Alpha-glutamyl-tryptophan as adjuvant reparative therapy after Helicobacter pylori eradication in chronic atrophic gastritis: A case report and literature review

Figure 1  Study design illustrating the timeline of patient evaluation and treatment.

Figure 2 Histological changes in gastric mucosal gland before and after eradication therapy and adjuvant reparative therapy with alpha-glutamyl-tryptophan. A: Pretreatment biopsy demonstrating reduced gland density and features of atrophic gastritis; B: Post-treatment biopsy demonstrating an increase in the number of glands per 1 mm² of gastric mucosa. Staining with hematoxylin and eosin; scale bar = 100 µm (× 100 magnification). Hematoxylin–eosin staining was used to visualize tissue architecture and identify pathological changes associated with gastric mucosal atrophy.

Figure 3 Histological changes in metaplastic atrophy of the gastric mucosa before and after eradication therapy and adjuvant reparative therapy with alpha-glutamyl-tryptophan. A: Pretreatment biopsy demonstrating intestinal metaplasia with alcian blue-positive mucin staining; B: Post-treatment biopsy demonstrating reduction of alcian blue-positive metaplastic changes. Alcian blue staining (pH 2.5); scale bar = 100 µm (× 100 magnification). Alcian blue staining was used to identify acidic mucins and assess intestinal metaplasia of the gastric mucosa.