracted data will include specific details about the title, authors, year of publication, HRQoL instrument utilized, participants, intervention design, and critical findings. The results will be presented in a narrative summary with data displayed in tabular and diagrammatic formats.

This proposed scoping review aims to provide a comprehensive overview of the existing methods for assessing health-related quality of life in university students. The results will help identify gaps in the literature and establish a foundation for guiding future research priorities.

Registration with Open Science Framework can be found under registration number https://doi.org/10.17605/OSF.IO/FY9GU .

Subjective suffering due to oral diseases and disorders has been conceptualized as oral health-related quality of life and is often assessed with a multidimensional version of the Oral Health Impact Profile (OHIP). In the current study, a secondary analysis of a Dutch-language translated version of the original OHIP-14 was performed in different samples of approximately 1000 participants from diverse contexts (i.e., The Netherlands, the Caribbean, and Nepal). The dimensional structure and reliability of the scales resulting from these analyses were also examined. Based on a number of Confirmatory Factor Analyses (CFAs) and Simultaneous Components Analysis (SCA) of the OHIP-14 scale, testing various models with different numbers of factors, several models were acceptable, but a two-factor solution, comprising psychological discomfort and physical discomfort was the most satisfactory in all three samples, although a one-factor solution, oral discomfort was also acceptable. Instead of using a large number of dimensions with a few items each, as often is done, it is most adequate and feasible to use no more than two scales, i.e., psychological discomfort and physical discomfort, comprising 11 items in total. These subscales of six and, respectively, five items are not only statistically, but also theoretically, the most adequate. Additionally, all items together, i.e., oral discomfort as a one-dimensional scale, are useful and easy to apply for practical use.

Autistic people are more likely to have co-occurring mental health conditions compared to the general population, and mental health interventions have been identified as a top research priority by autistic people and the wider autism community. Autistic adults have also communicated that quality of life is the outcome that matters most to them in relation to mental health research and that they want to be involved more actively in the research process. Our systematic review aimed to determine the extent and nature of (1) quality of life measurement in randomised controlled trials of mental health interventions for autistic adults and (2) community involvement taking place within identified randomised controlled trials. We searched Medline, Embase, APA PsycInfo, Web of Science and grey literature sources. After screening over 10,000 records, 19 studies were eligible and five of those studies measured quality of life as an outcome. Of those five, three included community involvement and two did not report on community involvement. We conclude there is a need for increased use of quality of life measurement when trialling mental health interventions, including the use of measures validated for autistic adults - which would be facilitated by greater autistic involvement in the research process.Lay AbstractAutistic people are more likely to have health problems than the general population. They, and people who care about them, have said mental health research is very important, and some autistic adults have said quality of life is the most helpful area to research when focusing on mental health. Autistic people should also be more deeply involved in making decisions in research. Our review aimed to find out if and how quality of life is being measured when mental health treatments are being tested, and how autistic people and the wider autism community are involved in these studies. We searched four databases and other sources and found over 10,000 records. But just 19 research studies were testing mental health treatments for autistic adults, and only five of those measured quality of life. When they did measure quality of life, it was measured in different ways and there was not much information given on how communities were involved. We suggest mental health research should measure quality of life more often and in ways that are more helpful for autistic people. Our analysis found that mental health research needs to include a wider variety of autistic people, and autistic people should be more involved in the various parts of research.

Consensus exists regarding the need to provide exercise interventions to individuals diagnosed with lung cancer (LC). Exercise interventions for this populations usually include multidisciplinary approaches, making the attempt to understand the effects of exercise a real challenge. Therefore, we designed a systematic review to identify the effects of exercise interventions among individuals with a LC diagnosis. Following the PRISMA guidelines, studies across 5 different databases were systematically screened. Eligible studies were randomised and non-randomised trials, including individuals with a LC diagnosis, administering exercise-only interventions. Three-level meta-analyses were performed for cardiorespiratory fitness, strength, physical function, anxiety, depression, and health-related quality of life. Differences between exercise types were also explored. The Cochrane Risk of Bias (RoB) II tool for randomised controlled trials and the RoB in non-randomised studies - of interventions were used to assess study quality. A total of 36,304 records were screened and 13 studies, including 547 LC survivors, were considered eligible. Randomised and non-randomised trials were mainly judged as "some concern" and at "serious" RoB, respectively. Meta-analyses reported significant improvements on physical function among exercise groups compared to control (ES = 0.62; 95 % CI: 0.10 to 1.15; p = 0.03), and no significant changes for all other variables. There is moderate evidence that exercise interventions appear to be an effective tool to improve physical function among individuals diagnosed with LC. Further studies are still needed to determine exercise prescription effectiveness on health outcomes, differences across exercise types and enhance individualized interventions.

The benefit of selective serotonin reuptake inhibitors (SSRIs) in improving quality of life (QoL) has been investigated in randomized-controlled trials (RCTs) with equivocal results. This study explored whether SSRIs could improve QoL in individuals with medical, psychiatric, and neuropsychiatric conditions. RCTs were searched in PubMed, Embase, Scopus, Ovid, and Google Scholar. Data were synthesized via a meta-analysis. Subgroup and meta-regression analyses were performed. The sample size was 9,070. Compared with placebo, SSRIs showed statistically significant improvements in QoL in cancer (d = 0.30), major depressive disorder (d = 0.27), premenstrual dysphoric disorder (d = 0.38), type 2 diabetes mellitus (d = 0.48), persistent depressive disorder (d = 0.32), and menopausal symptoms (d = 0.40). Paroxetine exhibited the highest effect size. No significant improvements were noted in chronic obstructive pulmonary disease (d = 0.65, P = 0.09), congestive heart failure (d = 0.46, P = 0.27), and irritable bowel syndrome (d = 0.26, P = 0.127). The reduction in depressive symptoms improved QoL. Small-study effects, high attrition rates, and demographic imbalances are limiting factors to recommend SSRIs to improve QoL. Future research should focus on QoL domains and pharmacological properties of each SSRI.

Decreased quality of life (QoL) is a significant complication of most rheumatic conditions in adults, whereas data on health-related quality of life (HRQoL) in children with juvenile idiopathic arthritis (JIA) are limited. Patient-Reported Outcomes Measurement Information System® (PROMIS® ) instruments assessing quality of life (QoL) components can be scored using disease-specific severity thresholds. Our study aimed to compare the results of generic and one of the JIA-specific scorings regarding PROMIS® Pediatric Mobility, Pain Interference, and Fatigue questionnaires, introduce PROMIS® Pediatric Global Health 7 questionnaire as a valuable method to assess QoL specifically in patients with JIA and determine differences in self-reported QoL in juvenile idiopathic arthritis (JIA) patients and their healthy peers in the Polish population.

In this single-center cross-sectional study, four self-reported questionnaires derived from the PROMIS® Pediatric Item Bank (Global Health, Pain Interference, Fatigue, Mobility) were administered to 52 patients with JIA (8-17 years; mean 13.2 ± 2.9; girls 59.6%) and 101 age-matched healthy controls. Questionnaires were scored based on generic or JIA-specific cut-off points.

Regardless of the domain (PROMIS® Pain Interference, Fatigue, or Mobility), JIA patients assigned by generic cut-off points to a more severe outcome were classified into milder outcomes when cut-off points for JIA were used. The usefulness of the PROMIS® Pediatric Global Health 7 questionnaire was evidenced in children with JIA. No significant differences were found in QoL assessment between children with JIA and healthy children; however, self-reported impaired mobility was more prevalent in patients with JIA. A negative correlation was found between overall QoL and the assessment of three domains: pain, fatigue, and mobility impairment.

Our study underscores the importance of JIA-specific scoring in clinical practice. While more research is needed to establish a single disease-specific scoring, our findings provide valuable insights into the negative influence of pain, fatigue, and mobility impairment on QoL in JIA. These results have the potential to significantly impact patient care and improve the health-related quality of life in children with JIA.

Background and Objectives: While the acute phase of pulmonary embolism (PE) is well studied, its long-term physical and mental consequences have received less attention. Here, we aim to evaluate health-related quality of life (HRQoL) during the follow-up of PE with the Heart QoL questionnaire and to assess its reliability and validity as a standardized tool. Materials and Methods: A prospective study was conducted at the PE Outpatient Clinic of the University Hospital of Larissa, enrolling 100 PE patients (63% male, mean age 56.97 ± 16.09 years). The internal consistency of the Heart QoL questionnaire was measured using Cronbach's alpha. Correlations between Heart QoL and SF-36 subscales were examined. Results: We included 100 patients with PE (63% males, 56.97 ± 16.09 years). A total of 59% of the patients reported reduced functional capacity post-PE. Heart QoL demonstrated excellent reliability (Cronbach's alpha = 0.947), with strong inter-item correlations (range: 0.337-0.949). Internal consistency coefficients for Heart QoL subscales were 0.558 (global), 0.606 (physical), and 0.871 (emotional). The inter-item correlation range from 0.337 to 0.949. Mean Heart QoL scores were significantly lower than the Greek norms (global: 2.15 ± 0.829, physical: 2.17 ± 0.86, emotional: 2.09 ± 1.03). Heart QoL subscales exhibit significant correlations, with most SF-36 subscales indicating strong convergent validity. In the multiple linear regression analysis, MRC, dyspnea, reduced functionality, and the presence of symptoms were independent predictors of Heart QoL global and physical score. The presence of bleeding complications and reduced functionality were independent predictors of Heart QoL emotional score. Conclusions: Heart QoL is a reliable and valid tool for assessing HRQoL in PE patients, offering an alternative to more time-consuming tools. Dyspnea, reduced functionality, and bleeding complications significantly impact long-term HRQoL, underscoring the need for structured, multidisciplinary follow-up care that integrates both physical and mental health support in order to optimize patient long-term outcomes, especially in those at risk for chronic thromboembolic consequences.

Hungarian SF-36 population norm data were last collected in 1997-1998 and have not been updated since, reducing their relevance and limiting their usability and comparability. This study aimed to establish contemporary normative data for the SF-36 domain and standardised summary scores in Hungary and compare them to the previous population norms.

An online cross-sectional survey, including the SF-36v1, was conducted among 1,700 members of the Hungarian adult general population in 2020. The sample demonstrated good representativeness across key sociodemographic characteristics. Normative data were calculated for domains using raw scores and for summary scores using country-specific factor score coefficients derived from exploratory factor analysis. Multivariate linear regression models were performed to examine the association of domain and summary scores with sociodemographic and health-related characteristics. Raw domain scores were compared with the 1997-1998 norms.

Males reported higher scores (better health) in seven out of eight domains (p < 0.001). Mean standardised PCS scores decreased, whereas MCS scores increased with age (p < 0.001). Compared to the 1997-1998 population norms, the 18-24 and 25-34 age groups reported lower, while the 65 + age group reported higher scores in all eight domains. Higher scores were reported in 2020 from the 35-44 age group onward on the role physical, bodily pain, social functioning, and role emotional domains.

This study established contemporary population norms for the SF-36 in Hungary. Our results highlight the changes in health status in the general population, particularly in young adults, compared to the 1997-1998 population norms, and provide valuable input to inform decision-makers.

The current study investigated Whiplash Associated Disorders (WAD) and health related quality of life (HRQOL) from the perspective of Swedish patients. Another aim was to assess medicine consumption and income loss due to WAD.

The present study was a planned secondary analysis using baseline data from a prospective, multicentre randomized controlled trial. The study participants were WAD patients, victims of four-wheel motor vehicle collisions at least six months but not more than five years ago. Neck Disability Index and HRQOL were measured. HRQOL was measured by the EQ-5D instrument. Cross tabulations, Box Plots, and regression analyses were performed.

The study was registered before data collection started (ClinicalTrials.gov Protocol ID: NCT03022812, initial release 12/20/2016).

There were 137 WAD participants (78.8% women), and almost three-fourths (74.5%) were married. The majority (54.7%) of the WAD patients were in white-collar jobs, followed by blue-collar jobs (35%) and students /unemployed (10.2%). Both consumption of medicine for neck pain and income loss due to WAD have a negative relation with the Neck Disability Index (NDI). On average, EQ-VAS for WAD women is 58.21 (± 17.625), and for men, it is 61.11 (± 16.444). WAD patients with a university education have the highest EQ-VAS average of 60.42 (± 17.738).

The low HRQOL seen in WAD patients in this study should warrant the attention of the medical fraternity, researchers and policymakers.

Background: Health literacy (HL) and irrational beliefs about happiness significantly influence adults' health-related quality of life (HRQoL). The purpose of this study was to examine whether irrational happiness mediates the relationship between HL and HRQoL among adults. Methods: A total of 686 adults (468 women and 218 men; mean age = 22.30  ±  6.83 years) completed self-report questionnaires, including the Health Literacy Scale-Short Form, the EUROHIS-QOL 8, and the Irrational Happiness Beliefs Scale. Data were analyzed using structural equation modeling and bootstrapping methods. Results: HL had both direct (β = 0.260, p < 0.01) and indirect effects on HRQoL. HL directly predicted irrational happiness (β = -0.369, p < 0.01), which in turn directly predicted HRQoL (β = -0.318, p < 0.01). Specifically, irrational happiness significantly mediated the relationship between HL and HRQoL (bootstrap coefficient = 0.117, 95% CI = 0.071-0.175). Conclusion: These findings suggest that interventions aiming to enhance adults' HRQoL should consider not only improving HL but also addressing irrational beliefs about happiness.

Colorectal anastomotic leakage remains one of the most frequent and dreaded postoperative complications after colorectal resection. However, limited research has been conducted on the impact of this complication on the quality of life of patients who have undergone colorectal cancer surgery.

The aim of this systematic review was to identify, appraise, and synthesize the available evidence regarding the quality of life in patients with anastomotic leakage after oncological colorectal resections to inform clinical decision-making.

PubMed, Embase, and the Cochrane Library were searched for studies reporting quality of life using validated questionnaires in patients with anastomotic leakage after oncological colorectal resections. The literature search was performed systematically and according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.

Outcomes from quality-of-life questionnaires of patients with and without anastomotic leakage were analyzed.

Thirteen articles reporting on 4618 individual patients were included, among which 527 patients developed anastomotic leakage. Quality of life was evaluated using 10 distinct questionnaires administered at various postoperative time points, ranging from 1 month to 14 years. Quality-of-life outcomes differed across studies and time points, but overall scores were most negatively affected by anastomotic leakage up to 12 months postoperatively.

There was a high heterogeneity between the included studies based on the questionnaires used and the time of assessment.

The published evidence suggests that anastomotic leakage after oncologic colorectal resection is associated with impaired quality of life, especially within the first postoperative year. The impact of anastomotic leakage on quality of life warrants further evaluation and discussion with patients.

Radiology is polyvalent, as it is valuable in many ways to many groups, such as to individuals, professionals, and populations. However, not all values are positive. While Value-Based HealthCare (VBHC) has moved the focus from volume-based to value-based health care and Value-Based Radiology (VBR) has highlighted a vast variety of values in radiology, such frameworks provide no measures to differentiate, assess, and balance the various values. Based on value theory this article provides a value map for radiology. The map can be helpful to a) identify and understand the complexity of values in radiology, b) differentiate and assess the values of radiology's various tasks and aspects, c) to address potential value conflicts in radiology, and d) to maximize the positive and minimize its negative value. Mapping the values of radiology thus is crucial for understanding and increasing the importance of imaging.

Despite increasing interest in the role of parks on children's health, there has been little empirical research on the impact of park interventions. We used a quasi-experimental pre-post study design with matched controls to evaluate the effects of park redesign and renovation on children's health-related quality of life (QoL) in underserved neighborhoods in New York City, with predominantly Hispanic and Black populations. Utilizing longitudinal data from the Physical Activity and Redesigned Community Spaces (PARCS) Study, we examined the parent-reported health-related QoL of 201 children aged 3-11 years living within a 0.3-mile radius of 13 renovated parks compared to 197 children living near 11 control parks before and after the park intervention. Health-related QoL was measured using a modified version of the KINDL questionnaire that assessed children's physical and emotional well-being, self-esteem, and well-being in home, peer, and school functioning. Linear mixed regression model was used to examine the difference in difference (DID) between the intervention vs. control group for QoL. We found a significant differential improvement in the physical well-being subscale of KINDL in the intervention vs. control group (DID = 6.35, 95% confidence interval [CI] = 0.85-11.85, p = 0.024). The effect was particularly strong among girls (DID = 7.88, p = 0.023) and children of the lowest socio-economic background (p < 0.05). No significant DID was found in other KINDL domains. Our study indicated a beneficial impact of improving park quality on the physical well-being of children residing in underserved neighborhoods. These findings lend support for investments in neighborhood parks to advance health equity.

Body contouring procedures following massive weight loss (MWL) are in increasing demand, with abdominoplasty emerging as one of the most frequently sought options to address excess skin and contour issues. This study comprehensively examines long-term changes in Quality of Life (QoL) following abdominoplasty in individuals who have undergone MWL.

In this retrospective, single-center study, 54 post-bariatric patients who had experienced MWL and subsequently underwent abdominoplasty were included. The mean age was 50.8 years. Multiple aspects of QoL were assessed using a specially designed questionnaire administered pre- and postoperatively. Inclusion criteria included a BMI < 35 and a previous bariatric procedure.

The physical component score (PCS-12) demonstrated significant improvement both early and late postoperatively, whereas the mental component score (MCS-12) showed no significant change. Vitality and self-acceptance exhibited significant improvements in both the short and long term. In contrast, body contact, sexuality, and self-esteem showed no long-term improvement post-surgery. Depression scores (PHQ-4) had no positive impact on long-term QoL. Body function (X-SMFA) showed significant long-term improvement, though the impairment score revealed no significant change.

Consistent with prior research, abdominoplasty following MWL leads to positive physical outcomes. However, the impact on body image is heterogeneous, with no sustained improvement observed in some psychosocial dimensions. As depression and body impairment scores also do not show lasting improvement, patients with expectations of broad QoL enhancements should be carefully selected and assessed for potential multidisciplinary treatment.

To compare inpatient rehabilitation outcomes after total knee arthroplasty (TKA) between groups with different baseline scores.

A retrospective observational study.

Patients with knee osteoarthritis who have previously undergone unilateral TKA.

Patients participated in 3-week inpatient rehabilitation following TKA and were assessed for patient-reported outcome measures (PROMs), which included the Numeric Pain Rating Scale (NPRS), the Health Assessment Questionnaire (HAQ), the European Quality of Life 5 Dimensions 5 Level Version (EQ-5D-5L), and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Furthermore, mobility scores for the range of motion (ROM) and the Timed Up and Go (TUG) test were recorded at the beginning and the end of rehabilitation. Patients were divided into quartile groups based on their initial examination scores.

329 patients were enrolled in the study. The study population consisted mostly of female patients (63.8% vs 36.2%) with a mean age of 68.25 (SD 9.24) years. The personalized 21-day in rehabilitation programme was safe for all patients and had no dropouts. Patients with better PROMs scores at T1 did not have the same potential for improvement in PROMs but showed effective improvement in mobility (η² = 0.103 for changes in the WOMAC vs η²=0.502 for changes in the TUG test).

Regardless of the baseline scores, all patients presented significant improvements in both subjective and objective measures. Age and baseline PROMs or mobility scores did not have a significant effect on score development.

This study aimed to explore the association between dietary antioxidant index (DAI) combined with serum albumin-to-globulin ratio (AGR) and postoperative Health-related quality of life (HRQOL) in patients with esophageal squamous cell carcinoma (ESCC).

All patients were newly diagnosed with ESCC and underwent radical esophagectomy. Dietary data and routine blood tests were collected preoperatively to compute DAI and AGR. HRQOL was assessed over 7 years post-surgery via telephone follow-up and analyzed longitudinally using a time to deterioration (TTD) model. The deterioration times were compared using the log-rank test, and the association of the combined DAI and AGR index with postoperative quality of life in ESCC patients was examined through Cox regression models.

A total of 238 ESCC patients were included in the study. The results indicate that compared to the low DAI-AGR group, the high DAI-AGR group had a lower rate of deterioration events, and the time to deterioration in emotional functioning (p=0.014), dysphagia (p=0.042), and speech problems (p=0.023) were significantly delayed. Cox proportional hazard model revealed that preoperative high DAI-AGR was associated with improvement in emotional functioning (HR=0.575, 95% CI: 0.368-0.898) and speech problems (HR=0.525, 95% CI: 0.298-0.925) in ESCC patients postoperatively, which remained significant even after adjusting for covariates. The stratified analysis revealed that this improvement was associated with demographic and clinical characteristics.

Our findings suggest that high preoperative DAI-AGR is linked to enhanced postoperative HRQOL in ESCC patients, offering crucial insights for patients, practitioners, and researchers.

Background and Objectives: End-stage renal disease threatens individuals' quality of life (QoL) and has a substantial influence on their daily lives. While several studies have explored the QoL of hemodialysis patients, none have comprehensively examined the relationship between patient QoL and their specific needs as well as the factors that predict these outcomes. This study aimed to investigate the intricate relationship and predictive factors between QoL and the needs of hemodialysis patients, serving as a foundational step toward enhancing their care. Materials and Methods: This cross-sectional study included 222 patients undergoing hemodialysis for ESRD between January and March 2023. Data were gathered through structured interviews utilizing the World Health Organization Quality of Life-BREF, and questionnaires were needed. To assess intergroup differences, t-tests and ANOVA were employed, while multiple linear regression and correlation coefficients were used to unveil predictive associations. Results: Our findings revealed that the majority of patients interviewed expressed satisfaction with their health and reported high QoL. Predictors of higher QoL included being under 60 years of age, married, strong familial support, and a body mass index < 30 kg/m2. Conversely, living alone has emerged as a predictor of diminished QoL. Moreover, middle-aged patients who were married and had a normal BMI were identified as having lower needs. Conclusions: A discernible association was observed between higher QoL and reduced need among hemodialysis patients. This study offers valuable insights into the multifaceted factors influencing the QoL and needs of these patients, offering guidance for enhancing patient care and ultimately improving their overall QoL.

To examine the nine-item National Eye Institute Vision Function Questionnaire (NEI-VFQ-9) scores at baseline and 12 months in participants enrolled in the Manhattan Vision Screening and Follow-up Study (NYC-SIGHT) and determine factors associated with improvements in vision-related quality-of-life (VRQOL).

Retrospective review of NEI-VFQ-9 scores at baseline and 12-month follow-up in a community-based eye health screening study conducted in Upper Manhattan, New York. Participants were age ≥ 40 years and older, living independently in public/affordable housing developments and able to provide informed consent. Paired t-tests compared baseline and 12-month NEI-VFQ-9 composite and sub-scores and a multivariable linear regression model identified significant predictors of improvement in quality-of-life at the 95% confidence interval (CI).

A total of 515 participants completed both the NEI-VFQ-9 at baseline and 12-months. Significant increases in the composite NEI-VFQ-9 score were seen with general vision, near vision tasks, and role limitation (P < 0.001). Multivariable linear regression showed that being unemployed was associated with a statistically significant increase in NEI-VFQ-9 composite score (β = 5.6, 95% CI: 0.5,10.7, P = 0.033), and the absence of ocular conditions was negatively associated with improvement in the composite score over 12 months (β = -5.4, 95% CI: -10.3, -0.5, P = 0.031).

These results can help researchers, clinicians, and eye health professionals better understand the factors associated with VRQOL outcomes in underserved populations utilizing the NEI-VFQ-9. Community-based vision research clinical trials can easily incorporate the NEI-VFQ-9 into baseline and follow-up instruments to assess VRQOL for future comparisons.

Globally, more than half of the adult population is overweight, including those who are obese, which increases the risk of premature death and reduces quality of life (QoL). Technologies such as digital health applications (DiHA) can potentially improve clinical outcomes (e.g., health status, illness duration, QoL) or patient-related factors (e.g., therapy monitoring, adherence, health literacy). To date, there is no systematic review addressing the effectiveness of DiHA on the QoL in patients with overweight or obesity.

The objective was to investigate the impact of DiHA on QoL in overweight or obese patients.

A systematic literature search was conducted in MEDLINE via PubMed, Cochrane Library, and Embase via Ovid in 2023, supplemented by additional manual searches. The eligibility criteria included patients with overweight and/or obesity who used a digital intervention independently and without interaction with a healthcare professional. The outcome of interest was QoL. As potentially eligible trials had to demonstrate effectiveness, only randomized controlled trials (RCT) were included as the minimum evidence standard. The study screening (title-abstract, full-text) was conducted independently by two researchers using pre-specified eligibility criteria. CONSORT-EHEALTH checklist was used for data extraction of qualitative and quantitative data (study characteristics and study results) and the Cochrane Risk of Bias Tool (version 2) for quality assessment independently by two researchers.

Seven RCT conducted in Europe and the United States were included in this systematic review with a total sample size of N = 946. Observation periods were heterogeneous and ranged from 3 to 24 months. The evaluated interventions consisted of websites or apps, all of which included nutrition and physical activity features, and functioned independently with minimal or no involvement of a healthcare professional. All studies showed a high risk of bias, no statistically significant improvement and no effects regarding QoL using different validated questionnaires.

This systematic review provides a comprehensive analysis of DiHA effectiveness on QoL in patients with overweight or obesity. Overall, there is heterogeneity regarding the operationalization of QoL and the examined interventions have no statistically significant impact on QoL. Comparable systematic reviews show that digital interventions have the potential to improve the QoL of these patients, but further RCT and high-quality studies are needed to assess the impact of DiHA on QoL.

PROSPERO CRD42023408994.

The purpose of this study was to investigate perceptions and opinions on what constitutes determinants for quality of life (QoL) in individuals with syndromic Heritable Aortic Disease (sHTAD), utilizing a qualitative study approach. Further to discuss clinical implications and direction for research.

A qualitative focus group interview study was conducted of 47 adults (Marfan syndrome (MFS) = 14, Loeys-Dietz syndrome (LDS) = 11, vascular Ehlers Danlos syndrome (EDS) = 11, relatives = 11). The interviews were digitally recorded and transcribed verbatim. Significant themes were identified, extracted, and organised undergoing content analyses.

The two main themes and 10 subthemes identified; I. Psychosocial well-being; (i) Social engagement and activity, (ii) Self-sufficient in daily living, (iii) Participation in education and work life, (iv) Coping with fear related to the disease, (v) Being able to control and accept fatigue and pain, (vi) Maintaining active engagement with family and friends (vii) Finding health-promoting physical activities. II. Monitoring and meetings with the health service: (viii) Feeling safe and receiving coordinated care, (ix) Being recognized, seen, and accepted, (x) Receiving factual and sober information and advice. The sub-themes seemed mutually interrelated in terms of barriers, strategies, and facilitators for improving quality of life. There was high degree of consensus regarding the factors emphasized as important for QoL among the various diagnostic groups and the relatives.

Based on our findings, to improve QoL in patients with sHTAD we should more effectively integrate the patient`s perspectives and voice on the elements crucial to QoL. In addition, it is vital for developing and customizing validated questionnaires to accurately reflect the factors deemed significant by this specific patient cohort. The research is limited on patients' perspectives on QoL, and more research is warranted. This might also be crucial for identifying relevant validated QoL instruments that reflect the patients` perceptions of what is vital for QoL.

This study aimed to investigate the relationships between generic health-related quality of life (HRQoL), the Big Five personality traits, speech understanding, and sociodemographic factors in a group of postlingually deaf cochlear implant (CI) users.

The study group included 81 participants who met the inclusion criteria: profound sensorineural hearing loss, 18 years of age or more, and using at least one CI implanted after 18 years of age. Some 18% were bilateral CI users. The mean age of the participants was 60 ± 11 years. They completed the Assessment of Quality of Life (AQoL-8D) and the Short Form IPIP-BFM-20 (shortened version of the 50-item Big Five Markers Questionnaire from the International Personality Item Pool). The response rate was 57%.

The HRQoL was lower in the study group than in the general population. Moreover, all Big Five personality characteristics were significantly lower than the Polish norm. The personality traits of intellect/imagination, emotional stability, and extraversion contributed to higher overall HRQoL scores, particularly for most psychosocial AQoL-8D dimensions. Higher agreeableness predicted higher HRQoL in the Independent Living, Pain, Coping, and Relations dimensions, whereas higher extraversion predicted higher physical HRQoL in the Senses dimension. Better speech understanding in quiet and noisy environments correlated with better physical HRQoL. Additionally, male gender and higher education were linked to higher global HRQoL. Conversely, being female was associated with lower global psychosocial and physical HRQoL, particularly in Pain. Higher education also contributed to improved physical HRQoL.

In general, CI users have lower physical and psychosocial HRQoL as well as in measures that depend on personality traits. In terms of physical HRQoL, speech understanding plays an important role. It might prove useful if CI candidates and users were given a Big Five personality evaluation and an HRQoL assessment based on which they might be offered counseling or psychological intervention.

The aim of this study was to assess quality of life and associated factors among hypertensive patients attending in public hospital at Addis Ababa.

An institutional -based cross-sectional study was conduct among adults in Addis Ababa selected public hospitals. Systematic sampling technique was used to select 423 study participants after proportional allocation was made on each hospital. Data was collected by questionnaire adapted from WHO STEP wise approach to Surveillance on NCDs modified by the FMOH and EPHI. Data entry, cleaning by data exploration and analysis was done by using SPSS. Descriptive and logistic regression models were used for data analysis. The result was considered statistically significant at p < 0.05.

The magnitude of high health-related quality of life in hypertensive patients was 53.6% (with 95% CI: 48.6-58.6). Having experienced any complications co morbidities HRQOL (AOR = 7.177; CI = 4.761-9.698), Starting treatment for hypertension below 3 years were (AOR= 3.029: CI=2.406-9.133, higher educational level (AOR=3.477: CI= 0.708-17.059), age 40 and above (AOR=3.216: CI= 1.073-9.643), having an income of <3000birr (AOR=1.75: CI= 1.14-2.68) were significantly associated with the dependent variable.

This study showed the magnitude of low health-related quality of life in hypertensive patients is high. Having complications or co morbidities, starting treatment for hypertension below 3 years, being educated, older age, income of less than 3000 per month were factors associated to low health related quality of life in hypertensive patients.

Previous studies have demonstrated that individuals with inflammatory bowel disease (IBD) experience distinct symptom clusters and generally have a lower quality of life compared to the general population. Rumination refers to the persistent and repetitive contemplation of the causes, consequences, and intricate details of a negative and stressful event. The multiple symptom clusters of IBD cause great distress, physical and financial stress, and thus may increase the level of rumination in patients. However, the relationship between rumination, symptom clusters, and quality of life in IBD patients remains unclear. Therefore, the objective of this study was to assess the state of rumination and examine its association with symptom clusters and quality of life among individuals with IBD. This study found a significant positive correlation between rumination and symptom clusters, while a significant negative correlation between rumination and quality of life in IBD patients (p < .001). Patients with higher levels of rumination in IBD exhibited more severe symptoms and poorer quality of life. Reducing rumination levels may prove beneficial in alleviating symptoms and improving the quality of life for IBD patients. In daily nursing practice, timely evaluation of rumination and appropriate interventions are essential to achieve better therapeutic outcomes.

The objective of this systematic review was to synthesise the evidence of the impact of pressure injuries (PIs) on the health-related quality of life (HRQoL) of adults aged 18 years and older. Electronic databases (Ovid Medline, Ovid Embase, CINAHL EBSCO, Scopus and Central Register of Controlled Trials) were searched for eligible studies published between January 2019 and April 2024. All identified articles were reviewed by two reviewers against the eligibility criteria. The risk of bias was assessed using the Mixed Methods Appraisal Tool and the Joanna Briggs Institute critical appraisal tool. Data were narratively synthesised due to methodological heterogeneity. Twenty-two studies (12 quantitative; 9 qualitative;1 mixed methods) met the inclusion criteria. The qualitative studies were grouped into four impact areas: symptoms, physical function, psychological well-being and social functioning. Five instruments were used to assess HRQoL and identified low scores in people with PIs, with the lowest scores mostly reported in physical functioning and role physical and emotional concepts. A complexity of factors influenced theHRQoL of people with PI. This review synthesised both quantitative and qualitative evidence indicating PI was associated with low HRQoL scores and negatively affected all aspects of HRQoL. This review emphasised the complexity of factors related to PI and its impact on HRQoL. Further emphasis on the impact of the complexity of factors on HRQoL of people with PI should be considered in future studies.

Connected health (CH) interventions may improve psychological wellbeing and quality of life (QoL) in caregivers and people with multiple sclerosis (MS); however, this impact has not been rigorously evaluated. This systematic review aims to synthesize the literature assessing CH technology's impact on psychological wellbeing and/or QoL of people with MS (PwMS) and/or their caregivers.

This systematic review's protocol is registered with International Prospective Register of Systematic Reviews (PROSPERO) with identification number CRD42023402434. CINAHL, Web of Science, PubMed, Embase, and PsycINFO databases were searched with terms relating to (a) CH; (b) MS; (c) psychological wellbeing/QoL; and (d) caregivers/people with MS. Of 2821 screened articles, 47 met the eligibility criteria, with just three including MS caregivers.

Heterogenous interventions supporting self-management (n = 20 studies), education (n = 17 studies), psychological (n = 14 studies) or physical (n = 9 studies) rehabilitation and peer support (n = 5 studies) were found. CH technologies had mixed effectiveness in improving psychological and QoL outcomes, with results potentially impacted by technology type, intervention and target group. The study's findings have limited generalizability to improve access across sub-national locations, with no studies disaggregating between urban and rural residence and the majority conducted in the USA and Western Europe.

CH technologies show promise in improving psychological wellbeing and QoL among PwMS and their caregivers. However, this necessitates further study comparing connected health and MS subtypes to improve reproducibility and effectiveness.

Although it is generally recognized that symptom clusters and quality of life are related, major ambiguity arises from the difficulty in determining their causal relationship. The present study aimed to investigate longitudinal causal relationships between symptom clusters and quality of life. 128 patients with rectal cancer from Nanchong City, Sichuan Province who underwent laparoscopic anus-preserving surgery completed 4 follow-up visits, and the survey time point are 2 weeks after surgery (T1), 1 month after surgery (T2), 3 months after surgery (T3), and 6 months after surgery (T4). We used the Anderson Gastrointestinal Cancer Symptom Assessment Scale and the Colorectal Cancer Quality of Life Measurement Scale to evaluate the patient's symptom incidence, symptom severity, and quality of life at four time points respectively. After extracting symptom clusters by symptom, we constructed A four-wave cross-lagged model analyzed the causal relationship between symptom clusters and quality of life. Our research results show that the patients with rectal cancer treated by laparoscopic anus-preserving surgery have four symptom clusters during the 6 months after surgery, which are named sickness symptom cluster, gastrointestinal symptom cluster, psychological-sleep symptom cluster and Psycho-therapy related symptom clusters. Pearson correlation analysis showed that symptom clusters and quality of life were negatively correlated. The cross-lagged path effect coefficient shows that the impact of quality of life on symptom clusters is stronger than the impact of symptom clusters on quality of life (β = - 0.164 to - 0.713, P<0.05). The four-wave cross-lagged model showed that quality of life can significantly negatively predict the sickness symptom cluster and gastrointestinal symptom cluster, but this relationship is not bidirectional. Only T3 quality of life significantly negatively predicted the psycho-sleep symptom cluster, and the reverse path was also not observed. These findings provide evidence that decreases in quality of life levels precede increases in symptom cluster severity. There is a one-way temporal correlation between symptom clusters and quality of life. The decrease in quality of life leads to an increase in the severity of symptom clusters. The improvement in overall quality of life is expected to alleviate the distress of symptom clusters.