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Baxter SM, Bjørge T, Bjerkvig R, Cardwell C, Engeland A, Eriksson J, Habel L, Igland J, Klungsøyr K, Lunde A, Miletic H, Olesen M, Pottegård A, Reutfors J, Sharifian MJ, Linder M, Hicks B. Use of psychotropic medications among glioma patients in Denmark, Norway, Sweden, and Wales. J Neurooncol 2025:10.1007/s11060-025-04996-0. [PMID: 40208515 DOI: 10.1007/s11060-025-04996-0] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/14/2025] [Accepted: 03/01/2025] [Indexed: 04/11/2025]
Abstract
PURPOSE Glioma patients often suffer from psychiatric and neurological conditions. However, little is known about the patterns of use of psychotropic drugs pre- and post-glioma diagnosis. Therefore, we assessed temporal patterns of psychotropic prescriptions among glioma patients, compared to an age and sex matched comparison cohort in four European countries. METHODS Incident gliomas were identified in Wales from the Secured Anonymized Information Linkage Databank (2005-2016) and population-based registries in Denmark (2001-2016), Norway (2006-2019), and Sweden (2008-2018). From each data source, a cancer-free comparison cohort was matched to the glioma cases by age and sex. We calculated rates of new psychotropic prescriptions and any psychotropic prescriptions during the 2 years prior to and post glioma diagnosis. Analyses were stratified by histological subtypes and subclasses of psychotropic medications. RESULTS We identified 16,007 glioma patients. The rate of new psychotropic drug use increased from 7 months before diagnosis, peaking around the month of glioma diagnosis (with peak rates ranging from 227 to 753 new psychotropic drugs per 1000 person-months). New use remained substantially higher among glioma patients than comparators throughout the 2-year follow-up period after glioma diagnosis, though rates of new use continued to decline throughout. New use was largely driven by antiepileptics, anxiolytics, hypnotics, and sedatives. Patterns were similar when analyses were stratified by histological subtype. CONCLUSION Psychotropic drug use among glioma patients was high, and elevations observed around the time of cancer diagnosis, largely driven by antiepileptics, anxiolytics, hypnotics, and sedatives, are likely associated with the consequences of the disease.
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Affiliation(s)
- Sarah M Baxter
- Centre for Public Health, Queen's University Belfast, Belfast, BT12 6BA, Northern Ireland
| | - Tone Bjørge
- Department of Global Public Health and Primary Care, University of Bergen, N-5020, Bergen, Norway
- Cancer Registry of Norway, Norwegian Institute of Public Health, NO-0304, Oslo, Norway
| | - Rolf Bjerkvig
- Department of Biomedicine, University of Bergen, N-5020, Bergen, Norway
| | - Christopher Cardwell
- Centre for Public Health, Queen's University Belfast, Belfast, BT12 6BA, Northern Ireland
| | - Anders Engeland
- Department of Global Public Health and Primary Care, University of Bergen, N-5020, Bergen, Norway
- Department of Chronic Diseases, Norwegian Institute of Public Health, N-0213, Oslo, Norway
| | - Julia Eriksson
- Centre for Pharmacoepidemiology, Karolinska Institutet, 171 76, Stockholm, Sweden
| | - Laurel Habel
- Division of Research, Kaiser Permanente Northern California, Oakland, CA, 94588, USA
| | - Jannicke Igland
- Department of Global Public Health and Primary Care, University of Bergen, N-5020, Bergen, Norway
- Department of Health and Caring Sciences, Western Norway University of Applied Sciences, 5020, Bergen, Norway
| | - Kari Klungsøyr
- Department of Global Public Health and Primary Care, University of Bergen, N-5020, Bergen, Norway
- Division of Mental and Physical Health, Norwegian Institute of Public Health, N-0213, Oslo, Norway
| | - Astrid Lunde
- Department of Global Public Health and Primary Care, University of Bergen, N-5020, Bergen, Norway
| | - Hrvoje Miletic
- Department of Biomedicine, University of Bergen, N-5020, Bergen, Norway
| | - Morten Olesen
- Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health, University of Southern Denmark, 5230, Odense, Denmark
| | - Anton Pottegård
- Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health, University of Southern Denmark, 5230, Odense, Denmark
| | - Johan Reutfors
- Centre for Pharmacoepidemiology, Karolinska Institutet, 171 76, Stockholm, Sweden
| | - Mohammad Jalil Sharifian
- Department of Global Public Health and Primary Care, University of Bergen, N-5020, Bergen, Norway
| | - Marie Linder
- Centre for Pharmacoepidemiology, Karolinska Institutet, 171 76, Stockholm, Sweden
| | - Blánaid Hicks
- Centre for Public Health, Queen's University Belfast, Belfast, BT12 6BA, Northern Ireland.
- Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health, University of Southern Denmark, 5230, Odense, Denmark.
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Bires J. Existing evidence for the use of psychedelics in patients with cancer and other serious illness: A narrative review. J Psychosoc Oncol 2025:1-15. [PMID: 40138527 DOI: 10.1080/07347332.2025.2482917] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 03/29/2025]
Abstract
OBJECTIVES Mood disorders and existential distress impact those with cancer or a serious illness at higher rates than the general population. There have been limited pharmacological advances in recent years, and available psychological interventions vary in degree of impact and durability as a treatment modality in this population. A recent renaissance in psychedelic research has suggested that this class of medications might offer an alternative treatment model for anxiety, depression, and existential and psychological distress that often accompanies the diagnosis of a serious illness. METHODS Utilizing a narrative review approach, EMBASE and PubMed databases were searched with no beginning date range through April 2024 to identify randomized controlled clinical trials (RCTs) on LSD, psilocybin and MDMA in palliative care or oncology and other life limiting illnesses. RESULTS Five articles published between 2011 and 2020 met the inclusion criteria. Three studies utilized psilocybin and one study evaluated MDMA and LSD. The number of participants ranged from 12 to 56 with four studies that utilized a crossover design. Four of the five studies showed a significant decrease in anxiety during at least one time point in their study and three studies indicated a significant decrease in depression. None of the studies reported serious adverse events related to the experimental drug sessions. CONCLUSIONS Psychedelic assisted therapy for the treatment of depression, anxiety and existential distress is a promising treatment modality as an addition or compliment to other available pharmacological and psychotherapeutic treatment modalities.
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Affiliation(s)
- Jennifer Bires
- Inova Health System, Inova Schar Cancer, Life with Cancer, Fairfax, Virginia, USA
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Heyder C, Büntzel J, Boyadzhiev H, Stegmaier P, Zomorodbakhsch B, Heißner K, Stoll C, von Weikersthal LF, Czekay J, Rudolph I, Hübner J. Does anxiety influence the use of complementary or alternative medicine among cancer patients? J Cancer Res Clin Oncol 2025; 151:123. [PMID: 40133678 PMCID: PMC11937123 DOI: 10.1007/s00432-025-06173-2] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/28/2025] [Accepted: 03/14/2025] [Indexed: 03/27/2025]
Abstract
PURPOSE The aim of this study was to investigate the extent to which patients' anxiety due to their cancerous disease has an influence on the use of complementary and alternative medicine (CAM) methods. METHODS 230 patients completed an anonymous voluntary questionnaire that was sent to outpatient oncological facilities participating in the survey. This questionnaire included standardised tests such as the Allgemeine Selbstwirksamkeit Kurzskala (ASKU, self-efficacy short scale) and the State-Trait-Anxiety-Inventory (STAI) as well as socio-demographic information and a section on CAM use. Statistical analyses and regression models were used to identify correlations. RESULTS Female gender, high level of education (high school diploma or university degree) and increased trait anxiety were related to CAM use. All other variables analysed showed no significant results. CONCLUSION This study demonstrates that trait anxiety and sociodemographic factors significantly influence CAM usage among cancer patients. Physicians and health care providers should consider this in consultations to guarantee the best possible care for patients.
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Affiliation(s)
- Caroline Heyder
- Hämatologie Und Internistische Onkologie, Klinik Für Innere Medizin II, Universitätsklinikum Jena, Friedrich-Schiller-Universität Jena, Am Klinikum 1, 07747, Jena, Germany.
| | - Judith Büntzel
- Klinik Für Hämatologie Und Medizinische Onkologie, Universitätsklinikum Göttingen, Robert-Koch-Straße 40, 37075, Göttingen, Germany
| | | | - Petra Stegmaier
- Zentrum Für Strahlentherapie, Wirthstraße 11C, 79110, Freiburg, Germany
| | | | - Klaus Heißner
- MVZ Für Innere Medizin, Hämatologie und Onkologie Weiden, Moslohstraße 53, 92637, Weiden, Germany
| | - Christoph Stoll
- Klinik Für Innere Medizin, Kulmbacher Straße 103, 95445, Bayreuth, Germany
| | | | - Jana Czekay
- Onkologisches Forum Celle E.V, Fritzenwiese 117, 29221, Celle, Germany
| | - Ivonne Rudolph
- Waldburg-Zeil Kliniken, Rehabilitationsklinik Bad Salzelmen, Badepark 5, 39218, Schönebeck, Germany
| | - Jutta Hübner
- Hämatologie Und Internistische Onkologie, Klinik Für Innere Medizin II, Universitätsklinikum Jena, Friedrich-Schiller-Universität Jena, Am Klinikum 1, 07747, Jena, Germany
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4
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Teike Lüthi F, Sterie AC, Guyaz C, Larkin P, Bernard M, Berna C. Home-Based Hypnosis: A Feasibility Study for End-of-Life Patients and Their Relatives. J Pain Symptom Manage 2025:S0885-3924(25)00553-6. [PMID: 40154758 DOI: 10.1016/j.jpainsymman.2025.03.019] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 12/13/2024] [Revised: 03/14/2025] [Accepted: 03/17/2025] [Indexed: 04/01/2025]
Abstract
CONTEXT Palliative care patients facing the end of their life often experience severe symptoms and seek complementary therapies for relief and improved well-being. Clinical hypnosis is a promising mind-body therapy in palliative settings, benefiting both patients and their relatives. Nevertheless, access at the end-of-life can be limited due to symptom severity and restricted mobility. OBJECTIVES This study aimed to assess the feasibility and acceptability of a home-based hypnosis intervention for end-of-life patients to alleviate symptoms and for their relatives to enhance coping resources. METHODS A mixed-method observational feasibility study was conducted from February 2022 to January 2023 in French-speaking Switzerland. Participants included 32 end-of-life patients and 14 relatives, receiving weekly 20-25-minute hypnosis sessions over four weeks. Quantitative data on symptom intensity and well-being were collected using numeric rating scales, while qualitative data were gathered through semi-structured interviews with those who completed the intervention. RESULTS Eighteen patients and eight relatives completed the four-sessions. Significant reductions were observed in patient anxiety (median 6.5-2.0, P=.001) and pain (median 5.0 to 3.0, P=.001). Patient well-being improved across all sessions (median 5-7, P=.001). Relatives reported increased well-being (median 5.0-8.0, P=.001), serenity (median 5.0-8.0, P=.001), and energy levels (median 5.0-7.5, P=.042). High levels of satisfaction and frequent use of self-hypnosis recordings were noted. CONCLUSION A home-based hypnosis intervention was feasible and seemed beneficial for both end-of-life patients and their relatives, reducing symptoms and enhancing coping resources. Future research should build upon these findings to further support the integration of complementary therapies into standard palliative care practices.
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Affiliation(s)
- Fabienne Teike Lüthi
- Chair of Palliative Care Nursing (F.T.L., P.L.), Palliative and Supportive Care Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland; Palliative and Supportive Care Service (A.C.S., M.B.), Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
| | - Anca-Cristina Sterie
- Palliative and Supportive Care Service (A.C.S., M.B.), Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland; Chair of Geriatric Palliative Care (A.C.S.), Service of Palliative and Supportive Care and Service of Geriatrics and Geriatric Rehabilitation, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
| | - Corine Guyaz
- Center for Integrative and Complementary Medicine (C.G., C.B.), Division of Anesthesiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
| | - Philip Larkin
- Chair of Palliative Care Nursing (F.T.L., P.L.), Palliative and Supportive Care Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland; Institute of Higher Education and Research in Healthcare (P.L.), University of Lausanne, Lausanne, Switzerland
| | - Mathieu Bernard
- Palliative and Supportive Care Service (A.C.S., M.B.), Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland; Chair of Palliative Psychology (M.B.), Palliative and Supportive Care Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
| | - Chantal Berna
- Center for Integrative and Complementary Medicine (C.G., C.B.), Division of Anesthesiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
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Alabdulla M, Reagu S, Alishaq M, Al Hammadi N, Hassan Elkordy M, Ghazouani H, Assar AH. The prevalence of depression and anxiety symptoms and their associated factors among patients with cancer in Qatar: A cross-sectional study. Qatar Med J 2025; 2025:4. [PMID: 40134819 PMCID: PMC11934930 DOI: 10.5339/qmj.2025.4] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/08/2024] [Accepted: 11/20/2024] [Indexed: 03/27/2025] Open
Abstract
Background Cancer is a significant global health challenge. One of the biggest health issues that cancer patients face is depression and anxiety. This has a significant impact on their quality of life and treatment outcomes. Aim The aim of this study was to investigate the frequency of depression and anxiety among cancer patients in Qatar. Materials and methods This study was a cross-sectional design using the Patient Health Questionnaire-9 (PHQ-9) and Generalized Anxiety Disorder-7 (GAD-7) scales. A total of 500 cancer patients were surveyed from the National Center for Cancer Care and Research in Doha. Results The study found that a significant proportion of cancer patients suffered from depression, with an average PHQ-9 score indicating mild levels of severity. Depression was commonly categorized as mild, with a smaller percentage experiencing moderate, moderate-to-severe, or severe depression. Additionally, patients were predominantly anxious, as reflected by an average GAD-7 score, with most patients experiencing mild to moderate symptoms, while a few experienced moderate or severe anxiety. These findings highlight the significant prevalence of both depression and anxiety among cancer patients, pointing to the importance of comprehensive mental health support. Moreover, patients with advanced-stage cancer, those in their 40s and 60s, those undergoing radiotherapy or hormone therapy, and female patients were found to be more susceptible to depression and anxiety. Conclusion Treatment of mental health issues is essential to enhancing the effectiveness of cancer treatment. Cancer patients can have a higher quality of life and better adherence to cancer treatments when mental illnesses such as depression and anxiety are identified and treated early. Furthermore, most patients reported having depression and anxiety, according to the study, which showed that these conditions were more common in Qatar than in other countries. Several demographic groups have been linked to higher rates of depression and anxiety, including women, middle-aged adults, people with stage IV cancer, and patients receiving therapies such as radiotherapy and chemotherapy.
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Affiliation(s)
| | - Shuja Reagu
- Department of Psychiatry, Hamad Medical Corporation, Doha, Qatar
| | - Moza Alishaq
- Corporate Quality Improvement and Patient Safety Department, Hamad Medical Corporation, Doha, Qatar
| | - Noora Al Hammadi
- National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar*Correspondence: Mohammed Hassan Elkordy.
| | - Mohammed Hassan Elkordy
- Corporate Quality Improvement and Patient Safety Department, Hamad Medical Corporation, Doha, Qatar
| | - Hafedh Ghazouani
- Corporate Quality Improvement and Patient Safety Department, Hamad Medical Corporation, Doha, Qatar
| | - Ahmed H. Assar
- Department of Psychiatry, Hamad Medical Corporation, Doha, Qatar
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6
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Post KE, Aribindi S, Traeger L, Hall D, Jacobs J, Temel JS, Greer JA. Not out of the woods: perspectives from patients with triple-negative breast cancer. Support Care Cancer 2024; 33:18. [PMID: 39663232 DOI: 10.1007/s00520-024-09084-z] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/05/2024] [Accepted: 12/09/2024] [Indexed: 12/13/2024]
Abstract
PURPOSE Patients with triple-negative breast cancer (TNBC) are at high risk for breast cancer recurrence and metastatic disease, yet the scholarly literature on the distress and uncertainty of this vulnerable population is limited. This study aimed to characterize the experiences of patients with TNBC and obtain feedback about the development of a supportive care intervention targeted to this population's psychosocial needs. METHODS From 9/2021 to 2/2023, we purposefully recruited 23 patients with stage I-III TNBC who recently completed curative therapy and conducted a parallel mixed qualitative and quantitative study. We conducted in-depth semi-structured interviews regarding the transition from curative therapy to surveillance. Patients also completed self-report measures of fear of cancer recurrence (FCR) (Fear of Cancer Recurrence Inventory Severity) and psychological distress (Hospital Anxiety and Depression Scale; PROMIS Anxiety). RESULTS Patients were, on average, 51 years old (SD = 13.56). Most patients (87.0%) reported elevated FCR (cutoff = 16; M = 18.91; SD = 6.22). Major themes identified in the qualitative interviews included feelings of dissimilarity among other breast cancer survivors, quality of life interference persisting in the surveillance phase, "shifting the focus away from cancer" as a coping strategy, and FCR as a primary concern. Patients also shared preferences for a TNBC-specific supportive care intervention. CONCLUSION Patients with TNBC experience significant challenges during the transition from curative therapy to surveillance and desire psychosocial support during this critical period. These findings illustrate potential intervention targets for a future supportive care intervention tailored to patients with TNBC.
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Affiliation(s)
- Kathryn E Post
- Massachusetts General Hospital, Yawkey Center, Suite 9A, 55 Fruit St, Boston, MA, 02114, USA.
- Harvard Medical School, Boston, MA, USA.
| | - Seetha Aribindi
- Georgetown University School of Medicine, Washington, D.C, USA
| | | | - Daniel Hall
- Massachusetts General Hospital, Yawkey Center, Suite 9A, 55 Fruit St, Boston, MA, 02114, USA
- Harvard Medical School, Boston, MA, USA
| | - Jamie Jacobs
- Massachusetts General Hospital, Yawkey Center, Suite 9A, 55 Fruit St, Boston, MA, 02114, USA
- Harvard Medical School, Boston, MA, USA
| | - Jennifer S Temel
- Massachusetts General Hospital, Yawkey Center, Suite 9A, 55 Fruit St, Boston, MA, 02114, USA
- Harvard Medical School, Boston, MA, USA
| | - Joseph A Greer
- Massachusetts General Hospital, Yawkey Center, Suite 9A, 55 Fruit St, Boston, MA, 02114, USA
- Harvard Medical School, Boston, MA, USA
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Bergerot C, Jacobsen PB, Rosa WE, Lam WWT, Dunn J, Fernández-González L, Mehnert-Theuerkauf A, Veeraiah S, Li M. Global unmet psychosocial needs in cancer care: health policy. EClinicalMedicine 2024; 78:102942. [PMID: 39634034 PMCID: PMC11615525 DOI: 10.1016/j.eclinm.2024.102942] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 06/19/2024] [Revised: 10/23/2024] [Accepted: 11/01/2024] [Indexed: 12/07/2024] Open
Abstract
Preventable psychosocial suffering is an unmet need in patients with cancer around the world, significantly compromising quality of life and impairing cancer health outcomes. This narrative review overviews the global prevalence of emotional distress and cancer-related needs and the access barriers to psychosocial care. The COVID-19 pandemic has served only to amplify the need for psychosocial care, exacerbating the inadequacy of available psychosocial resources, particularly in low- and middle-income countries. Proposed solutions include implementing routine screening for emotional distress, addressing stigma related to mental health needs, and increased attention to the psychosocial dimensions of cancer care in oncology training and interprofessional models of care. There is an urgent need to address health policy issues such as resource allocation in cancer control plans and to embrace technological innovation in order to fill the universal gaps to providing more equitable psychosocial cancer care. Funding None.
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Affiliation(s)
- Cristiane Bergerot
- Oncoclinicas&Co - Medica Scientia Innovation Research (MEDSIR), Sao Paulo, Brazil
| | - Paul B. Jacobsen
- Department of Psychology, University of South Florida, Tampa, FL, USA
| | - William E. Rosa
- Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA
| | - Wendy Wing Tak Lam
- LKS Faculty of Medicine, School of Public Health, Centre for Psycho-Oncology Research and Training, The University of Hong Kong, Hong Kong, Hong Kong SAR, China
| | - Jeff Dunn
- Centre for Health Research University of Southern Queensland, Australia
| | | | - Anja Mehnert-Theuerkauf
- Department of Medical Psychology and Medical Sociology, Comprehensive Cancer Center Central Germany (CCCG), University Medical Center Leipzig, Leipzig, Germany
| | - Surendran Veeraiah
- Department of Psycho-Oncology & Resource Centre for Tobacco Control. Cancer Institute, Adyar, Chennai, India
| | - Madeline Li
- Department of Supportive Care, Princess Margaret Cancer Center, University of Toronto, Toronto, Canada
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Chirico A, Palombi T, Alivernini F, Lucidi F, Merluzzi TV. Emotional Distress Symptoms, Coping Efficacy, and Social Support: A Network Analysis of Distress and Resources in Persons With Cancer. Ann Behav Med 2024; 58:679-691. [PMID: 38865355 DOI: 10.1093/abm/kaae025] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 06/14/2024] Open
Abstract
BACKGROUND The study's main aim was to analyze the structure and configuration of distress symptoms and resource factors. PURPOSE Common methods of assessing distress symptoms in cancer patients (i) do not capture the configuration of individual distress symptoms and (ii) do not take into account resource factors (e.g., social support, coping, caring health professionals). Network analysis focuses on the configuration and relationships among symptoms that can result in tailored interventions for distress. Network analysis was used to derive a symptom-level view of distress and resource factors. METHODS Nine hundred and ninety-two cancer patients (mixed diagnoses) completed an abridged Distress Screening Schedule that included 24 items describing symptoms related to distress (depression, anxiety) and resource factors (social support, coping, caring health professionals). RESULTS In network analysis, the centrality strength index (CSI) is the degree to which an item is connected to all other items, thus constituting an important focal point in the network. A depression symptom had the highest CSI value: felt lonely/isolated (CSI = 1.30). In addition, resource factors related to coping efficacy (CSI = 1.20), actively seeking support (CSI = 1.10), perceiving one's doctor as caring (CSI = 1.10), and receiving social support (CSI = 1.10) also all had very high CSI scores. CONCLUSIONS AND IMPLICATIONS These results emphasize the integral importance of the social symptoms of loneliness/isolation in distress. Thus, distress symptoms (loneliness) and resource factors (coping efficacy, seeking social support, and perceiving medical professionals as caring) should be integral aspects of distress management and incorporated into assessment tools and interventions to reduce distress.
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Affiliation(s)
- Andrea Chirico
- Department of Developmental and Social Psychology, Sapienza, University of Rome, Rome, Italy
| | - Tommaso Palombi
- Department of Developmental and Social Psychology, Sapienza, University of Rome, Rome, Italy
| | - Fabio Alivernini
- Department of Developmental and Social Psychology, Sapienza, University of Rome, Rome, Italy
| | - Fabio Lucidi
- Department of Developmental and Social Psychology, Sapienza, University of Rome, Rome, Italy
| | - Thomas V Merluzzi
- Department of Psychology, University of Notre Dame, South Bend, Indiana, USA
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Yu WZ, Wang HF, Huda N, Yen Y, Liu YL, Li CS, Ho YC, Chang HJ. Prevalence and Correlates of Depressive Symptoms among Patients with Cancer: A Cross-Sectional Study. Curr Oncol 2024; 31:5802-5820. [PMID: 39451735 PMCID: PMC11506764 DOI: 10.3390/curroncol31100431] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/21/2024] [Revised: 08/27/2024] [Accepted: 09/20/2024] [Indexed: 10/26/2024] Open
Abstract
The purpose of this study was to identify the correlates of depressive symptoms and the prevalence of depression, distress, and demoralization among patients with cancer in Taiwan in relation to their sociodemographics. A cross-sectional study design with convenience sampling was used to recruit 191 consecutive patients with cancer from the Cancer Center of a teaching hospital in northern Taiwan. Multiple linear regression was applied to analyze the determinants of depressive symptoms. The prevalence rates of depression (including suspected cases), distress, and demoralization were 17.8%, 36.1%, and 32.5%, respectively. The regression model explained 42.2% of the total variance, with significant predictors including marital status, life dependence, comorbidity, demoralization, and distress. The results demonstrated that higher levels of distress and demoralization were associated with more depressive symptoms. Demoralization and distress played vital roles in moderating depressive symptoms among patients with cancer. Nursing interventions should integrate appropriate mental health services, such as alleviating distress and demoralization, to prevent the occurrence of depression in patients with cancer.
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Affiliation(s)
- Wei-Zhen Yu
- School of Nursing, College of Nursing, Taipei Medical University, Taipei 110301, Taiwan;
- Nursing Department, Min-Sheng General Hospital, Taoyuan 330056, Taiwan
| | - Hsin-Fang Wang
- Cancer Medical Center, Lo-Hsu Medical Foundation, Lotung Poh-Ai Hospital, Yilan 265501, Taiwan;
| | - Nurul Huda
- Nursing Faculty, Universitas Riau, Pekanbaru 28131, Indonesia;
| | - Yun Yen
- Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 110301, Taiwan;
| | - Yen-Lin Liu
- Taipei Cancer Center, Taipei Medical University, Taipei 110301, Taiwan;
- Pediatric Oncology, Department of Pediatrics, Taipei Medical University Hospital, Taipei 110301, Taiwan
- Department of Pediatrics, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110301, Taiwan
| | - Chia-Sui Li
- Department of Community Medicine, En Chu Kong Hospital, New Taipei City 237414, Taiwan;
| | - Yen-Chung Ho
- Department of Nursing & Graduate Institute of Nursing, College of Nursing, Asia University, Taichung 413305, Taiwan;
| | - Hsiu-Ju Chang
- College of Nursing, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan
- Efficient Smart Care Research Center, College of Nursing, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan
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10
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Giesler JM, Weis J. Changes in health-related quality of life, depression, and fear of progression during oncological inpatient rehabilitation and beyond: a longitudinal study. Support Care Cancer 2024; 32:626. [PMID: 39225728 PMCID: PMC11371859 DOI: 10.1007/s00520-024-08800-z] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/27/2024] [Accepted: 08/11/2024] [Indexed: 09/04/2024]
Abstract
PURPOSE Studies evaluating oncological inpatient rehabilitation rarely include follow-up intervals beyond 6 months and larger proportions of patients other than those with breast cancer. Therefore, this study investigated changes in health-related quality of life (HRQoL), depression, and fear of progression of patients with breast, colorectal, or prostate cancer from the beginning to the end of oncological rehabilitation and a 9-month follow-up. METHODS Three hundred seventy-seven patients with breast, colorectal, or prostate cancer undergoing oncological inpatient rehabilitation (median age 61 years, 49% female) completed the EORTC QLQ-C30, the PHQ-9, and the FoP-Q-SF at each measurement point. Data analysis used 3 (tumor site) × 3 (time of measurement) repeated measures ANCOVAs with patient age and time since diagnosis as covariates. At each time point, we also compared our sample to the general population on the measures used. RESULTS Having controlled for the covariates, we found significant effects of tumor site, which were small except for Diarrhea. Effects of time of measurement were often significant and in part at least medium in size indicating improvement of HRQoL and depression during rehabilitation. At follow-up, some HRQoL domains and depression deteriorated. Women with breast cancer, in particular, showed a greater decrease in emotional functioning then. Compared to the general population, the sample's HRQoL and depression were significantly worse on most occasions. CONCLUSION Oncological inpatient rehabilitation may improve HRQoL. The subsequent and in part differential deterioration in some HRQoL domains suggests a need for further follow-up care within survivorship programs.
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Affiliation(s)
- Jürgen M Giesler
- Section of Health Care Research and Rehabilitation Research, Institute of Medical Biometry and Statistics, University of Freiburg Medical Center, Hugstetter Str. 49, 79106, Freiburg, Germany.
| | - Joachim Weis
- Comprehensive Cancer Center, Department of Self-Help Research, University of Freiburg Medical Center, Freiburg, Germany
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11
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Mehnert-Theuerkauf A, Springer F. [Psycho-oncology-psychosocial distress and supportive care needs]. UROLOGIE (HEIDELBERG, GERMANY) 2024; 63:878-885. [PMID: 38995422 DOI: 10.1007/s00120-024-02395-3] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Accepted: 06/26/2024] [Indexed: 07/13/2024]
Abstract
The number of patients living with or after cancer is constantly increasing due to improved diagnostics and care as well as the ageing society. This is particularly true for the group of older cancer survivors with complex health and supportive care needs. For many of those affected and their relatives, the disease and its treatment are accompanied by high levels of emotional stress, an impaired quality of life, and a variety of psychosocial challenges. Psychosocial distress, such as depression and anxiety, sometimes persists for years after treatment has ended. The most common unmet supportive care needs of patients include psychological and emotional needs as well as information needs. Therefore, it is essential to implement effective psychosocial screening and low-threshold needs-based referral to evidence-based psycho-oncological support services. Around a third of all cancer patients express a desire for professional psycho-oncological support. Although there is compelling evidence that psycho-oncological interventions can reduce psychosocial distress and improve quality of life, there is a need for further research into the design and effectiveness of intervention services for specific subgroups, such as prostate cancer patients.
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Affiliation(s)
- Anja Mehnert-Theuerkauf
- Abteilung für Medizinische Psychologie und Medizinische Soziologie, Universitätsklinikum Leipzig, Philipp-Rosenthal-Straße 55, 04103, Leipzig, Deutschland.
| | - Franziska Springer
- Abteilung für Medizinische Psychologie und Medizinische Soziologie, Universitätsklinikum Leipzig, Philipp-Rosenthal-Straße 55, 04103, Leipzig, Deutschland
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12
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Proctor M, Cassisi JE, Dvorak RD, Decker V. Medical tattooing as a complementary cosmetic intervention to reduce body-image distress and mental health symptoms in U.S. breast cancer survivors. Support Care Cancer 2024; 32:600. [PMID: 39167227 DOI: 10.1007/s00520-024-08809-4] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/13/2024] [Accepted: 08/13/2024] [Indexed: 08/23/2024]
Abstract
PURPOSE A review of the literature revealed a high incidence of body-image distress among breast cancer survivors who had surgery. This cross-sectional study examined the relationship between medical tattooing as a complementary cosmetic intervention and body-image distress and mental health outcomes among breast cancer survivors following surgery. METHODS We examined 330 post-surgical breast cancer survivors collected through a nationwide online survey in the U.S., pursuing two main objectives. First, we investigated body-image distress, depression and anxiety symptoms, and perceived stress in survivors who underwent breast cancer surgery, comparing those with medical tattooing (n = 89) and those without (n = 226). Second, we assessed the influence of the participant's surgery type on body-image distress, depression and anxiety symptoms, and perceived stress. Additionally, we evaluated whether individual factors, such as appearance investment, satisfaction with decision, and cosmetic expectation discrepancy, predicted the participant's body-image distress. RESULTS Findings suggest that participants with medical tattoos reported significantly lower body-image distress, depression and anxiety symptoms, and perceived stress compared to those without medical tattoos. The participant's surgery type did not significantly predict body-image distress, depression or anxiety symptoms, or perceived stress. However, participants who reported greater appearance investment endorsed higher body-image distress. Participants who reported higher satisfaction with their treatment decisions and lower cosmetic expectation discrepancy endorsed lower body-image distress. CONCLUSION Medical tattooing may be a valuable tool in improving body-image distress and mental health for those who wish to pursue it, but more research is needed. Empirical studies supporting the mental health benefits of medical tattooing among survivors are crucial to standardize insurance coverage and promote its inclusion as a complementary intervention across insurance providers nationwide. This complementary intervention should be considered using a patient-centered approach that aligns with the patient's values and preferences.
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Affiliation(s)
- Miranda Proctor
- College of Sciences, Department of Psychology, University of Central Florida, Pictor Lane, Psychology Bldg. Room 320, Orlando, FL, USA.
| | - Jeffrey E Cassisi
- College of Sciences, Department of Psychology, University of Central Florida, Pictor Lane, Psychology Bldg. Room 320, Orlando, FL, USA
| | - Robert D Dvorak
- College of Sciences, Department of Psychology, University of Central Florida, Pictor Lane, Psychology Bldg. Room 320, Orlando, FL, USA
| | - Veronica Decker
- College of Nursing, Department of Nursing Systems, University of Central Florida, Orlando, FL, 32816-2385, USA
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13
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Bakhsh A, Abudari G, Alhaidar S, Shamsy S, Alqahtani A, Haddadi R, Almsaud M, Callaghan S, Ahmad F. Prevalence of Anxiety, Depression, and Distress and Their Association With Problems Encountered by Advanced Cancer Patients in a Tertiary Hospital in Saudi Arabia. Cureus 2024; 16:e66219. [PMID: 39233933 PMCID: PMC11374431 DOI: 10.7759/cureus.66219] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 08/05/2024] [Indexed: 09/06/2024] Open
Abstract
BACKGROUND Patients with advanced cancer often suffer from significant psychological distress, anxiety, and depression, which can profoundly influence their quality of life. This study aimed to evaluate the prevalence and severity of these psychological factors in advanced cancer patients. Additionally, it sought to identify related psychosocial, practical, emotional, and physical problems and their association with the psychological factors. Furthermore, this study provides interventions and strategies to help mitigate the psychological burden experienced by these patients. METHODS A cross-sectional survey involving 180 patients with advanced cancer was conducted at a tertiary hospital in Saudi Arabia. Participants were assessed using the Distress Thermometer (DT) and the Hospital Anxiety and Depression Scale (HADS). Data analysis included descriptive statistics, chi-square tests for categorical variables, and multivariate regression to explore the factors associated with distress, anxiety, and depression. RESULTS The prevalence of distress, anxiety, and depression among patients was 40.6%, 46.1%, and 52.2%, respectively. Patients who experienced 'changes in urination' which is an item in DT had a 2.86 times higher risk of developing distress. Patients experiencing sadness (item in DT) and fatigue (item in DT) were at a 3.91 and 2.29 times higher risk of developing anxiety, respectively. Practical problems, such as childcare and treatment decisions, emotional problems, and physical problems, such as appearance, bathing/dressing, and eating difficulties, were significantly associated with distress. There was no significant association between patients' demographics and psychological factors. CONCLUSION The findings underscore the complex interplay of psychosocial, practical, emotional, and physical problems faced by advanced cancer patients receiving palliative care. These patients exhibit a high percentage of distress, anxiety, and depression. Addressing these multifaceted problems through targeted psychological and social interventions can significantly enhance the overall care and quality of life for this vulnerable population. This study advocates routine psychological screenings and tailored interventions to mitigate the psychological burden in this group.
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Affiliation(s)
- Abdulaziz Bakhsh
- Oncology Center, King Faisal Specialist Hospital and Research Centre, Riyadh, SAU
| | - Gassan Abudari
- Oncology Nursing, King Faisal Specialist Hospital and Research Centre, Riyadh, SAU
| | - Saud Alhaidar
- Oncology Center, King Faisal Specialist Hospital and Research Centre, Riyadh, SAU
| | - Saad Shamsy
- Oncology Center, King Faisal Specialist Hospital and Research Centre, Riyadh, SAU
| | - Ahlam Alqahtani
- Oncology Nursing, King Faisal Specialist Hospital and Research Centre, Riyadh, SAU
| | - Rania Haddadi
- Oncology Nursing, King Faisal Specialist Hospital and Research Centre, Riyadh, SAU
| | - Maiadh Almsaud
- Department of Social Services, King Faisal Specialist Hospital and Research Centre, Riyadh, SAU
| | - Steven Callaghan
- Oncology Nursing, King Faisal Specialist Hospital and Research Centre, Riyadh, SAU
| | - Fawad Ahmad
- Oncology Center, King Faisal Specialist Hospital and Research Centre, Riyadh, SAU
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14
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Shea S, Lionis C, Kite C, Lagojda L, Uthman OA, Dallaway A, Atkinson L, Chaggar SS, Randeva HS, Kyrou I. Non-alcoholic fatty liver disease and coexisting depression, anxiety and/or stress in adults: a systematic review and meta-analysis. Front Endocrinol (Lausanne) 2024; 15:1357664. [PMID: 38689730 PMCID: PMC11058984 DOI: 10.3389/fendo.2024.1357664] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/09/2024] [Accepted: 03/22/2024] [Indexed: 05/02/2024] Open
Abstract
Background Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease, affecting 25-30% of the general population globally. The condition is even more prevalent in individuals with obesity and is frequently linked to the metabolic syndrome. Given the known associations between the metabolic syndrome and common mental health issues, it is likely that such a relationship also exists between NAFLD and mental health problems. However, studies in this field remain limited. Accordingly, the aim of this systematic review and meta-analysis was to explore the prevalence of one or more common mental health conditions (i.e., depression, anxiety, and/or stress) in adults with NAFLD. Methods PubMed, EBSCOhost, ProQuest, Ovid, Web of Science, and Scopus were searched in order to identify studies reporting the prevalence of depression, anxiety, and/or stress among adults with NAFLD. A random-effects model was utilized to calculate the pooled prevalence and confidence intervals for depression, anxiety and stress. Results In total, 31 studies were eligible for inclusion, involving 2,126,593 adults with NAFLD. Meta-analyses yielded a pooled prevalence of 26.3% (95% CI: 19.2 to 34) for depression, 37.2% (95% CI: 21.6 to 54.3%) for anxiety, and 51.4% (95% CI: 5.5 to 95.8%) for stress among adults with NAFLD. Conclusion The present findings suggest a high prevalence of mental health morbidity among adults with NAFLD. Given the related public health impact, this finding should prompt further research to investigate such associations and elucidate potential associations between NAFLD and mental health morbidity, exploring potential shared underlying pathophysiologic mechanisms. Systematic review registration https://www.crd.york.ac.uk/prospero/, identifier CRD42021288934.
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Affiliation(s)
- Sue Shea
- Warwick Medical School, University of Warwick, Coventry, United Kingdom
- Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism (WISDEM), University Hospitals Coventry and Warwickshire NHS Trust, Coventry, United Kingdom
| | - Christos Lionis
- Laboratory of “Health and Science” School of Medicine, University of Crete, Heraklion, Greece
- Department of Health, Medicine and Caring Sciences, University of Linkoping, Linkoping, Sweden
- Department of Nursing, Frederick University, Nicosia, Cyprus
| | - Chris Kite
- Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism (WISDEM), University Hospitals Coventry and Warwickshire NHS Trust, Coventry, United Kingdom
- School of Health and Society, Faculty of Education, Health and Wellbeing, University of Wolverhampton, Wolverhampton, United Kingdom
- Chester Medical School, University of Chester, Shrewsbury, United Kingdom
- Centre for Sport, Exercise and Life Sciences, Research Institute for Health & Wellbeing, Coventry University, Coventry, United Kingdom
| | - Lukasz Lagojda
- Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism (WISDEM), University Hospitals Coventry and Warwickshire NHS Trust, Coventry, United Kingdom
- Clinical Evidence-Based Information Service (CEBIS), University Hospitals Coventry and Warwickshire NHS Trust, Coventry, United Kingdom
| | - Olalekan A. Uthman
- Division of Health Sciences, Warwick Centre for Global Health, Warwick Medical School, University of Warwick, Coventry, United Kingdom
| | - Alexander Dallaway
- Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism (WISDEM), University Hospitals Coventry and Warwickshire NHS Trust, Coventry, United Kingdom
- School of Health and Society, Faculty of Education, Health and Wellbeing, University of Wolverhampton, Wolverhampton, United Kingdom
| | - Lou Atkinson
- Warwick Medical School, University of Warwick, Coventry, United Kingdom
- Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism (WISDEM), University Hospitals Coventry and Warwickshire NHS Trust, Coventry, United Kingdom
- iPrescribe Exercise Digital Ltd (EXI), London, United Kingdom
| | | | - Harpal S. Randeva
- Warwick Medical School, University of Warwick, Coventry, United Kingdom
- Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism (WISDEM), University Hospitals Coventry and Warwickshire NHS Trust, Coventry, United Kingdom
- Centre for Sport, Exercise and Life Sciences, Research Institute for Health & Wellbeing, Coventry University, Coventry, United Kingdom
- Institute of Cardiometabolic Medicine, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, United Kingdom
| | - Ioannis Kyrou
- Warwick Medical School, University of Warwick, Coventry, United Kingdom
- Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism (WISDEM), University Hospitals Coventry and Warwickshire NHS Trust, Coventry, United Kingdom
- Centre for Sport, Exercise and Life Sciences, Research Institute for Health & Wellbeing, Coventry University, Coventry, United Kingdom
- Institute of Cardiometabolic Medicine, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, United Kingdom
- Aston Medical School, College of Health and Life Sciences, Aston University, Birmingham, United Kingdom
- College of Health, Psychology and Social Care, University of Derby, Derby, United Kingdom
- Laboratory of Dietetics and Quality of Life, Department of Food Science and Human Nutrition, School of Food and Nutritional Sciences, Agricultural University of Athens, Athens, Greece
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Wu JR, Chen VCH, Fang YH, Hsieh CC, Wu SI. The associates of anxiety among lung cancer patients: Dehydroepiandrosterone (DHEA) as a potential biomarker. BMC Cancer 2024; 24:476. [PMID: 38622547 PMCID: PMC11021003 DOI: 10.1186/s12885-024-12195-9] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/27/2023] [Accepted: 03/27/2024] [Indexed: 04/17/2024] Open
Abstract
OBJECTIVE Anxiety is a prevalent comorbidity in lung cancer (LC) patients associated with a decline in quality of life. Dehydroepiandrosterone (DHEA), a neuroactive steroid, levels rise in response to stress. Prior research on the association between DHEA and anxiety has yielded contradictory results and no study has investigated this association in LC patients. METHODS A total of 213 patients with LC were recruited from a general hospital. Data on demographic and cancer-related variables were collected. Using the Chinese version of the Hospital Anxiety and Depression Scale (HADS), the degree of anxiety was determined. Cortisol, DHEA, and Dehydroepiandrosterone sulfate (DHEA-S) levels in saliva were measured. Adjusting for confounding variables, a multivariate regression analysis was conducted. RESULTS 147 men and 66 women comprised our group with an average age of 63.75 years. After accounting for demographic and treatment-related factors, anxiety levels were significantly correlated with, post-traumatic stress symptoms (PTSSs) (β = 0.332, p < 0.001) and fatigue (β = 0.247, p = 0.02). Association between anxiety and three factors, including DHEA, PTSSs, and fatigue, was observed in patients with advanced cancer stages (III and IV) (DHEA β = 0.319, p = 0.004; PTSS β = 0.396, p = 0.001; fatigue β = 0.289, p = 0.027) and those undergoing chemotherapy (DHEA β = 0.346, p = 0.001; PTSS β = 0.407, p = 0.001; fatigue β = 0.326, p = 0.011). CONCLUSIONS The association between anxiety and DHEA remained positive in advanced cancer stages and chemotherapy patients. Further study is necessary to determine whether DHEA is a potential biomarker of anxiety in LC patients.
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Affiliation(s)
- Jia-Rong Wu
- Department of Psychiatry, Chang Gung Memorial Hospital, 6, Sec. West Chia-Pu Road, 613, Pu-Zi City, Chiayi County, Taiwan
| | - Vincent Chin-Hung Chen
- Department of Psychiatry, Chang Gung Memorial Hospital, 6, Sec. West Chia-Pu Road, 613, Pu-Zi City, Chiayi County, Taiwan
- School of Medicine, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan Tao-Yuan, Taiwan
| | - Yu-Hung Fang
- Division of Thoracic Oncology, Department of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, 6, Sec. West Chia-Pu Road, 613, Pu-Zi City, Chiayi County, Taiwan
| | - Ching-Chuan Hsieh
- Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang-Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan Tao-Yuan, Taiwan
- Department of Surgery, Chang-Gung Memorial Hospital, 6, Sec. West Chia-Pu Road, 613, Pu-Zi City, Chiayi County, Taiwan
| | - Shu-I Wu
- Department of Medicine, Mackay Medical College, No.46, Sec.3, Zhongzheng Rd., Sanzhi Dist, 25245, New Taipei City, Taiwan.
- Department of Psychiatry, Mackay Memorial Hospital, No. 92, Sec. 2, Zhongshan N. Rd., Zhongshan Dist., 104, Taipei City, Taiwan.
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Kaphle M, Bajracharya D, Regmi N, Aryal D, Karki R. Depression and anxiety among cancer patients visiting a tertiary care cancer hospital. World J Psychiatry 2024; 14:287-295. [PMID: 38464775 PMCID: PMC10921282 DOI: 10.5498/wjp.v14.i2.287] [Citation(s) in RCA: 1] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 09/29/2023] [Revised: 12/25/2023] [Accepted: 01/19/2024] [Indexed: 02/06/2024] Open
Abstract
BACKGROUND Cancer patients frequently experience psychological problems related to reactions to cancer diagnosis, cancer type and stage, treatment effects, recurrence, fear of end-of-life, survivorship, and financial burden. Depression and anxiety are both psychological and physiological disturbances among cancer patients. AIM To assess the prevalence of depression and anxiety among cancer patients attending a tertiary care cancer hospital. METHODS A cross-sectional study was conducted at Bhaktapur Cancer Hospital in Kathmandu Valley among 220 cancer patients aged from 18 years to 70 years. Ethical approval was taken from the Institutional Review Committee of CiST College. Convenient sampling was used to interview patients with the standardized Patient-Health Questionnaire (PHQ-9) for Depression and Hospital Anxiety and Depression sub-scale (HADS-A) for anxiety. Epi-Data was used for data entry and transferred to SPSS Version 25 for analysis. RESULTS The study revealed that of 220 patients, most of the respondents belonged to the age group 51-60 years. More than half 131 (59.6%) of the respondents were female, most of them had depression, and one-third had anxiety. Among the respondents, 124 (56.4%) had mild depression, 70 (31.8%) had moderate depression, and 3 (1.3%) had severe depression; 79 (35.9%) had mild anxiety, 64 (29.1%) had moderate anxiety, and 4 (1.8%) had severe anxiety. CONCLUSION Most respondents were depressed and one-third had anxiety. More than half and nearly one-third had mild and moderate depression, respectively, and nearly one-third had mild and moderate anxiety, which is higher than other studies.
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Affiliation(s)
- Maheshor Kaphle
- Department of Public Health, Peoples Dental College and Hospital, Tribhuvan University, Kathmandu 44600, Bagmati, Nepal
| | - Diya Bajracharya
- Department of Public Health, CiST College, Pokhara University, Kathmandu 44600, Bagmati, Nepal
| | - Nirmala Regmi
- Department of Oncology, Kanti Hospital, Maharajgunj, Kathmandu 44600, Nepal
| | - Dipsikha Aryal
- Department of Public Health, Peoples Dental College and Hospital, Tribhuvan University, Kathmandu 44600, Bagmati, Nepal
| | - Rajesh Karki
- Central Department of Public Health, Institute of Medicine, Tribhuvan University, Maharajgunj, Kathmandu 44600, Bagmati, Nepal
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Ghowinam MA, Albokhari AA, Badheeb AM, Lamlom M, Alwadai M, Hamza A, Aladalah A. Prevalence of Depression and Anxiety Symptoms Among Patients With Cancer in Najran, Saudi Arabia. Cureus 2024; 16:e54349. [PMID: 38500908 PMCID: PMC10945987 DOI: 10.7759/cureus.54349] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 02/17/2024] [Indexed: 03/20/2024] Open
Abstract
BACKGROUND Depression and anxiety are associated with poor health consequences in patients with cancer, and these mental health issues may affect cancer treatment. They are frequently triggered by stress, and cancer is among the most stressful conditions experienced by a person. Depression and anxiety are related to several sociodemographic variables in patients with cancer. However, only a few studies have examined the prevalence of depression and anxiety symptoms in patients with cancer in Saudi Arabia. OBJECTIVES To detect the prevalence of depression and anxiety symptoms among patients with cancer at the Najran Oncology Center in Najran, Saudi Arabia, and determine the risk factors associated with these symptoms. METHODS A cross-sectional study was conducted from April 1, 2023, to September 30, 2023, on a convenience sample of patients diagnosed with cancer who were receiving chemotherapy at Najran Oncology Center, King Khalid Hospital, Najran, Saudi Arabia, and who agreed to participate in the study. The Hospital Anxiety and Depression Scale was used. Data on the demographic characteristics of the patients were collected using a self-administered questionnaire. Moreover, medical data were collected from the medical records of the patients. RESULTS In total, 92 patients with various cancer diagnoses were recruited in this study. Among them, 51 and 41 were women and men, respectively. Moreover, 81 were married and 11 were either single, widow, or divorced. The mean age of the participants was 51.24 ± 15.15 years. The prevalence rates of depression and anxiety were 42.4% and 23.9%, respectively. There were significant associations between depression and marital status in patients with cancer-associated pain and those with a current history of chemotherapy. Furthermore, the association between anxiety and cancer-associated pain was significant. However, marital status was not associated with anxiety. Age, sex, family history of mental disorders, cancer duration, current cancer stage, and surgical interventions were not associated with the prevalence of depression and anxiety. CONCLUSIONS Our findings underline the importance of identifying depression and anxiety in patients with cancer. Marital status, presence of pain, and current chemotherapy history were significantly associated with depression and pain with anxiety. RECOMMENDATIONS Further studies with a higher number of patients with cancer should be conducted in Saudi Arabia and other Arab countries. Screening for depression and anxiety symptoms should be a part of the comprehensive evaluation of patients with cancer. Appropriate treatment interventions must be provided to patients with cancer who present with mental disorders.
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Affiliation(s)
| | | | | | | | - Mari Alwadai
- Psychiatry, Eradah Complex and Mental Health Services, Najran, SAU
| | - Aseel Hamza
- Psychiatry, Eradah Complex and Mental Health Services, Jeddah, SAU
| | - Ali Aladalah
- Psychiatry, Eradah Complex and Mental Health Services, Najran, SAU
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