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World J Med Genet. Sep 30, 2026; 14(1): 115237
Published online Sep 30, 2026. doi: 10.5496/wjmg.115237
Published online Sep 30, 2026. doi: 10.5496/wjmg.115237
Mineralocorticoid receptor genetics: A scoping review
Sebastián Pedro Antonio Jaurretche, Uro-Onco-Nephrology and Transplant, Sanatorio Parque SA, Rosario 2000, Santa Fe, Argentina
Sebastián Pedro Antonio Jaurretche, Clara Balañá, Renata Máxima Bascolo, Biophysics and Human Physiology, School of Medicine, Instituto Universitario Italiano de Rosario, Rosario 2000, Santa Fe, Argentina
Author contributions: Jaurretche SPA contributed to manuscript conceptualization and writing, methodological design, and final manuscript revision; Balañá C, Bascolo RM contributed to writing of the manuscript and performed the research. All authors approved the final version of the manuscript.
AI contribution statement: AI tools (ChatGpt) were used solely for linguistic refinement and formatting assistance. No AI tool was involved in the generation of research data, interpretation of results, or formulation of conclusions. All AI-generated outputs were critically reviewed and revised by the authors.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest with the content of this manuscript.
Corresponding author: Sebastián Pedro Antonio Jaurretche, Professor, Uro-Onco-Nephrology and Transplant, Sanatorio Parque SA, Oroño 860, Rosario 2000, Santa Fe, Argentina.
Received: October 14, 2025
Revised: November 20, 2025
Accepted: February 11, 2026
Published online: September 30, 2026
Processing time: 352 Days and 13.6 Hours
Revised: November 20, 2025
Accepted: February 11, 2026
Published online: September 30, 2026
Processing time: 352 Days and 13.6 Hours
Core Tip
Core Tip: The mineralocorticoid receptor (MR) has emerged as a multifaceted regulator extending beyond electrolyte and blood pressure control to roles in cardiovascular, renal, metabolic, and neural physiology. In addition, MR is expressed in various tissues and organs in humans. However, the genetic dimension of MR function remains underexplored, and the genotype-phenotype correlation is only known for a few MR gene mutations. The genetics of the MR determine its functionality; therefore, a better understanding of it can be the basis of a personalized medicine approach.