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World J Pharmacol. Sep 16, 2026; 15(2): 120862
Published online Sep 16, 2026. doi: 10.5497/wjp.120862
Published online Sep 16, 2026. doi: 10.5497/wjp.120862
Alpha-glutamyl-tryptophan as adjuvant reparative therapy after Helicobacter pylori eradication in chronic atrophic gastritis: A case report and literature review
Natalia V Baryshnikova, Department of Molecular Microbiology (named after the Academician A.A. Totolyan), Institute of Experimental Medicine, St. Petersburg 197376, Russia
Natalia V Baryshnikova, Zaurbek K Gulunov, Yury P Uspenskiy, Department of Faculty Therapy (named after the professor V.A. Waldman), St. Petersburg State Pediatric Medical University, St. Petersburg 194100, Russia
Author contributions: Baryshnikova NV contributed to study conceptualization, methodology, software, formal analysis, investigation, and supervision; Gulunov ZK contributed to validation; Baryshnikova NV and Gulunov ZK contributed to resources, data curation, and writing of the original draft; Uspenskiy YP contributed to visualization and project administration; all authors have read and approved the final version of the manuscript.
AI contribution statement: Artificial intelligence (AI) tools, specifically ChatGPT, were used solely for linguistic refinement and formatting assistance. No AI tool was involved in the generation of research data, interpretation of results, or formulation of conclusions. All AI-generated content was critically reviewed and revised by the authors before submission.
Informed consent statement: Informed written consent was obtained from the patient for the publication of this report and any accompanying images.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Natalia V Baryshnikova, Department of Molecular Microbiology (named after the Academician A.A. Totolyan), Institute of Experimental Medicine, Pavlova 12A, St. Petersburg 197376, Russia. baryshnikova_nv@mail.ru
Received: March 10, 2026
Revised: May 13, 2026
Accepted: May 26, 2026
Published online: September 16, 2026
Processing time: 185 Days and 11.3 Hours
Revised: May 13, 2026
Accepted: May 26, 2026
Published online: September 16, 2026
Processing time: 185 Days and 11.3 Hours
Core Tip
Core Tip: The use of alpha-glutamyl-tryptophan as adjuvant reparative therapy following Helicobacter pylori (H. pylori) eradication may represent a promising approach to supporting gastric mucosal recovery and attenuating inflammatory activity in patients with H. pylori-associated chronic atrophic gastritis.