Basic Study
Copyright ©The Author(s) 2023.
World J Pharmacol. Jun 16, 2023; 12(3): 25-34
Published online Jun 16, 2023. doi: 10.5497/wjp.v12.i3.25
Figure 1
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Figure 1 Structures of Amurensinine and Ifenprodil. A: Amurensinine in the non-protonated state; B: Amurensinine in the protonated state at pH 7.4; C: Ifenprodil. These structures were designed using ACD/Schemsketch software.
Figure 2
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Figure 2 Binding geometry of antagonists to the amino terminal domain on the GluN1A/GluN2B N-methyl-D-Aspartate receptor. A: Non-protonated Amurensinine; B: Protonated Amurensinine; C: Ifenprodil. The structures in thick sticks are the antagonists; the thin sticks are the amino acid residues of the receptor. Chemical bonds are represented by dashed lines. These structures were designed using ACD/Schemsketch software.
Figure 3
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Figure 3 Structure of the GluN1A/GluN2B N-methyl-D-Aspartate receptor. A: The dashed circle indicates the amino terminal domain (ATD). A-Chain: Orange; B-Chain: Green; C-Chain: Red; D-Chain: Blue. In the B-Chain are located the binding sites for Amurensinine and Ifenprodil; B: B-Chain with Ifenprodil (red) and non-protonated Amurensinine (pink) bound to the ATD. These structures were designed using ACD/Schemsketch software.