|
1
|
Fisher H, Jaffe N, Pidvirny K, Tierney A, Pizzagalli D, Webb C. Using Natural Language Processing to Track Negative Emotions in the Daily Lives of Adolescents. RESEARCH SQUARE 2025:rs.3.rs-6414400. [PMID: 40321753 PMCID: PMC12047991 DOI: 10.21203/rs.3.rs-6414400/v1] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Grants] [Track Full Text] [Figures] [Subscribe] [Scholar Register] [Indexed: 05/09/2025]
Abstract
Tracking emotion fluctuations in adolescents' daily lives is essential for understanding mood dynamics and identifying early markers of affective disorders. This study examines the potential of text-based approaches for emotion prediction by comparing nomothetic (group-level) and idiographic (individualized) models in predicting adolescents' daily negative affect (NA) from text features. Additionally, we evaluate different Natural Language Processing (NLP) techniques for capturing within-person emotion fluctuations. We analyzed ecological momentary assessment (EMA) text responses from 97 adolescents (ages 14-18, 77.3% female, 22.7% male, NEMA=7,680). Text features were extracted using a dictionary-based approach, topic modeling, and GPT-derived emotion ratings. Random Forest and Elastic Net Regression models predicted NA from these text features, comparing nomothetic and idiographic approaches. All key findings, interactive visualizations, and model comparisons are available via a companion web app: https://emotracknlp.streamlit.app/. Idiographic models combining text features from different NLP approaches exhibited the best performance: they performed comparably to nomothetic models in R2 but yielded lower prediction error (Root Mean Squared Error), improving within-person precision. Importantly, there were substantial between-person differences in model performance and predictive linguistic features. When selecting the best-performing model for each participant, significant correlations between predicted and observed emotion scores were found for 90.7-94.8% of participants. Our findings suggest that while nomothetic models offer initial scalability, idiographic models may provide greater predictive precision with sufficient within-person data. A flexible, personalized approach that selects the optimal model for each individual may enhance emotion monitoring, while leveraging text data to provide contextual insights that could inform appropriate interventions.
Collapse
Affiliation(s)
| | | | | | | | - Diego Pizzagalli
- Noel Drury, M.D. Institute for Translational Depression Discoveries, University of California
| | | |
Collapse
|
|
2
|
Yu TF, Liu L, Shang LN, Xu FF, Chen ZM, Qian LJ. Dysfunctional attitudes, social support, negative life events, and depressive symptoms in Chinese adolescents: A moderated mediation model. World J Psychiatry 2024; 14:1671-1680. [PMID: 39564176 PMCID: PMC11572672 DOI: 10.5498/wjp.v14.i11.1671] [Citation(s) in RCA: 2] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 04/22/2024] [Revised: 05/22/2024] [Accepted: 07/31/2024] [Indexed: 11/07/2024] Open
Abstract
BACKGROUND Depression is a prevalent psychological issue in adolescents that is significantly related to negative life events (NLEs) and dysfunctional attitudes. High levels of social support can significantly buffer NLEs' effect on depression. Currently, there is limited research on how social support moderates the relationship between NLEs, dysfunctional attitudes, and depression in adolescents in China. It is imperative to investigate this moderating effect to mitigate dysfunctional attitudes in adolescent undergoing depressive mood, ultimately enhancing their overall mental health. AIM To investigate the relationship and underlying mechanisms between specific dysfunctional attitudes, social support, and depression among Chinese adolescents. METHODS This is a cross-sectional study which selected five middle schools in Shandong Province for investigation in March 2022. Participants included 795 adolescents (49.87% male, mage = 15.15, SD = 1.84, age range = 11-18 years old). All participants completed the Dysfunctional Attitude Scale, Adolescent Life Event Scale, Beck Depression Inventory, and Social Support Rating Scale. A moderated mediation model was conducted to examine the relationship between specific dysfunctional attitudes, social support, and depression. RESULTS Results indicated that NLEs affected depression through the mediating role of specific dysfunctional attitudes (autonomy attitudes β = 0.21; perfectionism β = 0.25). Moreover, social support was found to moderate the mediating effect between NLEs, specific dysfunctional attitudes, and depressive symptoms (autonomy attitudes b2 = -0.08; perfectionism b2 = -0.09). CONCLUSION Dysfunctional attitudes mediated and social support moderated the relationship between NLEs and depression. Social support can buffer depression symptoms among adolescents with autonomy attitudes and perfectionism.
Collapse
Affiliation(s)
- Teng-Fei Yu
- Department of Children and Adolescent Mental Health, Shandong Daizhuang Hospital, Jining 272000, Shandong Province, China
| | - Li Liu
- Department of Alcohol Addition, Shandong Daizhuang Hospital, Jining 272000, Shandong Province, China
| | - Lu-Ning Shang
- Department of Children and Adolescent Mental Health, Shandong Daizhuang Hospital, Jining 272000, Shandong Province, China
| | - Fang-Fang Xu
- Department of Children and Adolescent Mental Health, Shandong Daizhuang Hospital, Jining 272000, Shandong Province, China
| | - Zhi-Min Chen
- Department of Alcohol Addition, Shandong Daizhuang Hospital, Jining 272000, Shandong Province, China
| | - Li-Ju Qian
- Department of Children and Adolescent Mental Health, Shandong Daizhuang Hospital, Jining 272000, Shandong Province, China
| |
Collapse
|
|
3
|
Schwartz JJ, Roske C, Liu Q, Tobe RH, Ely BA, Gabbay V. C-Reactive Protein Does Not Predict Future Depression Onset in Adolescents: Preliminary Findings from a Longitudinal Study. J Child Adolesc Psychopharmacol 2024; 34:233-240. [PMID: 38669109 PMCID: PMC11322627 DOI: 10.1089/cap.2023.0091] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 04/28/2024]
Abstract
Introduction: Neuroinflammatory processes have been extensively implicated in the underlying neurobiology of numerous neuropsychiatric disorders. Elevated C-reactive protein (CRP), an indicator of nonspecific inflammation commonly utilized in clinical practice, has been associated with depression in adults. In adolescents, our group previously found CRP to be associated with altered neural reward function but not with mood and anxiety symptoms assessed cross-sectionally. We hypothesized that the distinct CRP findings in adolescent versus adult depression may be due to chronicity, with neuroinflammatory effects on psychiatric disorders gradually accumulating over time. Here, we conducted a longitudinal study to evaluate if CRP levels predicted future onset or progression of depression in adolescents. Methods: Participants were 53 adolescents (age = 14.74 ± 1.92 years, 35 female), 40 with psychiatric symptoms and 13 healthy controls. At baseline, participants completed semistructured diagnostic evaluations; dimensional assessments for anxiety, depression, anhedonia, and suicidality severity; and bloodwork to quantify CRP levels. Clinical assessments were repeated at longitudinal follow-up after ∼1.5 years. Spearman's correlation between CRP levels and follow-up symptom severity were controlled for body mass index, age, sex, and follow-up interval and considered significant at the two-tailed, Bonferroni-adjusted p < 0.05 level. Results: After correction for multiple comparisons, no relationships were identified between baseline CRP levels and follow-up symptom severity. Conclusion: CRP levels were not significantly associated with future psychiatric symptoms in adolescents in this preliminary analysis. This may suggest that CRP is not a useful biomarker for adolescent depression and anxiety. However, future longitudinal studies with larger sample sizes and incorporating additional indicators of neuroinflammation are needed.
Collapse
Affiliation(s)
- Joshua J. Schwartz
- Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, New York, USA
| | - Chloe Roske
- Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, New York, USA
- Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, Florida, USA
| | - Qi Liu
- Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, New York, USA
| | - Russel H. Tobe
- The Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York, USA
| | - Benjamin A. Ely
- Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, Florida, USA
| | - Vilma Gabbay
- Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, Florida, USA
- The Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York, USA
| |
Collapse
|
|
4
|
Gupta T, Eckstrand KL, Forbes EE. Annual Research Review: Puberty and the development of anhedonia - considering childhood adversity and inflammation. J Child Psychol Psychiatry 2024; 65:459-480. [PMID: 38391011 PMCID: PMC10939801 DOI: 10.1111/jcpp.13955] [Citation(s) in RCA: 4] [Impact Index Per Article: 4.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Accepted: 01/12/2024] [Indexed: 02/24/2024]
Abstract
Anhedonia, or diminished pleasure and motivation, is a symptom of severe mental illness (e.g., depressive disorder, bipolar disorder, schizophrenia) that emerges during adolescence. Anhedonia is a pernicious symptom that is related to social impairments, treatment resistance, and suicide. As the mechanisms of anhedonia are postulated to include the frontostriatal circuitry and the dopamine neuromodulatory system, the development and plasticity of these systems during the vulnerable period of adolescence, as well as their sensitivity to pubertal hormones, suggest that pubertal maturation could play a role in the development of anhedonia. This review takes a developmental perspective, considering the possibility that anhedonia emerges in the context of pubertal maturation and adolescent development, with childhood adversity and chronic inflammation influencing neural reward systems to accelerate anhedonia's progression. Here, we review the relevant extant literature on the components of this model and suggest directions for future research.
Collapse
Affiliation(s)
- Tina Gupta
- University of Pittsburgh, Department of Psychiatry, Pittsburgh, PA USA
| | | | - Erika E. Forbes
- University of Pittsburgh, Department of Psychiatry, Pittsburgh, PA USA
- University of Pittsburgh, Department of Psychology, Pittsburgh, PA USA
- University of Pittsburgh, Department of Pediatrics, Pittsburgh PA USA
- University of Pittsburgh, Department of Clinical and Translational Science, Pittsburgh PA USA
| |
Collapse
|
|
5
|
Gupta T, Eckstrand KL, Lenniger CJ, Haas GL, Silk JS, Ryan ND, Phillips ML, Flores LE, Pizzagalli DA, Forbes EE. Anhedonia in adolescents at transdiagnostic familial risk for severe mental illness: Clustering by symptoms and mechanisms of association with behavior. J Affect Disord 2024; 347:249-261. [PMID: 37995926 PMCID: PMC10843785 DOI: 10.1016/j.jad.2023.11.062] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/25/2023] [Revised: 11/07/2023] [Accepted: 11/17/2023] [Indexed: 11/25/2023]
Abstract
BACKGROUND Anhedonia is a transdiagnostic symptom of severe mental illness (SMI) and emerges during adolescence. Possible subphenotypes and neural mechanisms of anhedonia in adolescents at risk for SMI are understudied. METHODS Adolescents at familial risk for SMI (N = 81) completed anhedonia (e.g., consummatory, anticipatory, social), demographic, and clinical measures and one year prior, a subsample (N = 46) completed fMRI scanning during a monetary reward task. Profiles were identified using k-means clustering of anhedonia type and differences in demographics, suicidal ideation, impulsivity, and emotional processes were examined. Moderation analyses were conducted to investigate whether levels of brain activation of reward regions moderated the relationships between anhedonia type and behaviors. RESULTS Two-clusters emerged: a high anhedonia profile (high-anhedonia), characterized by high levels of all types of anhedonia, (N = 32) and a low anhedonia profile (low-anhedonia), characterized by low levels of anhedonia types (N = 49). Adolescents in the high-anhedonia profile reported more suicidal ideation and negative affect, and less positive affect and desire for emotional closeness than low-anhedonia profile. Furthermore, more suicidal ideation, less positive affect, and less desire for emotional closeness differentiated the familial high-risk, high-anhedonia profile adolescents from the familial high-risk, low-anhedonia profile adolescents. Across anhedonia profiles, moderation analyses revealed that adolescents with high dmPFC neural activation in response to reward had positive relationships between social, anticipatory, and consummatory anhedonia and suicidal ideation. LIMITATIONS Small subsample with fMRI data. CONCLUSION Profiles of anhedonia emerge transdiagnostically and vary on clinical features. Anhedonia severity and activation in frontostriatal reward areas have value for clinically important outcomes such as suicidal ideation.
Collapse
Affiliation(s)
- T Gupta
- University of Pittsburgh, Department of Psychiatry, Pittsburgh, PA, USA.
| | - K L Eckstrand
- University of Pittsburgh, Department of Psychiatry, Pittsburgh, PA, USA
| | - C J Lenniger
- University of Pittsburgh, Department of Psychology, Pittsburgh, PA, USA
| | - G L Haas
- University of Pittsburgh, Department of Psychiatry, Pittsburgh, PA, USA; University of Pittsburgh, Department of Psychology, Pittsburgh, PA, USA; VA Pittsburgh Healthcare System, Pittsburgh, PA, USA
| | - J S Silk
- University of Pittsburgh, Department of Psychiatry, Pittsburgh, PA, USA; University of Pittsburgh, Department of Psychology, Pittsburgh, PA, USA
| | - N D Ryan
- University of Pittsburgh, Department of Psychiatry, Pittsburgh, PA, USA
| | - M L Phillips
- University of Pittsburgh, Department of Psychiatry, Pittsburgh, PA, USA
| | - L E Flores
- Queens University, Department of Psychology, Kingston, Ontario, CA, USA
| | - D A Pizzagalli
- Harvard Medical School and McLean Hospital, Department of Psychiatry, Boston, MA, USA
| | - E E Forbes
- University of Pittsburgh, Department of Psychiatry, Pittsburgh, PA, USA; University of Pittsburgh, Department of Psychology, Pittsburgh, PA, USA; University of Pittsburgh, Department of Pediatrics, Pittsburgh, PA, USA; University of Pittsburgh, Department of Clinical and Translational Science, Pittsburgh, PA, USA
| |
Collapse
|
|
6
|
Schwartz JJ, Roske C, Liu Q, Tobe RH, Ely BA, Gabbay V. C-reactive protein does not predict future depression onset in adolescents: preliminary findings from a longitudinal study. MEDRXIV : THE PREPRINT SERVER FOR HEALTH SCIENCES 2023:2023.10.26.23297634. [PMID: 37961448 PMCID: PMC10635217 DOI: 10.1101/2023.10.26.23297634] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 11/15/2023]
Abstract
Introduction Neuroinflammatory processes have been extensively implicated in the underlying neurobiology of numerous neuropsychiatric disorders. Elevated C-reactive protein (CRP), an indicator of non-specific inflammation commonly utilized in clinical practice, has been associated with depression in adults. In adolescents, our group previously found CRP to be associated with altered neural reward function but not with mood and anxiety symptoms assessed cross-sectionally. We hypothesized that the distinct CRP findings in adolescent vs. adult depression may be due to chronicity, with neuroinflammatory effects on psychiatric disorders gradually accumulating over time. Here, we conducted a longitudinal study to evaluate if CRP levels predicted future onset or progression of depression in adolescents. Methods Participants were 53 adolescents (ages 14.74 ± 1.92, 35 female), 40 with psychiatric symptoms and 13 healthy controls. At baseline, participants completed semi-structured diagnostic evaluations; dimensional assessments for anxiety, depression, anhedonia, and suicidality severity; and bloodwork to quantify CRP levels. Clinical assessments were repeated at longitudinal follow-up after approximately 1.5 years. Spearman's correlation between CRP levels and follow-up symptom severity were controlled for BMI, age, sex, and follow-up interval and considered significant at the two-tailed, Bonferroni-adjusted p < 0.05 level. Results After correction for multiple comparisons, no relationships were identified between baseline CRP levels and follow-up symptom severity. Conclusion CRP levels were not significantly associated with future psychiatric symptoms in adolescents in this preliminary analysis. This may suggest that CRP is not a useful biomarker for adolescent depression and anxiety. However, future longitudinal studies with larger sample sizes and incorporating additional indicators of neuroinflammation are needed.
Collapse
Affiliation(s)
- Joshua J Schwartz
- Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, NY
| | - Chloe Roske
- Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, NY
| | - Qi Liu
- Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, NY
| | - Russel H Tobe
- The Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY
| | - Benjamin A Ely
- Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, NY
| | - Vilma Gabbay
- Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, NY
- The Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY
| |
Collapse
|
|
7
|
Potsch L, Rief W. Transdiagnostic considerations of the relationship between reward sensitivity and psychopathological symptoms - a cross-lagged panel analysis. BMC Psychiatry 2023; 23:650. [PMID: 37667190 PMCID: PMC10478275 DOI: 10.1186/s12888-023-05139-3] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/23/2023] [Accepted: 08/25/2023] [Indexed: 09/06/2023] Open
Abstract
BACKGROUND Reward sensitivity constitutes a potential key mechanism regarding the etiology and maintenance of mental disorders, especially depression. However, due to a lack of longitudinal studies, the temporal dynamics are not clear yet. Although some evidence indicates that reward processing could be a transdiagnostic mechanism of disorders, these observations could be also a product of comorbidity with depression. This study aimed at investigating the temporal dynamics of reward sensitivity and the course of psychopathological symptoms in a longitudinal investigation, while taking a possible mediating role of depression into account. METHODS We conducted a three-wave longitudinal online survey with a 4-week interval. A total of N = 453 participants filled out all three questionnaires. Reward sensitivity was assessed with the Positive Valence System Scale-21 (PVSS-21), depression with the Patient Health Questionnaire (PHQ-9), eating disorder symptoms with the Eating Disorder Examination-Questionnaire-8 (EDE-Q-8), social anxiety with the Mini-social phobia inventory (Mini-SPIN) and alcohol consumption with the Alcohol Use Disorders Identification Test-Consumption (AUDIT-C). Cross-lagged panels and mediation analyses were calculated using path analyses. RESULTS Depressive and eating disorder symptoms predicted reward insensitivity at later points in time. Effects were larger from T2 to T3. A bidirectional relationship concerning social anxiety was found. Higher alcohol consumption predicted higher reward sensitivity. Depression at T2 fully mediated the association between psychopathological symptoms at T1 and reward sensitivity at T3 for social anxiety and eating disorder symptoms. CONCLUSIONS Our findings imply that reduced reward sensitivity seems to be a consequence rather than an antecedent of psychopathological symptoms. Comorbid depression plays a crucial role in other mental disorders regarding observed hyposensitivity towards rewards. Therefore, our results do not support a transdiagnostic notion of reward sensitivity, but they indicate a potential role of reward sensitivity for symptom persistence. TRIAL REGISTRATION The study was preregistered at the Open Science Framework (OSF) ( https://archive.org/details/osf-registrations-6n3s8-v1 ; registration DOI https://doi.org/10.17605/OSF.IO/6N3S8 ).
Collapse
Affiliation(s)
- L Potsch
- Clinical Psychology and Psychotherapy, Department of Psychology, Philipps-University of Marburg, Gutenbergstr. 18, D-35032, Marburg, Germany.
| | - W Rief
- Clinical Psychology and Psychotherapy, Department of Psychology, Philipps-University of Marburg, Gutenbergstr. 18, D-35032, Marburg, Germany
| |
Collapse
|
|
8
|
Burkhouse KL, Dao A, Argiros A, Granros M, Cárdenas E, Dickey L, Feurer C, Hill K, Pegg S, Venanzi L, Kujawa A. Targeting positive valence systems function in children of mothers with depressive symptoms: A pilot randomized trial of an RDoC-Informed preventive intervention. Behav Res Ther 2023; 168:104384. [PMID: 37591042 PMCID: PMC10542884 DOI: 10.1016/j.brat.2023.104384] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/26/2023] [Revised: 07/27/2023] [Accepted: 08/03/2023] [Indexed: 08/19/2023]
Abstract
Reduced activation of the Research Domain Criteria (RDoC) positive valence systems (PVS) is observed in high-risk (HR) children of depressed mothers and predictive of future psychopathologies. We developed a dyadic, neuroscience-informed preventive intervention, Family Promoting Positive Emotions (FPPE), designed to prevent psychopathology in HR children by targeting PVS processes. We evaluated the initial efficacy of FPPE compared to written information (WI) psychoeducation in engaging PVS-related targets and reducing perceived stress and emotional distress symptoms in HR youth. Participants included 74 children ages 8-12 years and their biological mothers reporting elevated depressive symptoms. Following random assignment, 55 dyads completed FPPE (n = 29) or WI (n = 26) and pre-post assessments of child clinical symptoms. Youth completed a reinforcement learning task and 10 days of positive affect ratings to assess PVS-related targets. Results revealed a small within-subjects increase in child daily positive affect in FPPE, but not WI. Further, FPPE resulted in reductions in mother-reported child perceived stress and symptoms of anger, anxiety, and depression with medium-to-large within-subjects effects. Intervention effects on reinforcement learning and child-rated clinical symptoms were not observed. This study suggests FPPE shows promise in enhancing positive affect and reducing the emergence of clinical symptoms in HR children. CLINICALTRIALS.GOV IDENTIFIER: NCT05223842.
Collapse
Affiliation(s)
- Katie L Burkhouse
- The Research Institute, Nationwide Children's Hospital, USA; The Ohio State University, Department of Psychiatry and Behavioral Health, USA
| | - Anh Dao
- Vanderbilt University, Department of Psychology and Human Development, USA
| | - Alexandra Argiros
- Vanderbilt University, Department of Psychology and Human Development, USA
| | - Maria Granros
- University of Illinois at Chicago, Department of Psychiatry, USA
| | - Emilia Cárdenas
- Vanderbilt University, Department of Psychology and Human Development, USA
| | - Lindsay Dickey
- Vanderbilt University, Department of Psychology and Human Development, USA
| | - Cope Feurer
- University of Illinois at Chicago, Department of Psychiatry, USA
| | - Kaylin Hill
- Vanderbilt University, Department of Psychology and Human Development, USA
| | - Samantha Pegg
- Vanderbilt University, Department of Psychology and Human Development, USA
| | - Lisa Venanzi
- Vanderbilt University, Department of Psychology and Human Development, USA
| | - Autumn Kujawa
- Vanderbilt University, Department of Psychology and Human Development, USA.
| |
Collapse
|
|
9
|
Medina CM, Ingram KM, Espelage DL. Proxies of Emotion Dysregulation and Teen Dating Violence Perpetration: A Latent Profile Analysis. J Adolesc Health 2023; 73:88-94. [PMID: 37031093 DOI: 10.1016/j.jadohealth.2023.02.012] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 06/20/2022] [Revised: 12/12/2022] [Accepted: 02/06/2023] [Indexed: 04/10/2023]
Abstract
PURPOSE Teen dating violence (TDV) must be addressed as a public health issue due to its prevalence and association with negative health outcomes among victims. To prevent TDV, it is essential to examine the risk factors of dating violence perpetration's applicability to younger samples. Using a population health approach, this study explored the associations among variables that affect emotion regulation and TDV perpetration of multiple types among a diverse sample of high school students. METHODS Latent profile analysis of four self-reported variables related to emotion regulation (anger regulation, depressive symptoms, impulsivity, and alcohol use) was conducted among a sample of 1,508 students. Next, regression analyses were used to test the relation between latent profile membership and self-reported TDV perpetration across two time points. RESULTS A three-profile solution was found to be the solution of best fit (profile 1: n = 1,023, profile 2: n = 43, and profile 3: n = 442). Profile one had low means across all indicators; profile two had a high mean of recent alcohol use; and profile three had low to moderate means across all indicators. Profile two was associated with the most frequent lifetime perpetration and perpetration one year later. However, all three profiles were only associated with infrequent perpetration. DISCUSSION This study found that an emotional regulatory framework was applicable to assess some risks of TDV. These findings justify further research on the relation between emotion regulation and TDV perpetration; however, risk factors at other socio-ecological levels should be incorporated to strengthen existing theories.
Collapse
Affiliation(s)
- Courtney M Medina
- Peabody School of Education, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
| | - Katherine M Ingram
- Peabody School of Education, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
| | - Dorothy L Espelage
- Peabody School of Education, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
| |
Collapse
|
|
10
|
Intersecting identities and adolescent depression: Patterns of depressed mood and anhedonia in the past decade. J Affect Disord 2022; 319:518-525. [PMID: 36162694 DOI: 10.1016/j.jad.2022.09.088] [Citation(s) in RCA: 4] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/10/2022] [Revised: 09/16/2022] [Accepted: 09/20/2022] [Indexed: 10/14/2022]
Abstract
BACKGROUND Research suggests adolescent depression is increasing and certain adolescents may be uniquely vulnerable. However, limited conceptualizations of identity and time, as well as the reliance on unitary conceptualizations of depression, inhibits a nuanced perspective on these trends. In response, we examined how adolescent depressive symptoms, depressed mood, and anhedonia, vary across intersecting identities over time. METHODS Secondary data analysis on the National Survey on Drug Use and Health between 2009 and 2017 was conducted. In total 145,499 nationally representative adolescents (ages 12-17) completed a diagnostic assessment for depression. Lifetime and past year reports of depressive symptoms, depressed mood, and anhedonia were treated as separate variables. A novel, mixed-level model in which participants were nested within identity (defined by one's age, gender, race/ethnicity, poverty level) and time was used to test our aims. RESULTS Overall, the relation between depression outcomes and identity did not vary over time (p > .01). Further, identity's impact on depression was approximately ten-fold that of temporal effects. Multiracial, late adolescent, female adolescents were at particular risk. Findings concerning depressed mood and anhedonia were similar across analyses. LIMITATIONS All facets of identity (e.g., sexual identity) were not included in the model and a unidimensional measure of poverty may have underestimated its depressogenic influence. CONCLUSION Adolescent depression outcomes are mostly consistent across criterial symptom subtypes and time, but vary as a function of identity. Prevention protocols that highlight mechanisms of risk tethered to social identity, and include salient experiences of females, late adolescents, and multiracial youth in particular, need to be prioritized in mental health initiatives.
Collapse
|
|
11
|
Wang X, Lu J, Liu Q, Yu Q, Fan J, Gao F, Han Y, Liu X, Yao R, Zhu X. Childhood experiences of threat and deprivation predict distinct depressive symptoms: A parallel latent growth curve model. J Affect Disord 2022; 319:244-251. [PMID: 36162654 DOI: 10.1016/j.jad.2022.09.061] [Citation(s) in RCA: 15] [Impact Index Per Article: 5.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 04/15/2022] [Revised: 05/31/2022] [Accepted: 09/20/2022] [Indexed: 12/01/2022]
Abstract
BACKGROUND/AIM There is growing awareness that specific childhood trauma (CT) may confer to the unique risk of depression, but little is known about this. The present study seeks to provide insight into how CT subtypes may impact distinct depressive symptoms over time based on the dimensional model of adversity (DMA). METHODS A total of 3535 college freshmen participated in a 2-year, four waves longitudinal tracking study. A conditional parallel latent growth curve model (LGCM) was constructed to examine the impacts of different types of CT (threat and deprivation) on the development of depressed mood and anhedonia, and whether these relationships vary across gender. RESULTS Our findings revealed that threat and deprivation could differentially relate to depressed mood and anhedonia. Both threat and deprivation predicted initial depressed mood levels (β = 0.309, p < 0.001; β = 0.175, p < 0.001, respectively) and its trajectory (β = -0.139, p = 0.068; β = -0.168, p < 0.05, respectively). Only deprivation predicted anhedonia levels (β = 0.318, p < 0.001) and trajectory (β = -0.218, p < 0.001). This pattern of relationships between CT and depressive symptoms varied across gender. CONCLUSION These findings highlight specific pathways and symptomatic manifestations of the impacts of different CT subtypes on depression and are consistent with the hypothesis of DMA. Threat and deprivation predicted more severe depressed mood, whereas deprivation uniquely conferred to the risk of depression via elevated anhedonia. Meanwhile, the deleterious effects of CT would persist during early adulthood. Gender differences were also discussed.
Collapse
Affiliation(s)
- Xiang Wang
- Medical Psychological Center, the Second Xiangya Hospital of Central South University, Changsha, Hunan, China; Medical Psychological Institute of Central South University, Changsha, Hunan, China; National Clinical Research Center for Mental Disorders, Changsha, Hunan, China
| | - Jingjie Lu
- Medical Psychological Center, the Second Xiangya Hospital of Central South University, Changsha, Hunan, China; Medical Psychological Institute of Central South University, Changsha, Hunan, China; National Clinical Research Center for Mental Disorders, Changsha, Hunan, China
| | - Qian Liu
- Medical Psychological Center, the Second Xiangya Hospital of Central South University, Changsha, Hunan, China; Medical Psychological Institute of Central South University, Changsha, Hunan, China; National Clinical Research Center for Mental Disorders, Changsha, Hunan, China
| | - Quanhao Yu
- Medical Psychological Center, the Second Xiangya Hospital of Central South University, Changsha, Hunan, China; Medical Psychological Institute of Central South University, Changsha, Hunan, China; National Clinical Research Center for Mental Disorders, Changsha, Hunan, China
| | - Jie Fan
- Medical Psychological Center, the Second Xiangya Hospital of Central South University, Changsha, Hunan, China; Medical Psychological Institute of Central South University, Changsha, Hunan, China; National Clinical Research Center for Mental Disorders, Changsha, Hunan, China
| | - Feng Gao
- Medical Psychological Center, the Second Xiangya Hospital of Central South University, Changsha, Hunan, China; Medical Psychological Institute of Central South University, Changsha, Hunan, China; National Clinical Research Center for Mental Disorders, Changsha, Hunan, China
| | - Yan Han
- Medical Psychological Center, the Second Xiangya Hospital of Central South University, Changsha, Hunan, China; Medical Psychological Institute of Central South University, Changsha, Hunan, China; National Clinical Research Center for Mental Disorders, Changsha, Hunan, China
| | - Xingze Liu
- Medical Psychological Center, the Second Xiangya Hospital of Central South University, Changsha, Hunan, China; Medical Psychological Institute of Central South University, Changsha, Hunan, China; National Clinical Research Center for Mental Disorders, Changsha, Hunan, China
| | - Rui Yao
- Center for Psychological Development and Service, Hunan University of Chinese Medicine, Changsha, Hunan, China
| | - Xiongzhao Zhu
- Medical Psychological Center, the Second Xiangya Hospital of Central South University, Changsha, Hunan, China; Medical Psychological Institute of Central South University, Changsha, Hunan, China; National Clinical Research Center for Mental Disorders, Changsha, Hunan, China.
| |
Collapse
|
|
12
|
Alsayednasser B, Widnall E, O'Mahen H, Wright K, Warren F, Ladwa A, Khazanov GK, Byford S, Kuyken W, Watkins E, Ekers D, Reed N, Fletcher E, McMillan D, Farrand P, Richards D, Dunn BD. How well do Cognitive Behavioural Therapy and Behavioural Activation for depression repair anhedonia? A secondary analysis of the COBRA randomized controlled trial. Behav Res Ther 2022; 159:104185. [PMID: 36371903 DOI: 10.1016/j.brat.2022.104185] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/28/2021] [Revised: 08/19/2022] [Accepted: 08/19/2022] [Indexed: 12/14/2022]
Abstract
A secondary analysis of the COBRA randomized controlled trial was conducted to examine how well Cognitive Behavioural Therapy (CBT) and Behavioural Activation (BA) repair anhedonia. Patients with current major depressive disorder (N = 440) were randomized to receive BA or CBT, and anhedonia and depression outcomes were measured after acute treatment (six months) and at two further follow up intervals (12 and 18 months). Anhedonia was assessed using the Snaith Hamilton Pleasure Scale (SHAPS; a measure of consummatory pleasure). Both CBT and BA led to significant improvements in anhedonia during acute treatment, with no significant difference between treatments. Participants remained above healthy population averages of anhedonia at six months, and there was no further significant improvement in anhedonia at 12-month or 18-month follow up. Greater baseline anhedonia severity predicted reduced repair of depression symptoms and fewer depression-free days across the follow-up period in both the BA and CBT arms. The extent of anhedonia repair was less marked than the extent of depression repair across both treatment arms. These findings demonstrate that CBT and BA are similarly and only partially effective in treating anhedonia. Therefore, both therapies should be further refined or novel treatments should be developed in order better to treat anhedonia.
Collapse
Affiliation(s)
| | | | | | - Kim Wright
- Mood Disorders Centre, University of Exeter, UK
| | - Fiona Warren
- College of Medicine and Health, University of Exeter, UK
| | - Asha Ladwa
- Mood Disorders Centre, University of Exeter, UK
| | | | - Sarah Byford
- Health Service & Population Research Department, Kings College London, UK
| | | | - Ed Watkins
- Mood Disorders Centre, University of Exeter, UK
| | - David Ekers
- Department of Health Science, University of York, UK; Tees Esk and Wear Valleys NHS Foundation Trust, UK
| | - Nigel Reed
- Mood Disorders Centre, University of Exeter, UK
| | - Emily Fletcher
- College of Medicine and Health, University of Exeter, UK
| | - Dean McMillan
- Department of Health Sciences and Hull York Medical School, University of York, UK
| | | | - David Richards
- College of Medicine and Health, University of Exeter, UK; Department of Health and Caring Sciences, Western Norway University of Applied Sciences, Norway
| | | |
Collapse
|
|
13
|
Yang X, Guo Y, Harrison P, Liu X. Social and general anhedonia in adolescents: Stability and associations with other symptoms. J Adolesc 2022; 94:380-389. [DOI: 10.1002/jad.12029] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/24/2021] [Accepted: 11/16/2021] [Indexed: 11/11/2022]
Affiliation(s)
- Xinhua Yang
- The Affiliated Kangning Hospital Wenzhou Medical University Wenzhou China
- Centre for Affective Disorders, Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience King's College London London UK
| | - Yuqi Guo
- Department of Psychology, Institute of Education, Rural Children and Adolescents Research Center for Health Promotion Hunan Agricultural University Changsha China
| | - Phillippa Harrison
- Centre for Affective Disorders, Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience King's College London London UK
| | - Xiaoqun Liu
- Xiangya School of Public Health Central South University Changsha China
| |
Collapse
|
|
14
|
Neppala GK, Terkuhle I, Wagner A, Lepow L, Shaik RB, Freed R, Kimhy D, Pietrzak RH, Velthorst E, Feder A, Ivanov I, Parvaz MA. Social Isolation-Mediated Exacerbation of Negative Affect in Young Drinkers during the COVID-19 Pandemic. Brain Sci 2022; 12:brainsci12020214. [PMID: 35203977 PMCID: PMC8870361 DOI: 10.3390/brainsci12020214] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/20/2021] [Revised: 01/26/2022] [Accepted: 02/02/2022] [Indexed: 02/04/2023] Open
Abstract
Emerging research on psychological adjustment during the COVID-19 outbreak has suggested that young people may be particularly vulnerable to increases in negative affect during the pandemic. However, the association between alcohol use in youth and change in negative affect during this unprecedented time is not clear. Using an online survey, this study obtained scores on negative affect (before and during the COVID-19 pandemic), pandemic-related stress, change in drinking frequency, and traits including resilience, impulsivity and anhedonia, from a sample of drinkers and non-drinkers, up to the age of 21. Young drinkers experienced a greater increase in negative affect during the pandemic compared to non-drinkers, and this differential rise in negative affect was mediated by the pandemic-related stress of social isolation. Young drinkers also experienced a decrease in alcohol use during the pandemic, but this was not associated with a change in negative affect. Interestingly, young drinkers with greater resilience and lower anhedonia reported less increase in negative affect during the COVID-19 pandemic. Taken together, these results show that the greater increase in negative affect that young drinkers experienced during the COVID-19 pandemic, compared to their non-drinking counterparts, was mediated by pandemic-related social isolation. Moreover, greater resilience and lower anhedonia may have served as protective factors for mitigating the social isolation-induced worsening of negative affect in young drinkers during the pandemic. These findings may inform future studies investigating potential indicators of maladaptive affective responses to public health crises in vulnerable adolescent populations.
Collapse
Affiliation(s)
- Gopi K. Neppala
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; (G.K.N.); (I.T.); (A.W.); (L.L.); (R.B.S.); (R.F.); (D.K.); (E.V.); (A.F.); (I.I.)
| | - Isabel Terkuhle
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; (G.K.N.); (I.T.); (A.W.); (L.L.); (R.B.S.); (R.F.); (D.K.); (E.V.); (A.F.); (I.I.)
| | - Ariella Wagner
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; (G.K.N.); (I.T.); (A.W.); (L.L.); (R.B.S.); (R.F.); (D.K.); (E.V.); (A.F.); (I.I.)
| | - Lauren Lepow
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; (G.K.N.); (I.T.); (A.W.); (L.L.); (R.B.S.); (R.F.); (D.K.); (E.V.); (A.F.); (I.I.)
| | - Riaz B. Shaik
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; (G.K.N.); (I.T.); (A.W.); (L.L.); (R.B.S.); (R.F.); (D.K.); (E.V.); (A.F.); (I.I.)
| | - Rachel Freed
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; (G.K.N.); (I.T.); (A.W.); (L.L.); (R.B.S.); (R.F.); (D.K.); (E.V.); (A.F.); (I.I.)
| | - David Kimhy
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; (G.K.N.); (I.T.); (A.W.); (L.L.); (R.B.S.); (R.F.); (D.K.); (E.V.); (A.F.); (I.I.)
| | - Robert H. Pietrzak
- U.S. Department of Veterans Affairs, National Center for Posttraumatic Stress Disorder, VA Connecticut Healthcare System, West Haven, CT 06516, USA;
- Department of Psychiatry, Yale School of Medicine, New Haven, CT 06511, USA
- Department of Social and Behavioral Sciences, Yale School of Public Health, New Haven, CT 06520, USA
| | - Eva Velthorst
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; (G.K.N.); (I.T.); (A.W.); (L.L.); (R.B.S.); (R.F.); (D.K.); (E.V.); (A.F.); (I.I.)
| | - Adriana Feder
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; (G.K.N.); (I.T.); (A.W.); (L.L.); (R.B.S.); (R.F.); (D.K.); (E.V.); (A.F.); (I.I.)
| | - Iliyan Ivanov
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; (G.K.N.); (I.T.); (A.W.); (L.L.); (R.B.S.); (R.F.); (D.K.); (E.V.); (A.F.); (I.I.)
| | - Muhammad A. Parvaz
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; (G.K.N.); (I.T.); (A.W.); (L.L.); (R.B.S.); (R.F.); (D.K.); (E.V.); (A.F.); (I.I.)
- Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
- Correspondence:
| |
Collapse
|
|
15
|
Abstract
Anhedonia reflects a reduced ability to engage in previously pleasurable activities and has been reported in children as young as 3 years of age. It manifests early and is a strong predictor of psychiatric disease onset and progression over the course of development and into adulthood. However, little is known about its mechanistic origins, particularly in childhood and adolescence. In this chapter, we provide a socio-cognitive model of the development of anhedonia. This model is substantiated by past literature presented in this chapter to account for how the individual trajectories of emotion knowledge, autobiographical memory, and self-concept representations contribute to the onset, persistence, and progression of anhedonia from early childhood through adolescence.
Collapse
Affiliation(s)
- Janani Prabhakar
- Section on Clinical and Computational Psychiatry, National Institute of Mental Health, Bethesda, MD, USA.
| | - Dylan M Nielson
- Section on Clinical and Computational Psychiatry, National Institute of Mental Health, Bethesda, MD, USA
- Machine Learning Team, National Institute of Mental Health, Bethesda, MD, USA
| | - Argyris Stringaris
- Division of Psychiatry and Division of Psychology and Language Sciences, University College London, London, UK
- National and Kapodistrian University Athens, Athens, Greece
| |
Collapse
|
|
16
|
Distinct trajectories of depression symptoms in early and middle adolescence: Preliminary evidence from longitudinal network analysis. J Psychiatr Res 2021; 142:198-203. [PMID: 34365068 DOI: 10.1016/j.jpsychires.2021.07.053] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 04/22/2021] [Revised: 07/16/2021] [Accepted: 07/31/2021] [Indexed: 11/27/2022]
Abstract
Adolescent depression is a clinically relevant concern that has major implications for mental and physical health. The trajectory of depressive symptoms among adolescents suggests that there is likely variability throughout this developmental period. The aim of the study was to assess the longitudinal relationship between individual symptoms of depression among early and middle adolescents to provide guidance for future research investigating targeted intervention efforts. Data were extracted from electronic medical records (2015-2017) from a pediatric primary care clinic in an urban setting. Cross-Lagged Panel Network analysis was used to evaluate symptoms of depression measured with the Patient Health Questionnaire (PHQ-9) measured twice over a 1-year period among early adolescents (ages 11-13 years; n = 309) and middle adolescents (ages 14-16 years; n = 255). The sample was predominantly Hispanic (90%) and 56% female. The analyses highlighted key differences and similarities between early and middle adolescence, largely focused on the role of suicidal ideation and tightly linked with feelings of failure and appetitive disturbance. In early adolescence suicidal ideation was highly likely to lead to other symptoms. In middle adolescence, however, suicidal ideation no longer had connections to other symptoms and instead the strongest connections were toward suicidal ideation. Interestingly, across both early and middle adolescence feelings of failure and appetitive disturbance were highly likely to lead to suicidal ideation. These exploratory findings highlight several longitudinal associations between early and middle adolescence that provide insight into differences and similarities regarding how symptoms might progress within those developmental periods. Taken together these results can provide direction for future research to evaluate brief, targeted interventions for adolescents.
Collapse
|
|
17
|
Sherwood SN, Youngstrom JK, Findling RL, Youngstrom EA, Freeman AJ. Irritability Is Associated with Illness Severity and Anhedonia Is Associated with Functional Impairment Among Depressed Children and Adolescents. J Child Adolesc Psychopharmacol 2021; 31:531-537. [PMID: 34283918 DOI: 10.1089/cap.2021.0018] [Citation(s) in RCA: 8] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 11/13/2022]
Abstract
Objectives: Irritability and anhedonia are cardinal symptoms of depression for children and adolescents. However, anhedonia may be more strongly associated with illness severity compared with irritability. The present study evaluated the impact of irritability and anhedonia on symptom severity and functional impairment among depressed children and adolescents. Methods: Participants were 383 children and adolescents presenting for outpatient treatment at a community mental health center or academic medical center. Children and adolescents were diagnosed with unipolar depression or bipolar disorder. Regression models predicted depression severity and functional impairment from irritability and anhedonia after covarying age, gender, depressive and hypomanic symptoms, and diagnosis. Results: Greater irritability and anhedonia were associated with more severe depression symptoms. Greater irritability, but not anhedonia, was associated with lower global functioning and family quality of life (QoL), and more externalizing problems. Greater anhedonia was associated with lower overall, emotional, self-esteem, and social QoL. Neither irritability nor anhedonia was associated with school or physical QoL, nonsuicidal self-injury, suicidal ideation, number of comorbid diagnoses, or internalizing problems. Conclusions: Irritability was associated with more markers of depression severity, whereas anhedonia was associated with indicators of functional impairment. This study used a cross-sectional observational design and therefore cannot provide information about cause and effect relationships between variables. Irritability and anhedonia were derived from their respective subscales of the General Behavior Inventory and included only caregiver-reported symptoms but not child- or adolescent-reported symptoms. Identifying the impact of specific symptoms of depression may assist clinicians in delivering more individualized interventions to target symptoms that result in greater impairment.
Collapse
Affiliation(s)
- Samantha N Sherwood
- Department of Psychology, University of Nevada, Las Vegas, Las Vegas, Nevada, USA
| | - Jennifer K Youngstrom
- Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
| | - Robert L Findling
- Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia, USA
| | - Eric A Youngstrom
- Department of Psychology and Neuroscience and Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
| | - Andrew J Freeman
- Division of Child and Family Services, Nevada Department of Health and Human Services, Las Vegas, Nevada, USA
| |
Collapse
|
|
18
|
Sydnor VJ, Larsen B, Kohler C, Crow AJD, Rush SL, Calkins ME, Gur RC, Gur RE, Ruparel K, Kable JW, Young JF, Chawla S, Elliott MA, Shinohara RT, Nanga RPR, Reddy R, Wolf DH, Satterthwaite TD, Roalf DR. Diminished reward responsiveness is associated with lower reward network GluCEST: an ultra-high field glutamate imaging study. Mol Psychiatry 2021; 26:2137-2147. [PMID: 33479514 PMCID: PMC8292427 DOI: 10.1038/s41380-020-00986-y] [Citation(s) in RCA: 10] [Impact Index Per Article: 2.5] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/10/2020] [Revised: 11/22/2020] [Accepted: 12/03/2020] [Indexed: 12/12/2022]
Abstract
Low reward responsiveness (RR) is associated with poor psychological well-being, psychiatric disorder risk, and psychotropic treatment resistance. Functional MRI studies have reported decreased activity within the brain's reward network in individuals with RR deficits, however the neurochemistry underlying network hypofunction in those with low RR remains unclear. This study employed ultra-high field glutamate chemical exchange saturation transfer (GluCEST) imaging to investigate the hypothesis that glutamatergic deficits within the reward network contribute to low RR. GluCEST images were acquired at 7.0 T from 45 participants (ages 15-29, 30 females) including 15 healthy individuals, 11 with depression, and 19 with psychosis spectrum symptoms. The GluCEST contrast, a measure sensitive to local glutamate concentration, was quantified in a meta-analytically defined reward network comprised of cortical, subcortical, and brainstem regions. Associations between brain GluCEST contrast and Behavioral Activation System Scale RR scores were assessed using multiple linear regressions. Analyses revealed that reward network GluCEST contrast was positively and selectively associated with RR, but not other clinical features. Follow-up investigations identified that this association was driven by the subcortical reward network and network areas that encode the salience of valenced stimuli. We observed no association between RR and the GluCEST contrast within non-reward cortex. This study thus provides new evidence that reward network glutamate levels contribute to individual differences in RR. Decreased reward network excitatory neurotransmission or metabolism may be mechanisms driving reward network hypofunction and RR deficits. These findings provide a framework for understanding the efficacy of glutamate-modulating psychotropics such as ketamine for treating anhedonia.
Collapse
Affiliation(s)
- Valerie J. Sydnor
- Penn Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
| | - Bart Larsen
- Penn Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
| | - Christian Kohler
- Penn Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA;,Penn-CHOP Lifespan Brain Institute, University of Pennsylvania, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
| | - Andrew J. D. Crow
- Penn Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
| | - Sage L. Rush
- Penn Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
| | - Monica E. Calkins
- Penn Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA;,Penn-CHOP Lifespan Brain Institute, University of Pennsylvania, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
| | - Ruben C. Gur
- Penn Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA;,Penn-CHOP Lifespan Brain Institute, University of Pennsylvania, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
| | - Raquel E. Gur
- Penn Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA;,Penn-CHOP Lifespan Brain Institute, University of Pennsylvania, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
| | - Kosha Ruparel
- Penn Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA;,Penn-CHOP Lifespan Brain Institute, University of Pennsylvania, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
| | - Joseph W. Kable
- Department of Psychology, University of Pennsylvania, Philadelphia, PA, USA;,MindCORE, University of Pennsylvania, Philadelphia, PA, USA
| | - Jami F. Young
- Penn Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA;,Penn-CHOP Lifespan Brain Institute, University of Pennsylvania, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
| | - Sanjeev Chawla
- Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA
| | - Mark A. Elliott
- Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA
| | - Russell T. Shinohara
- Penn Statistics in Imaging and Visualization Endeavor, Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA;,Center for Biomedical Image Computing and Analytics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
| | | | - Ravinder Reddy
- Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA
| | - Daniel H. Wolf
- Penn Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA;,Penn-CHOP Lifespan Brain Institute, University of Pennsylvania, Children’s Hospital of Philadelphia, Philadelphia, PA, USA;,Center for Biomedical Image Computing and Analytics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
| | - Theodore D. Satterthwaite
- Penn Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA;,Penn-CHOP Lifespan Brain Institute, University of Pennsylvania, Children’s Hospital of Philadelphia, Philadelphia, PA, USA;,Center for Biomedical Image Computing and Analytics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
| | - David R. Roalf
- Penn Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA;,Penn-CHOP Lifespan Brain Institute, University of Pennsylvania, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
| |
Collapse
|
|
19
|
Gregory D, Turnbull D, Bednarz J, Gregory T. The role of social support in differentiating trajectories of adolescent depressed mood. J Adolesc 2020; 85:1-11. [DOI: 10.1016/j.adolescence.2020.09.004] [Citation(s) in RCA: 6] [Impact Index Per Article: 1.2] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/09/2019] [Revised: 09/04/2020] [Accepted: 09/06/2020] [Indexed: 12/19/2022]
|
|
20
|
Abstract
Social anhedonia is well established as a transdiagnostic factor, but little is known about its development. This study examined whether temperament and parenting in early childhood predict social anhedonia in early adolescence. We also explored whether the relationships between early predictors and social anhedonia are moderated by a child's sex. A community sample of children participated in laboratory observations of temperament and parenting practices at age 3 (n = 275). The participants returned at age 12 and completed the Anticipatory and Consummatory Interpersonal Pleasure Scale-Child Version (ACIPS-C). Our results indicated that, at age 3, lower observed sociability predicted higher levels of social anhedonia at age 12. These associations were moderated by child sex, such that males with diminished sociability reported greater social anhedonia. These findings indicate that predictors of early adolescent social anhedonia are evident as early as 3 years of age. However, these effects were evident only for males, suggesting that the pathways to social anhedonia in early adolescence differ as a function of sex.
Collapse
|
|
21
|
Yang X, Wang D, Liu S, Liu G, Harrison P. Trajectories of state anhedonia and recent changes in anhedonia in college students: Associations with other psychiatric syndromes. J Affect Disord 2020; 262:337-343. [PMID: 31735407 DOI: 10.1016/j.jad.2019.11.043] [Citation(s) in RCA: 6] [Impact Index Per Article: 1.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 07/19/2019] [Revised: 09/20/2019] [Accepted: 11/09/2019] [Indexed: 01/25/2023]
Abstract
BACKGROUND Recent works suggest recent changes in anhedonia may be specifically predictive of key elements of psychopathology. The present study aimed to identify the trajectories of state anhedonia and recent changes in anhedonia, and to investigate their associations with other psychiatric syndromes over time. METHODS A total of 859 college students were assessed at three time points. State anhedonia was assessed using the Snaith Hamilton Pleasure Scale and recent changes in anhedonia were assessed with a subscale extracted from the Symptom Check-List-90. The Latent Growth Curve Modelling analysis was used to analyze trajectories. Associations with anhedonia were investigated with logistic regression models. RESULTS Three state anhedonia trajectories and two recent changes in anhedonia trajectories were identified. The decreasing trajectory was the most prevalent class in both two types of anhedonia. Depression and suicidal ideation predicted recent changes in anhedonia whereas other psychiatric syndromes predicted state anhedonia. CONCLUSIONS The current study highlighted the development trajectories of different measures of anhedonia. The results showed that the relationships between anhedonia and psychiatric syndromes were different according to the kind of anhedonia.
Collapse
Affiliation(s)
- Xinhua Yang
- Department of Psychology, Institute of Education, Hunan Agricultural University, No. 1 Nongda Road, Changsha, Hunan 410128, China.
| | - Dongfang Wang
- Department of Psychology, Institute of Education, Hunan Agricultural University, No. 1 Nongda Road, Changsha, Hunan 410128, China.
| | - Sixun Liu
- Department of Psychology, Institute of Education, Hunan Agricultural University, No. 1 Nongda Road, Changsha, Hunan 410128, China.
| | - Guangya Liu
- Department of psychiatry, Brains Hospital of Hunan Province, Changsha, Hunan, China.
| | - Phillippa Harrison
- Centre for Affective Disorders, Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
| |
Collapse
|
|
22
|
Cloos M, Di Simplicio M, Hammerle F, Steil R. Mental images, entrapment and affect in young adults meeting criteria of nonsuicidal self-injury disorder (NSSID) - a daily diary study. Borderline Personal Disord Emot Dysregul 2020; 7:4. [PMID: 32071721 PMCID: PMC7014591 DOI: 10.1186/s40479-019-0117-0] [Citation(s) in RCA: 5] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 04/25/2019] [Accepted: 11/12/2019] [Indexed: 01/16/2023] Open
Abstract
BACKGROUND Incidents of nonsuicidal self-injury (NSSI) are often accompanied by mental images which could be perceived as distressing and/or soothing; yet existing data is derived from participants with a history of NSSI using retrospective methods. This study investigated mental images related to NSSI ("NSSI-images"), and their relationship to the proposed Nonsuicidal Self-Injury Disorder (NSSID). METHODS An e-mail was sent to all female students of the local University providing the link to an online screening and 201 students with a history of repetitive NSSI responded. Nineteen eligible participants meeting criteria of NSSID (mean age = 25; 32% with migrant background) further completed a baseline interview and a ten-day-diary protocol. RESULTS Among the sample of N = 201, 83.6% reported NSSI-images. In the subsample of n = 19 diagnosed with NSSID, the frequencies of NSSI and NSSI-images were correlated; about 80% of the most significant NSSI-images were either of NSSI or of an instrument associated with NSSI (i.e., a razorblade). In the diary, 53% of the sample self-injured. NSSI-images were reported on 94% of NSSI-days, and on days with NSSI and NSSI-images, the images almost always occurred first; the images were overall perceived as twice more distressing than comforting. Images on NSSI-days were characterized by more comfort, intrusiveness and compellingness yet less vividness, and increased subsequent positive and negative affect compared to non-NSSI days. NSSI-days were further marked by increased entrapment beliefs and increased negative yet decreased positive affect at night. These results were non-significant. LIMITATIONS Due to non-significant results among a small sample size and a low rate of NSSI among the NSSID-group, results remain preliminary. CONCLUSIONS The study provides information on feasibility and methodological challenges such as intervention effects of the diary. NSSI-images may be common among individuals who engage in NSSI; they may capture ambivalent (positive and negative) appraisals of NSSI and thus play a role in NSSI and possibly a disorder such as NSSID. The preoccupation with NSSI (Criterion C of NSSID in DSM-5) may as well be imagery-based. REGISTRATION The study was retrospectively registered with the DRKS under the number DRKS00011854.
Collapse
Affiliation(s)
- Marie Cloos
- 1Department of Clinical Psychology and Psychotherapy, Institute of Psychology, Goethe University, Frankfurt Main, Germany
| | - Martina Di Simplicio
- 2Division of Psychiatry, Department of Brain Sciences, Imperial College London, London, UK
| | - Florian Hammerle
- 3Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany
| | - Regina Steil
- 1Department of Clinical Psychology and Psychotherapy, Institute of Psychology, Goethe University, Frankfurt Main, Germany
| |
Collapse
|
|
23
|
Frank DW, Stevens EM, Versace F. A neurophysiological measure of reward sensitivity and its association with anhedonia in psychiatrically healthy adolescents and young adults. Int J Psychophysiol 2019; 141:56-64. [PMID: 31071360 DOI: 10.1016/j.ijpsycho.2019.05.002] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/09/2018] [Revised: 04/19/2019] [Accepted: 05/05/2019] [Indexed: 12/31/2022]
Abstract
Anhedonia (i.e., the attenuated ability to enjoy pleasurable stimuli) characterizes multiple mood disorders, but its neurophysiological underpinnings are not yet clear. Here, we measured event-related potentials in 116 adolescents and young adults engaged in an asymmetric reinforcement procedure designed to objectively characterize the anhedonic phenotype. In line with previous studies, the behavioral results showed that approximately 35% of the sample did not develop a response bias towards the more frequently rewarded stimuli (a sign of low hedonic capacity). The event-related potentials (ERPs) evoked by the reward feedback stimuli delivered during the task showed that individuals that did not develop a response bias had less cortical positivity at Fz from 224 ms to 316 ms post feedback onset compared to those that developed a response bias during the task. However, further analyses showed that this between groups difference was relatively weak, as it disappeared when we controlled for response-locked ERPs. Furthermore, the response bias observed in the asymmetric reinforcement procedure was not strongly associated with self-reported ratings of hedonic capacity. We conclude that even though the asymmetric reinforcement procedure may be used as a reward sensitivity measure in neurotypical adolescents and young adults, this task may only be able to detect clinically significant levels of anhedonia in this particular population.
Collapse
Affiliation(s)
- David W Frank
- Department of Behavioral Science, The University of Texas MD Anderson Cancer Center, Houston, TX, United States of America.
| | - Elise M Stevens
- The Oklahoma Tobacco Research Center, Stephenson Cancer Center, Oklahoma City, OK, United States of America
| | - Francesco Versace
- Department of Behavioral Science, The University of Texas MD Anderson Cancer Center, Houston, TX, United States of America.
| |
Collapse
|
|
24
|
Bock A, Huber E, Müller S, Henkel M, Sevecke K, Schopper A, Steinmayr-Gensluckner M, Wieser E, Benecke C. [Levels of structural integration in adolescents and the relationship to later mental disorders - A longitudinal study]. ZEITSCHRIFT FUR KINDER-UND JUGENDPSYCHIATRIE UND PSYCHOTHERAPIE 2019; 47:400-410. [PMID: 30939974 DOI: 10.1024/1422-4917/a000656] [Citation(s) in RCA: 7] [Impact Index Per Article: 1.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 11/19/2022]
Abstract
Levels of structural integration in adolescents and the relationship to later mental disorders - A longitudinal study Abstract. Objective: Psychological disorders frequently manifest during adolescence. Because of the multifactorial influencing factors, the courses of the diseases are heterogeneous, from relapsing-remitting to chronic. This study investigated whether the level of structural integration of the Operationalized Psychodynamic Diagnostics in Childhood and Adolescence (OPD-CA) correlates with later symptomatic burden. Method: This long-term study assessed the levels of structural integration according to the OPD-CA of 60 adolescents (mean age = 15.6; SD = 0.9). Seven years later, we then measured symptomatic burden (SCID axis I and II) and overall burden (GAF, BSI-GSI) (73.3 % follow-up participation rate). Results: The results showed high correlations between deficient structural integration in adolescence and later symptoms and overall burden in early adulthood. Conclusion: The follow-up examination after a 7-year time period showed significant correlations, which argue for the predictive value of structural integration. This suggests that early specific treatment, e.g., in the form of intensive psychotherapy, be urgently recommended in order to influence this course.
Collapse
Affiliation(s)
- Astrid Bock
- Abteilung für Kinder- und Jugendpsychiatrie, Psychotherapie und Psychosomatik, Tirol Kliniken, Hall in Tirol, Österreich
| | - Eva Huber
- Institut für Psychologie, Universität Innsbruck, Österreich
| | - Steffen Müller
- Institut für Psychologie, Universität Kassel, Deutschland
| | - Miriam Henkel
- Institut für Psychologie, Universität Kassel, Deutschland
| | - Kathrin Sevecke
- Abteilung für Kinder- und Jugendpsychiatrie, Psychotherapie und Psychosomatik, Tirol Kliniken, Hall in Tirol, Österreich.,Universitätsklinik für Psychiatrie, Psychotherapie und Psychosomatik im Kindes- und Jugendalter, Medizinische Universität Innsbruck, Österreich
| | - Alexander Schopper
- Institut für Psychologie, Universität Innsbruck, Österreich.,Klinik für Kinder- und Jugendpsychiatrie und Psychosomatik, DRK-Kinderklinik Siegen , Deutschland
| | - Maria Steinmayr-Gensluckner
- Abteilung für Kinder- und Jugendpsychiatrie, Psychotherapie und Psychosomatik, Tirol Kliniken, Hall in Tirol, Österreich
| | - Elke Wieser
- Abteilung für Kinder- und Jugendpsychiatrie, Psychotherapie und Psychosomatik, Tirol Kliniken, Hall in Tirol, Österreich
| | - Cord Benecke
- Institut für Psychologie, Universität Kassel, Deutschland
| |
Collapse
|
|
25
|
Babinski DE, Welkie J. Feasibility of Ecological Momentary Assessment of Negative Emotion in Girls With ADHD: A Pilot Study. Psychol Rep 2019; 123:1027-1043. [PMID: 30917744 DOI: 10.1177/0033294119838757] [Citation(s) in RCA: 7] [Impact Index Per Article: 1.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/20/2022]
Abstract
This study explores the feasibility of using mobile phone ecological momentary assessment to evaluate negative emotion in adolescent girls with attention-deficit/hyperactivity disorder (ADHD). A total of 13 girls with ADHD, ages 12-16 years old (38.5% with comorbid depression), and their mothers completed several daily surveys assessing the intensity and variability of youth negative emotion using mobile phone-based ecological momentary assessment for approximately one week. The rate of response to survey prompts by youth and maternal reports was examined. In addition, associations between girls' and mothers' ratings of negative emotion were calculated. Finally, the severity and fluctuation in negative emotion were compared between girls with and without depression. Girls and their mothers demonstrated a high level of compliance with assessment procedures, and maternal and youth ratings were significantly correlated. In addition, girls with comorbid depression and their mothers endorsed significantly more intense and variable negative emotion compared to girls with ADHD alone. These preliminary findings show that ecological momentary assessment is a feasible and valid method for collecting information on emotion regulation among girls with ADHD and their mothers that can be applied to future work aimed at collecting ecologically valid assessments of functioning in girls with ADHD.
Collapse
Affiliation(s)
- Dara E Babinski
- Department of Psychiatry, Penn State College of Medicine, Hershey, PA, USA
| | - Janelle Welkie
- Department of Psychiatry, Penn State College of Medicine, Hershey, PA, USA
| |
Collapse
|
|
26
|
Cohen JR, McNeil SL, Shorey RC, Temple JR. Maltreatment subtypes, depressed mood, and anhedonia: A longitudinal study with adolescents. PSYCHOLOGICAL TRAUMA-THEORY RESEARCH PRACTICE AND POLICY 2018; 11:704-712. [PMID: 30589315 DOI: 10.1037/tra0000418] [Citation(s) in RCA: 30] [Impact Index Per Article: 4.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 01/16/2023]
Abstract
OBJECTIVE Maltreatment exposure is a robust predictor of adolescent depression. Yet despite this well-documented association, few studies have simultaneously examined how maltreatment subtypes relate to qualitatively distinct depressive symptoms. The present multiwave longitudinal study addressed this gap in the literature by examining how different maltreatment subtypes independently impact depressed mood and anhedonia over time in a diverse adolescent sample. METHOD Adolescents (N = 673, Mage = 14.83, SDage = 0.66, 57.1% female, 32.8% Hispanic, 30.4% Caucasian, 25.0% African American) completed self-report inventories for child-maltreatment and annual self-report measures of depressed mood and anhedonia over the course of 6 years. We used latent-growth-curve modeling to test how maltreatment exposure predicted anhedonia and depressed mood, and whether these relations differed as a function of sex and/or race/ethnicity. RESULTS Overall, both emotional abuse (p < .001) and neglect (p = .002) predicted levels of depressed mood over time, whereas only emotional neglect predicted levels (p < .001) and trajectories (p = .001) of anhedonia. Physical and sexual abuse did not predict depressive symptoms after accounting for emotional abuse and neglect (ns). These findings were largely invariant across sex and race. CONCLUSION Findings suggest that the consequences of emotional neglect may be especially problematic in adolescence because of its impact on both depressed mood and anhedonia, and that emotional abuse's association with depression is best explained via symptoms of depressed mood. These findings are congruent with recent findings that more "silent types" of maltreatment uniquely predict depression, and that abuse and neglect experiences confer distinct profiles of risk for psychological distress. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
Collapse
|
|
27
|
Finan LJ, Ohannessian CM, Gordon MS. Trajectories of depressive symptoms from adolescence to emerging adulthood: The influence of parents, peers, and siblings. Dev Psychol 2018; 54:1555-1567. [PMID: 30047776 DOI: 10.1037/dev0000543] [Citation(s) in RCA: 37] [Impact Index Per Article: 5.3] [Reference Citation Analysis] [Abstract] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/13/2022]
Abstract
The primary purpose of this study was to examine whether social relationship factors are associated with trajectories of depressive symptoms from adolescence into emerging adulthood. Specifically, adolescent-parent communication with mothers and fathers, peer support, and sibling warmth and hostility were examined in relation to depressive symptoms for girls and boys. Adolescents (N = 372; Mage = 16.09; SD = .69; 55% female) from the Mid-Atlantic United States completed surveys in the spring of 2007, 2008, and 2009 and again in the fall of 2014 when they were emerging adults. Growth curve modeling results suggested that communication with mothers and fathers and peer support predicted lower levels of depressive symptoms in adolescence for girls. For boys, peer support predicted lower whereas sibling hostility predicted higher levels of depressive symptoms in adolescence. Further, adolescent-mother communication for girls and adolescent-father communication for boys predicted the decline in depressive symptoms into emerging adulthood. Both sibling warmth and hostility for girls, whereas only sibling hostility for boys, predicted less steep declines in depressive symptoms over time. Findings draw attention to differences in experiences with depressive symptoms by sex and the importance of social relationship factors in the lives of adolescents and emerging adults. Implications for intervention and prevention are discussed. (PsycINFO Database Record
Collapse
Affiliation(s)
| | | | - Mellissa S Gordon
- Department of Human Development Family Studies, University of Delaware
| |
Collapse
|
|
28
|
Turning gold into lead: Dampening appraisals reduce happiness and pleasantness and increase sadness during anticipation and recall of pleasant activities in the laboratory. Behav Res Ther 2018; 107:19-33. [DOI: 10.1016/j.brat.2018.05.003] [Citation(s) in RCA: 10] [Impact Index Per Article: 1.4] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/03/2017] [Revised: 02/21/2018] [Accepted: 05/03/2018] [Indexed: 11/20/2022]
|
|
29
|
Linking anhedonia symptoms with behavioural and neural reward responses in adolescent depression. Curr Opin Behav Sci 2018. [DOI: 10.1016/j.cobeha.2018.07.001] [Citation(s) in RCA: 14] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/25/2022]
|
|
30
|
Slofstra C, Nauta MH, Holmes EA, Bos EH, Wichers M, Batalas N, Klein NS, Bockting CL. Exploring the relation between visual mental imagery and affect in the daily life of previously depressed and never depressed individuals. Cogn Emot 2017; 32:1131-1138. [DOI: 10.1080/02699931.2017.1365047] [Citation(s) in RCA: 5] [Impact Index Per Article: 0.6] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/18/2023]
Affiliation(s)
- Christien Slofstra
- Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, Groningen, The Netherlands
| | - Maaike H. Nauta
- Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, Groningen, The Netherlands
| | - Emily A. Holmes
- Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
| | - Elisabeth H. Bos
- Department of Developmental Psychology, University of Groningen, Groningen, The Netherlands
| | - Marieke Wichers
- Department of Psychiatry (UCP), University of Groningen, University Medical Center Groningen (UMCG), Interdisciplinary Center for Psychopathology and Emotion regulation (ICPE), Groningen, The Netherlands
| | - Nikolaos Batalas
- Department of Industrial Design, Eindhoven University of Technology, Eindhoven, The Netherlands
| | - Nicola S. Klein
- Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, Groningen, The Netherlands
| | - Claudi L.H. Bockting
- Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, Groningen, The Netherlands
- Department of Clinical Psychology, Utrecht University, Utrecht, The Netherlands
| |
Collapse
|
|
31
|
Masselink M, Van Roekel E, Oldehinkel AJ. Self-esteem in Early Adolescence as Predictor of Depressive Symptoms in Late Adolescence and Early Adulthood: The Mediating Role of Motivational and Social Factors. J Youth Adolesc 2017; 47:932-946. [PMID: 28785953 PMCID: PMC5878202 DOI: 10.1007/s10964-017-0727-z] [Citation(s) in RCA: 82] [Impact Index Per Article: 10.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/02/2017] [Accepted: 07/20/2017] [Indexed: 11/01/2022]
Abstract
Ample research has shown that low self-esteem increases the risk to develop depressive symptoms during adolescence. However, the mechanism underlying this association remains largely unknown, as well as how long adolescents with low self-esteem remain vulnerable to developing depressive symptoms. Insight into this mechanism may not only result in a better theoretical understanding but also provide directions for possible interventions. To address these gaps in knowledge, we investigated whether self-esteem in early adolescence predicted depressive symptoms in late adolescence and early adulthood. Moreover, we investigated a cascading mediational model, in which we focused on factors that are inherently related to self-esteem and the adolescent developmental period: approach and avoidance motivation and the social factors social contact, social problems, and social support. We used data from four waves of the TRAILS study (N = 2228, 51% girls): early adolescence (mean age 11 years), middle adolescence (mean age 14 years), late adolescence (mean age 16 years), and early adulthood (mean age 22 years). Path-analyses showed that low self-esteem is an enduring vulnerability for developing depressive symptoms. Self-esteem in early adolescence predicted depressive symptoms in late adolescence as well as early adulthood. This association was independently mediated by avoidance motivation and social problems, but not by approach motivation. The effect sizes were relatively small, indicating that having low self-esteem is a vulnerability factor, but does not necessarily predispose adolescents to developing depressive symptoms on their way to adulthood. Our study contributes to the understanding of the mechanisms underlying the association between self-esteem and depressive symptoms, and has identified avoidance motivation and social problems as possible targets for intervention.
Collapse
Affiliation(s)
- M Masselink
- Interdisciplinary Center Psychopathology and Emotion regulation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
| | - E Van Roekel
- Interdisciplinary Center Psychopathology and Emotion regulation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.,Department of Developmental Psychology, Tilburg University, Tilburg, The Netherlands
| | - A J Oldehinkel
- Interdisciplinary Center Psychopathology and Emotion regulation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
| |
Collapse
|
|
32
|
Sheth C, McGlade E, Yurgelun-Todd D. Chronic Stress in Adolescents and Its Neurobiological and Psychopathological Consequences: An RDoC Perspective. ACTA ACUST UNITED AC 2017. [PMID: 29527590 PMCID: PMC5841253 DOI: 10.1177/2470547017715645] [Citation(s) in RCA: 56] [Impact Index Per Article: 7.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/21/2022]
Abstract
The Research Domain Criteria (RDoC) initiative provides a strategy for classifying psychopathology based on behavioral dimensions and neurobiological measures. Neurodevelopment is an orthogonal dimension in the current RDoC framework; however, it has not yet been fully incorporated into the RDoC approach. A combination of both a neurodevelopmental and RDoC approach offers a multidimensional perspective for understanding the emergence of psychopathology during development. Environmental influence (e.g., stress) has a profound impact on the risk for development of psychiatric illnesses. It has been shown that chronic stress interacts with the developing brain, producing significant changes in neural circuits that eventually increase the susceptibility for development of psychiatric disorders. This review highlights effects of chronic stress on the adolescent brain, as adolescence is a period characterized by a combination of significant brain alterations, high levels of stress, and emergence of psychopathology. The literature synthesized in this review suggests that chronic stress-induced changes in neurobiology and behavioral constructs underlie the shared vulnerability across a number of disorders in adolescence. The review particularly focuses on depression and substance use disorders; however, a similar argument can also be made for other psychopathologies, including anxiety disorders. The summarized findings underscore the need for a framework to integrate neurobiological findings from disparate psychiatric disorders and to target transdiagnostic mechanisms across disorders.
Collapse
Affiliation(s)
- Chandni Sheth
- Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, UT, USA.,Diagnostic Neuroimaging, University of Utah, Salt Lake City, UT, USA
| | - Erin McGlade
- Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, UT, USA.,Diagnostic Neuroimaging, University of Utah, Salt Lake City, UT, USA.,George E. Wahlen Department of Veterans Affairs Medical Center, VA VISN 19 Mental Illness Research, Education and Clinical Center (MIRREC), Salt Lake City, UT, USA
| | - Deborah Yurgelun-Todd
- Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, UT, USA.,Diagnostic Neuroimaging, University of Utah, Salt Lake City, UT, USA.,George E. Wahlen Department of Veterans Affairs Medical Center, VA VISN 19 Mental Illness Research, Education and Clinical Center (MIRREC), Salt Lake City, UT, USA
| |
Collapse
|
|
33
|
Van Roekel E, Vrijen C, Heininga VE, Masselink M, Bos EH, Oldehinkel AJ. An Exploratory Randomized Controlled Trial of Personalized Lifestyle Advice and Tandem Skydives as a Means to Reduce Anhedonia. Behav Ther 2017; 48:76-96. [PMID: 28077223 DOI: 10.1016/j.beth.2016.09.009] [Citation(s) in RCA: 29] [Impact Index Per Article: 3.6] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 05/02/2016] [Revised: 09/28/2016] [Accepted: 09/29/2016] [Indexed: 10/20/2022]
Abstract
Anhedonia is a major public health concern and has proven particularly difficult to counteract. It has been hypothesized that anhedonia can be deterred by engagement in rewarding social and physical events. The aims of the present study were to examine (1) the effects of personalized lifestyle advice based on observed individual patterns of lifestyle factors and experienced pleasure in anhedonic young adults; and (2) whether a tandem skydive can enhance the motivation to carry out the recommended lifestyle changes. Participants (N = 69; Mage = 21.5, SD = 2.0; 79.7% female) were selected through an online screening survey among young adults. Inclusion criteria were persistent anhedonia and willingness to perform a tandem skydive. Participants filled out questionnaires on their smartphones for 2 consecutive months (3 times per day). After the first month, they were randomly assigned to one of three groups: (1) no intervention, (2) lifestyle advice, and (3) lifestyle advice and tandem skydive. The momentary questionnaire data were analyzed using interrupted time series analyses (ITSA) in a multilevel model and monthly pleasure and depression questionnaires by repeated measures ANOVA. No group differences were found in monthly depression and pleasure scores, but the momentary data showed higher positive affect (PA) and pleasure ratings in the month following the intervention in the two intervention groups than in the control group. The tandem skydive did not have any effects above the effects of the lifestyle advice. Our results indicate that providing personalized lifestyle advice to anhedonic young adults can be an effective way to increase PA and pleasure.
Collapse
Affiliation(s)
| | | | - Vera E Heininga
- University of Groningen, University Medical Center Groningen
| | | | - Elisabeth H Bos
- University of Groningen, University Medical Center Groningen
| | | |
Collapse
|
|
34
|
Renner KH, Hock M, Bergner-Köther R, Laux L. Differentiating anxiety and depression: the State-Trait Anxiety-Depression Inventory. Cogn Emot 2016; 32:1409-1423. [DOI: 10.1080/02699931.2016.1266306] [Citation(s) in RCA: 22] [Impact Index Per Article: 2.4] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/20/2022]
Affiliation(s)
- Karl-Heinz Renner
- Department of Psychology, Bundeswehr University Munich, Neubiberg, Germany
| | - Michael Hock
- Department of Psychology, University of Bamberg, Bamberg, Germany
| | | | - Lothar Laux
- Department of Psychology, University of Bamberg, Bamberg, Germany
| |
Collapse
|
|
35
|
Olino TM. Future Research Directions in the Positive Valence Systems: Measurement, Development, and Implications for Youth Unipolar Depression. JOURNAL OF CLINICAL CHILD AND ADOLESCENT PSYCHOLOGY : THE OFFICIAL JOURNAL FOR THE SOCIETY OF CLINICAL CHILD AND ADOLESCENT PSYCHOLOGY, AMERICAN PSYCHOLOGICAL ASSOCIATION, DIVISION 53 2016; 45:681-705. [PMID: 26891100 PMCID: PMC5021627 DOI: 10.1080/15374416.2015.1118694] [Citation(s) in RCA: 29] [Impact Index Per Article: 3.2] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 12/22/2022]
Abstract
The Positive Valence Systems (PVS) have been introduced by the National Institute of Mental Health as a domain to help organize multiple constructs focusing on reward-seeking behaviors. However, the initial working model for this domain is strongly influenced by adult constructs and measures. Thus, the present review focuses on extending the PVS into a developmental context. Specifically, the review provides some hypotheses about the structure of the PVS, how PVS components may change throughout development, how family history of depression may influence PVS development, and potential means of intervening on PVS function to reduce onsets of depression. Future research needs in each of these areas are highlighted.
Collapse
|
|
36
|
Gooding DC, Pflum MJ, Fonseca-Pedero E, Paino M. Assessing social anhedonia in adolescence: The ACIPS-A in a community sample. Eur Psychiatry 2016; 37:49-55. [PMID: 27447103 DOI: 10.1016/j.eurpsy.2016.05.012] [Citation(s) in RCA: 20] [Impact Index Per Article: 2.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 03/01/2016] [Revised: 05/09/2016] [Accepted: 05/16/2016] [Indexed: 10/21/2022] Open
Abstract
To date, nearly all self-report measures of anhedonia have been developed for use with adult samples. A valid measure of anhedonia that can be used with adolescents would be useful in order to address key questions about the nature and course of anhedonia during adolescence. This study examined the psychometric properties of an adolescent version of a relatively new measure of social anhedonia, namely, the Anticipatory and Consummatory Interpersonal Pleasure Scale (ACIPS-A). The ACIPS-A was administered to a general, community-derived Spanish adolescent sample of 449 students, including 251 males (55.9%), who ranged in age from 13 to 19 years old. Other measures included the Temporal Experience of Pleasure Scale (TEPS), anhedonia subscales from the Oviedo Schizotypy Assessment Questionnaire (ESQUIZO-Q), and the General Health Questionnaire-12 (GHQ-12). Exploratory factor analysis yielded a four-factor solution (close relationships, casual friendships and relationships, social bonding, and negative affiliation/emancipation). The total ACIPS-A showed excellent internal consistency, with ordinal alpha=0.95. The ACIPS-A total scores were positively correlated with the TEPS-Anticipatory scores (r=0.44, P<0.001) and TEPS-Consummatory scores (r=0.30, P<0.001) but not with total GHQ-12 scores. The ACIPS-A total scores were negatively correlated with social anhedonia subscale scores (r=-0.55) taken from a measure developed for use with adolescents. These results suggest that the ACIPS-A is a valid measure for use with non-clinical adolescents and is likely to prove useful for screening purposes.
Collapse
Affiliation(s)
- D C Gooding
- University of Wisconsin-Madison, Department of Psychology, Madison, WI, USA; University of Wisconsin-Madison, Department of Psychiatry, Madison, WI, USA.
| | - M J Pflum
- University of Wisconsin-Madison, Department of Psychology, Madison, WI, USA
| | - E Fonseca-Pedero
- University of La Rioja, Department of Educational Sciences, La Rioja, Spain; Center for Biomedical Research in the Mental Health Network (CIBERSAM), Madrid, Spain
| | - M Paino
- University of Oviedo, Department of Psychology, Oviedo, Spain
| |
Collapse
|
|
37
|
van Roekel E, Masselink M, Vrijen C, Heininga VE, Bak T, Nederhof E, Oldehinkel AJ. Study protocol for a randomized controlled trial to explore the effects of personalized lifestyle advices and tandem skydives on pleasure in anhedonic young adults. BMC Psychiatry 2016; 16:182. [PMID: 27260011 PMCID: PMC4893264 DOI: 10.1186/s12888-016-0880-z] [Citation(s) in RCA: 11] [Impact Index Per Article: 1.2] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 04/21/2016] [Accepted: 05/20/2016] [Indexed: 02/08/2023] Open
Abstract
BACKGROUND Anhedonia is generally defined as the inability to feel pleasure in response to experiences that are usually enjoyable. Anhedonia is one of the two core symptoms of depression and is a major public health concern. Anhedonia has proven particularly difficult to counteract and predicts poor treatment response generally. It has often been hypothesized that anhedonia can be deterred by a healthy lifestyle. However, it is quite unlikely that a one-size-fits-all approach will be effective for everyone. In this study the effects of personalized lifestyle advice based on observed individual patterns of lifestyle behaviors and experienced pleasure will be examined. Further, we will explore whether a tandem skydive following the personalized lifestyle advice positively influences anhedonic young adults' abilities to carry out the recommended lifestyle changes, and whether this ultimately improves their self-reported pleasure. METHODS Our study design is an exploratory intervention study, preceded by a cross-sectional survey as a screening instrument. For the survey, 2000 young adults (18-24 years old) will be selected from the general population. Based on survey outcomes, 72 individuals (36 males and 36 females) with persistent anhedonia (i.e., more than two months) and 60 individuals (30 males and 30 females) without anhedonia (non-anhedonic control group) will be selected for the intervention study. The non-anhedonic control group will fill out momentary assessments of pleasure and lifestyle behaviors three times a day, for one month. The anhedonic individuals will fill out momentary assessments for three consecutive months. After the first month, the anhedonic individuals will be randomly assigned to (1) no intervention, (2) lifestyle advice only, (3) lifestyle advice plus tandem skydive. The personalized lifestyle advice is based on patterns observed in the first month. DISCUSSION The present study is the first to examine the effects of a personalized lifestyle advice and tandem skydive on pleasure in anhedonic young adults. Results of the present study may improve treatment for anhedonia, if the interventions are found to be effective. TRIAL REGISTRATION Dutch Trial Register, NTR5498 , registered September 22, 2015 (retrospectively registered).
Collapse
Affiliation(s)
- Eeske van Roekel
- University of Groningen, University Medical Center Groningen, Interdisciplinary Center Psychopathology and Emotion regulation, CC 72, P.O. Box 30001, 9700 RB, Groningen, The Netherlands.
| | - Maurits Masselink
- University of Groningen, University Medical Center Groningen, Interdisciplinary Center Psychopathology and Emotion regulation, CC 72, P.O. Box 30001, 9700 RB, Groningen, The Netherlands
| | - Charlotte Vrijen
- University of Groningen, University Medical Center Groningen, Interdisciplinary Center Psychopathology and Emotion regulation, CC 72, P.O. Box 30001, 9700 RB, Groningen, The Netherlands
| | - Vera E Heininga
- University of Groningen, University Medical Center Groningen, Interdisciplinary Center Psychopathology and Emotion regulation, CC 72, P.O. Box 30001, 9700 RB, Groningen, The Netherlands
| | - Tom Bak
- University of Groningen, University Medical Center Groningen, Interdisciplinary Center Psychopathology and Emotion regulation, CC 72, P.O. Box 30001, 9700 RB, Groningen, The Netherlands
| | - Esther Nederhof
- University of Groningen, University Medical Center Groningen, Interdisciplinary Center Psychopathology and Emotion regulation, CC 72, P.O. Box 30001, 9700 RB, Groningen, The Netherlands
- Van Hall Larenstein, University of Applied Science, Leeuwarden, The Netherlands
| | - Albertine J Oldehinkel
- University of Groningen, University Medical Center Groningen, Interdisciplinary Center Psychopathology and Emotion regulation, CC 72, P.O. Box 30001, 9700 RB, Groningen, The Netherlands
| |
Collapse
|
|
38
|
Leventhal AM, Unger JB, Audrain-McGovern J, Sussman S, Volk HE, Strong DR. Measuring Anhedonia in Adolescents: A Psychometric Analysis. J Pers Assess 2015; 97:506-14. [PMID: 25893676 DOI: 10.1080/00223891.2015.1029072] [Citation(s) in RCA: 48] [Impact Index Per Article: 4.8] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/23/2022]
Abstract
Anhedonia-the reduced capacity to experience pleasure-is a trait implicated in mental and physical health. Yet, psychometric data on anhedonia measures in adolescents are absent. We conducted an in-depth psychometric analysis of the Snaith-Hamilton Pleasure Scale (SHAPS; Snaith et al., 1995 )-a self-report measure of anticipated pleasure response to 14 pleasant experiences-in adolescents. Adolescents (N = 585, M age = 14.5) completed the SHAPS and other paper-and-pencil surveys. Item response theory models were used to evaluate the psychometric performance of each SHAPS item. Correlations of the SHAPS with other personality and psychopathology measures were calculated to evaluate construct validity. Results showed that (a) certain items (e.g., reported pleasure from basic experiences like "seeing smiling faces" or "smelling flowers") provided more information about latent anhedonia than others; and (b) SHAPS scales exhibited construct-consistent convergent and discriminant validity (i.e., stronger correlations with low positive affect constructs, weaker correlations with negative affect). Reporting diminished pleasure from basic pleasant experiences accurately indicates adolescent anhedonia, which is important for future scale development and understanding the phenomenology of anhedonia in teens. These data support using the SHAPS for assessing anhedonia in epidemiological research and school-based universal prevention programming in general adolescent populations.
Collapse
Affiliation(s)
- Adam M Leventhal
- a Department of Preventive Medicine , University of Southern California Keck School of Medicine
| | | | | | | | | | | |
Collapse
|
|
39
|
Oldehinkel AJ, Rosmalen JG, Buitelaar JK, Hoek HW, Ormel J, Raven D, Reijneveld SA, Veenstra R, Verhulst FC, Vollebergh WA, Hartman CA. Cohort Profile Update: the TRacking Adolescents' Individual Lives Survey (TRAILS). Int J Epidemiol 2014; 44:76-76n. [PMID: 25431468 PMCID: PMC4339762 DOI: 10.1093/ije/dyu225] [Citation(s) in RCA: 120] [Impact Index Per Article: 10.9] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/19/2023] Open
Abstract
TRAILS consists of a population cohort (N = 2230) and a clinical cohort (N = 543), both of which were followed from about age 11 years onwards. To date, the population cohort has been assessed five times over a period of 11 years, with retention rates ranging between 80% and 96%. The clinical cohort has been assessed four times over a period of 8 years, with retention rates ranging between 77% and 85%. Since the IJE published a cohort profile on the TRAILS in 2008, the participants have matured from adolescents into young adults. The focus shifted from parents and school to entry into the labour market and family formation, including offspring. Furthermore, psychiatric diagnostic interviews were administered, the database was linked to a Psychiatric Case Registry, and the availability of genome-wide SNP variations opened the door to genome-wide association studies regarding a wide range of (endo)phenotypes. With some delay, TRAILS data are available to researchers outside the TRAILS consortium without costs; access can be obtained by submitting a publication proposal (see www.trails.nl).
Collapse
Affiliation(s)
- Albertine J Oldehinkel
- Department of Psychiatry, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands, Department of Cognitive Neuroscience, Radboud University Medical Centre, Nijmegen, The Netherlands, Parnassia Bavo Academy, The Hague, The Netherlands, Department of Health Sciences, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands, Department of Sociology, University of Groningen, Groningen, The Netherlands, Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Centre, Rotterdam, The Netherlands and Department of Interdisciplinary Social Science, Utrecht University, Utrecht, The Netherlands
| | - Judith Gm Rosmalen
- Department of Psychiatry, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands, Department of Cognitive Neuroscience, Radboud University Medical Centre, Nijmegen, The Netherlands, Parnassia Bavo Academy, The Hague, The Netherlands, Department of Health Sciences, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands, Department of Sociology, University of Groningen, Groningen, The Netherlands, Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Centre, Rotterdam, The Netherlands and Department of Interdisciplinary Social Science, Utrecht University, Utrecht, The Netherlands
| | - Jan K Buitelaar
- Department of Psychiatry, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands, Department of Cognitive Neuroscience, Radboud University Medical Centre, Nijmegen, The Netherlands, Parnassia Bavo Academy, The Hague, The Netherlands, Department of Health Sciences, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands, Department of Sociology, University of Groningen, Groningen, The Netherlands, Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Centre, Rotterdam, The Netherlands and Department of Interdisciplinary Social Science, Utrecht University, Utrecht, The Netherlands
| | - Hans W Hoek
- Department of Psychiatry, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands, Department of Cognitive Neuroscience, Radboud University Medical Centre, Nijmegen, The Netherlands, Parnassia Bavo Academy, The Hague, The Netherlands, Department of Health Sciences, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands, Department of Sociology, University of Groningen, Groningen, The Netherlands, Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Centre, Rotterdam, The Netherlands and Department of Interdisciplinary Social Science, Utrecht University, Utrecht, The Netherlands Department of Psychiatry, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands, Department of Cognitive Neuroscience, Radboud University Medical Centre, Nijmegen, The Netherlands, Parnassia Bavo Academy, The Hague, The Netherlands, Department of Health Sciences, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands, Department of Sociology, University of Groningen, Groningen, The Netherlands, Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Centre, Rotterdam, The Netherlands and Department of Interdisciplinary Social Science, Utrecht University, Utrecht, The Netherlands
| | - Johan Ormel
- Department of Psychiatry, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands, Department of Cognitive Neuroscience, Radboud University Medical Centre, Nijmegen, The Netherlands, Parnassia Bavo Academy, The Hague, The Netherlands, Department of Health Sciences, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands, Department of Sociology, University of Groningen, Groningen, The Netherlands, Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Centre, Rotterdam, The Netherlands and Department of Interdisciplinary Social Science, Utrecht University, Utrecht, The Netherlands
| | - Dennis Raven
- Department of Psychiatry, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands, Department of Cognitive Neuroscience, Radboud University Medical Centre, Nijmegen, The Netherlands, Parnassia Bavo Academy, The Hague, The Netherlands, Department of Health Sciences, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands, Department of Sociology, University of Groningen, Groningen, The Netherlands, Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Centre, Rotterdam, The Netherlands and Department of Interdisciplinary Social Science, Utrecht University, Utrecht, The Netherlands
| | - Sijmen A Reijneveld
- Department of Psychiatry, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands, Department of Cognitive Neuroscience, Radboud University Medical Centre, Nijmegen, The Netherlands, Parnassia Bavo Academy, The Hague, The Netherlands, Department of Health Sciences, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands, Department of Sociology, University of Groningen, Groningen, The Netherlands, Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Centre, Rotterdam, The Netherlands and Department of Interdisciplinary Social Science, Utrecht University, Utrecht, The Netherlands
| | - René Veenstra
- Department of Psychiatry, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands, Department of Cognitive Neuroscience, Radboud University Medical Centre, Nijmegen, The Netherlands, Parnassia Bavo Academy, The Hague, The Netherlands, Department of Health Sciences, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands, Department of Sociology, University of Groningen, Groningen, The Netherlands, Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Centre, Rotterdam, The Netherlands and Department of Interdisciplinary Social Science, Utrecht University, Utrecht, The Netherlands
| | - Frank C Verhulst
- Department of Psychiatry, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands, Department of Cognitive Neuroscience, Radboud University Medical Centre, Nijmegen, The Netherlands, Parnassia Bavo Academy, The Hague, The Netherlands, Department of Health Sciences, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands, Department of Sociology, University of Groningen, Groningen, The Netherlands, Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Centre, Rotterdam, The Netherlands and Department of Interdisciplinary Social Science, Utrecht University, Utrecht, The Netherlands
| | - Wilma Am Vollebergh
- Department of Psychiatry, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands, Department of Cognitive Neuroscience, Radboud University Medical Centre, Nijmegen, The Netherlands, Parnassia Bavo Academy, The Hague, The Netherlands, Department of Health Sciences, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands, Department of Sociology, University of Groningen, Groningen, The Netherlands, Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Centre, Rotterdam, The Netherlands and Department of Interdisciplinary Social Science, Utrecht University, Utrecht, The Netherlands
| | - Catharina A Hartman
- Department of Psychiatry, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands, Department of Cognitive Neuroscience, Radboud University Medical Centre, Nijmegen, The Netherlands, Parnassia Bavo Academy, The Hague, The Netherlands, Department of Health Sciences, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands, Department of Sociology, University of Groningen, Groningen, The Netherlands, Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Centre, Rotterdam, The Netherlands and Department of Interdisciplinary Social Science, Utrecht University, Utrecht, The Netherlands
| |
Collapse
|
|
40
|
Henje Blom E, Duncan LG, Ho TC, Connolly CG, LeWinn KZ, Chesney M, Hecht FM, Yang TT. The development of an RDoC-based treatment program for adolescent depression: "Training for Awareness, Resilience, and Action" (TARA). Front Hum Neurosci 2014; 8:630. [PMID: 25191250 PMCID: PMC4137278 DOI: 10.3389/fnhum.2014.00630] [Citation(s) in RCA: 26] [Impact Index Per Article: 2.4] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/23/2014] [Accepted: 07/28/2014] [Indexed: 01/08/2023] Open
Abstract
Major depressive disorder (MDD) is one of the current leading causes of disability worldwide. Adolescence is a vulnerable period for the onset of depression, with MDD affecting 8–20% of all youth. Traditional treatment methods have not been sufficiently effective to slow the increasing prevalence of adolescent depression. We therefore propose a new model for the treatment of adolescent depression – Training for Awareness, Resilience, and Action (TARA) – that is based on current understanding of developmental and depression neurobiology. The TARA model is aligned with the Research Domain Criteria (RDoC) of the National Institute of Mental Health. In this article, we first address the relevance of RDoC to adolescent depression. Second, we identify the major RDoC domains of function involved in adolescent depression and organize them in a way that gives priority to domains thought to be driving the psychopathology. Third, we select therapeutic training strategies for TARA based on current scientific evidence of efficacy for the prioritized domains of function in a manner that maximizes time, resources, and feasibility. The TARA model takes into consideration the developmental limitation in top-down cognitive control in adolescence and promotes bottom-up strategies such as vagal afference to decrease limbic hyperactivation and its secondary effects. The program has been informed by mindfulness-based therapy and yoga, as well as modern psychotherapeutic techniques. The treatment program is semi-manualized, progressive, and applied in a module-based approach designed for a group setting that is to be conducted one session per week for 12 weeks. We hope that this work may form the basis for a novel and more effective treatment strategy for adolescent depression, as well as broaden the discussion on how to address this challenge.
Collapse
Affiliation(s)
- Eva Henje Blom
- Department of Clinical Neuroscience, Karolinska Institutet Stockholm, Sweden ; Department of Psychiatry, Division of Child and Adolescent Psychiatry, University of California San Francisco San Francisco, CA, USA
| | - Larissa G Duncan
- Department of Family and Community Medicine, University of California San Francisco San Francisco, CA, USA ; Osher Center for Integrative Medicine, University of California San Francisco San Francisco, CA, USA
| | - Tiffany C Ho
- Department of Psychiatry, Division of Child and Adolescent Psychiatry, University of California San Francisco San Francisco, CA, USA
| | - Colm G Connolly
- Department of Psychiatry, Division of Child and Adolescent Psychiatry, University of California San Francisco San Francisco, CA, USA
| | - Kaja Z LeWinn
- Department of Psychiatry, Division of Child and Adolescent Psychiatry, University of California San Francisco San Francisco, CA, USA
| | - Margaret Chesney
- Osher Center for Integrative Medicine, University of California San Francisco San Francisco, CA, USA ; Department of Medicine, University of California San Francisco San Francisco, CA, USA
| | - Frederick M Hecht
- Osher Center for Integrative Medicine, University of California San Francisco San Francisco, CA, USA ; Department of Medicine, University of California San Francisco San Francisco, CA, USA
| | - Tony T Yang
- Department of Psychiatry, Division of Child and Adolescent Psychiatry, University of California San Francisco San Francisco, CA, USA
| |
Collapse
|