Revealing the neurophysiological mechanisms underlying pain empathy has profound implications for the understanding of social emotions and pain regulation. This study aimed to elucidate the mechanisms by which pain empathy modulates individual experiences, focusing on two primary questions: When individuals empathize with pain, do they attend more to the emotional content associated with pain or the nociceptive experience itself? How does lexical labeling modulate negative affect during pain empathy? In this EEG study, we employed a labeling paradigm divided into pain labeling, affect labeling and tool labeling to distinguish emotional content from the nociceptive experience of pain stimuli. We collected data from 39 participants and analyzed their EEG components and frequency-specific brain activity across the experimental conditions. Cross-frequency coupling analyses were conducted to uncover the mechanisms by which pain empathy modulates emotional responses. Our findings revealed that compared to pain labeling and tool labeling, affect labeling more effectively reduces the negative affect associated with pain empathy. This was evidenced by the decreased amplitude of the P300 component and lower theta-band activity within the prefrontal cortex, predominantly during the later stages of labeling. Additionally, affect labeling was associated with enhanced theta-gamma phase-amplitude coupling, with theta phase modulation in the posterior parietal and sensorimotor cortices influencing prefrontal gamma-band activity. These results suggest that, during pain empathy, individuals allocate greater attentional and cognitive resources to the emotional aspects of pain. Thus, implicit regulation of pain empathy involves coordinated interactions across multiple brain regions.

Previous studies have shown that high-arousal positive and negative facial expressions influence event-related potential (ERP) and time-frequency responses depending on attentional focuses. However, little is known about how relevant neural responses are influenced by surprised facial expressions, which are also high in arousal but ambiguous in valence. To address the issue, 38 participants were presented with surprised, happy, angry and neutral facial expressions. Attention was manipulated to focus on facial emotional attributes, facial non-emotional attributes, non-facial attributes, or was free to the participants. ERP results showed larger N170 responses to surprised compared to neutral facial expressions when attention focused on facial attributes and to surprised compared to angry and neutral facial expressions when attention focused on facial non-emotional attributes. Time-frequency analyses revealed reduced power of early occipital theta to surprised compared to happy and angry expressions when attention focused on facial emotions and to surprised compared to angry expressions when attention focused on non-facial stimuli. Parietal delta power was smaller for surprised facial expressions than for angry facial expressions when attention focused on facial emotions and for surprised facial expressions than for angry and neutral facial expressions when attention was directed to non-facial stimuli. These findings might suggest that neural responses to surprised facial expressions are modulated by attentional focus.

The effectiveness of imagery rescripting (IR) in reducing psychological symptoms associated with aversive memories has been confirmed across various disorders. To better understand the neural mechanisms underlying IR, we assessed the immediate and lasting effects and their associations with imagery tendency by using unpleasant pictures depicting child maltreatment within a population with childhood maltreatment (CM) history. Participants (n = 68) were instructed to engage in two experimental phases while electroencephalogram was recorded. In the rescripting phase, participants viewed neutral or unpleasant pictures and then either imagined the same pictures or rescripted unpleasant ones to assess immediate effect. In the re-exposure phase, participants passively viewed all pictures without instruction to assess lasting effect. Participants rated their subjective valence and imagery vividness in the rescripting phase or intensity of negative feelings in the re-exposure phase. IR led to an attenuation of the late positive potential (LPP) amplitude in the late time window (2000-6000 ms at parietal-occipital electrodes) and a decrease in self-reported unpleasantness during the rescripting phase. After 5-min interval, unpleasant pictures with rescripted history elicited smaller LPP (400-1500 ms at centro-parietal electrodes) and negative feelings than those with imagery history in the re-exposure phase. The higher habitual use of imagery was associated with a greater reduction in late LPP during the rescripting phase and full-time range LPP during the re-exposure phase. The current findings suggest that IR has an immediate effect and a lasting effect on subjective and neural response in the CM population. Individuals with higher imagery tendency are likely to profit more from IR.

Negative emotions are common among patients in medical settings. It is important to investigate impacts of patient power and affect labeling on emotional experience in patients.

Behavioral judgments and event-related potentials (ERPs) were recorded while participants with high or low patient power made emotional judgments (positive, negative) about neutral faces, as well as investigating how affect labeling (affect labeling, viewing) influenced emotional judgments about neutral faces in participants with low patient power.

Individuals with low patient power made more and faster negative emotion judgements. A larger late positive component (LPC) amplitude was found in negative emotion judgments for individuals with low patient power, a component related to allocation of attentional resources to motivationally salient stimuli. Affect labeling elicited less and slower negative emotion judgments in individuals with low patient power.

These results suggest that low patient power triggers negative emotion, which can be reduced by affect labeling.

The current findings provide valuable insights into reducing negative emotions in patients, fostering promising targets for training for medical professionals and education for patients aiming to ensure more humanistic and higher-quality care delivery.

A questionnaire survey and an event-related potential (ERP) experiment were used to reveal the impact of safety attitudes on risk perception. The results revealed that during hazard identification, the N130 amplitude of subjects with negative safety attitude was significantly higher, which implied that subjects with negative safety attitude were more likely to feel confused. During risk analysis, subjects with positive safety attitude were more inclined to overestimate the probability and damage degree of risks; subjects with positive safety attitudes displayed higher P150 and late positive potential amplitudes, which indicated that subjects with positive safety attitudes devoted more attention to risks in the early stage of risk analysis and had a more intense affective response in the later period. The risk judgment ability of subjects with positive safety attitude was affected by time pressure, and they exhibited higher risk judgment accuracy only under no time pressure.

In daily life, faces are often memorized within contexts involving interpersonal interactions. However, little is known about whether interpersonal interaction-related contexts influence face memory. The present study aimed to understand this question by investigating how social comparison-related context affects face encoding and recognition. To address this issue, 40 participants were informed that they and another player each played a monetary game and were then presented with both of their outcomes (either monetary gain or loss). Subsequently, participants were shown the face of the player whom they were just paired with. After all the faces had been encoded, participants were asked to perform a sudden old/new recognition task involving these faces. The results showed that, during the encoding phase, another player's monetary gain, compared to loss, resulted in more negative responses in the N170 and early posterior negativity (EPN)/N250 to relevant players' faces when participants encountered monetary loss and a smaller late positive potential (LPP) response irrespective of self-related outcomes. In the subsequent recognition phase, preceding another player's monetary gain as compared to loss led to better recognition performance and stronger EPN/N250 and LPP responses to the faces of relevant players when participants had lost some amount of money. These findings suggest that the social comparison-related context, particularly self-disadvantageous outcomes in the context, influences the memory of comparators' faces.

Panic disorder (PD) involves emotion dysregulation, but its underlying mechanisms remain poorly understood. Previous research suggests that implicit emotion regulation may play a central role in PD-related emotion dysregulation and symptom maintenance. However, there is a lack of studies exploring the neural mechanisms of implicit emotion regulation in PD using neurophysiological indicators.

To study the neural mechanisms of implicit emotion regulation in PD with event-related potentials (ERP).

A total of 25 PD patients and 20 healthy controls (HC) underwent clinical eva-luations. The study utilized a case-control design with random sampling, selecting participants for the case group from March to December 2018. Participants performed an affect labeling task, using affect labeling as the experimental condition and gender labeling as the control condition. ERP and behavioral data were recorded to compare the late positive potential (LPP) within and between the groups.

Both PD and HC groups showed longer reaction times and decreased accuracy under the affect labeling. In the HC group, late LPP amplitudes exhibited a dynamic pattern of initial increase followed by decrease. Importantly, a significant group × condition interaction effect was observed. Simple effect analysis revealed a reduction in the differences of late LPP amplitudes between the affect labeling and gender labeling conditions in the PD group compared to the HC group. Furthermore, among PD patients under the affect labeling, the late LPP was negatively correlated with disease severity, symptom frequency, and intensity.

PD patients demonstrate abnormalities in implicit emotion regulation, hampering their ability to mobilize cognitive resources for downregulating negative emotions. The late LPP amplitude in response to affect labeling may serve as a potentially valuable clinical indicator of PD severity.