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World J Pharmacol. Dec 9, 2014; 3(4): 110-119
Published online Dec 9, 2014. doi: 10.5497/wjp.v3.i4.110
Published online Dec 9, 2014. doi: 10.5497/wjp.v3.i4.110
Harnessing pharmacological knowledge for personalized medicine and pharmacotyping: Challenges and lessons learned
Ioannis S Vizirianakis, Laboratory of Pharmacology, Department of Pharmaceutical Sciences, School of Health Sciences, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece
Author contributions: Vizirianakis IS contributed to this manuscript from its concept to writing and submission
Correspondence to: Ioannis S Vizirianakis, PhD, Laboratory of Pharmacology, Department of Pharmaceutical Sciences, School of Health Sciences, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece. ivizir@pharm.auth.gr
Telephone: +30-2310-997658 Fax: +30-2310-997645
Received: June 12, 2014
Revised: October 17, 2014
Accepted: October 28, 2014
Published online: December 9, 2014
Revised: October 17, 2014
Accepted: October 28, 2014
Published online: December 9, 2014
Core Tip
Core tip: Drug prescription in order to be improved, the drug delivery process needs to confront the challenges of genomics knowledge translation to ensure the maximum clinical outcome for most, if not all, patients, i.e., achieving pharmacotyping. The practical clinical utility of personalized medicine decisions needs to be documented and validated in the clinical setting. Physiologically based pharmacokinetic models represent an approach by which the faster and more efficient implementation of pharmacogenomics knowledge in evidence-based medicine could be achieved. Pharmacotyping represents a major challenge in modern therapeutics for which pharmacologists needs to work both in academia and research in successfully fulfilling this task.