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Dasuqi SA, Alshaer LM, Omran RA, Hamad MA. Recurrent ciprofloxacin induced hypoglycemia in a non-diabetic patient: A case report. World J Pharmacol 2023; 12(2): 12-17 [DOI: 10.5497/wjp.v12.i2.12]
World J Pharmacol. Mar 22, 2023; 12(2): 12-17 Published online Mar 22, 2023. doi: 10.5497/wjp.v12.i2.12
Recurrent ciprofloxacin induced hypoglycemia in a non-diabetic patient: A case report
Shereen A Dasuqi, Linah M Alshaer, Rasha A Omran, Mohammed A Hamad
Shereen A Dasuqi, Department of Pharmacy, King Khalid University Hospital, King Saudi University Medical City, Riyadh 11362, Saudi Arabia
Linah M Alshaer, College of Pharmacy, Almaarefa University, Riyadh 11234, Saudi Arabia
Rasha A Omran, Department of Pharmaceutics and Pharmaceutical Technology, School of Pharmacy, University of Jordan, Amman 11180, Jordan
Mohammed A Hamad, Critical Care, King Khalid University Hospital, King Saud University Medical City, Riyadh 11362, Saudi Arabia
Mohammed A Hamad, Department of Acute Medicine, Wirral University Teaching Hospital NHS Foundation Trust, Arrowe Park Hospital, Wirral, Merseyside CH49 5PE, United Kingdom
Author contributions: All the authors wrote the manuscript, contributed to the case report, interpreted the data, and edited the manuscript; All authors have read and agreed to the published version of the manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All the authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Shereen A Dasuqi, BCPS, BSc, MSc, Adjunct Associate Professor, Chief Pharmacist, Pharmacist, Department of Pharmacy, King Khalid University Hospital, King Saudi University Medical City, Riyadh KSA, Riyadh 11362, Saudi Arabia. shereen.dasuqi@gmail.com
Received: November 25, 2022 Peer-review started: November 25, 2022 First decision: January 31, 2023 Revised: February 13, 2023 Accepted: March 9, 2023 Article in press: March 9, 2023 Published online: March 22, 2023 Processing time: 115 Days and 12.9 Hours
Core Tip
Core Tip: Fluoroquinolones are a class of broad-spectrum antimicrobials used to treat various bacterial infections. Frequent use has been doubted due to associated adverse severe effects, including hypoglycemia or hyperglycemia due to an alternation in glucose metabolism. Recent clinical trials showed the association of poor clinical outcomes with hypoglycemia in critically ill patients without diabetes, emphasizing the harm of severe hypoglycemia. Ciprofloxacin has demonstrated the lowest incidence in the class in the diabetic population. We report a case of recurrent ciprofloxacin-induced hypoglycemia for non-diabetic critically ill patient despite total parenteral nutrition and nasogastric tube feeding. The hypoglycemia resolved successfully after ciprofloxacin discontinuation.
