Published online Jun 20, 2020. doi: 10.5496/wjmg.v9.i1.1
Peer-review started: March 14, 2020
First decision: April 12, 2020
Revised: April 19, 2020
Accepted: May 14, 2020
Article in press: May 14, 2020
Published online: June 20, 2020
Core tip: Chromatinopathies are a highly heterogeneous group of syndromic conditions in which the underlying genetic anomaly consists of disruption of one of the components of the epigenetic machinery. Within this group, which contains more than 40 diseases, including Kabuki, Sotos, Kleefstra, Koolen-De-Vries/KANSL1 haploinsufficiency, Rubinstein-Taybi, KAT6B-related syndromes, Smith-Magenis, Rett, Townes-Brock, Bohring-Opitz, ATRX, CHARGE, and Floating-Harbor syndromes, an emerging member is represented by Wiedemann-Steiner syndrome, which has very interesting features.